Benzodiazepine

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Benzodiazepines

Author : H. Schütz
Publisher : Springer
ISBN 13 : 9783642684289
Total Pages : 0 pages
Book Rating : 4.6/5 (842 download)

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Book Synopsis Benzodiazepines by : H. Schütz

Download or read book Benzodiazepines written by H. Schütz and published by Springer. This book was released on 2011-11-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: To comment at length on the importance of the benzodiazepines seems superfluous within the scope of this preface. No other class of active substances has experienced an even approximately compa rable advance in the past two decades. It is therefore not surprising that the formerly dominant barbiturates and bromocarbamides have had to give way in many fields to the benzodiazepines, which now rank first (Proudfoot and Park [1828]). Closely linked with the great therapeutic importance of the benzodia zepines are analytical problems. Detection and the determination of blood levels can be necessary under therapeutic aspects, for instance in working out optimally effective levels in the treatment of epileptic conditions ("drug monitoring"), but also in connection with questions at issue in toxicology and traffic medicine. A toxicological analysis can be subdivided into the following steps: Detection (identification including screening) Determination (e. g. blood, plasma or serum levels) Interpretation of the analytical results. This book is intended as a contribution to each of these chapters: The part "Analytical Data" (pp.I-122) gives a comprehensive collec tion of data, e.g. general and chromatographic data (TLC, GLC) as well as spectra (UV, IR, MS) of 19 commercial preparations, 23 important metabolites and 18 hydrolysis derivatives. Information about biotransformation and the possible formation of aminobenzo phenone derivatives is also given. The most important analytical methods are presented in an extensive review on pp.123-204 in order to make it possible to select the optimum method on the basis of the essential data.

The Benzodiazepines Crisis

Author : John Peppin
Publisher : Oxford University Press
ISBN 13 : 0197517293
Total Pages : 289 pages
Book Rating : 4.1/5 (975 download)

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Book Synopsis The Benzodiazepines Crisis by : John Peppin

Download or read book The Benzodiazepines Crisis written by John Peppin and published by Oxford University Press. This book was released on 2020-10-01 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed decades ago to treat a legitimate medical need, benzodiazepines promisingly displaced less-effective and less-safe drugs, though prescribing has since exceeded their intended use and outpaced the available data. The current situation is characterized by excessive prescribing and extended utilization beyond good therapeutic practice. Evidence indicates that prolonged use of benzodiazepines causes a wide range of adverse reactions, and withdrawal can be particularly challenging. Misused, abused, diverted, and counterfeited, benzodiazepines have serious potential for substance use disorder, and are among the leading causes of drug-related overdose deaths. The Benzodiazepines Crisis sounds the alarm against the overuse of benzodiazepines, presenting an updated, evidence-based overview of this class of drugs and their negative consequences. Bringing together years of research, clinical expertise, and scientific evidence, this book aims to address a perceived lag between evidence and action in order to call for rational and dramatically reduced usage of benzodiazepines.

Modern Anesthetics

Author : Jürgen Schüttler
Publisher : Springer Science & Business Media
ISBN 13 : 3540748067
Total Pages : 497 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Modern Anesthetics by : Jürgen Schüttler

Download or read book Modern Anesthetics written by Jürgen Schüttler and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.

Pharmacological Treatment of Mental Disorders in Primary Health Care

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9241547693
Total Pages : 80 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Pharmacological Treatment of Mental Disorders in Primary Health Care by : World Health Organization

Download or read book Pharmacological Treatment of Mental Disorders in Primary Health Care written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual attempts to provide simple, adequate and evidence-based information to health care professionals in primary health care especially in low- and middle-income countries to be able to provide pharmacological treatment to persons with mental disorders. The manual contains basic principles of prescribing followed by chapters on medicines used in psychotic disorders; depressive disorders; bipolar disorders; generalized anxiety and sleep disorders; obsessive compulsive disorders and panic attacks; and alcohol and opioid dependence. The annexes provide information on evidence retrieval, assessment and synthesis and the peer view process.

Beyond Benzos

Author : Taite Adams
Publisher : Rapid Response Press
ISBN 13 : 9780990767435
Total Pages : 210 pages
Book Rating : 4.7/5 (674 download)

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Book Synopsis Beyond Benzos by : Taite Adams

Download or read book Beyond Benzos written by Taite Adams and published by Rapid Response Press. This book was released on 2015-08-20 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beyond Benzos - Benzo Addiction, Benzo Withdrawal, and Long-term Recovery from Benzodiazepines Now termed by some as the world's deadliest pill, the class of drugs known as benzodiazepines are on the cusp of racing past opiates to earn the label as this nation's most widely abused class of drugs. With over 150 million prescriptions written annually in the U.S. alone for such popular drugs as Xanax, Ativan, Klonopin, and Valium, benzo addiction has reached epidemic proportions in this country and many are still not willing to give it the press it deserves. Let's change that. Benzodiazepine addiction is something that is inherently difficult to treat because of the stigma attached to it, the often unresolved underlying issues, and the difficulty of benzo withdrawal. Beyond Benzos can help. Written as a guide to benzodiazepine addiction and recovery by someone who has been there, these drugs and the steps needed to break free from them are dissected at every level. To the millions of people and their loved ones trapped in the vicious circle of benzo addiction, there is a solution to break free from the madness. Author Taite Adams not only explains how benzos work but gives the reader their options for benzo withdrawal and long term recovery from addiction. Whether taking benzos for an anxiety disorder, insomnia or another issue, Adams offers hope, inspiration, and solutions for a life Beyond Benzos . Tags: benzo addiction, benzodiazepines, xanax withdrawal, prescription drug addiction, benzo withdrawal, benzodiazepine withdrawal, xanax addiction, klonopin addiction, benzos, ativan addiction

Advances in Patient Safety

Author : Kerm Henriksen
Publisher :
ISBN 13 :
Total Pages : 526 pages
Book Rating : 4.7/5 (54 download)

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Book Synopsis Advances in Patient Safety by : Kerm Henriksen

Download or read book Advances in Patient Safety written by Kerm Henriksen and published by . This book was released on 2005 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: v. 1. Research findings -- v. 2. Concepts and methodology -- v. 3. Implementation issues -- v. 4. Programs, tools and products.

Benzodiazepines II

Author : Harald Schütz
Publisher : Springer Science & Business Media
ISBN 13 : 3642740316
Total Pages : 621 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Benzodiazepines II by : Harald Schütz

Download or read book Benzodiazepines II written by Harald Schütz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: " ... this is an excellent compilation of data which should be on the bookshelves of all analysts interested in the benzodiazepines. It is to be hoped that, with the introduction of so many new ben zodiazepines, the author will quickly add these in a second edi tion" (A. C. Moffat in: Trends in Analytical Chemistry, 1983). This review, deputizing for many others, reflects the friendly reception enjoyed by the first volume of Benzodiazepines, which was published in 1982 and apparently closed a gap in the ben zodiazepine literature. In the meantime, Benzodiazepines has established itself as a standard book, as evidenced by numerous letters and quotations. Suggestions were also soon made for a new edition in view of the unusually rapid development in the field of the benzodiazepines. It became quickly obvious, however, that it would not be sufficient to publish a revised second edition, but that a completely new second volume would be required for which, however, the successful previous format could be largely retained. The following considerations seem worth mentioning in connection with the preparation of Volume II: - To ensure continuity with Volume I as far as possible, the list of references was consecutively numbered (references 1 to 3779 in Volume I, references 3780 to 11338 in Volume II). Whereas in Vol. I the substances appear in the sequential order of their historical development they are listed in alphabetical order in Vol. II.

Hepatotoxicity

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 848 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

The Benzo Book

Author : Jack Hobson-Dupont
Publisher : Lulu.com
ISBN 13 : 1411692594
Total Pages : 262 pages
Book Rating : 4.4/5 (116 download)

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Book Synopsis The Benzo Book by : Jack Hobson-Dupont

Download or read book The Benzo Book written by Jack Hobson-Dupont and published by Lulu.com. This book was released on 2006-06-01 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: FROM THE BACK COVER: Are you--or is someone you care about--taking tranquilizers or sleeping pills? You could be at risk of addiction without even knowing it. Benzos are the most commonly prescribed tranquilizers and sleeping pills, in use by millions of people. Doctors prescribe these drugs routinely without ever warning patients that regular use may cause a dangerous dependency. For many people, Benzos are much harder to quit than heroin, cocaine, crack and other illegal substances, even when taken under a physician's supervision. Benzo Withdrawal may last for months, even years. Get the facts about the drugs in your medicine cabinet--facts the pharmaceutical companies, and even the FDA, don't want you to know. The Benzo Book recounts the author's experience as an unwitting addict, with full details about minimizing withdrawal symptoms, and exposes the sociological, medical and economic factors which cause this widespread--yet largely unknown--problem.

The Ashton Manual (Revised)

Author : Prof Ashton
Publisher : Blurb
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (814 download)

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Book Synopsis The Ashton Manual (Revised) by : Prof Ashton

Download or read book The Ashton Manual (Revised) written by Prof Ashton and published by Blurb. This book was released on 2024-04-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication presents insights into the impacts of benzodiazepines on both the mind and body, elucidating the mechanisms through which these effects manifest. It offers comprehensive guidance on safely discontinuing usage following extended periods, furnishing tailored tapering plans for various benzodiazepines. The text delves into withdrawal symptoms, both immediate and prolonged, elucidating their underlying causes and strategies for managing them. Ultimately, the overarching message underscores the potential for successful withdrawal among most long-term benzodiazepine users, leading to enhanced well-being and contentment.

Benzodiazepines and GHB

Author : Salvatore J. Salamone
Publisher : Springer Science & Business Media
ISBN 13 : 1592591094
Total Pages : 157 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Benzodiazepines and GHB by : Salvatore J. Salamone

Download or read book Benzodiazepines and GHB written by Salvatore J. Salamone and published by Springer Science & Business Media. This book was released on 2001-09-14 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prominent experts explain the pharmacology and metabolism of benzodiazepines (LDB) and g-hydroxybutyric acid (GHB) and offer powerful and effective methodologies that will enable better detection of these drugs in various body fluids, as well as in hair. The techniques include highly sensitive immunoassay detection of LDBs, the detection of Rohypnol® and other LDBs by mass spectrometry, and the ultrasensitive detection of GHB. State-of-the-art and highly practical, Benzodiazepines and GHB: Detection and Pharmacology offers toxicologists, forensic scientists, and clinical chemists today's most effective methods for detecting these widely abused drugs that are sometimes found associated with criminal acts.

Calming the Brain

Author : Adam Doble
Publisher : CRC Press
ISBN 13 : 1000144461
Total Pages : 196 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Calming the Brain by : Adam Doble

Download or read book Calming the Brain written by Adam Doble and published by CRC Press. This book was released on 2020-09-08 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the entire field of research in the area of minor tranquillizers and its application to current clinical practice in the treatment of anxiety and insomnia. These drugs are principally the benzodiazepines and related drugs with a similar mechanism of action, such as zolpidem and zopiclone. The molecular mechanism of action of benzodiazepines is described, focussing on the interaction of these drugs with the different isoform of the GABAA^O >receptor, and the consequences of this for brain function. Recent advances in this knowledge have provided a framework for defining the physiochemical nature of the interaction between such drugs and their receptor protein, and thus pave the way for the design of new anxiolytic and hypnotic drugs. The animal models available for evaluating the potential of such new therapeutic agents in the treatment of anxiety and insomnia are discussed. Furthermore, understanding of the physiological regulation of the GABAA receptor may provide insights into the aetiopathology of these diseases. The clinical use of benzodiazepines and related drugs in the treatment of anxiety, insomnia, epilepsy and as anaesthetics are explored. The advantages and limitations of such treatments are discussed, and the impact of drugs evaluated. A chapter is devoted to the issue of independence, the clinical pertinence of tolerence and dependence, and evaluates treatment options that may minimise the risk of dependence.

Drug-Induced Liver Disease

Author : Neil Kaplowitz
Publisher : CRC Press
ISBN 13 : 0203909127
Total Pages : 790 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Drug-Induced Liver Disease by : Neil Kaplowitz

Download or read book Drug-Induced Liver Disease written by Neil Kaplowitz and published by CRC Press. This book was released on 2002-10-16 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.

Naturally Occurring Benzodiazepines

Author : Ivan Izquierdo
Publisher : CRC Press
ISBN 13 : 9780130154880
Total Pages : 146 pages
Book Rating : 4.1/5 (548 download)

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Book Synopsis Naturally Occurring Benzodiazepines by : Ivan Izquierdo

Download or read book Naturally Occurring Benzodiazepines written by Ivan Izquierdo and published by CRC Press. This book was released on 1993-01-01 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exploration of benzodiazepines (BZDs), including the widely-used drug Valium, which have been in wide circulation in clinical practice since the 1960s as sedatives, antidepressants, hypnotics and anticonvulsants. It reveals research results with naturally-occurring BZDs in plants and animals.

Benzodiazepine Dependence, Toxicity, and Abuse

Author : American Psychiatric Association
Publisher : American Psychiatric Pub
ISBN 13 : 9780890422281
Total Pages : 132 pages
Book Rating : 4.4/5 (222 download)

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Book Synopsis Benzodiazepine Dependence, Toxicity, and Abuse by : American Psychiatric Association

Download or read book Benzodiazepine Dependence, Toxicity, and Abuse written by American Psychiatric Association and published by American Psychiatric Pub. This book was released on 1990 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, patients, lay publications, and consumer groups have expressed concern about whether benzodiazepines are overprescribed. Psychiatrists have raised questions about the potential for these medications -- especially some of the newer, high-potency, short half-life compounds -- to produce serious side effects as well as to induce drug dependence. Benzodiazepine Dependence, Toxicity, and Abuse provides clinicians with a review of the available information on the potential hazards of benzodiazepine treatment and offers suggestions for the rational prescription of these medications.

Drug-Induced Liver Injury

Author :
Publisher : Academic Press
ISBN 13 : 0128173173
Total Pages : 288 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug-Induced Liver Injury by :

Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Benzodiazepines

Author : H. Schütz
Publisher : Springer Science & Business Media
ISBN 13 : 3642684262
Total Pages : 452 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Benzodiazepines by : H. Schütz

Download or read book Benzodiazepines written by H. Schütz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: To comment at length on the importance of the benzodiazepines seems superfluous within the scope of this preface. No other class of active substances has experienced an even approximately compa rable advance in the past two decades. It is therefore not surprising that the formerly dominant barbiturates and bromocarbamides have had to give way in many fields to the benzodiazepines, which now rank first (Proudfoot and Park [1828]). Closely linked with the great therapeutic importance of the benzodia zepines are analytical problems. Detection and the determination of blood levels can be necessary under therapeutic aspects, for instance in working out optimally effective levels in the treatment of epileptic conditions ("drug monitoring"), but also in connection with questions at issue in toxicology and traffic medicine. A toxicological analysis can be subdivided into the following steps: Detection (identification including screening) Determination (e. g. blood, plasma or serum levels) Interpretation of the analytical results. This book is intended as a contribution to each of these chapters: The part "Analytical Data" (pp.I-122) gives a comprehensive collec tion of data, e.g. general and chromatographic data (TLC, GLC) as well as spectra (UV, IR, MS) of 19 commercial preparations, 23 important metabolites and 18 hydrolysis derivatives. Information about biotransformation and the possible formation of aminobenzo phenone derivatives is also given. The most important analytical methods are presented in an extensive review on pp.123-204 in order to make it possible to select the optimum method on the basis of the essential data.