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Biological Roles Of Sialic Acid
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Book Synopsis Biological Roles of Sialic Acid by : Abraham Rosenberg
Download or read book Biological Roles of Sialic Acid written by Abraham Rosenberg and published by Springer. This book was released on 2012-04-02 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a startling amount of research activity concerning the role of sialic acid in mammalian cells and in the mammalian organism. One may discern in the early literature premonitions of compounds containing sialic acid, traceable by descriptions of color reactions, as far back as the turn of the century. Work spanning the 1930s to the 1950s culmi nated in the crystallization of sialic acid from a wide variety of biological materials. The ubiquitous nature of the sialic acids, and the biological importance of the substances in which they occur, then became generally manifest. Since then, the chemistry and metabolism of sialic acid and its occurrence, notably, but not exclusively, in the outer cell surfaces of mammalian cells and in key extracellular glycoproteins, have received great attention. The involvement of sialic acid-containing substances in tumorigenicity and in numerous metabolic and infectious pathological conditions, and in the growth, development, and integrity of mammalian cells has achieved widespread recognition. Intensive inquiry into the biological roles of sialic acid continues in a large number of research laboratories throughout the world. This book is intended to represent for the uninitiated as well as for the expert a wide and detailed overview of the current state of knowledge. Major efforts and pioneering break throughs have emerged from several laboratories, located on both sides of the Atlantic, of which we make no special individual mention here since they will to some extent appear in the pages that follow.
Book Synopsis Essentials of Glycobiology by : Ajit Varki
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Book Synopsis Biological Roles of Sialic Acid by : Abraham Rosenberg
Download or read book Biological Roles of Sialic Acid written by Abraham Rosenberg and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a startling amount of research activity concerning the role of sialic acid in mammalian cells and in the mammalian organism. One may discern in the early literature premonitions of compounds containing sialic acid, traceable by descriptions of color reactions, as far back as the turn of the century. Work spanning the 1930s to the 1950s culmi nated in the crystallization of sialic acid from a wide variety of biological materials. The ubiquitous nature of the sialic acids, and the biological importance of the substances in which they occur, then became generally manifest. Since then, the chemistry and metabolism of sialic acid and its occurrence, notably, but not exclusively, in the outer cell surfaces of mammalian cells and in key extracellular glycoproteins, have received great attention. The involvement of sialic acid-containing substances in tumorigenicity and in numerous metabolic and infectious pathological conditions, and in the growth, development, and integrity of mammalian cells has achieved widespread recognition. Intensive inquiry into the biological roles of sialic acid continues in a large number of research laboratories throughout the world. This book is intended to represent for the uninitiated as well as for the expert a wide and detailed overview of the current state of knowledge. Major efforts and pioneering break throughs have emerged from several laboratories, located on both sides of the Atlantic, of which we make no special individual mention here since they will to some extent appear in the pages that follow.
Book Synopsis Biology of the Sialic Acids by : A. Rosenberg
Download or read book Biology of the Sialic Acids written by A. Rosenberg and published by Springer Science & Business Media. This book was released on 1995-07-31 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abraham Rosenberg assembles the groundbreaking work of preeminent international scientists to provide the most current, state-of-the-art presentation of research in siabiology. This concise volume examines the historical development of the field and reviews current knowledge on the genetic, immunologic, oncologic, neurodevelopmental, pathogenic, and cell regulatory properties of sialic acid. Outstanding features of this work include exhaustive reference material and detailed information tables.
Book Synopsis Biological Roles of Sialic Acid by : Abraham Rosenberg
Download or read book Biological Roles of Sialic Acid written by Abraham Rosenberg and published by . This book was released on 2014-01-15 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Glycoconjugates by : Martin Horowitz
Download or read book The Glycoconjugates written by Martin Horowitz and published by Elsevier. This book was released on 2012-12-02 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Glycoconjugates: Mammalian Glycoproteins and Glycolipids, Volume I is a collaboration of different experts in the field of molecular biology on the subject of glycoconjugates. The text discusses the historical aspect, nomenclature, biosynthesis, and catabolism of glycoconjugates and their role in normal and pathological processes. Also covered are topics such as the purification of glycoproteins; the elucidation of the amino acid sequence of glycoproteins; the glycoproteins found in the different parts of the human body; glycoenzymes; and glycohormones. The book is recommended for molecular biologists, organic chemists, and biochemists who would like to know more about glycolipids and glycoproteins and their applications.
Book Synopsis Selective Glycosylations by : Clay S. Bennett
Download or read book Selective Glycosylations written by Clay S. Bennett and published by John Wiley & Sons. This book was released on 2017-01-25 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive summary of novel approaches to the stereoselective construction of glycosidic linkages, covering modern glycosylation methods and their use and application in natural product synthesis and drug discovery. Clearly divided into five sections, the first describes recent advances in classical methodologies in carbohydrate chemistry, while the second goes on to deal with newer chemistries developed to control selectivity in glycosylation reactions. Section three is devoted to selective glycosylation reactions that rely on the use of catalytic promoters. Section four describes modern approaches for controlling regioselectivity in carbohydrate synthesis. The final section focuses on new developments in the construction of "unusual" sugars and is rounded off by a presentation of modern procedures for the construction of glycosylated natural products. By providing the latest advances in glycosylation as well as information on mechanistic aspects of the reaction, this is an invaluable reference for both specialists and beginners in this booming interdisciplinary field that includes carbohydrate chemistry, organic synthesis, catalysis, and biochemistry.
Book Synopsis Handbook of Carbohydrate Engineering by : Kevin J. Yarema
Download or read book Handbook of Carbohydrate Engineering written by Kevin J. Yarema and published by CRC Press. This book was released on 2005-05-27 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Carbohydrate Engineering provides an overview of the basic science, theory, methods, and applications of this broad, interdisciplinary field. The text provides background information along with practical knowledge for current and future research methodologies used in the characterization and synthesis of various carbohydrates. This
Book Synopsis Antibody Glycosylation by : Marija Pezer
Download or read book Antibody Glycosylation written by Marija Pezer and published by Springer Nature. This book was released on 2021-10-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Sialic Acids written by Roland Schauer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid progress in the field of sialic acids has made it desirable to collect the new data about these unique sugars and to continue the series of books on this topic. In 1960, A. GOTTSCHALK wrote "The Chemistry and Biology of Sialic Acids and Related Substances" (Cambridge University Press) and in 1976, A. ROSENBERG and C. -L. SCHENGRUND published "Biological Roles of Sialic Acids" (Plenum Press). In this book emphasis is given to various modern methods used in the isolation and analysis of sialic acids. New approaches to the synthesis of free and bound sialic acids are described and the vast field of occurrence and metabolism of these substances is reviewed. Sialidoses are dealt with in one of the chapters, because sialidases have been recognized as factors of pathophysiological im portance. As knowledge is increasing about the involvement of sialic acids in many aspects of cell biology, another chapter is devoted to these phenomena. With this book I intend to demonstrate modern trends in sialic acid chemistry and biochemistry, and I hope that it will be of practical use and find its place in laboratories rather than in libraries. This publication offers an opportunity to thank all colleagues in many countries, including my coworkers at the universities of Bochum and Kiel, for their cooperation, stimulating discussions and, very important, useful criticism. The continuous cooperation with J. F. G. VLIEGENTHART and his coworkers, Utrecht, has been rewarding in many respects.
Book Synopsis Introduction to Glycobiology by : Maureen E. Taylor
Download or read book Introduction to Glycobiology written by Maureen E. Taylor and published by Oxford University Press, USA. This book was released on 2011-04-21 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level and their clinical relevance.
Download or read book Glycoproteins II written by J. Montreuil and published by Elsevier Science. This book was released on 1997-12-22 with total page 651 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part II of this excellent work covers proteoglycans and mucins and deals with many more examples of glycoprotein function. It also covers glycoproteins from four more species (slime mold, snails, fish, batracians). The content of the volume is very comprehensive in that most contributors are focussed on discussing, in depth, the wealth of most recent advances in their field, referring to previous reviews of older work for background information. This method effectively produces a very wide subject coverage in a smaller number of chapters/volumes. The volume is an important information source for all glycobiologist researchers (senior investigators, post-doctoral fellows and graduate students), and as a good, comprehensive, reference text for scientists working in the life sciences.
Book Synopsis Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease by : Shyamasree Ghosh
Download or read book Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease written by Shyamasree Ghosh and published by Academic Press. This book was released on 2020-01-08 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease enables the reader to understand the role of sialylation as a post translational modification. The book provides insights on the latest knowledge in the field of sialoglycobiology. Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Synthesized post translationally, they play an important role in recognition, signaling, immunological response and cell-cell interaction. Improper sialylations have been associated with several diseases including cancer. In the post genomics and proteomics era, sialoglybiology has become more and more important in deciphering health and disease conditions. Discusses the sialic acids and their role in different diseases (other than cancer) Provides an understanding of sialylations as post translational modifications (PTM) Demonstrates the impact sialylation has on infectious diseases, the autoimmune system and health Gives insights on the importance of sialic acid biology through animal models
Book Synopsis The Art of Carbohydrate Analysis by : Gerrit J. Gerwig
Download or read book The Art of Carbohydrate Analysis written by Gerrit J. Gerwig and published by Springer Nature. This book was released on 2021-10-23 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.
Book Synopsis Novel Proteins for Food, Pharmaceuticals, and Agriculture by : Maria Hayes
Download or read book Novel Proteins for Food, Pharmaceuticals, and Agriculture written by Maria Hayes and published by John Wiley & Sons. This book was released on 2018-11-28 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: A groundbreaking text that highlights the various sources, applications and advancements concerning proteins from novel and traditional sources Novel Proteins for Food, Pharmaceuticals and Agriculture offers a guide to the various sources, applications, and advancements that exist and are currently being researched concerning proteins from novel and traditional sources. The contributors—noted experts in the field—discuss sustainable protein resources and include illustrative examples of bioactive compounds isolated from several resources that have or could obtain high market value in specific markets. The text also explores a wide range of topics such as functional food formulations and pharmaceutical applications, and how they alter biological activity to provide therapeutic benefits, nutritional values and health protection. The authors also examine the techno-functional applications of proteins and looks at the screening process for identification of bioactive molecules derived from protein sources. In addition, the text provides insight into the market opportunities that exist for novel proteins such as insect, by-product derived, macroalgal and others. The authors also discuss the identification and commercialization of new proteins for various markets. This vital text: Puts the focus on the various sources, applications and advancements concerning proteins from novel and traditional sources Contains a discussion on how processing technologies currently applied to dairy could be applied to novel protein sources such as insect and macroalgal Reviews the sustainability of protein sources and restrictions that exist concerning development Offers ideas for creating an innovative and enterprising economy that is built on recent developments Details the potential to exploit key market opportunities in sports, infant and elderly nutrition and techno-functional protein applications Written for industrial researchers as well as PhD and Post-doctoral researchers, and undergraduate students studying biochemistry, food engineering and biological sciences and those interested in market developments, Novel Proteins for Food, Pharmaceuticals and Agriculture offers an essential guide to the sources, applications and most recent developments of the proteins from both innovative and traditional sources.
Book Synopsis The Molecular Immunology of Complex Carbohydrates by : Albert M. Wu
Download or read book The Molecular Immunology of Complex Carbohydrates written by Albert M. Wu and published by Springer. This book was released on 1988-07-01 with total page 882 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past three decades, the sugar moiety of complex carbohydrates has been found to be involved in important interactions of immunological specificity of antigens and to participate in a variety of cellular functions. The long polysaccharide side chains of the lipopolysaccharides on the outer membrane of Gram negative organisms provide surface antigens for differential serodiagnosis. Bacterial surface lectins are important in mediating the attachment of bacteria to host cells in the of infectious diseases. The carbohydrate pathogenesis moieties of cell surface glycoconjugates (glycoproteins and glycolipids) of mammals are the sites for intercellular recognition and for the regulatory molecular interactions such as interaction of complex carbohydrate with hormones or hepatic lectins. The carbohydrate side chains of many complex carbohydrates play essential roles as antigenic determinants b of human blood group ABH, Lea, Le , I, and i activities, as the Forssman specific determinant, and as tumor associated antigenic determinants. Prompted by these and other advances in the field, a Symposium on Molecular Immunology of Complex Carbohydrates was organized as a satellite meeting of the 8th International Glycoconjugate Conference held on September 8- 13, 1985, in Houston, Texas, U. S . A. Many eminent scientists contributed their knowledge at this meeting. The lecture and poster materials of the symposium are contained in this proceeding book, which is divided into four Sections and one Appendix. Section I is entitled Antibody Specificity, Epitope, and Lectinology. Dr. Elvin A.
Book Synopsis Biology of the Sialic Acids by : A. Rosenberg
Download or read book Biology of the Sialic Acids written by A. Rosenberg and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abraham Rosenberg assembles the groundbreaking work of preeminent international scientists to provide the most current, state-of-the-art presentation of research in siabiology. This concise volume examines the historical development of the field and reviews current knowledge on the genetic, immunologic, oncologic, neurodevelopmental, pathogenic, and cell regulatory properties of sialic acid. Outstanding features of this work include exhaustive reference material and detailed information tables.
