Biology And Therapeutic Potential Of Brown Adipose Tissue

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Biology and therapeutic potential of brown adipose tissue

Author : Patrick Seale
Publisher : Frontiers E-books
ISBN 13 : 2889191346
Total Pages : 135 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Biology and therapeutic potential of brown adipose tissue by : Patrick Seale

Download or read book Biology and therapeutic potential of brown adipose tissue written by Patrick Seale and published by Frontiers E-books. This book was released on 2013-06-03 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brown adipose tissue (BAT) has long been recognized as a key thermogenic tissue in eutherian mammals. Brown fat cells contain large numbers of highly specialized mitochondria that oxidize fat and carbohydrate to produce heat. This metabolic inefficiency is due to the presence of Ucp1 in the inner mitochondrial membrane of brown fat cells which dissociates the electrochemical gradient from ATP production. BAT presumably evolved to protect animals against hypothermia in response to cold exposure. However, energy expended by BAT has the added benefit of counteracting obesity and associated metabolic disease, at least in rodents. A very large number of studies have consistently shown that mice carrying increased amounts of active brown fat are lean and healthy. Until recently, it was generally believed that the amount of brown fat tissue was negligible in healthy adult humans. However, PET imaging studies have refuted this notion, and revealed the existence of active BAT in most, if not all, adult humans. Notably, there is a very strong inverse correlation between the amount of activated BAT and fatness in humans. Moreover, activated brown fat is lost with ageing, which also correlates with tendency to gain weight. The field must now address whether variation in brown fat activity is a cause or consequence of weight gain. Brown fat cells are localized in discrete depots of BAT and are also found as clusters interspersed in white fat tissues. The prevalence and function of these so-called “brite” (brown in white) cells in humans remains unknown. The development of strategies to increase the amount and/or activity of brown fat may hold exciting prospects for the treatment of obesity and its associated health consequences. In this Research Topics issue, we would propose to examine the following areas related to brown fat biology: 1. Development of brown and “brite” cells (including: historical/evolutionary perspective, transcriptional pathways, developmental origins) 2. Pathways that influence brown fat cell development (BMP7, TZDs, Prostaglandins, FGF21) 3. Activation of brown fat - focus on sympathetic and sensory innervation (signaling by beta-adrenergic receptors, nerve-fat connections 4. Brown fat thermogenesis in response to cold, diet and hibernation 5. Brown fat in humans including: human brown fat precursors, methods for imaging, factors that influence prevalence, relationship between body mass/obesity and amount of brown fat. 6. Brown fat mitochondria including mechanism of uncoupling (Ucp1 history/structure/function, mitochondrial biogenesis.

The Adipose Organ

Author : Saverio Cinti
Publisher :
ISBN 13 : 9788885030329
Total Pages : 94 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis The Adipose Organ by : Saverio Cinti

Download or read book The Adipose Organ written by Saverio Cinti and published by . This book was released on 1999 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Adipose-Derived Stem Cells

Author : Jeffrey M. Gimble
Publisher : Humana Press
ISBN 13 : 9781617379611
Total Pages : 474 pages
Book Rating : 4.3/5 (796 download)

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Book Synopsis Adipose-Derived Stem Cells by : Jeffrey M. Gimble

Download or read book Adipose-Derived Stem Cells written by Jeffrey M. Gimble and published by Humana Press. This book was released on 2011-08-24 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, a wide range of scientific disciplines have adopted the use of adipose-derived stem/stromal cells (ASCs) as an important tool for research and discovery. In Adipose-Derived Stem Cells: Methods and Protocols, experts from the field, including members of the esteemed International Federation of Adipose Therapeutics and Science (IFATS), provide defined and established protocols in order to further codify the utilization of these powerful and accessible cells. With chapters organized around approaches spanning the discovery, pre-clinical, and clinical processes, much of the emphasis is placed on human ASC, while additional techniques involving small and large animal species are included. As a volume in the highly successful Methods in Molecular BiologyTM series, the detailed contributions include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Adipose-Derived Stem Cells: Methods and Protocols serves as a vital reference text for experienced researchers as well as new students on the path to further exploring the incredible potential of ASCs.

Cellular Metabolism and Related Disorders

Author : Jesmine Khan
Publisher : BoD – Books on Demand
ISBN 13 : 1838801812
Total Pages : 230 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Cellular Metabolism and Related Disorders by : Jesmine Khan

Download or read book Cellular Metabolism and Related Disorders written by Jesmine Khan and published by BoD – Books on Demand. This book was released on 2020-07-15 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with a vital topic: metabolism in the cells of the body and various disorders due to its imbalance and/or diseases that disrupt the metabolism of the body. The objective of this book was to collect and compile up-to-date information from reputed researchers in their respective fields to disseminate the latest information about topics that have profound effects on the metabolic processes in the body including insulin resistance, diabetes mellitus, hypothyroidism, metabolic syndrome, glycogen storage disease, and the urea cycle disorder. In total, there are 12 chapters in this book in which the authors have shared their research findings and real-life experiences in managing their patients.

Adipose Tissue in Health and Disease

Author : Todd Leff
Publisher : John Wiley & Sons
ISBN 13 : 9783527629534
Total Pages : 530 pages
Book Rating : 4.6/5 (295 download)

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Book Synopsis Adipose Tissue in Health and Disease by : Todd Leff

Download or read book Adipose Tissue in Health and Disease written by Todd Leff and published by John Wiley & Sons. This book was released on 2010-03-19 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.

Metabolism and Pathophysiology of Bariatric Surgery

Author : Victor R Preedy
Publisher : Academic Press
ISBN 13 : 0128040637
Total Pages : 685 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Metabolism and Pathophysiology of Bariatric Surgery by : Victor R Preedy

Download or read book Metabolism and Pathophysiology of Bariatric Surgery written by Victor R Preedy and published by Academic Press. This book was released on 2016-11-26 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathophysiology of Bariatric Surgery: Metabolism, Nutrition, Procedures, Outcomes and Adverse Effects uses a metabolic and nutritional theme to explain the complex interrelationships between obesity and metabolic profiles before and after bariatric surgery. The book is sectioned into seven distinct areas, Features of Obesity, Surgical Procedures, Nutritional Aspects, Metabolic Aspects, Diabetes, Insulin Resistance and Glucose Control, Cardiovascular and Physiological Effects, and Psychological and Behavioral Effects. Included is coverage on the various types of bariatric surgery, including Roux-en-Y gastric bypass, gastric banding, sleeve gastrectomy, biliopancreatic diversion, and jejunoileal bypass, as well as the variations upon these procedures. - Provides information on diet, nutrition, surgical procedures, outcomes, and side effects in relation to bariatric surgery in one comprehensive text - Contains a Dictionary of Terms, Key Facts, and Summary Points in each chapter - Includes access to a companion website with accompanying videos

Epicardial Adipose Tissue

Author : Gianluca Iacobellis
Publisher : Springer Nature
ISBN 13 : 3030405702
Total Pages : 198 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Epicardial Adipose Tissue by : Gianluca Iacobellis

Download or read book Epicardial Adipose Tissue written by Gianluca Iacobellis and published by Springer Nature. This book was released on 2020-03-25 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease. It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic targets of EAT in atrial fibrillation, heart failure and coronary artery disease. Comprehensive yet focused, Epicardial Adipose Tissue: From Cell to Clinic is an essential resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.

Clinical Anatomy by Systems

Author : Richard S. Snell
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781791649
Total Pages : 964 pages
Book Rating : 4.7/5 (916 download)

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Book Synopsis Clinical Anatomy by Systems by : Richard S. Snell

Download or read book Clinical Anatomy by Systems written by Richard S. Snell and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 964 pages. Available in PDF, EPUB and Kindle. Book excerpt: Included CD-ROM contains clinical notes, information on congenital anomalies, radiographic anatomy, and clinical problem-solving exercises, all of which correlate directly with the text.

Genomic and Precision Medicine

Author : Geoffrey S. Ginsburg
Publisher : Academic Press
ISBN 13 : 0128006544
Total Pages : 372 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genomic and Precision Medicine by : Geoffrey S. Ginsburg

Download or read book Genomic and Precision Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2017-03-30 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care. One of the major areas where genomic and personalized medicine is most active is the realm of the primary care practitioner. Risk, family history, personal genomics and pharmacogenomics are becoming increasingly important to the PCP and their patients, and this book discusses the implications as they relate to primary care practitioners. - Presents a comprehensive volume for primary care providers - Provides succinct commentary and key learning points that will assist providers with their local needs for the implementation of genomic and personalized medicine - Includes a current overview on major opportunities for genomic and personalized medicine in practice - Highlights case studies that illustrate the practical use of genomics in the management in patients

Multidisciplinary Approach to Obesity

Author : Andrea Lenzi
Publisher : Springer
ISBN 13 : 3319090453
Total Pages : 346 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Multidisciplinary Approach to Obesity by : Andrea Lenzi

Download or read book Multidisciplinary Approach to Obesity written by Andrea Lenzi and published by Springer. This book was released on 2014-11-18 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes in detail the multidisciplinary management of obesity, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical exercise, psychological issues, nutritional strategies, pharmacological options and bariatric surgery. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of obesity, which has rapidly become a major public health problem.

Tissue-Specific Cell Signaling

Author : Joana Vieira Silva
Publisher : Springer Nature
ISBN 13 : 3030444368
Total Pages : 444 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Tissue-Specific Cell Signaling by : Joana Vieira Silva

Download or read book Tissue-Specific Cell Signaling written by Joana Vieira Silva and published by Springer Nature. This book was released on 2020-05-29 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Obesity

Author : Shamim I. Ahmad
Publisher : Springer
ISBN 13 : 3319198211
Total Pages : 375 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Obesity by : Shamim I. Ahmad

Download or read book Obesity written by Shamim I. Ahmad and published by Springer. This book was released on 2015-10-19 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings a comprehensive treatise about obesity, examining the measures that can be taken to stop and even reduce obesity if these right measures are taken in time. Recent studies show that obesity is on the increase at an alarming rate, especially in the industrialized and affluent countries. A number of reasons have been put forward for this increase, including life style choices, over-eating, over-use of commercially processed food, addiction for fast food, high caloric diet specially containing high levels of sugar and fat, lack of exercise and sedentary life style. Also genetic make up has been associated with obesity. Obesity can lead to a variety of lethal diseases, notably coronary heart disease, cancer and diabetes. These diseases account for the highest number of human death amongst all other causes. There are also a number of other side effects associated with obesity including increased stress, loss of intelligentsia, pancreatitis, premature birth and osteoarthritis. In recent years media have been playing important roles in highlighting the lethality and damage caused by obesity, nevertheless no significant effects can be seen in the population and obesity remains on the increase, especially amongst children. The editors believe that it is important that more education, campaign and research are used to stop this increasing disease.

Obesity and Diabetes

Author : Joel Faintuch
Publisher : Springer Nature
ISBN 13 : 3030533700
Total Pages : 994 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Obesity and Diabetes by : Joel Faintuch

Download or read book Obesity and Diabetes written by Joel Faintuch and published by Springer Nature. This book was released on 2020-12-14 with total page 994 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its second edition, this comprehensive handbook provides a state-of-the-art overview of recent advances in drug and non-drug therapies for obesity and diabetes. It also addresses major comorbidities, covering topics such as, cardiovascular diseases, renal and neuropsychiatric disorders, appetite control and micro RNAs. Special attention is also devoted to pediatric care, including the latest recommendations for therapy and prevention. Obesity and type 2 diabetes are among the top global health-care budget concerns worldwide and impact professional practice at all levels: in hospitals, clinics and physicians’ offices alike. They prominently feature in headlines, and virtually no family, community or country is exempt from their protean, deleterious consequences. Furthermore, given the multiple intersections in their pathways, they often go hand in hand. The good news is that scientific advances in all fields, including genomics, metabolomics, lipidomics and microbiomics, are increasing our understanding of these two disease areas. At the same time, artificial intelligence, machine learning, mobile health and advanced implantable and external devices are rendering prevention and management more available, safe and cost-effective. In addition, bariatric and metabolic surgery has evolved from a niche specialty to an officially endorsed option for several modalities of obesity and diabetes. This book presents the latest lifestyle, pharmacological, surgical and non-surgical treatment options, including endoscopic intervention and cell therapy. Objectively reviewing natural and artificial sweeteners and critically examining issues such as public health initiatives, government mandated taxes for unhealthy foods and environmental planning, no stone is left unturned in gathering the latest practical information. As such, the book will appeal to seasoned specialists, as well as students and healthcare professionals in training.

Free Fatty Acid Receptors

Author : Graeme Milligan
Publisher : Springer
ISBN 13 : 3319506935
Total Pages : 258 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Free Fatty Acid Receptors by : Graeme Milligan

Download or read book Free Fatty Acid Receptors written by Graeme Milligan and published by Springer. This book was released on 2017-02-08 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.

Williams Textbook of Endocrinology

Author : Robert Hardin Williams
Publisher : W B Saunders Company
ISBN 13 : 9780721691848
Total Pages : 1927 pages
Book Rating : 4.6/5 (918 download)

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Book Synopsis Williams Textbook of Endocrinology by : Robert Hardin Williams

Download or read book Williams Textbook of Endocrinology written by Robert Hardin Williams and published by W B Saunders Company. This book was released on 2003 with total page 1927 pages. Available in PDF, EPUB and Kindle. Book excerpt: The state-of-the-art, tenth edition of endocrinology's classic text bridges the gap between basic science and endocrinology clinical practice. Thoroughly revised and updated, it includes new material on the thyroid and diabetes mellitus to reflect today's explosive increase in knowledge. Written by an outstanding team of authors, the 10th edition features numerous new authors who provide fresh perspectives. Presents a wealth of clinical information in a manageable size and format Contributors are at the forefronts of their disciplines Serves as a bridge between basic science and clinical endocrinology Diabetes mellitus and it complications has been greatly expanded and now includes 3 separate chapters. 4 new chapters Two new editors provide a fresh perspective on the material Figures have been added to the Diabetes Mellitus chapters Much of the art has been revised and includes new algorithms in many chapters Access to abstracts is available through Medline With 71 expert contributors

Angiogenesis in Adipose Tissue

Author : Yihai Cao
Publisher : Springer Science & Business Media
ISBN 13 : 1461480698
Total Pages : 374 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Angiogenesis in Adipose Tissue by : Yihai Cao

Download or read book Angiogenesis in Adipose Tissue written by Yihai Cao and published by Springer Science & Business Media. This book was released on 2013-09-05 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis has recently played a critical role in regulation of adipose tissue expansion and regression. Like most other tissues in the body, adipose expansion and regression is accompanied by alteration of blood vessel density and structures. The vascular alteration plays an active role in regulation of adipose tissue size and functions. Targeting blood vessels in the adipose tissue have demonstrated to be a novel approach for possibly treatment of cancer, obesity and other metabolic diseases. This book provides the most updated information on this type research and discusses future opportunities for therapy..

Brown Adipose Tissue

Author : Alexander Pfeifer
Publisher : Springer
ISBN 13 : 303010513X
Total Pages : 418 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Brown Adipose Tissue by : Alexander Pfeifer

Download or read book Brown Adipose Tissue written by Alexander Pfeifer and published by Springer. This book was released on 2019-04-02 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.