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Biochemical Applications Of Electrospray Ionization Coupled With Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
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Book Synopsis Biochemical Applications of Electrospray Ionization Coupled with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Philip Spencer Green
Download or read book Biochemical Applications of Electrospray Ionization Coupled with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Philip Spencer Green and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry in Biological Applications by : Huan He
Download or read book Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry in Biological Applications written by Huan He and published by . This book was released on 2009 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: Chapter 2 describes various aspects of a developed method for polar lipid semi-quantification. Simple liquid-liquid extraction and one-step nano-LC separation are important for analyses of complex cellular lipid mixtures -- We observed more than 20 fold increases in detected lipid species after nano-LC separation. This method was applied on glioma cell lines, U87, under different combination of gene-/chemotherapy. Combination of adenovirus wt-p53 transfection and topoisomerase inhibition results in cells' G2 arrest and apoptosis. A sugar binding protein, galectin-1, was down-regulated under such treatment. Lipidomics study identified the associated changes in the polar lipidome - the decrease of short chain asialo-GM1 (a ligand of galectin-1), decreases of long chain gangliosides, increases of short chain sulfatides and increases of all phospholipids, especially hydroxylated phospholipids.
Book Synopsis Electrospray and MALDI Mass Spectrometry by : Richard B. Cole
Download or read book Electrospray and MALDI Mass Spectrometry written by Richard B. Cole and published by John Wiley & Sons. This book was released on 2011-09-26 with total page 900 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces Part C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra Part E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.
Book Synopsis Electrospray Ionization Mass Spectrometry by : Richard B. Cole
Download or read book Electrospray Ionization Mass Spectrometry written by Richard B. Cole and published by Wiley-Interscience. This book was released on 1997-05-06 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive, up-to-date coverage of a revolutionary technique Electrospray ionization mass spectrometry (ESI-MS) has completely changed the way physicists, chemists, and biologists view the study of large molecules. The technique derives detailed information about molecular weights and structures from extremely small sample quantities. ESI-MS can create highly charged forms of very high molecular weight compounds, it is naturally compatible with many types of separation techniques, and it allows noncovalent interactions between molecules in solution to be preserved in the gas phase. But many researchers may not use the technique to its full potential because they are unfamiliar with the different perspectives of its underlying processes, the varied approaches to implementation, and the wide-ranging utility of the technique. In this book, Richard B. Cole and an assemblage of leading researchers present a single-volume compilation of different approaches to the understanding and exploitation of ESI-MS. This comprehensive guide: * Examines the physical and chemical aspects of the electrospray process and describes the events involved in ion formation as well as the electro-chemical phenomena that are central to charged droplet formation during the process * Explores the coupling of electrospray ionization to various mass spectrometers, including quadrupole, magnetic, time-of-flight, quadrupole ion trap, and Fourier transform ion cyclotron resonance instruments * Describes recent progress in interfacing ESI with solution-based separation techniques, including liquid chromatography and capillary electrophoresis * Charts the rapid development of ESI applications and categorizes them by compound type: peptides and proteins, nucleic acids and their constituents, carbohydrates and lipids, small molecules related to pharmacology and drug metabolism, and organometallics and inorganic compounds Electrospray Ionization Mass Spectrometry is the indispensable handbook and reference for anyone who wishes to understand, implement, or apply this technique, including researchers in chemistry, metallochemistry, biochemistry, biology, pharmacology, and physics.
Book Synopsis Applying Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry to Structural Problems in Inorganic and Biochemistry by : Robert Edward Bossio
Download or read book Applying Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry to Structural Problems in Inorganic and Biochemistry written by Robert Edward Bossio and published by . This book was released on 2002 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Internal and External Source Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Ragulan Ramanathan
Download or read book Internal and External Source Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Ragulan Ramanathan and published by . This book was released on 2019-05-31 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Design, development, and coupling of an electrospray ionization (ESI) source with a Fourier Transform Ion Cyclotron (FTICR) Mass Spectrometer (MS). Developed ESI source was used for detection and characterization of small and large molecules. Dissertation Discovery Company and University of Florida are dedicated to making scholarly works more discoverable and accessible throughout the world. This dissertation, "Internal and External Source Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry" by Ragulan Ramanathan, was obtained from University of Florida and is being sold with permission from the author. A digital copy of this work may also be found in the university's institutional repository, IR@UF. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation.
Book Synopsis Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Analysis of Biological Molecules by : Ying Xiong
Download or read book Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Analysis of Biological Molecules written by Ying Xiong and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development and Characterization of an Atmospheric Pressure Ionization Source Matrix-Assisted Laser Desorption Electrospray Ionization Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Analysis of Biological Macromolecules by :
Download or read book Development and Characterization of an Atmospheric Pressure Ionization Source Matrix-Assisted Laser Desorption Electrospray Ionization Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Analysis of Biological Macromolecules written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of mass spectrometry has grown tremendously over the past few decades due in large part to the continued application to new and interesting areas of exploration. The advent of soft ionization sources such as electrospray ionization and matrix-assisted laser desorption/ionization have dramatically increased the capabilities of mass spectrometry and increased the amount of information derived from biological samples. As a result, there has been tremendous growth in the development of new ionization source technology in recent years. One of the main driving forces behind the development of new ionization technology is for the reduction of sample preparation required prior to analysis, yielding high throughput sample analysis. Demonstrated herein is the development and characterization of an atmospheric pressure ionization source called matrix-assisted laser desorption electrospray ionization (MALDESI). MALDESI is a hybrid combination of MALDI and ESI which utilizes laser desorption with electrospray postionization for the generation of multiply-charged ions. Multiply-charged ions are of particular importance when using Fourier transform mass spectrometry, due to the increase in resolving power and mass accuracy with increasing charge on the molecule. Top-down characterization of intact polypeptides is demonstrated as well as high mass accuracy utilizing internal calibration. A newly designed highly robust and versatile atmospheric pressure ionization platform is developed and described in detail. Solid- and liquid state analysis of three out of the four classes of biological molecules is demonstrated utilizing the newly developed versatile ionization platform. MALDESI utilizing ultraviolet and infrared laser desorption is demonstrated at various wavelengths (UV, 337 nm and 349 nm and IR, 2.94 Ã'Âæm and 10.6 Ã'Âæm) with and without ESI postionization for the generation of multiply-charged ions. The characteristics of liquid-state samples are described as a mac.
Book Synopsis Development and Characterization of an Atmospheric Pressure Ionization Source Matrix-assisted Laser Desorption Electrospray Ionization Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Analysis of Biological Macromolecules by : Jason Scott Sampson
Download or read book Development and Characterization of an Atmospheric Pressure Ionization Source Matrix-assisted Laser Desorption Electrospray Ionization Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Analysis of Biological Macromolecules written by Jason Scott Sampson and published by . This book was released on 2009 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: FT-ICR, hybrid ionization, electrospray, matrix-assisted laser desorption electrospray ion, MALDESI.
Book Synopsis The Analysis of Biological Molecules by Electrospray Ionisation Fourier Transform Ion Cyclotron Resonance (ESI-FTICR) Mass Spectrometry by : James Ian Wallace
Download or read book The Analysis of Biological Molecules by Electrospray Ionisation Fourier Transform Ion Cyclotron Resonance (ESI-FTICR) Mass Spectrometry written by James Ian Wallace and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Asphaltenes, Heavy Oils, and Petroleomics by : Oliver C. Mullins
Download or read book Asphaltenes, Heavy Oils, and Petroleomics written by Oliver C. Mullins and published by Springer Science & Business Media. This book was released on 2007-11-08 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: With substantial contributions from experienced industrial scientists and engineers, this work will have real application towards improving process efficiency and improvement in the trillion-dollar global petroleum industry. It presents an overview of the emerging field of petroleomics, which endeavors to understand the fundamental components of crude oil. Petroleomics promises to revolutionize petroleum science in much the same way that genomics transformed the study of medicine not long ago. Asphaltenes are a particular focus, with many chapters devoted to the analysis of their structure and properties.
Book Synopsis Characterisation of Macromolecules Using Electrospray Ionization and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Liam Andrew McDonnell
Download or read book Characterisation of Macromolecules Using Electrospray Ionization and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Liam Andrew McDonnell and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmaceutical Applications of Electrospray Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTMS) by : Sarah Anne Lorenz
Download or read book Pharmaceutical Applications of Electrospray Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTMS) written by Sarah Anne Lorenz and published by . This book was released on 2000 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis External Ion Injection Techniques and Biological Applications of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Forest M. White
Download or read book External Ion Injection Techniques and Biological Applications of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Forest M. White and published by . This book was released on 1997 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis LC/MS Applications in Drug Development by : Mike S. Lee
Download or read book LC/MS Applications in Drug Development written by Mike S. Lee and published by John Wiley & Sons. This book was released on 2002-03-07 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases. In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include: Proteomics Glycoprotein Mapping Natural Products Dereplication Lead Identification Screening Open-Access LC/MS In Vitro Drug Screening Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.
Book Synopsis Proteomic Profiling and Analytical Chemistry by : Pawel Ciborowski
Download or read book Proteomic Profiling and Analytical Chemistry written by Pawel Ciborowski and published by Elsevier. This book was released on 2016-03-02 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomic Profiling and Analytical Chemistry: The Crossroads, Second Edition helps scientists without a strong background in analytical chemistry to understand principles of the multistep proteomic experiment necessary for its successful completion. It also helps researchers who do have an analytical chemistry background to break into the proteomics field. Highlighting points of junction between proteomics and analytical chemistry, this resource links experimental design with analytical measurements, data analysis, and quality control. This targeted point of view will help both biologists and chemists to better understand all components of a complex proteomic study. The book provides detailed coverage of experimental aspects such as sample preparation, protein extraction and precipitation, gel electrophoresis, microarrays, dynamics of fluorescent dyes, and more. The key feature of this book is a direct link between multistep proteomic strategy and quality control routinely applied in analytical chemistry. This second edition features a new chapter on SWATH-MS, substantial updates to all chapters, including proteomic database search and analytical quantification, expanded discussion of post-hoc statistical tests, and additional content on validation in proteomics. - Covers the analytical consequences of protein and peptide modifications that may have a profound effect on how and what researchers actually measure - Includes practical examples illustrating the importance of problems in quantitation and validation of biomarkers - Helps in designing and executing proteomic experiments with sound analytics
Book Synopsis Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry by : A. Peter Snyder
Download or read book Biochemical and Biotechnological Applications of Electrospray Ionization Mass Spectrometry written by A. Peter Snyder and published by . This book was released on 1996 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents new ways of creating ions of polar and labile biopolymeric species with remarkable ease and efficiency. Introduces better characterization of proteins and other biological molecules. Presents major fundamental issues in such areas as immunology, biochemistry, and natural toxins. Demonstrates methods used to resolve the data from various biological process investigations into useful information. Provides an application-driven approach, presenting valuable insights into the experiments in the volume.
