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Biochemistry Molecular Biology And Physiology Of Phospholipase A2 And Its Regulatory Factors
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Book Synopsis Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors by : Anil B. Mukherjee
Download or read book Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors written by Anil B. Mukherjee and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade there has been a dramatic expansion of our knowledge on phospholipases in general, and phospholipase A2 (PLA2) in particular. Progress in this field has been evident on many fronts, with novel information rapidly accumulating in the literature regarding the chemistry and molecular biology of this enzyme and its role in many important physiological processes. These include cellular signal transduction via the G-protein cycle, and in the generation of many cellular mediators, such as the platelet activating factor (PAF) and the eicosanoids that participate in the initiation and propagation of inflammation, to mention a few. This symposium was organized to obtain an overview of current investigations on this enzyme from the standpoint of its chemistry, molecular biology and physiology. Another important focus of this symposium concerns the regulation of PLA2, including endogenous and synthetic inhibitors and activators of this enzyme. To review these important areas in PLA2 research we invited scientists who made significant contributions in this field. The papers in this volume are organized to emphasize the recent advances in several areas of investigation, including: (I) the structure and mechanism of action of PLA2, (2) mechanism of activation of PLA2, (3) molecular biology, physiology and endogenous inhibitors of this enzyme and finally, (4) clinical investigations emphasizing the pathophysiological role of this enzyme in human diseases. The first article in this volume is by Dr.
Book Synopsis Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors by : Anil B. Mukherjee
Download or read book Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors written by Anil B. Mukherjee and published by Springer. This book was released on 1991-02-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade there has been a dramatic expansion of our knowledge on phospholipases in general, and phospholipase A2 (PLA2) in particular. Progress in this field has been evident on many fronts, with novel information rapidly accumulating in the literature regarding the chemistry and molecular biology of this enzyme and its role in many important physiological processes. These include cellular signal transduction via the G-protein cycle, and in the generation of many cellular mediators, such as the platelet activating factor (PAF) and the eicosanoids that participate in the initiation and propagation of inflammation, to mention a few. This symposium was organized to obtain an overview of current investigations on this enzyme from the standpoint of its chemistry, molecular biology and physiology. Another important focus of this symposium concerns the regulation of PLA2, including endogenous and synthetic inhibitors and activators of this enzyme. To review these important areas in PLA2 research we invited scientists who made significant contributions in this field. The papers in this volume are organized to emphasize the recent advances in several areas of investigation, including: (I) the structure and mechanism of action of PLA2, (2) mechanism of activation of PLA2, (3) molecular biology, physiology and endogenous inhibitors of this enzyme and finally, (4) clinical investigations emphasizing the pathophysiological role of this enzyme in human diseases. The first article in this volume is by Dr.
Book Synopsis Biochemistry, Molecular Biology, and Physiology of Phospholipase A2, and Its Regulatory Factors by :
Download or read book Biochemistry, Molecular Biology, and Physiology of Phospholipase A2, and Its Regulatory Factors written by and published by . This book was released on 1989 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Relaxation in Complex Systems and Related Topics by : I.A. Campbell
Download or read book Relaxation in Complex Systems and Related Topics written by I.A. Campbell and published by Springer. This book was released on 1990-11-30 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the workshop was to bring together specialists in various fields where non-exponential relaxation is observed in order to compare models and experimental results and to examine the general physical principles governing this type of behaviour. Non-exponential relaxation is found in extremely diverse physical systems all of which can be classified as complex. The form of the relaxation is generally parametrized using logarithmic, algebraic or stretched exponential decay forms. The conceptually simplest mechanism for the non-exponential decay is a spectrum of relaxation rates due to non-interacting units each of which relaxes with a different intrinsic time constant. Clear experimental examples can be given where for instance the relaxation of a collection of isolated polymer molecules leads to an overall stretched exponential decay. Non-exponential relaxation is observed in all strongly interacting complex systems (structural glasses, spin glasses, etc ... ) where each elementary unit is in interaction with many other units.
Book Synopsis Phospholipase A2 by : Patrick Y-K Wong
Download or read book Phospholipase A2 written by Patrick Y-K Wong and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the Advances in Experimental Medicine and Biology Series is dedicated to developing an overall view of the "state-of the-art" of knowledge in the field of phospholipase A2 and to exploring the role and function of this enzyme in various inflammatory diseases. This book grew out of two major symposia on phospholipase A2 held in 1989: I). "Phospholipase A2: Pathophysiological Role of Soluble and Membrane-Bound Enzymes" organized by Dr. Doug Morgan and Dr. Ann Welton of Hoffmann-La Roche and sponsored by the New York Academy of Sciences (January 24, 1989). II). "Release and Function of Phospholipase A2 from Inflammatory Cells" organized by Dr. Patrick Wong and Dr. Edward Dennis at the FASEB meeting in New Orleans (March 22, 1989). Readers will find exciting advances in our understanding of the structure, function and molecular biology of phospholipase A2 research which is presented in this volume. The elucidation of gene structures of phospholipase A2 should lead to new insights and new approches in the control and regulation of the enzyme activity. This is primary to better understanding the function of phospholipase A2 and the determination of its activity in cellular and animal systems. Of great importance is the development of animal models for inflammatory disease in order to evaluate the role of phospholipase A2 and its inhibitors. We are convinced that this volume will be an excellent reference that surveys this field in which numerous investigators are currently actively at work.
Book Synopsis Phospholipases in Health and Disease by : Paramjit S. Tappia
Download or read book Phospholipases in Health and Disease written by Paramjit S. Tappia and published by Springer Science & Business Media. This book was released on 2014-03-13 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.
Book Synopsis Phospholipase A2 by : Patrick Y-K Wong
Download or read book Phospholipase A2 written by Patrick Y-K Wong and published by Springer. This book was released on 1990-08-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the Advances in Experimental Medicine and Biology Series is dedicated to developing an overall view of the "state-of the-art" of knowledge in the field of phospholipase A2 and to exploring the role and function of this enzyme in various inflammatory diseases. This book grew out of two major symposia on phospholipase A2 held in 1989: I). "Phospholipase A2: Pathophysiological Role of Soluble and Membrane-Bound Enzymes" organized by Dr. Doug Morgan and Dr. Ann Welton of Hoffmann-La Roche and sponsored by the New York Academy of Sciences (January 24, 1989). II). "Release and Function of Phospholipase A2 from Inflammatory Cells" organized by Dr. Patrick Wong and Dr. Edward Dennis at the FASEB meeting in New Orleans (March 22, 1989). Readers will find exciting advances in our understanding of the structure, function and molecular biology of phospholipase A2 research which is presented in this volume. The elucidation of gene structures of phospholipase A2 should lead to new insights and new approches in the control and regulation of the enzyme activity. This is primary to better understanding the function of phospholipase A2 and the determination of its activity in cellular and animal systems. Of great importance is the development of animal models for inflammatory disease in order to evaluate the role of phospholipase A2 and its inhibitors. We are convinced that this volume will be an excellent reference that surveys this field in which numerous investigators are currently actively at work.
Book Synopsis Phospholipases in Physiology and Pathology by : Sajal Chakraborti
Download or read book Phospholipases in Physiology and Pathology written by Sajal Chakraborti and published by Elsevier. This book was released on 2023-08-01 with total page 2974 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases. Discusses the biochemical and molecular mechanisms of normal and abnormal cell function in different disease processes Covers a wide range of basic and translational research appropriate for scientists engaged in studying the regulation of phospholipases from interdisciplinary perspectives Features state-of-the-art chapter contributions from international leaders in the field
Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1991 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis American Journal of Respiratory Cell and Molecular Biology by :
Download or read book American Journal of Respiratory Cell and Molecular Biology written by and published by . This book was released on 1994 with total page 838 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Coronaviruses and their Diseases by : David Cavanagh
Download or read book Coronaviruses and their Diseases written by David Cavanagh and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the coronaviruses has never been greater. Their economic impact is considerable as they infect humans, livestock, poultry and companion animals. Murine hepatitis virus (MHV) infection of the mouse and rat central nervous systems are the subject of intense study; these investigations are providing insights into the potential role of viruses in human neurological diseases and, more generally, into mechanisms causing neurological damage. The single-stranded, positive-sense RNA genomes of two species of these enveloped viruses (IBV and MHV) have been cloned completely and one of them (lBV) sequenced in its entirety, revealing a genome size of some 27000 nucleotides. This has made possible more incisive investigations into the nature of those polypeptides, encoded by more than half of the genome, which are likely to contribute, in the main, to RNA polymerase/replicase activity. Intriguingly, ribosomal frameshifting is exhibited within the mRNA coding for these polypeptides. The cloning/sequencing phase of coronavirology for which the 1980's will be partly remembered, has provided a sound framework for furthex: studies of the virus structural proteins and also some provocative insights relevant to these studies. The large spike glycoprotein(s), responsible for membrane fusion and bearing important antigenic sites, varies amazingly in length and composition both within as well as between coronavirus species. Receptors on host cells have been identified. The integral membrane glycoprotein (M) has been shown to use internal hydrophobic sequences to direct translocation within membranes.
Book Synopsis Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis by : Chung Yuan Liu
Download or read book Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis written by Chung Yuan Liu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Scientific Symposium on Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis was held in Academia Sinica, Taipei, Taiwan, Republic of China, on August 30 - September 1, 1989. This Symposium has provided a forum for the free exchange of information in this important and rapidly advancing research field. This proceedings volume provides a published record of 46 papers presented at the Symposium. The sponsors have exerted no influence on the scientific opinions or positions of the participants in the Symposium. It is hoped that this Symposium will stimulate further worldwide cooperation and collaboration in these vital fields for the benefit of all human kind. This volume is composed of four parts. The first part consists of 8 papers on Fibrinogen and Fibrin: Biochemistry, Molecular Biology, and Physiology. The second part contains 16 papers on Coagulation and Fibrinolysis: Biochemistry, Molecular Biology, and Physiology. The third part has 10 papers on Cardiovascular Cell Biology: Biochemistry, Molecular Biology, and Physiology. The fourth part comprises 12 papers on Clinical Studies of the Cardiovascular System: Thrombotic and Bleeding Disorders and Thrombolytic Therapy. The Author Index with addresses of all contributors and the Subject Index of all 46 papers are arranged at the end of this volume.
Book Synopsis Tobacco Smoking and Atherosclerosis by : John N. Diana
Download or read book Tobacco Smoking and Atherosclerosis written by John N. Diana and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atherosclerosis is the principal underlying cause of cardiovascular and cerebrovascular disease in people of the Western world. Cigarette smoking has been implicated in both the initiation and exacerbation of the atherosclerotic process. Data to support this implication derives primarily from epidemiologic studies where the relationship between the incidence of atherosclerosis in people who smoke cigarettes has been shown to have a strong correlation. There are few well established explanations for this phenomenon, and basic molecular, biochemical, and cellular mechanisms associated with smoking and the development of atherosclerosis remain both undefined and virtually unexplored. Even the epidemiologic correlation between cigarette smoking and the development of atherosclerosis needs further critical studies. It is known that individuals who do not smoke cigarettes develop athero sclerosis and it is also known that in people who smoke but have normal or low blood cholesterol/lipoprotein levels, the incidence of development of atherosclerosis is no different from that which is found in a non smoking population. Answers which explain such observations must address fundamental biological mechanisms. Toward this end, the purpose of this volume is to assemble, in a single publication, information which will address the questions; what basic cellular and/or molecular mechanisms are associated with the development of atherosclerosis and how does cigarette smoking influence such mechanisms to initiate or exacerbate the atherosclerotic process? Clearly, the development of atherosclerosis is a complex, multifactorial biological event.
Book Synopsis Myoblast Transfer Therapy by : Robert C. Griggs
Download or read book Myoblast Transfer Therapy written by Robert C. Griggs and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: I am pleased to introduce this volume on Myoblast Transfer Therapy on behalf of the Muscular Dystrophy Association and all of its Advisory Committees. The international conference which led to this volume brought together leading basic scientists and clinical investigators for the purpose of coordinating the development of this new field in the fight against muscular dystrophy. The Muscular Dystrophy Association is the nation's most rapidly growing voluntary health agency in terms of its programs of patient care, research, and professional and public education. Success is attributable to its National Chairman, Jerry Lewis, to its effective corporate membership, and to the many physicians and scientists who give their time freely to advise on policies, to review grant applications, and to participate in meetings such as this. I should like to acknowledge a large number of other individuals to whom we are indebted: the broad segment of the American public which continually and generously supports our spectrum of services. The Muscular Dystrophy Association, next year, should raise in excess of $115,000,000. These contributions are derived from more than 10 million American families. These families are not only pledging their money but expressing their hopes that we will find answers to the tragic problem of neuromuscular disease. We are confident that the fruits of this meeting will move the frontier of research forward toward that goal.
Book Synopsis Chemical and Structural Approaches to Rational Drug Design by : David B. Weiner
Download or read book Chemical and Structural Approaches to Rational Drug Design written by David B. Weiner and published by CRC Press. This book was released on 2020-12-18 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.
Download or read book Bibliography of Agriculture written by and published by . This book was released on 1991 with total page 1810 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Structural Basis for Secretory Phospholipase A2 Function and Pharmacological Control by : David L. Scott
Download or read book The Structural Basis for Secretory Phospholipase A2 Function and Pharmacological Control written by David L. Scott and published by . This book was released on 1992 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt:
