Biological Consequences Of Oxidative Stress

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Aging of the Genome

Author : Jan Vijg
Publisher : OUP Oxford
ISBN 13 : 0191524581
Total Pages : 384 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Aging of the Genome by : Jan Vijg

Download or read book Aging of the Genome written by Jan Vijg and published by OUP Oxford. This book was released on 2007-01-25 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

Oxidative Stress and Biomaterials

Author : Thomas Dziubla
Publisher : Academic Press
ISBN 13 : 0128032707
Total Pages : 405 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Oxidative Stress and Biomaterials by : Thomas Dziubla

Download or read book Oxidative Stress and Biomaterials written by Thomas Dziubla and published by Academic Press. This book was released on 2016-05-31 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death Brings together the two fields of biomaterials and the biology of oxidative stress Provides approaches for the design of biomaterials with improved biocompatibility

Inflammation and Cancer

Author : Bharat B. Aggarwal
Publisher : Springer
ISBN 13 : 3034808372
Total Pages : 489 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Inflammation and Cancer by : Bharat B. Aggarwal

Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Biological Consequences of Mitochondrial DNA Damage and Oxidative Stress

Author : Haihong Zhang
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.:/5 (164 download)

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Book Synopsis Biological Consequences of Mitochondrial DNA Damage and Oxidative Stress by : Haihong Zhang

Download or read book Biological Consequences of Mitochondrial DNA Damage and Oxidative Stress written by Haihong Zhang and published by . This book was released on 2006 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oxidative Stress

Author : Helmut Sies
Publisher : Academic Press
ISBN 13 : 0128196963
Total Pages : 876 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Oxidative Stress by : Helmut Sies

Download or read book Oxidative Stress written by Helmut Sies and published by Academic Press. This book was released on 2019-11-07 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections: A conceptual framework for studying oxidative stress. Processes and oxidative stress responses. Signaling in major enzyme systems (oxidative eustress), and damaging modification of biomolecules (oxidative distress). The exposome addresses lifelong exposure and impact on health, nutrient sensing, exercise and environmental pollution. Health and disease processes, including ischemia-reperfusion injury, developmental and psychological disorders, hepatic encephalopathy, skeletal muscle disorders, pulmonary disease, gut disease, organ fibrosis, and cancer. Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science. Characterizes oxidative stress within the framework of redox biology, redox signaling, and medicine. Empowers researchers and students to quantify specific reactants noninvasively, identify redox biomarkers, and advance translational studies. Features contributions from international leaders in oxidative stress and redox biology research.

Oxidative Stress and Antioxidant Protection

Author : Donald Armstrong
Publisher : John Wiley & Sons
ISBN 13 : 1118832485
Total Pages : 610 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Oxidative Stress and Antioxidant Protection by : Donald Armstrong

Download or read book Oxidative Stress and Antioxidant Protection written by Donald Armstrong and published by John Wiley & Sons. This book was released on 2016-04-11 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Biological Consequences of Oxidative Stress

Author : Lawrence Spatz
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 216 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Biological Consequences of Oxidative Stress by : Lawrence Spatz

Download or read book Biological Consequences of Oxidative Stress written by Lawrence Spatz and published by Oxford University Press, USA. This book was released on 1992 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxygen radicals are highly reactive forms of oxygen that upset the body's normal chemistry. They are created by the reaction of oxygen with radiation, air pollution, and other environmental agents, or generated in metabolism by one-electron transfers to an unstable oxygen molecule. Reactive species of oxygen and the damage they cause have been implicated in a variety of diseases. This volume focuses on their possible role in cardiovascular disease and cancer. It examines the molecular mechanisms by which oxidative damage occurs, the consequences of that damage, and some of the ways in which the damage might be mitigated. The book is based on a study group sponsored by the Conte Institute for Environmental Health, Pittsfield, Massachusetts.

Effects of Oxidative Stress on Plasma Membrane Fluidity

Author : Carlos de la Haba Fonteboa
Publisher :
ISBN 13 : 9788449053245
Total Pages : 112 pages
Book Rating : 4.0/5 (532 download)

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Book Synopsis Effects of Oxidative Stress on Plasma Membrane Fluidity by : Carlos de la Haba Fonteboa

Download or read book Effects of Oxidative Stress on Plasma Membrane Fluidity written by Carlos de la Haba Fonteboa and published by . This book was released on 2015 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oxidative Stress and Space Biology An Organ-Based Approach

Author : Melpo Christofidou-Solomidou
Publisher : MDPI
ISBN 13 : 3038429031
Total Pages : 191 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Oxidative Stress and Space Biology An Organ-Based Approach by : Melpo Christofidou-Solomidou

Download or read book Oxidative Stress and Space Biology An Organ-Based Approach written by Melpo Christofidou-Solomidou and published by MDPI. This book was released on 2018-05-04 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Oxidative Stress and Space Biology: An Organ-Based Approach" that was published in IJMS

Oxidative Stress and Redox Regulation

Author : Ursula Jakob
Publisher : Springer Science & Business Media
ISBN 13 : 9400757875
Total Pages : 488 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Oxidative Stress and Redox Regulation by : Ursula Jakob

Download or read book Oxidative Stress and Redox Regulation written by Ursula Jakob and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.

Oxidative Stress in Aquatic Ecosystems

Author : Doris Abele
Publisher : John Wiley & Sons
ISBN 13 : 1444345966
Total Pages : 818 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Oxidative Stress in Aquatic Ecosystems by : Doris Abele

Download or read book Oxidative Stress in Aquatic Ecosystems written by Doris Abele and published by John Wiley & Sons. This book was released on 2011-11-03 with total page 818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactive oxygen species (ROS) are increasingly appreciated as down-stream effectors of cellular damage and dysfunction under natural and anthropogenic stress scenarios in aquatic systems. This comprehensive volume describes oxidative stress phenomena in different climatic zones and groups of organisms, taking into account specific habitat conditions and how they affect susceptibility to ROS damage. A comprehensive and detailed methods section is included which supplies complete protocols for analyzing ROS production, oxidative damage, and antioxidant systems. Methods are also evaluated with respect to applicability and constraints for different types of research. The authors are all internationally recognized experts in particular fields of oxidative stress research. This comprehensive reference volume is essential for students, researchers, and technicians in the field of ROS research, and also contains information useful for veterinarians, environmental health professionals, and decision makers.

Brain Aging

Author : David R. Riddle
Publisher : CRC Press
ISBN 13 : 9781420005523
Total Pages : 408 pages
Book Rating : 4.0/5 (55 download)

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Book Synopsis Brain Aging by : David R. Riddle

Download or read book Brain Aging written by David R. Riddle and published by CRC Press. This book was released on 2007-04-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Biochemical Ecotoxicology

Author : Francois Gagne
Publisher : Elsevier
ISBN 13 : 012411623X
Total Pages : 282 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Biochemical Ecotoxicology by : Francois Gagne

Download or read book Biochemical Ecotoxicology written by Francois Gagne and published by Elsevier. This book was released on 2014-07-07 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical Ecotoxicology: Principles and Methods presents practical approaches to biochemical ecotoxicology experiments for environmental protection and conservation. With its methodical, stepped approach this essential reference introduces readers to current techniques for toxicity endpoint testing, suitable for laboratories of any size and budget. Each chapter presents a state-of-the-art principle, a quick and inexpensive procedure (including appropriate reagents), case studies, and demonstrations on how to analyze your results. Generic techniques are covered, suitable for a variety of organisms, as well as high-throughput techniques like quantitative polymerase chain reactions and enzyme-linked immunoassays. Cutting-edge approaches, including gPCR arrays and lipidomic techniques, are also included, making this is an essential reference for anyone who needs to assess environmental toxicity. Practical, cost-effective approaches to assess environmental toxicity endpoints for all types of organism Presents theory, methods, case studies and information on how to analyze results State-of-the-art techniques, such as ‘omics’ approaches to toxicology

Analysis of Free Radicals in Biological Systems

Author : A. Favier
Publisher : Birkhäuser
ISBN 13 : 3034890745
Total Pages : 314 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Analysis of Free Radicals in Biological Systems by : A. Favier

Download or read book Analysis of Free Radicals in Biological Systems written by A. Favier and published by Birkhäuser. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Oxidative stress" is used as the generic term describing the involve ment of reactive oxygen species in various human diseases. The scope of such a topic is becoming increasingly wide. The recent interest in radicals such as nitric oxide and the discovery of new mechanisms such as the effect of free radicals on redox sensitive proteins and genes are enlarging our understanding of the physiological role of free radicals. Oxidative stress is involved in numerous pathological. processes such as ageing, respiratory or cardiovascular diseases, cancer, neurological pathologies such as dementia or Parkinson's disease. It still remains difficult, however, to demonstrate by chemical measurement the in vivo production of free radicals and even more to realise their speciation. Therefore, the development of new tools and indicators is engrossing many researchers working in this field. Reliable indicators are abso lutely necessary not only to monitor the evolution of oxidative stress in patients but also to evaluate the efficiency of new antioxidant treat ments. The French Free radical club of Grenoble, the CERLIB has been involved for many years in the organisation of international training programs on methodology, in order to provide both theoretical and practical help to researchers from various countries. Such training sessions have been highly successful and participants value the oppor tunity to learn reliable techniques. This positive echo explains why the researchers of CERLIB decided, with the help of Prof. Dr. B. Kalyanaraman, to publish selected techniques on free radical re search.

Antioxidants in Sport Nutrition

Author : Manfred Lamprecht
Publisher : CRC Press
ISBN 13 : 1466567570
Total Pages : 304 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Antioxidants in Sport Nutrition by : Manfred Lamprecht

Download or read book Antioxidants in Sport Nutrition written by Manfred Lamprecht and published by CRC Press. This book was released on 2014-09-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

Oxidative Stress

Author : Cassidy Croft
Publisher : Nova Science Publishers
ISBN 13 : 9781536100402
Total Pages : 0 pages
Book Rating : 4.1/5 (4 download)

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Book Synopsis Oxidative Stress by : Cassidy Croft

Download or read book Oxidative Stress written by Cassidy Croft and published by Nova Science Publishers. This book was released on 2016-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Active oxygen species are produced as inescapable by-products of a normal aerobic metabolism, and their production is further enhanced by exposure to certain environmental conditions, or as a result of some diseases. Oxidative stress is defined as an imbalance between the production of free radicals (FR) and antioxidant defences in favour of the former, which can result from an excess of prooxidant, antioxidant deficiency or both factors. There are many kinds of FR, but these can be grouped together under the name of reactive oxygen species (ROS) or reactive nitrogen species (RNS), determined by the ability of each species according to the four basic characteristics: reactivity, specificity, selectivity and diffusivity. This book aims to discuss the biological effects, role in diseases, and causes of oxidative stress. Some of the topics provided include oxidative stress in biofilms; age realtion to oxidative stress; controlling of oxidative stress in non-alcoholic steatohepatitis; and the role of nitric oxide toxicity and oxidative stress in graft versus host disease.

Advances in DNA Damage and Repair

Author : Miral Dizdaroglu
Publisher : Springer Science & Business Media
ISBN 13 : 1461548659
Total Pages : 502 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Advances in DNA Damage and Repair by : Miral Dizdaroglu

Download or read book Advances in DNA Damage and Repair written by Miral Dizdaroglu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.