Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria

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Publisher : Frontiers Media SA
ISBN 13 : 2889632563
Total Pages : 281 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria by : Natalia V. Kirienko

Download or read book Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria written by Natalia V. Kirienko and published by Frontiers Media SA. This book was released on 2019-12-24 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Treating Infectious Diseases in a Microbial World

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Publisher : National Academies Press
ISBN 13 : 0309180686
Total Pages : 102 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Treating Infectious Diseases in a Microbial World by : National Research Council

Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Non-traditional Approaches to Combat Antimicrobial Drug Resistance

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Author :
Publisher : Springer Nature
ISBN 13 : 9811991677
Total Pages : 328 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Non-traditional Approaches to Combat Antimicrobial Drug Resistance by : Mohmmad Younus Wani

Download or read book Non-traditional Approaches to Combat Antimicrobial Drug Resistance written by Mohmmad Younus Wani and published by Springer Nature. This book was released on 2023-02-13 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed overview of the progress and challenges of non-traditional approaches for tackling antimicrobial resistance. The first chapter covers the factors that make microbes more likely to develop multidrug resistance. The book goes on to discuss the antimicrobial properties of propolis, essential oils and other microbial constituents that are used or under investigation to treat multidrug-resistant infections. Additionally, it covers alternative compounds that work as antimicrobial agents, their mechanisms of action, and how they might be utilized in conjunction with conventional drugs to circumvent drug resistance. The book explores the application of phage therapy and recent advancements in phage-based infection control with an emphasis on multidrug-resistant infections and discusses drug repurposing as a strategy to develop new antimicrobial agents efficiently and expeditiously. Additionally, it discusses the uses of nanoparticles in the treatment of infections brought on by multidrug-resistant pathogens and examines the use of different nanotechnology-based approaches to fudge microbial resistance mechanisms. It concludes by reviewing recent studies on microbial quorum-sensing systems and focuses on the significance of quorum-sensing systems in controlling microbial resistance mechanisms and at the same time highlights the importance and role of antimicrobial stewardship program to fight microbial infections. The book is an invaluable source of knowledge and information for academics, basic and clinical researchers, clinicians, and paramedic staff involved in one way or the other in the development and use of antimicrobial agents and strategies to combat multidrug resistance.​

Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine

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Publisher : National Academies Press
ISBN 13 : 9780309269452
Total Pages : pages
Book Rating : 4.2/5 (694 download)

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Book Synopsis Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine by : National Academies Of Sciences Engineeri

Download or read book Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine written by National Academies Of Sciences Engineeri and published by National Academies Press. This book was released on 2022-07-20 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Strategy for Combating Antibiotic Resistant Bacteria, published in 2014, sets out a plan for government work to mitigate the emergence and spread of resistant bacteria. Direction on the implementation of this strategy is provided in five-year national action plans, the first covering 2015 to 2020, and the second covering 2020 to 2025. Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine evaluates progress made against the national strategy. This report discusses ways to improve detection of resistant infections and estimate the risk to human health from environmental sources of resistance. In addition, the report considers the effect of agricultural practices on human and animal health and animal welfare and ways these practices could be improved, and advises on key drugs and diseases for which animal-specific test breakpoints are needed.

The Use of Drugs in Food Animals

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Publisher : National Academies Press
ISBN 13 : 0309175771
Total Pages : 276 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Use of Drugs in Food Animals by : National Research Council

Download or read book The Use of Drugs in Food Animals written by National Research Council and published by National Academies Press. This book was released on 1999-01-12 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of drugs in food animal production has resulted in benefits throughout the food industry; however, their use has also raised public health safety concerns. The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the major food-producing animal industriesâ€"poultry, dairy, beef, swine, and aquaculture. The volume discusses the prevalence of human pathogens in foods of animal origin. It also addresses the transfer of resistance in animal microbes to human pathogens and the resulting risk of human disease. The committee offers analysis and insight into these areas: Monitoring of drug residues. The book provides a brief overview of how the FDA and USDA monitor drug residues in foods of animal origin and describes quality assurance programs initiated by the poultry, dairy, beef, and swine industries. Antibiotic resistance. The committee reports what is known about this controversial problem and its potential effect on human health. The volume also looks at how drug use may be minimized with new approaches in genetics, nutrition, and animal management.

Mechanisms of antibiotic resistance

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Publisher : Frontiers Media SA
ISBN 13 : 2889195260
Total Pages : 226 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Mechanisms of antibiotic resistance by : Jun Lin

Download or read book Mechanisms of antibiotic resistance written by Jun Lin and published by Frontiers Media SA. This book was released on 2015-06-01 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Current Developments in the Detection and Control of Multi Drug Resistance

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Publisher : Bentham Science Publishers
ISBN 13 : 9815049887
Total Pages : 181 pages
Book Rating : 4.8/5 (15 download)

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Book Synopsis Current Developments in the Detection and Control of Multi Drug Resistance by : Sanket Kaushik

Download or read book Current Developments in the Detection and Control of Multi Drug Resistance written by Sanket Kaushik and published by Bentham Science Publishers. This book was released on 2022-07-26 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rise in the incidence of infections is caused by multi drugresistant (MDR) bacteria, it is essential to elucidate the basic mechanism ofantibiotic resistance to discover effective methods for diagnosis and treatmentof infections. The use of pathogen-specific probes offers a faster alternative forpathogen detection and could improve the diagnosis of infection. High resolutionmelting analysis techniques are useful for the detection of multi drugresistant pathogens. Rational Structural Based Drug Design is a common methodto identify a lead compound and take it forward for further developments.This book provides information about recent strategies involved in thediagnosis and treatment of infections caused by MDR bacteria. The volume coversthe use of molecular probes for the quantification of pathogenic bacteria, alongwith other techniques mentioned above. Chapters also cover the use of identificationof novel drug targets from the Lipid A biosynthesis and also from quorum sensingmediated biofilm formation in MDR bacteria. Chapters also cover herbal alternatives for the treatment of MDRbacteria like the use of Cassiaaungustifolia in treatment of various diseases. The reference is suitablefor biomedical students, cellular and molecular biologists.

Chemistry of Antibiotics and Related Drugs

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Publisher : Springer Nature
ISBN 13 : 303107582X
Total Pages : 276 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Chemistry of Antibiotics and Related Drugs by : Mrinal K. Bhattacharjee

Download or read book Chemistry of Antibiotics and Related Drugs written by Mrinal K. Bhattacharjee and published by Springer Nature. This book was released on 2022-08-23 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook builds on the success of the earlier edition, offering alternative strategies for discovering new antibiotics. It discusses how the various types of antibiotics and related drugs work to cure infections. Then it delves into the very serious matter of how bacteria are becoming resistant to these antibiotics. It also covers the global action plan on antimicrobial resistance from the World Health Organization and discusses several Antibiotic Stewardship Programs adopted by agencies at local levels. Appropriate for a one-semester course at either the graduate or advanced undergraduate level, the book is self-contained and written in accessible language. It includes all necessary background biochemistry material and a discussion of the latest developments in the field of antibiotics. Original research works are frequently cited and experimental procedures and interpretation of results are emphasized.

Nanostructures for Antimicrobial Therapy

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Publisher : Elsevier
ISBN 13 : 0323461514
Total Pages : 724 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Nanostructures for Antimicrobial Therapy by : Anton Ficai

Download or read book Nanostructures for Antimicrobial Therapy written by Anton Ficai and published by Elsevier. This book was released on 2017-05-29 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. - Shows how nanoantibiotics can be used to more effectively treat disease - Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs - Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area

Antimicrobial Resistance in Developing Countries

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Publisher : Springer Science & Business Media
ISBN 13 : 0387893709
Total Pages : 553 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Antimicrobial Resistance in Developing Countries by : Aníbal de J. Sosa

Download or read book Antimicrobial Resistance in Developing Countries written by Aníbal de J. Sosa and published by Springer Science & Business Media. This book was released on 2009-10-08 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Avoiding infection has always been expensive. Some human populations escaped tropical infections by migrating into cold climates but then had to procure fuel, warm clothing, durable housing, and crops from a short growing season. Waterborne infections were averted by owning your own well or supporting a community reservoir. Everyone got vaccines in rich countries, while people in others got them later if at all. Antimicrobial agents seemed at first to be an exception. They did not need to be delivered through a cold chain and to everyone, as vaccines did. They had to be given only to infected patients and often then as relatively cheap injectables or pills off a shelf for only a few days to get astonishing cures. Antimicrobials not only were better than most other innovations but also reached more of the world’s people sooner. The problem appeared later. After each new antimicrobial became widely used, genes expressing resistance to it began to emerge and spread through bacterial populations. Patients infected with bacteria expressing such resistance genes then failed treatment and remained infected or died. Growing resistance to antimicrobial agents began to take away more and more of the cures that the agents had brought.

Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung

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Publisher : Springer Science & Business Media
ISBN 13 : 3642461662
Total Pages : 254 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung by : W. Arber

Download or read book Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung written by W. Arber and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: "When we give a definition it is for the purpose of using it". HENRI POINCARE in Science and Method A. Objectives The first version of this paper was written to introduce new students and fellows of my laboratory to the mysteries of herpesviruses. Consonant with this design sections dealing with well documented data were trimmed to the bone whereas many obscure phenomena, controversial data and seemingly trivial observations were discussed generously and at length. There is some doubt as to whether it was meant to be published, but it was not a review. The objective of reviews is frequently to bring order. But alas, even the most fluent summation of credible data frequently makes dull reading and too much plausible order, like very little entropy in chemical reactions, is not the most suitable environment on which to nurture the urge to discover. This version is more charitable but not less inbalanced. The bibliography reflects the intent of the paper and was updated last in December of 1968. It should be obvious without saying that no single account such as this can do justice or injustice, as the case may be, to the several hundred papers published on herpesviruses each year or to the many thousand papers published on herpesviruses since the first of the members of the family was experimentally transmitted to a heterologous host more than half a century ago (GRUTER, 1924). B. Definition 1.

International Environmental Law and Governance

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Publisher : BRILL
ISBN 13 : 9004297847
Total Pages : 165 pages
Book Rating : 4.0/5 (42 download)

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Book Synopsis International Environmental Law and Governance by : Malgosia Fitzmaurice

Download or read book International Environmental Law and Governance written by Malgosia Fitzmaurice and published by BRILL. This book was released on 2015-08-04 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book analyzes the question of legitimacy and efficacy of certain organs created on the basis of Multilateral Environmental Agreements, i.e. Conferences and Meetings of the Parties. It analyzes their structure, new developments and collaborative efforts regarding the powers of these bodies in achieving desired goals of environmental protection. Contributors are: Michael Bowman, Edward J. Goodwin, Peter G.G. Davies, Feja Lesniewska and Philippe Cullet

Phage Therapy: Past, Present and Future

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Publisher : Frontiers Media SA
ISBN 13 : 2889452514
Total Pages : 394 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Phage Therapy: Past, Present and Future by : Stephen T. Abedon

Download or read book Phage Therapy: Past, Present and Future written by Stephen T. Abedon and published by Frontiers Media SA. This book was released on 2017-09-05 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically, the first observation of a transmissible lytic agent that is specifically active against a bacterium (Bacillus anthracis) was by a Russian microbiologist Nikolay Gamaleya in 1898. At that time, however, it was too early to make a connection to another discovery made by Dmitri Ivanovsky in 1892 and Martinus Beijerinck in 1898 on a non-bacterial pathogen infecting tobacco plants. Thus the viral world was discovered in two of the three domains of life, and our current understanding is that viruses represent the most abundant biological entities on the planet. The potential of bacteriophages for infection treatment have been recognized after the discoveries by Frederick Twort and Felix d’Hérelle in 1915 and 1917. Subsequent phage therapy developments, however, have been overshadowed by the remarkable success of antibiotics in infection control and treatment, and phage therapy research and development persisted mostly in the former Soviet Union countries, Russia and Georgia, as well as in France and Poland. The dramatic rise of antibiotic resistance and especially of multi-drug resistance among human and animal bacterial pathogens, however, challenged the position of antibiotics as a single most important pillar for infection control and treatment. Thus there is a renewed interest in phage therapy as a possible additive/alternative therapy, especially for the infections that resist routine antibiotic treatment. The basis for the revival of phage therapy is affected by a number of issues that need to be resolved before it can enter the arena, which is traditionally reserved for antibiotics. Probably the most important is the regulatory issue: How should phage therapy be regulated? Similarly to drugs? Then the co-evolving nature of phage-bacterial host relationship will be a major hurdle for the production of consistent phage formulae. Or should we resort to the phage products such as lysins and the corresponding engineered versions in order to have accurate and consistent delivery doses? We still have very limited knowledge about the pharmacodynamics of phage therapy. More data, obtained in animal models, are necessary to evaluate the phage therapy efficiency compared, for example, to antibiotics. Another aspect is the safety of phage therapy. How do phages interact with the immune system and to what costs, or benefits? What are the risks, in the course of phage therapy, of transduction of undesirable properties such as virulence or antibiotic resistance genes? How frequent is the development of bacterial host resistance during phage therapy? Understanding these and many other aspects of phage therapy, basic and applied, is the main subject of this Topic.

Challenges to Tackling Antimicrobial Resistance

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Publisher : Cambridge University Press
ISBN 13 : 1108799450
Total Pages : 273 pages
Book Rating : 4.1/5 (87 download)

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Book Synopsis Challenges to Tackling Antimicrobial Resistance by : Michael Anderson

Download or read book Challenges to Tackling Antimicrobial Resistance written by Michael Anderson and published by Cambridge University Press. This book was released on 2020-04-23 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accessible overview of the challenges in tackling AMR, and the economic and policy responses of the 'One Health' approach. It will appeal to policy-makers seeking to strengthen national and local polices tackling AMR, as well as students and academics who want an overview of the latest scientific evidence regarding effective AMR policies.

Antimicrobial Resistance

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Publisher :
ISBN 13 : 9789241564748
Total Pages : 232 pages
Book Rating : 4.5/5 (647 download)

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Book Synopsis Antimicrobial Resistance by : World Health Organization

Download or read book Antimicrobial Resistance written by World Health Organization and published by . This book was released on 2014 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.

Exploring the Frontiers of Innovation to Tackle Microbial Threats

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Publisher : National Academies Press
ISBN 13 : 0309675332
Total Pages : 179 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Exploring the Frontiers of Innovation to Tackle Microbial Threats by : National Academies of Sciences, Engineering, and Medicine

Download or read book Exploring the Frontiers of Innovation to Tackle Microbial Threats written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-09-10 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: On December 4â€"5, 2019, the National Academies of Sciences, Engineering, and Medicine held a 1.5-day public workshop titled Exploring the Frontiers of Innovation to Tackle Microbial Threats. The workshop participants examined major advances in scientific, technological, and social innovations against microbial threats. Such innovations include diagnostics, vaccines (both development and production), and antimicrobials, as well as nonpharmaceutical interventions and changes in surveillance. This publication summarizes the presentations and discussions from the workshop.

Combating Antimicrobial Resistance

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Publisher : National Academies Press
ISBN 13 : 0309466520
Total Pages : 173 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Combating Antimicrobial Resistance by : National Academies of Sciences, Engineering, and Medicine

Download or read book Combating Antimicrobial Resistance written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-01-08 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: As of 2017, the emergence and spread of antimicrobial resistance continues unabated around the world, leaving devastating health and economic outcomes in its wake. Those consequences will multiply if collaborative global action is not taken to address the spread of resistance. Major drivers of antimicrobial resistance in humans have been accelerated by inappropriate antimicrobial prescribing in health care practices; the inappropriate use of antimicrobials in livestock; and the promulgation of antibiotic resistance genes in the environment. To explore the issue of antimicrobial resistance, the Forum of Microbial Threats planned a public workshop. Participants explored issues of antimicrobial resistance through the lens of One Health, which is a collaborative approach of multiple disciplines - working locally, nationally, and globally - for strengthening systems to counter infectious diseases and related issues that threaten human, animal, and environmental health, with an end point of improving global health and achieving gains in development. They also discussed immediate and short-term actions and research needs that will have the greatest effect on reducing antimicrobial resistance, while taking into account the complexities of bridging different sectors and disciplines to address this global threat. This publication summarizes the presentations and discussions from the workshop.