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Bayesian Modelling Of Positively Skewed Data With Particular Application To The Cost Aspect Of Medical Cost Effectiveness Analysis
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Book Synopsis Bayesian Modelling of Positively Skewed Data with Particular Application to the Cost Aspect of Medical Cost-effectiveness Analysis by : Peter Leonard Gregory
Download or read book Bayesian Modelling of Positively Skewed Data with Particular Application to the Cost Aspect of Medical Cost-effectiveness Analysis written by Peter Leonard Gregory and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The motivation for this research was the study of a medical cost data set from a clinical trial. If a Regulatory Body were to be accept the new intervention that has been proposed then a Health Care provider has to budget for future treatments for some members of the rest of the population. In this Bayesian analysis we want to be able to calculate the expected value for one unobserved member of this finite population from its posterior predictive distribution by firstly establishing the parametric data model that best captures the positive skew characteristics of the costs. We then develop a novel approach to modelling the priors that enable an expert's prior beliefs to be elicited while permitting a limited analytical study of the model. These techniques have been applied to recent medical data sets to establish their comparative efficiency when compared with classical estimators.
Book Synopsis Bayesian Cost-Effectiveness Analysis of Medical Treatments by : Elias Moreno
Download or read book Bayesian Cost-Effectiveness Analysis of Medical Treatments written by Elias Moreno and published by CRC Press. This book was released on 2019-01-30 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cost-effectiveness analysis is becoming an increasingly important tool for decision making in the health systems. Cost-Effectiveness of Medical Treatments formulates the cost-effectiveness analysis as a statistical decision problem, identifies the sources of uncertainty of the problem, and gives an overview of the frequentist and Bayesian statistical approaches for decision making. Basic notions on decision theory such as space of decisions, space of nature, utility function of a decision and optimal decisions, are explained in detail using easy to read mathematics. Features Focuses on cost-effectiveness analysis as a statistical decision problem and applies the well-established optimal statistical decision methodology. Discusses utility functions for cost-effectiveness analysis. Enlarges the class of models typically used in cost-effectiveness analysis with the incorporation of linear models to account for covariates of the patients. This permits the formulation of the group (or subgroup) theory. Provides Bayesian procedures to account for model uncertainty in variable selection for linear models and in clustering for models for heterogeneous data. Model uncertainty in cost-effectiveness analysis has not been considered in the literature. Illustrates examples with real data. In order to facilitate the practical implementation of real datasets, provides the codes in Mathematica for the proposed methodology. The motivation for the book is to make the achievements in cost-effectiveness analysis accessible to health providers, who need to make optimal decisions, to the practitioners and to the students of health sciences. Elías Moreno is Professor of Statistics and Operational Research at the University of Granada, Spain, Corresponding Member of the Royal Academy of Sciences of Spain, and elect member of ISI. Francisco José Vázquez-Polo is Professor of Mathematics and Bayesian Methods at the University of Las Palmas de Gran Canaria, and Head of the Department of Quantitative Methods. Miguel Ángel Negrín is Senior Lecturer in the Department of Quantitative Methods at the ULPGC. His main research topics are Bayesian methods applied to Health Economics, economic evaluation and cost-effectiveness analysis, meta-analysis and equity in the provision of healthcare services.
Book Synopsis Bayesian Methods in Health Economics by : Gianluca Baio
Download or read book Bayesian Methods in Health Economics written by Gianluca Baio and published by CRC Press. This book was released on 2012-11-12 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health economics is concerned with the study of the cost-effectiveness of health care interventions. This book provides an overview of Bayesian methods for the analysis of health economic data. After an introduction to the basic economic concepts and methods of evaluation, it presents Bayesian statistics using accessible mathematics. The next chapters describe the theory and practice of cost-effectiveness analysis from a statistical viewpoint, and Bayesian computation, notably MCMC. The final chapter presents three detailed case studies covering cost-effectiveness analyses using individual data from clinical trials, evidence synthesis and hierarchical models and Markov models. The text uses WinBUGS and JAGS with datasets and code available online.
Book Synopsis Bayesian Cost-Effectiveness Analysis with the R package BCEA by : Gianluca Baio
Download or read book Bayesian Cost-Effectiveness Analysis with the R package BCEA written by Gianluca Baio and published by Springer. This book was released on 2017-05-25 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a description of the process of health economic evaluation and modelling for cost-effectiveness analysis, particularly from the perspective of a Bayesian statistical approach. Some relevant theory and introductory concepts are presented using practical examples and two running case studies. The book also describes in detail how to perform health economic evaluations using the R package BCEA (Bayesian Cost-Effectiveness Analysis). BCEA can be used to post-process the results of a Bayesian cost-effectiveness model and perform advanced analyses producing standardised and highly customisable outputs. It presents all the features of the package, including its many functions and their practical application, as well as its user-friendly web interface. The book is a valuable resource for statisticians and practitioners working in the field of health economics wanting to simplify and standardise their workflow, for example in the preparation of dossiers in support of marketing authorisation, or academic and scientific publications.
Book Synopsis Statistical Analysis of Cost-Effectiveness Data by : Andrew R. Willan
Download or read book Statistical Analysis of Cost-Effectiveness Data written by Andrew R. Willan and published by John Wiley & Sons. This book was released on 2006-08-14 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: The statistical analysis of cost-effectiveness data is becoming increasingly important within health and medical research. Statistical Analysis of Cost-Effectiveness Data provides a practical book that synthesises the huge amount of research that has taken place in the area over the last two decades. Comprising an up-to-date overview of the statistical analysis of cost-effectiveness data, the book is supported by numerous worked examples from the author’s own experience. It has been written in a style suitable for medical statisticians and health care professionals alike. Key features include: an overview of statistical methods used in the analysis of cost-effectiveness data. coverage of Bayesian methodology. illustrated throughout by worked examples using real data. suitability for health care professionals with limited statistical knowledge. discussion of software used for data analysis. An essential reference for biostatisticians and health economists engaged in cost-effectiveness analysis of health-care interventions, both in academia and industry. Also of interest to graduate students of biostatistics, public health and economics.
Book Synopsis Bayesian Approaches to Clinical Trials and Health-Care Evaluation by : David J. Spiegelhalter
Download or read book Bayesian Approaches to Clinical Trials and Health-Care Evaluation written by David J. Spiegelhalter and published by John Wiley & Sons. This book was released on 2004-05-05 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: READ ALL ABOUT IT! David Spiegelhalter has recently joined the ranks of Isaac Newton, Charles Darwin and Stephen Hawking by becoming a fellow of the Royal Society. Originating from the Medical Research Council’s biostatistics unit, David has played a leading role in the Bristol heart surgery and Harold Shipman inquiries. Order a copy of this author’s comprehensive text TODAY! The Bayesian approach involves synthesising data and judgement in order to reach conclusions about unknown quantities and make predictions. Bayesian methods have become increasingly popular in recent years, notably in medical research, and although there are a number of books on Bayesian analysis, few cover clinical trials and biostatistical applications in any detail. Bayesian Approaches to Clinical Trials and Health-Care Evaluation provides a valuable overview of this rapidly evolving field, including basic Bayesian ideas, prior distributions, clinical trials, observational studies, evidence synthesis and cost-effectiveness analysis. Covers a broad array of essential topics, building from the basics to more advanced techniques. Illustrated throughout by detailed case studies and worked examples Includes exercises in all chapters Accessible to anyone with a basic knowledge of statistics Authors are at the forefront of research into Bayesian methods in medical research Accompanied by a Web site featuring data sets and worked examples using Excel and WinBUGS - the most widely used Bayesian modelling package Bayesian Approaches to Clinical Trials and Health-Care Evaluation is suitable for students and researchers in medical statistics, statisticians in the pharmaceutical industry, and anyone involved in conducting clinical trials and assessment of health-care technology.
Book Synopsis Modeling in Medical Decision Making by : Giovanni Parmigiani
Download or read book Modeling in Medical Decision Making written by Giovanni Parmigiani and published by John Wiley & Sons. This book was released on 2002-03 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes Bayesian inference, Monte Carlo simulation, utility theory and gives case studies of their use.
Book Synopsis Bayesian Cost-effectiveness Analysis Based on a Decision Analytic Model by : Rita Esther Zapata Vazquez
Download or read book Bayesian Cost-effectiveness Analysis Based on a Decision Analytic Model written by Rita Esther Zapata Vazquez and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Palgrave Handbook of Econometrics by : Terence C. Mills
Download or read book Palgrave Handbook of Econometrics written by Terence C. Mills and published by Springer. This book was released on 2009-06-25 with total page 1406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following theseminal Palgrave Handbook of Econometrics: Volume I , this second volume brings together the finestacademicsworking in econometrics today andexploresapplied econometrics, containing contributions onsubjects includinggrowth/development econometrics and applied econometrics and computing.
Book Synopsis Cochrane Handbook for Systematic Reviews of Interventions by : Julian P. T. Higgins
Download or read book Cochrane Handbook for Systematic Reviews of Interventions written by Julian P. T. Higgins and published by Wiley. This book was released on 2008-11-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.
Book Synopsis Bayesian Data Analysis, Third Edition by : Andrew Gelman
Download or read book Bayesian Data Analysis, Third Edition written by Andrew Gelman and published by CRC Press. This book was released on 2013-11-01 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, this classic book is widely considered the leading text on Bayesian methods, lauded for its accessible, practical approach to analyzing data and solving research problems. Bayesian Data Analysis, Third Edition continues to take an applied approach to analysis using up-to-date Bayesian methods. The authors—all leaders in the statistics community—introduce basic concepts from a data-analytic perspective before presenting advanced methods. Throughout the text, numerous worked examples drawn from real applications and research emphasize the use of Bayesian inference in practice. New to the Third Edition Four new chapters on nonparametric modeling Coverage of weakly informative priors and boundary-avoiding priors Updated discussion of cross-validation and predictive information criteria Improved convergence monitoring and effective sample size calculations for iterative simulation Presentations of Hamiltonian Monte Carlo, variational Bayes, and expectation propagation New and revised software code The book can be used in three different ways. For undergraduate students, it introduces Bayesian inference starting from first principles. For graduate students, the text presents effective current approaches to Bayesian modeling and computation in statistics and related fields. For researchers, it provides an assortment of Bayesian methods in applied statistics. Additional materials, including data sets used in the examples, solutions to selected exercises, and software instructions, are available on the book’s web page.
Book Synopsis Bayesian Cost-effectiveness Analysis Based on a Decision Analytic Model by :
Download or read book Bayesian Cost-effectiveness Analysis Based on a Decision Analytic Model written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Economic Evaluation in Clinical Trials by : Henry A. Glick
Download or read book Economic Evaluation in Clinical Trials written by Henry A. Glick and published by OUP Oxford. This book was released on 2014-10-02 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is becoming increasingly important to examine the relationship between the outcomes of a clinical trial and the costs of the medical therapy under study. The results of such analysis can affect reimbursement decisions for new medical technologies, drugs, devices or diagnostics. It can aid companies seeking to make claims about the cost-effectiveness of their product, as well as allowing early consideration of the economic value of therapies which may be important to improving initial adoption decisions. It is also vital for addressing the requirements of regulatory bodies. Economic Evaluation in Clinical Trials provides practical advice on how to conduct cost-effectiveness analyses in controlled trials of medical therapies. This new edition has been extensively rewritten and revised; topics discussed range from design issues such as the types of services that should be measured and price weights, to assessment of quality-adjusted life years. Illustrative materials, case histories and worked examples are included to encourage the reader to apply the methods discussed. These exercises are supported with datasets, programmes and solutions made available online.
Book Synopsis Designing and Conducting Cost-Effectiveness Analyses in Medicine and Health Care by : Peter Muennig
Download or read book Designing and Conducting Cost-Effectiveness Analyses in Medicine and Health Care written by Peter Muennig and published by Jossey-Bass. This book was released on 2002-03-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of cost-effectiveness analysis has lacked an entry-level textbook until now. Designing and Conducting Cost-Effectiveness Analyses in Medicine and Health Care is a hands-on guide for conducting economic analyses that closely follows the recommendations of the Panel on Cost-Effectiveness in Health and Medicine. Step by step, Dr. Muennig outlines the theory and practice of cost-effectiveness and shows how to develop an original research question, retrieve data, design a decision analysis tree, calculate quality-adjusted life years, and test for error in analysis. The book provides clear and detailed instruction and includes a review of the epidemiological and biostatistical skills students need to conduct cost-effectiveness analyses. While the book is designed for students, it includes advanced topics for policymakers, community health experts, and preventive medicine residents who are interested in the field. The book uses a worked example to walk the reader through the process of designing and conducting an analysis and provides links to all of the major Internet-accessible sources of government data. This book will be a welcome addition to the library of students and seasoned researchers alike.
Book Synopsis Bayesian Biostatistics by : Donald A. Berry
Download or read book Bayesian Biostatistics written by Donald A. Berry and published by CRC Press. This book was released on 2018-10-03 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides descriptions, explanations and examples of the Bayesian approach to statistics, demonstrating the utility of Bayesian methods for analyzing real-world problems in the health sciences. The work considers the individual components of Bayesian analysis.;College or university bookstores may order five or more copies at a special student price, available on request from Marcel Dekker, Inc.
Book Synopsis Bayesian Statistical Modelling by : Peter Congdon
Download or read book Bayesian Statistical Modelling written by Peter Congdon and published by John Wiley & Sons. This book was released on 2007-04-04 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian methods combine the evidence from the data at hand with previous quantitative knowledge to analyse practical problems in a wide range of areas. The calculations were previously complex, but it is now possible to routinely apply Bayesian methods due to advances in computing technology and the use of new sampling methods for estimating parameters. Such developments together with the availability of freeware such as WINBUGS and R have facilitated a rapid growth in the use of Bayesian methods, allowing their application in many scientific disciplines, including applied statistics, public health research, medical science, the social sciences and economics. Following the success of the first edition, this reworked and updated book provides an accessible approach to Bayesian computing and analysis, with an emphasis on the principles of prior selection, identification and the interpretation of real data sets. The second edition: Provides an integrated presentation of theory, examples, applications and computer algorithms. Discusses the role of Markov Chain Monte Carlo methods in computing and estimation. Includes a wide range of interdisciplinary applications, and a large selection of worked examples from the health and social sciences. Features a comprehensive range of methodologies and modelling techniques, and examines model fitting in practice using Bayesian principles. Provides exercises designed to help reinforce the reader’s knowledge and a supplementary website containing data sets and relevant programs. Bayesian Statistical Modelling is ideal for researchers in applied statistics, medical science, public health and the social sciences, who will benefit greatly from the examples and applications featured. The book will also appeal to graduate students of applied statistics, data analysis and Bayesian methods, and will provide a great source of reference for both researchers and students. Praise for the First Edition: “It is a remarkable achievement to have carried out such a range of analysis on such a range of data sets. I found this book comprehensive and stimulating, and was thoroughly impressed with both the depth and the range of the discussions it contains.” – ISI - Short Book Reviews “This is an excellent introductory book on Bayesian modelling techniques and data analysis” – Biometrics “The book fills an important niche in the statistical literature and should be a very valuable resource for students and professionals who are utilizing Bayesian methods.” – Journal of Mathematical Psychology
Book Synopsis Bayesian Applications in Pharmaceutical Development by : Mani Lakshminarayanan
Download or read book Bayesian Applications in Pharmaceutical Development written by Mani Lakshminarayanan and published by CRC Press. This book was released on 2019-11-07 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cost for bringing new medicine from discovery to market has nearly doubled in the last decade and has now reached $2.6 billion. There is an urgent need to make drug development less time-consuming and less costly. Innovative trial designs/ analyses such as the Bayesian approach are essential to meet this need. This book will be the first to provide comprehensive coverage of Bayesian applications across the span of drug development, from discovery, to clinical trial, to manufacturing with practical examples. This book will have a wide appeal to statisticians, scientists, and physicians working in drug development who are motivated to accelerate and streamline the drug development process, as well as students who aspire to work in this field. The advantages of this book are: Provides motivating, worked, practical case examples with easy to grasp models, technical details, and computational codes to run the analyses Balances practical examples with best practices on trial simulation and reporting, as well as regulatory perspectives Chapters written by authors who are individual contributors in their respective topics Dr. Mani Lakshminarayanan is a researcher and statistical consultant with more than 30 years of experience in the pharmaceutical industry. He has published over 50 articles, technical reports, and book chapters besides serving as a referee for several journals. He has a PhD in Statistics from Southern Methodist University, Dallas, Texas and is a Fellow of the American Statistical Association. Dr. Fanni Natanegara has over 15 years of pharmaceutical experience and is currently Principal Research Scientist and Group Leader for the Early Phase Neuroscience Statistics team at Eli Lilly and Company. She played a key role in the Advanced Analytics team to provide Bayesian education and statistical consultation at Eli Lilly. Dr. Natanegara is the chair of the cross industry-regulatory-academic DIA BSWG to ensure that Bayesian methods are appropriately utilized for design and analysis throughout the drug-development process.
