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Beam Characterization For Accelerator Based Boron Neutron Capture Therapy Using The 9bed N Nuclear Reaction
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Book Synopsis Beam Characterization for Accelerator-based Boron Neutron Capture Therapy Using the 9Be(d, N) Nuclear Reaction by : Susan Marie White
Download or read book Beam Characterization for Accelerator-based Boron Neutron Capture Therapy Using the 9Be(d, N) Nuclear Reaction written by Susan Marie White and published by . This book was released on 1998 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neutron Beam Design, Development, and Performance for Neutron Capture Therapy by : Otto K. Harling
Download or read book Neutron Beam Design, Development, and Performance for Neutron Capture Therapy written by Otto K. Harling and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: For this Workshop, the organizers have attempted to invite experts from all known centers which are engaged in neutron beam development for neutron capture therapy. The Workshop was designed around a series of nineteen invited papers which dealt with neutron source design and development and beam characterization and performance. Emphasis was placed on epithermal beams because they offer clinical advantages and are more challenging to implement than thermal beams. Fission reactor sources were the basis for the majority of the papers; however three papers dealt with accelerator neutron sources. An additional three invited papers provided a summary of clinical results of Ncr therapy in Japan between 1968 and 1989 and overviews of clinical considerations for neutron capture therapy and of the status of tumor targeting chemical agents for Ncr. Five contributed poster papers dealing with NCT beam design and performance were also presented. A rapporteurs' paper was prepared after the Workshop to attempt to summarize the major aspects, issues, and conclusions which resulted from this Workshop. Many people contributed to both the smooth functioning of the Workshop and to the preparation of these proceedings. Special thanks are reserved for Ms. Dorothy K.
Book Synopsis Accelerator-Based Neutron Branchytherapy by : Haijun Song
Download or read book Accelerator-Based Neutron Branchytherapy written by Haijun Song and published by . This book was released on 1998 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development and Characterization of an Epithermal Beam for Boron Neutron Capture Therapy at the MITR-II Research Reactor by : Jong-Hoi Richard Choi
Download or read book Development and Characterization of an Epithermal Beam for Boron Neutron Capture Therapy at the MITR-II Research Reactor written by Jong-Hoi Richard Choi and published by . This book was released on 1991 with total page 901 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Boron and Gadolinium Neutron Capture Therapy for Cancer Treatment by : Narayan S. Hosmane
Download or read book Boron and Gadolinium Neutron Capture Therapy for Cancer Treatment written by Narayan S. Hosmane and published by World Scientific. This book was released on 2012 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs have turned the area to be the hottest one and worthy of further investigation with the new clinical trials in the USA and elsewhere.
Book Synopsis Spectral Characterization of Accelerator-based Epithermal Neutron Beams for BNCT and BNCS Using Neutron Activation Foils by : Laura Grace Murphy
Download or read book Spectral Characterization of Accelerator-based Epithermal Neutron Beams for BNCT and BNCS Using Neutron Activation Foils written by Laura Grace Murphy and published by . This book was released on 1999 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design of an Intense Accelerator-based Epithermal Neutron Beam Prototype for BNCT Using Near-threshold Reactions by : Charles Leon Lee
Download or read book The Design of an Intense Accelerator-based Epithermal Neutron Beam Prototype for BNCT Using Near-threshold Reactions written by Charles Leon Lee and published by . This book was released on 1998 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neutron Beam Characterization at the Finnish BNCT Facility -- Measurements and Calculations by : T. Serén
Download or read book Neutron Beam Characterization at the Finnish BNCT Facility -- Measurements and Calculations written by T. Serén and published by . This book was released on 2001 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Boron Neutron Capture Therapy (BNCT) treatment facility with an epithermal neutron beam has been successfully completed at the Finnish FiR 1 TRIGA reactor at VTT, Espoo. The clinical trials on human patients were started in May 1999. The beam utilizes a specially developed moderator material FLUENTALTM. Extensive measurements and calculations have been carried out to characterize the neutron and gamma fields, both in the "free beam" and in tissue substitute phantoms. Despite the fairly low reactor power (250 kW) an epithermal fluence rate of 1.06 x 109 n cm-2 s-1 is achieved at the beam exit aperture with low fast-neutron contamination. The beam has been modeled in detail using the DORT transport code with the BUGLE-80 library. The neutron spectrum has been adjusted with the LSL-M2 code based on multiple-foil activation. Similar calculations and measurements have been performed by the Finnish BNCT team at the BMRR facility for direct comparison.
Book Synopsis Optimized Accelerator Based Epithermal Neutron Beams for Boron Neutron Capture Therapy by : Rajat Kudchadker
Download or read book Optimized Accelerator Based Epithermal Neutron Beams for Boron Neutron Capture Therapy written by Rajat Kudchadker and published by . This book was released on 1996 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron Neutron capture therapy (BNCT) is a form of radiation therapy in which nuclides having a high tendency for capturing thermal neutrons, react by emitting charged particles of short range and leaving essentially no residual radioactivity. If these capture nuclides are selectively introduced into the tumor cells, it is theoretically possible to destroy only the tumor and in the process spare the neighboring healthy tissue. Currently, reactors are the only known source of neutrons being used for BNCT. A number of studies have been done using Monte Carlo computer codes such as MCNP to determine an optimum design of a moderator reflector configuration for an accelerator based neutron source utilizing the Li-7(p, n)Be-7 reaction. To confirm this, benchmark experiments were conducted using both a 2.0 MeV Radio Frequency Quadrupole (RFQ) accelerator and a 2.0 MeV Van de Graaff generator. All previous studies had concluded that 2.5 MeV protons would be optimum, which produces neutron having a maximum energy of 787 keV. For BNCT the desired neutron energies are between 1 eV and nominally 10 keV, i.e. in the epithermal region. These neutrons must hence be moderated to bring them down to the desired energy range. The moderator-reflector assemblies for reactor neutrons or those from 2.5 MeV protons on lithium require a little less than a meter of material to achieve the desired neutron spectrum. This research work focuses on using protons with energies just above the Li-7(p, n)Be-7 reaction threshold. These lower energy protons produce neutrons with a maximum energy of just a few hundred keV requiring much less moderation as compared to the 2.5 MeV proton lithium source. The penalty for the low energy neutron spectrum is the low yield of neutrons per proton as compared to the 2.5 MeV protons on lithium. But, less moderation implies that the patient can be moved closer to the lithium target (neutron source), thus making a more efficient use of the source neutrons. This would partially or wholly compensate for the lower yield per proton. In addition the smaller moderator-reflector assembly would result in less scattering occurring, thereby not degrading the forward directional quality of the beam as much as in current assemblies designed for use with the 2.5 MeV protons on a lithium target.
Book Synopsis An Accelerator-based Epithermal Photoneutron Source for Boron Neutron Capture Therapy by :
Download or read book An Accelerator-based Epithermal Photoneutron Source for Boron Neutron Capture Therapy written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron neutron capture therapy is an experimental binary cancer radiotherapy modality in which a boronated pharmaceutical that preferentially accumulates in malignant tissue is first administered, followed by exposing the tissue in the treatment volume to a thermal neutron field. Current usable beams are reactor-based but a viable alternative is the production of an epithermal neutron beam from an accelerator. Current literature cites various proposed accelerator-based designs, most of which are based on proton beams with beryllium or lithium targets. This dissertation examines the efficacy of a novel approach to BNCT treatments that incorporates an electron linear accelerator in the production of a photoneutron source. This source may help to resolve some of the present concerns associated with accelerator sources, including that of target cooling. The photoneutron production process is discussed as a possible alternate source of neutrons for eventual BNCT treatments for cancer. A conceptual design to produce epithermal photoneutrons by high photons (due to bremsstrahlung) impinging on deuterium targets is presented along with computational and experimental neutron production data. A clinically acceptable filtered epithermal neutron flux on the order of 10[sup 7] neutrons per second per milliampere of electron current is shown to be obtainable. Additionally, the neutron beam is modified and characterized for BNCT applications by employing two unique moderating materials (an Al/AlF[sub 3] composite and a stacked Al/Teflon design) at various incident electron energies.
Download or read book קונטרס בהלכות שבת written by and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Optimal Neutron Source & Beam Shaping Assembly for Boron Neutron Capture Therapy by :
Download or read book Optimal Neutron Source & Beam Shaping Assembly for Boron Neutron Capture Therapy written by and published by . This book was released on 2003 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: There were three objectives to this project: (1) The development of the 2-D Swan code for the optimization of the nuclear design of facilities for medical applications of radiation, radiation shields, blankets of accelerator-driven systems, fusion facilities, etc. (2) Identification of the maximum beam quality that can be obtained for Boron Neutron Capture Therapy (BNCT) from different reactor-, and accelerator-based neutron sources. The optimal beam-shaping assembly (BSA) design for each neutron source was also to e obtained. (3) Feasibility assessment of a new neutron source for NCT and other medical and industrial applications. This source consists of a state-of-the-art proton or deuteron accelerator driving and inherently safe, proliferation resistant, small subcritical fission assembly.
Book Synopsis Boron Neutron Capture Therapy of Malignant Brain Tumors at the Brookhaven Medical Research Reactor by :
Download or read book Boron Neutron Capture Therapy of Malignant Brain Tumors at the Brookhaven Medical Research Reactor written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron neutron capture therapy (BNCT) is a bimodal form of radiation therapy for cancer. The first component of this treatment is the preferential localization of the stable isotope[sup 10]B in tumor cells by targeting with boronated compounds. The tumor and surrounding tissue is then irradiated with a neutron beam resulting in thermal neutron/[sup 10]B reactions ([sup 10]B(n, [alpha])[sup 7]Li) resulting in the production of localized high LET radiation from alpha and[sup 7]Li particles. These products of the neutron capture reaction are very damaging to cells, but of short range so that the majority of the ionizing energy released is microscopically confined to the vicinity of the boron-containing compound. In principal it should be possible with BNCT to selectively destroy small nests or even single cancer cells located within normal tissue. It follows that the major improvements in this form of radiation therapy are going to come largely from the development of boron compounds with greater tumor selectivity, although there will certainly be advances made in neutron beam quality as well as the possible development of alternative sources of neutron beams, particularly accelerator-based epithermal neutron beams.
Book Synopsis Boron Neutron Capture Therapy by : Detlef Gabel
Download or read book Boron Neutron Capture Therapy written by Detlef Gabel and published by Springer. This book was released on 2012-10-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The European Collaboration on Boron Neutron Capture Therapy (BNCT), conceived in 1987 and successful in 1989 in gaining financial support as a Concerted Action through the Medical and Health Research Programme of the Commission ofthe European Communities (CEC) in Brussels, considered it an opportune moment to hold its annual Plenary Meeting on 18-20 Septem ber 1991 as an International Workshop entitled "Towards Clinical Trials of Glioma with BNCT". The background to this consideration was influenced by the world-wide resurgence ofinterest in NCT over the last 2 decades and by the exemplifica tions at the Fourth International Symposium on Neutron Capture Therapy for Cancer held in Sydney in December 1990, where it was strongly indicated that within the next 2 years clinical trials would be started both in Europe and the United States. In particular at the High Flux Reactor of the Joint Research Centre of the CEC at Petten in The Netherlands, an epithermal neutron beam designed and installed in the summer of 1990 recently became operable at full reactor power. An extensive series ofexperiments, including the nuclear and radiobiological characterisation of the beam and a healthy tissue tolerance study on canines has started and has the aim to define the preconditions for clinical trials onpatients with Grade III/IV glioma. However, as with any other new therapy modality, it must be demon strated that BNCT is safe for the patient and has a reasonable chance of being an effective therapy.
Book Synopsis High-power Target Development for Accelerator-based Neutron Capture Therapy by : Brandon William Blackburn
Download or read book High-power Target Development for Accelerator-based Neutron Capture Therapy written by Brandon William Blackburn and published by . This book was released on 2002 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Cont.) Because of its low melting-point, lithium targets were able to achieve 10 kW only if the beam power density was kept below 11.6 MW/m2. No significant difference in figures of merit used to characterize neutron beams for ABNCT were found when water was replaced by liquid gallium as the cooling fluid.
Book Synopsis Advances in Boron Neutron Capture Therapy by : International Atomic Energy Agency
Download or read book Advances in Boron Neutron Capture Therapy written by International Atomic Energy Agency and published by . This book was released on 2023-07-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron neutron capture therapy (BNCT) is a neutron-based technique that allows selective cancer treatment at the tumour cellular level. BNCT is especially suitable for the treatment of brain, head, neck and skin cancers. Using the reaction between a neutron and boron to selectively destroy cancer cells, BNCT is a treatment that differs radically from conventional radiotherapy and promises to become a more widely adopted option for cancer treatment. BNCT is undergoing a major resurgence of interest around the world as some recent progress in accelerator technology allows the procedure to be undertake in clinics. In addition, the approval of BNCT in Japan as a routine clinical treatment for certain tumour types offers valuable insights for other states considering a similar approach. This publication comprehensively reports on the current state of the science as well as the supporting technology. It covers accelerator-based neutron sources, beam design, physical dosimetry, facility design and operation, pharmaceuticals, radiobiology, dose calculation, treatment planning and clinical trials. It has been written to assist in decision making at the national level as well as offering practical guidance for all those involved in implementation and ongoing management of BNCT programmes.
Book Synopsis A Design of an Accelerator-based Epithermal Neutron Beam for Boron Neuton Capture Therapy by : Xiao-Lin Zhou
Download or read book A Design of an Accelerator-based Epithermal Neutron Beam for Boron Neuton Capture Therapy written by Xiao-Lin Zhou and published by . This book was released on 1990 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt:
