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Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (251 download)
Download or read book Biochemical Pharmacology and Toxicology written by and published by . This book was released on 1985 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biochemical Pharmacology and Toxicology written by and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bernard B. Brodie
Publisher : Springer Science & Business Media
ISBN 13 : 3642651771
Total Pages : 797 pages
Book Rating : 4.6/5 (426 download)
Download or read book Concepts in Biochemical Pharmacology written by Bernard B. Brodie and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 797 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bio chemical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. Byron Clark, Director of the Pharmacology-Toxicology Program at the National Institutes of Health whose support made possible much of the work described in this volume. Contents Section Four: Methods 01 Stooging the MetoholiBm 01 Drugs Subsection A. Assay 01 Drugs and Their M etoholites Chapter 22 : Basic Principles in Development of Methods for Drug Assay. B. B. BRODIE. With 2 Figures 1 1 A. Introduction . . . . . . . . . . B. Principles of Developing a Method. . . . . . 1 I. Section of Method of Assay . . . . . . 1 II. Choice of Solvent for Extraction of Drug 2 III. Adsorption of Drugs by Glass Surfaces . . . . . . . . . . . . . . 3 IV. Recoveries of Known Amounts of Compound from Biological Material. 4 V. Assessment of Sensitivity 5 VI. Assessment of Specificity 5 References. . . . . . . . . . .
Author : P.S. Randall
Publisher : Springer Science & Business Media
ISBN 13 : 3642463142
Total Pages : 509 pages
Book Rating : 4.6/5 (424 download)
Download or read book Concepts in Biochemical Pharmacology written by P.S. Randall and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part 3 of the Handbook of Experimental Pharmacology (Concepts in Biochem ical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man. Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmaco kinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader. Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, entero hepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.
Author : H.S. Ackermann
Publisher : Springer Science & Business Media
ISBN 13 : 364265052X
Total Pages : 486 pages
Book Rating : 4.6/5 (426 download)
Download or read book Concepts in Biochemical Pharmacology written by H.S. Ackermann and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bioche mical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. BYRON CLARKE, Director of the Pharmacology-Toxicology Program at the National Insti tutes of Health, whose support made possible much of the work described in this volume. Contents Section One: Routes of Drug Administration Chapter 1: Biological Membranes and Their Passage by Drugs. C. A. M. HOGBEN 1 References. . . . . . . . . . . . . . . . . . . . . . . . . . 8 Chapter 2: Absorption of Drugs from the Gastrointestinal Tract. L. S. SCHANKER. With 5 Figures. 9 I. Introduction. . . . . . . . . . . . . . . . . . . . . . . 9 II. Methods of Study. . . . . . . . . . . . . . . . . . . . . 9 III. Absorption from the Stomach . . . . . . . . . . . . . . . 11 IV. Intestinal Absorption of Non-Electrolytes and Weak Electrolytes 15 V. Absorption of Weak Electrolytes from the Colon and Rectum 18 VI. Intestinal Absorption of Organic Ions. . . . . . . . . . 19 VII. Intestinal Absorption of Macromolecules . . . . . . . . . . 19 VIII. Active Transport across the Intestinal Epithelium . . . . . 20 IX. Effect of EDTA on Drug Absorption from the Intestine . . . . . . .
Author :
Publisher : Academic Press
ISBN 13 : 0323911102
Total Pages : 436 pages
Book Rating : 4.3/5 (239 download)
Download or read book Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary written by and published by Academic Press. This book was released on 2022-08-09 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more. Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more. Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450. Comprehensive coverage of major progress in the last 60 years on the P450 research in pharmacology and toxicology Discussion of possible future directions of the research on P450s, especially for improved pharmacotherapy in humans Encouragement to young scientists to join this important and exciting basic, translational, and advanced world of P450
Author : Edward Majchrowicz
Publisher : Springer
ISBN 13 : 9781468475302
Total Pages : 367 pages
Book Rating : 4.4/5 (753 download)
Download or read book Biochemical Pharmacology of Ethanol written by Edward Majchrowicz and published by Springer. This book was released on 2012-10-20 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of excellent symposia, reviews and monographs on the biology of ethanol have been published during the last decade. Al though it may appear that another such publication may be superflu ous, the subject of alcohol abuse is still open for further explora tion and the field of the biochemical pharmacology of ethanol is in its infancy. This is evidenced, for example, by the unavailability of any drugs that are designed specifically for the treatment of alcohol intoxication or alcohol addiction. The impetus for this publication was generated by a spontane ous enthusiasm following the symposium on BiochemicaZ Ph~acoZogy of EthanoZ that was organized at the annual meeting of the American Chemical Society, Division of Biological Chemistry in August 1973 in Chicago. It was the first symposium on such a topic ever in cluded in the program of that large society of American chemists. The original aim of the symposium was to acquaint the members of the society with some basic facts about the biological chemistry of ethanol. The symposium included seven papers and covered a rela tively narrow range of ethanol biochemistry. In view of the enthu siasm shown at the Chemical Society meeting, the panelists decided to publish the program and to amplify it by inclusion of additional topics which have remained relatively unexplored in earlier publica tions. In addition, reviews have been included which discuss old topics from a new perspective.
Author : Michael Palmer
Publisher : John Wiley & Sons
ISBN 13 : 1118819985
Total Pages : 388 pages
Book Rating : 4.1/5 (188 download)
Download or read book Notes to Biochemical Pharmacology written by Michael Palmer and published by John Wiley & Sons. This book was released on 2013-08-08 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains lecture notes intended for teaching biochemical pharmacology. The content is based on and best understood as an ancillary with the authors' textbook Biochemical Pharmacology (Wiley, 2012). Most of the figures have been adapted, with enhancements and occasional corrections, whereas the text is new and more condensed -- making it easier to cover most or all of the content in a single term. The focus is on principles, not on comprehensive coverage or clinical relevance. It uses a simple layout, presenting lecture slides in sequence, augmented with the explanatory text below each. This is an ideal format for ebook reading, yielding easier on-screen reading than a traditional book layout.
Author : P. Hlavica
Publisher : Springer Science & Business Media
ISBN 13 : 9401131120
Total Pages : 487 pages
Book Rating : 4.4/5 (11 download)
Download or read book N-Oxidation of Drugs written by P. Hlavica and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Doris Clouet
Publisher : Springer Science & Business Media
ISBN 13 : 1468418696
Total Pages : 527 pages
Book Rating : 4.4/5 (684 download)
Download or read book Narcotic Drugs written by Doris Clouet and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: The riddle of the biochemical nature of drug dependence of the opiate type has stimulated many studies directed toward understanding the molecular basis of the action of opiates, and, particularly, the phenomena of tolerance, physical dependence, and drug-seeking behavior-phenomena exhibited by man and experimental animals exposed persistently to these drugs. The results of these studies provided a substantial body of information which has been published in the scientific and medical literature. The purely pharma cological responses in man and animals to the opiates have been described and evaluated in many monographs and text-books of pharmacology. However, there is no single source for specific and detailed information on the responses of the body and its tissues to narcotic analgesic drugs at the level of biochemical pharmacology; that is, the molecular history of the drug in the body and the biochemical consequences of its presence in tissue. This volume has been prepared in an effort to repair the deficiency. Two factors have contributed a special urgency to making this infor mation available in convenient form: (1) the current need for a better under standing of the biochemical mechanisms underlying addiction to narcotic drugs, and (2) the progress made in molecular biology which promises that significant advances in the elucidation of fundamental processes in the central nervous system and their drug-induced aberrations may soon be possible.
Author : Bernard B. Brodie
Publisher :
ISBN 13 : 9780387053899
Total Pages : 778 pages
Book Rating : 4.0/5 (538 download)
Download or read book Concepts in Biochemical Pharmacology written by Bernard B. Brodie and published by . This book was released on 1971 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael D. Coleman
Publisher : John Wiley & Sons
ISBN 13 : 1119458560
Total Pages : 688 pages
Book Rating : 4.1/5 (194 download)
Download or read book Human Drug Metabolism written by Michael D. Coleman and published by John Wiley & Sons. This book was released on 2020-02-19 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a timely update to a key textbook on human drug metabolism The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact. Human Drug Metabolism, 3rd Edition begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s. Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact Reflects refinements in the author's teaching method, particularly with respect to helping students understand biological systems and how they operate Illustrates the growing relationship between drug metabolism and personalized medicine Includes recent developments in drug discovery, genomics, and stem cell technologies Human Drug Metabolism, 3rd Edition is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to their practice.
Author : Z. M. Bacq
Publisher : Elsevier
ISBN 13 : 1483181626
Total Pages : 694 pages
Book Rating : 4.4/5 (831 download)
Download or read book Fundamentals of Biochemical Pharmacology written by Z. M. Bacq and published by Elsevier. This book was released on 2014-05-17 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Biochemical Pharmacology explains the molecular aspects of drugs and the changes in bio-chemical systems. The cellular movements that result from such changes are also evaluated. Biochemical lesion is extensively defined in the book. A discussion on electromagnetic radiation is also provided. A chapter of the book is devoted to the principles of electronic and nuclear magnetic resonance. The principles and applications of mass spectrometry and combined gas chromatography are then discussed. The scientific advances made with the use of immunological methods are the focus of a section of the book. Another section provides an introduction to the kinetic properties of reactions made by enzymes. The process called homogenization is clearly explained along with a discussion on the use of electron microscopy. Autoradiography shows the distribution of compounds at the subcellular level. The theoretical background of molecular spectroscopy is presented completely. The book is intended for chemists, biochemists, physicists, micro-biologists, zoologists, and botanists .
Author : Michael D. Coleman
Publisher : John Wiley & Sons
ISBN 13 : 9780470689349
Total Pages : 360 pages
Book Rating : 4.6/5 (893 download)
Download or read book Human Drug Metabolism written by Michael D. Coleman and published by John Wiley & Sons. This book was released on 2010-03-30 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
Author : David Zakim
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 398 pages
Book Rating : 4.3/5 (91 download)
Download or read book Biomedical Pharmacology and Toxicology, Methodological Aspects of Drug Metabolizing Enzymes written by David Zakim and published by Wiley-Interscience. This book was released on 1985-08-13 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of authoritative reviews on membrane-bound and soluble-fraction epoxide hydrolases; preparation and characterization of sulfotransferases; methods of characterizing the function of VDP-Glucurotransferases; mitochondrial monarmine oxidase; measurement of cytochrome P-450; preparation and characterization of glutathione S-transferases.
Author : John Caldwell
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (45 download)
Download or read book Metabolic and Kinetic Aspects of Toxicological Studies written by John Caldwell and published by . This book was released on 1987 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert M. Featherstone
Publisher :
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.3/5 (91 download)
Download or read book A Guide to Molecular Pharmacology-toxicology written by Robert M. Featherstone and published by . This book was released on 1973 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
