Basic And Clinical Aspects Of Growth Hormone

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Growth Hormone Deficiency in Adults

Author : Jens O. L. Jørgensen
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805579926
Total Pages : 241 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Growth Hormone Deficiency in Adults by : Jens O. L. Jørgensen

Download or read book Growth Hormone Deficiency in Adults written by Jens O. L. Jørgensen and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.

Growth Hormone in Adults

Author : Anders Juul
Publisher : Cambridge University Press
ISBN 13 : 9780521641883
Total Pages : 536 pages
Book Rating : 4.6/5 (418 download)

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Book Synopsis Growth Hormone in Adults by : Anders Juul

Download or read book Growth Hormone in Adults written by Anders Juul and published by Cambridge University Press. This book was released on 2000-04-27 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.

Basic and Clinical Aspects of Growth Hormone

Author : Barry D. Bercu
Publisher : Springer Science & Business Media
ISBN 13 : 1468455052
Total Pages : 369 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Basic and Clinical Aspects of Growth Hormone by : Barry D. Bercu

Download or read book Basic and Clinical Aspects of Growth Hormone written by Barry D. Bercu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this era of proliferation of synthetic growth hormone in the marketplace, there is a parallel and accentuated interest in growth hormone in the scientific arena. Because many more people can be treated with available growth hormone, clinicians must be prepared to answer hard questions regarding appropriate therapeutic usage and their decisions should be based on substantiated research in growth hormone. In June 1987, an international group of basic and clinical inves tigators gathered in Tampa, Florida, to address these issues and to further explore the very nature of growth hormone. The presentations contained within this book bring together their most current and vital research related to growth hormone. Section I deals with an examination of the molecular and biochemical events which define the growth hormone process. In Section II the neuroregulation of growth hormone secretion is highlighted from contrasting perspectives. The third section emphasizes and defines methods of diagnosis of growth hormone deficiency states. Section IV reviews the physiology, biochemistry and molecular actions of growth hormone and somatomedin. Section V represents an assessment of growth hormone treatment for various disorders, and the sixth section expands current uses of growth hormone therapy as it evolves into the next decade. The symposium upon which this book is based proved to be a dynamic blending of scholarly interaction between basic and clinical scientists. I am indebted to the participants whose worthy contributions are reflected in these pages.

Gigantism and Acromegaly

Author : Constantine A. Stratakis
Publisher : Academic Press
ISBN 13 : 0128145382
Total Pages : 312 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Gigantism and Acromegaly by : Constantine A. Stratakis

Download or read book Gigantism and Acromegaly written by Constantine A. Stratakis and published by Academic Press. This book was released on 2021-06-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim's appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. - Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism - Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics - Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism

Growth Hormone Therapy in Pediatrics

Author : Michael B. Ranke
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805582560
Total Pages : 534 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Growth Hormone Therapy in Pediatrics by : Michael B. Ranke

Download or read book Growth Hormone Therapy in Pediatrics written by Michael B. Ranke and published by Karger Medical and Scientific Publishers. This book was released on 2007-01-01 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention in children and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community.

Growth Hormone And The Heart

Author : Andrea Giustina
Publisher : Springer Science & Business Media
ISBN 13 : 9780792372127
Total Pages : 538 pages
Book Rating : 4.3/5 (721 download)

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Book Synopsis Growth Hormone And The Heart by : Andrea Giustina

Download or read book Growth Hormone And The Heart written by Andrea Giustina and published by Springer Science & Business Media. This book was released on 2000-11-30 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growth Hormone and the Heart endeavors to bring together knowledge that has been accumulated in the area of GH and the heart, from basic to clinical studies, by research groups working on this topic throughout the world. Lessons from different experimental models and from several human diseases (acromegaly, adult GH deficiency, heart failure) suggest to endocrinologists and cardiologists that GH may not only have a role in the physiology and pathophysiology of heart function, but that GH itself may have a place in the treatment of primary heart diseases (such as dilated cardiomyopathy) or of cardiac complications of hypopituitarism. Growth Hormone and the Heart will be a useful update of the research produced in the field of cardiovascular endocrinology. The Editors also hope that this book will serve as the primary step in the recognition of the wide physiological and clinical significance of GH and heart interactions.

Hormonal Regulation of Growth

Author : Herwig Frisch
Publisher :
ISBN 13 :
Total Pages : 332 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Hormonal Regulation of Growth by : Herwig Frisch

Download or read book Hormonal Regulation of Growth written by Herwig Frisch and published by . This book was released on 1989 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Growth Hormone Secretagogues

Author : E. Ghigo
Publisher : Elsevier
ISBN 13 : 0080532691
Total Pages : 341 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Growth Hormone Secretagogues by : E. Ghigo

Download or read book Growth Hormone Secretagogues written by E. Ghigo and published by Elsevier. This book was released on 1999-09-07 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growth hormone secretagogues (GHS) administered alone or in combination with growth hormone releasing hexapeptides, are effective probes for the diagnosis of GH deficiency in both children and adults. Current research has developed and tested different GHS compounds that are active by the oral route, and have improved potency and bioavailability, giving rise to exciting therapeutic possibilities. There was an enthusiastic response from experts in this area to the idea of distilling the huge amount of available data into one multi-authored volume. Each contributor has advanced the field of knowledge, and has here emphasized the practical aspects of their work, reviewing the subject in the light of their own experience. Therefore, the theme of the book is a practical one. The volume deals with all aspects of GHS that are relevant to the field, from the chemical structure to the different analogues, to the cloning and expression of the GHS-receptor and the role of these compounds in the physiological control of GH secretion. Also discussed are the most recent advances in relation to the possible role of these compounds in the diagnostic therapeutic settings in different clinical situations, either in children, adults or the elderly. The book meets the requirement of covering most, if not all of the advances in the field. It will enable scientists and clinicians to keep abreast of the rapidly evolving knowledge of the most recent years, and will also prove useful as a review for all interested in this topic.

Clinical Neuroendocrinology

Author : Michael Wilkinson
Publisher : Cambridge University Press
ISBN 13 : 1316645193
Total Pages : 207 pages
Book Rating : 4.3/5 (166 download)

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Book Synopsis Clinical Neuroendocrinology by : Michael Wilkinson

Download or read book Clinical Neuroendocrinology written by Michael Wilkinson and published by Cambridge University Press. This book was released on 2019-01-03 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.

Human Growth Hormone

Author : Adair Stuart Mason
Publisher :
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Human Growth Hormone by : Adair Stuart Mason

Download or read book Human Growth Hormone written by Adair Stuart Mason and published by . This book was released on 1972 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Growth Hormone is a compendium of papers that discusses all aspects of human growth hormone (HGH) relevant in the treatment of dwarfs who are HGH deficient. This book discusses the approach of growth hormone treatment including the preparation of the hormone, its effect and interactions with other hormones, the methods used to detect growth hormone in human plasma, as well as its clinical applications. One author discusses the preparation of human growth hormone, its storage, method of bioassay, and procedures for ampouling HGH for clinical use. A couple of authors review the metabolic a ...

Greenspan's Basic and Clinical Endocrinology, Tenth Edition

Author : David G. Gardner
Publisher : McGraw Hill Professional
ISBN 13 : 1259589293
Total Pages : 941 pages
Book Rating : 4.2/5 (595 download)

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Book Synopsis Greenspan's Basic and Clinical Endocrinology, Tenth Edition by : David G. Gardner

Download or read book Greenspan's Basic and Clinical Endocrinology, Tenth Edition written by David G. Gardner and published by McGraw Hill Professional. This book was released on 2017-10-13 with total page 941 pages. Available in PDF, EPUB and Kindle. Book excerpt: A full-color guide to the entire field of clinical endocrinology and its scientific underpinnings – updated with the latest breakthroughs and developments A Doody’s Core Title for 2021! Greenspan’s Basic & Clinical Endocrinology delivers a succinct, leading-edge overview of the underlying molecular biology of the endocrine system and the latest perspectives on the diagnosis and treatment of specific diseases and disorders. Featuring an enhanced design that includes hundreds of full-color illustrations and clinical photographs, Greenspan’s is a true must-have during traditional or integrated courses in endocrinology, endocrinology rotation, or exam prep in internal medicine and endocrinology and as reference for disease management. Greenspan’s provides clinically relevant coverage of metabolic bone disease, pancreatic hormones and diabetes mellitus, hypoglycemia, obesity, geriatric endocrinology, and many other diseases and disorders. Supporting this essential material is a handy appendix of normal hormone reference ranges across the lifespan. Here’s why Greenspan’s is an essential tool for learning how to manage endocrine patients: • The Tenth Edition is enhanced by updated content throughout each chapter • NEW CHAPTERS on Transgender Endocrinology and Disorders of Sexual Determination and Differentiation • Important chapter on Evidence-Based Endocrinology and Clinical Epidemiology • Concise, balanced coverage of both scientific and clinical principles that guide patient management • The best source for current concepts in endocrine pathophysiology to aid clinical decision making • The most practical, current insights into diagnostic testing • More than 270 full-color illustrations and clinical photographs If you are in need of a well-illustrated, completely up-to-date guide to the entire field of clinical endocrinology, this trusted classic belongs on your desk or computer.

Sex-Steroid Interactions with Growth Hormone

Author : Johannes D. Veldhuis
Publisher : Springer Science & Business Media
ISBN 13 : 1461215463
Total Pages : 367 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Sex-Steroid Interactions with Growth Hormone by : Johannes D. Veldhuis

Download or read book Sex-Steroid Interactions with Growth Hormone written by Johannes D. Veldhuis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sex-Steroid Interactions with Growth Hormone presents the proceedings of an international symposium held from October 22-25 in Naples, Florida. The proceedings provide new insights and concepts gained by molecular, cellular and neuroendocrine research into mechanistic interactions of the reproductive and somatotrophic axes. Chapters include discussions of the impact of sex steroids on growth hormone secretion in both children and adults; sex steroids, growth hormone releasing factor, and somatostatin; how sex steroids modulate growth hormone action on target issues; and differential effects of growth hormone secretagogues in men and women. This volume is designed for physicians, scientists and other health professionals interested or trained in clinical and basic endocrinology, growth or reproduction.

Human Growth Hormone

Author : Roy G. Smith
Publisher : PennWell Corporation
ISBN 13 : 9780896035058
Total Pages : 372 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Human Growth Hormone by : Roy G. Smith

Download or read book Human Growth Hormone written by Roy G. Smith and published by PennWell Corporation. This book was released on 2000-01-28 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH in clinical studies. Timely and innovative, Human Growth Hormone: Research and Clinical Practice will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.

Biologic Rhythms in Clinical and Laboratory Medicine

Author : Yvan Touitou
Publisher : Springer Science & Business Media
ISBN 13 : 3642787347
Total Pages : 747 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Biologic Rhythms in Clinical and Laboratory Medicine by : Yvan Touitou

Download or read book Biologic Rhythms in Clinical and Laboratory Medicine written by Yvan Touitou and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 747 pages. Available in PDF, EPUB and Kindle. Book excerpt: Everyone has heard of nature's "biological clocks", the phenomenon of periodic activity in plants, animals and humans. But what does chronobiology have to do with modern medicine? This book presents in a concise but comprehensive fashion the basic principles of chronobiology and their application to clinical medicine. The chapters are written by specialists in the field; they summarize the physiology, pathophysiology and pathology of the human time structure and outline the application of chronobiologic principles and techniques for diagnosis and treatment.

The Practical Handbook of Perioperative Metabolic and Nutritional Care

Author : M. Isabel T.D Correia
Publisher : Academic Press
ISBN 13 : 0128175117
Total Pages : 344 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Practical Handbook of Perioperative Metabolic and Nutritional Care by : M. Isabel T.D Correia

Download or read book The Practical Handbook of Perioperative Metabolic and Nutritional Care written by M. Isabel T.D Correia and published by Academic Press. This book was released on 2019-06-25 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for any healthcare professional working with surgical patients, including medical students, residents, surgeons and internists, nurses, dieticians, pharmacists, and physical therapists, The Practical Handbook of Perioperative Metabolic and Nutritional Care focuses on topics from the history of surgery and metabolism, to organic response to stress. Based on clinical processes, the author explores screening, assessment, and the impact of nutritional status on outcomes, in addition to investigating nutritional requirements, including macronutrients and micronutrients. Chapters examine wound healing as well as metabolic and nutritional surgical preconditioning, including coverage of preoperative counseling, preoperative nutrition, and preoperative fasting. Physical exercise is addressed, as well as nutritional therapy in the form of oral supplements, and enteral and parenteral approaches. Additional topics explored include nutrition therapy complications and immunomodulatory nutrients, pro, pre and symbiotics, postoperative oral, enteral and parenteral nutrition, enteral access, vascular access, fluid therapy, and more. With up-to-date information, practical and cost-effective data, this resource is critical for translating theory to practice. - Focuses on preoperative metabolic and nutritional preparation for surgery - Explores processes for intra and postoperatively assessing metabolic and nutritional state to ensure patient progress - Contains content based on clinical process

Growth Hormone Secretagogues in Clinical Practice

Author : Barry B. Bercu
Publisher : CRC Press
ISBN 13 : 9780824798321
Total Pages : 468 pages
Book Rating : 4.7/5 (983 download)

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Book Synopsis Growth Hormone Secretagogues in Clinical Practice by : Barry B. Bercu

Download or read book Growth Hormone Secretagogues in Clinical Practice written by Barry B. Bercu and published by CRC Press. This book was released on 1998-04-28 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognizing the urgent need for an up-to-date review of new and innovative research on growth hormone (GH) secretagogues, this exclusive work furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, and clinical applications of GH secretagogues, including orally active and xenobiotic GH-releasing compounds. Beginning with a thorough historical perspective on the discovery and evolution of GH-releasing peptides (GHRPs) as therapeutic agents, Growth Hormone Secretagogues in Clinical Practice analyzes structural requirements for GH secretagogue efficacy demonstrates the use of mathematical models to predict differential values of individual stimuli for GH secretion from the pituitary reports on the development of a simple screening system based on polyclonal antibodies discusses laboratory synthesis of agonistic analogs intended for human and veterinary use proposes applications in managing conditions such as Turner's syndrome, acromegaly, diabetic retinopathy, glomerulosclerosis, tumors, and cancer provides physiological evidence for the effects of GHRP on behavior with a series of trials involving voluntary and forced exercise describes a new diagnostic test for evaluating pituitary function in slowly growing children and aging adults explores the interactions of GH secretagogues with other hormones and endogenous substances from sex steroids to interferons and much more!

Hormone Signaling

Author : Vincent Goffin
Publisher : Springer Science & Business Media
ISBN 13 : 9780792376606
Total Pages : 340 pages
Book Rating : 4.3/5 (766 download)

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Book Synopsis Hormone Signaling by : Vincent Goffin

Download or read book Hormone Signaling written by Vincent Goffin and published by Springer Science & Business Media. This book was released on 2002-03-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.