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Author : R. Colin Garner
Publisher : Springer Science & Business Media
ISBN 13 : 146130539X
Total Pages : 262 pages
Book Rating : 4.4/5 (613 download)
Download or read book Biochemistry of Chemical Carcinogenesis written by R. Colin Garner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : R Colin Garner
Publisher :
ISBN 13 : 9781461305408
Total Pages : 280 pages
Book Rating : 4.3/5 (54 download)
Download or read book Biochemistry of Chemical Carcinogenesis written by R Colin Garner and published by . This book was released on 1990-05-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Trevor M. Penning
Publisher : Springer Science & Business Media
ISBN 13 : 1617379956
Total Pages : 447 pages
Book Rating : 4.6/5 (173 download)
Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Author :
Publisher : Springer
ISBN 13 : 9783642747762
Total Pages : 604 pages
Book Rating : 4.7/5 (477 download)
Download or read book Chemical Carcinogenesis and Mutagenesis I written by and published by Springer. This book was released on 2011-12-21 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.
Author : Colin S. Cooper
Publisher : Springer Science & Business Media
ISBN 13 : 3642747787
Total Pages : 482 pages
Book Rating : 4.6/5 (427 download)
Download or read book Chemical Carcinogenesis and Mutagenesis II written by Colin S. Cooper and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABETH CA VERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.
Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642747752
Total Pages : 617 pages
Book Rating : 4.6/5 (427 download)
Download or read book Chemical Carcinogenesis and Mutagenesis I written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.
Author : Paul On Pong Ts'o
Publisher :
ISBN 13 :
Total Pages : 474 pages
Book Rating : 4.:/5 (318 download)
Download or read book Chemical Carcinogenesis written by Paul On Pong Ts'o and published by . This book was released on 1974 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jesse P. Greenstein
Publisher : Elsevier
ISBN 13 : 1483274241
Total Pages : 400 pages
Book Rating : 4.4/5 (832 download)
Download or read book Biochemistry of Cancer written by Jesse P. Greenstein and published by Elsevier. This book was released on 2013-10-22 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Cancer focuses on cancer research, including induction, chemical composition, and growth of tumors and chemotherapy. The book first offers information on the general phenomena and taxonomy of cancer. Discussions focus on the transmissibility of tumors and experimental basis of cancer research; cancerous transformation of animal tissues in vitro; growth and the vascular reactions of tumors; and classification of animal tumors. The text also ponders on the extrinsic factors in the induction of tumors, including comparative carcinogenicity of hydrocarbons, metabolic fate of injected hydrocarbons, dosage and response to carcinogenic hydrocarbons, and polycyclic hydrocarbons. The manuscript takes a look at the intrinsic factors in the induction of tumors. Topics include influence of sex hormones on carcinogenesis of sex and accessory sex tissues; viruses as causative agents for fowl tumors and rabbit papillomas; and possibility of relatively non-specific endogenous carcinogens. The publication also elaborates on attempts to control tumor induction and growth and the chemistry of tumors. The book is a vital reference for readers interested in the biochemistry of cancer.
Author : World Symposium on Model Studies in Chemical Carcinogenesis, Baltimore, 1972
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (976 download)
Download or read book Chemical Carcinogenesis written by World Symposium on Model Studies in Chemical Carcinogenesis, Baltimore, 1972 and published by . This book was released on 1974 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : H.F. Stich
Publisher : Springer Science & Business Media
ISBN 13 : 1461258472
Total Pages : 535 pages
Book Rating : 4.4/5 (612 download)
Download or read book Short-Term Tests for Chemical Carcinogens written by H.F. Stich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be tween the carcinogenicity and mutagenicity of chemicals and physical agents and by the assumption that DNA alteration, mutations, and chromosome aberrations are somehow involved in neoplastic transformation. Moreover, it has been tacitly assumed that the mutagenic capacity alone of compounds would induce regulatory agencies to pass rules for their removal from the environment and would lead the public to avoid them. The actual response, however, is quite different. Governmental departments shy away from making any decisions on the basis of in vitro test systems. The public at large is becoming irritated by daily an nouncements that many of their cherished habits could adversely affect their health. Industry appears to feel threatened and may reduce its search for new beneficial chemicals. The reluctance to accept wholeheartedly the mutagenicity tests for the detection of carcinogens is partly due to uncertainty about the in volvement of mutations in neoplastic transformation, partly due to the present difficulty of extrapolating results from various endpoints obtained on numerous organisms to man, and partly due to a multitude of complex events that lead in vivo to the evolvement of benign or malignant tumors.
Author : Beatrice Singer
Publisher : Springer Science & Business Media
ISBN 13 : 1461337720
Total Pages : 352 pages
Book Rating : 4.4/5 (613 download)
Download or read book Molecular Biology of Mutagens and Carcinogens written by Beatrice Singer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis. It seemed the appro priate time to sit back and summarize the results of several decades of research in laboratories in different countries. We are very grateful to the Rockefeller Foundation for inviting us to formulate and begin writing the book at the Center for International Studies in Bellagio, Italy, where we were Resident Scholars. We are fortunate to have had the assistance of so many colleagues around the world who cheerfully sent original data, figures, and preprints and lis tened patiently to us as we worked out the various conflicting ideas in this fast-moving. field. The names of these scientists are found within the tables, figures, and references. There is one person whose contributions we especially wish to acknowl edge. Professor Heinz Fraenkel-Conrat was present at the inception of this book and throughout the writing encouraged and criticized in apprOximately equal proportion. Finally, his editing and amalgamation of our two styles gave us great comfort. B.S. D.G.
Author : Dietrich Schmähl
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 300 pages
Book Rating : 4.E/5 ( download)
Download or read book Combination Effects in Chemical Carcinogenesis written by Dietrich Schmähl and published by John Wiley & Sons. This book was released on 1988 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Springer
ISBN 13 : 9783540511823
Total Pages : 604 pages
Book Rating : 4.5/5 (118 download)
Download or read book Chemical Carcinogenesis and Mutagenesis I written by and published by Springer. This book was released on 1989-11-27 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.
Author : D. E. Hathway
Publisher : Butterworth-Heinemann
ISBN 13 : 1483192466
Total Pages : 145 pages
Book Rating : 4.4/5 (831 download)
Download or read book Mechanisms of Chemical Carcinogenesis written by D. E. Hathway and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Chemical Carcinogenesis provides information pertinent to the fundamental mechanisms of chemical carcinogenesis. This book surveys the interactions of chemical carcinogens with native DNA, the activation of normal cellular sequences, and the transforming role of the activated genes. Organized into seven chapters, this book begins with an overview of the relationship between the incidence of lung cancer and the frequency and duration of cigarette smoking. This text then examines the concept that carcinogens may require metabolic activation before they initiate carcinogenesis. Other chapters consider the structure of the nucleoside adducts resulting from the hydrolysis of salmon-sperm DNA and rat-liver ribosomal RNA. This book discusses as well the persistence of nucleoside analogues in target-tissue nucleic acid. The final chapter deals with mutational theory. This book is a valuable resource for workers involved with cancer research, toxicology, and molecular biology. Specialists in drug development, industrial hygiene and occupational medicine will also find this book useful.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309175712
Total Pages : 433 pages
Book Rating : 4.3/5 (91 download)
Download or read book Carcinogens and Anticarcinogens in the Human Diet written by National Research Council and published by National Academies Press. This book was released on 1996-02-12 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.
Author : Minor Coon
Publisher : Elsevier
ISBN 13 : 0323144098
Total Pages : 645 pages
Book Rating : 4.3/5 (231 download)
Download or read book Microsomes, Drug Oxidations and Chemical Carcinogenesis V1 written by Minor Coon and published by Elsevier. This book was released on 2012-12-02 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume I, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July 1979. The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and toxicological perspective. The book contains 117 contributions made by researchers at the symposium, which are organized into three sections. The papers in Section I focus on the chemical and physical characteristics of cytochrome P-450. Section II examines the mechanisms of action of cytochrome P-450 and related enzymes. The studies in Section III deal with the influence of membrane structure and protein synthesis on electron transfer components. This book seeks to aid future progress in understanding the complexities of metabolic transformations by these versatile enzyme systems that act on physiologically important lipids as well as on a wide array of foreign substances, including drugs, anesthetics, industrial chemicals, food additives, pesticides, carcinogens, and nonnutrient dietary chemicals.
Author : Joseph C. Arcos
Publisher : Elsevier
ISBN 13 : 148326372X
Total Pages : 805 pages
Book Rating : 4.4/5 (832 download)
Download or read book Aliphatic Carcinogens written by Joseph C. Arcos and published by Elsevier. This book was released on 2013-10-22 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Induction of Cancer: Structural Bases and Biological Mechanisms Volume IIIA deals with the organic and biochemical principles behind cancer. This volume contains the continuation of Volume IIA, which tackles structure-activity relationships of chemical carcinogens, the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity. Under this is non-conjugated organic compounds. The text is recommended for doctors, organic chemists, and biochemists with an advanced knowledge in biochemistry and organic chemistry and would like to know more the biochemical processes of cancer.
