Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Base Metal Catalyzed Cross Couplings Of Unconventional Oxygen Based Electrophiles And Total Synthesis Of Tubingensin A
Download Base Metal Catalyzed Cross Couplings Of Unconventional Oxygen Based Electrophiles And Total Synthesis Of Tubingensin A full books in PDF, epub, and Kindle. Read online Base Metal Catalyzed Cross Couplings Of Unconventional Oxygen Based Electrophiles And Total Synthesis Of Tubingensin A ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Base Metal-catalyzed Cross-couplings of Unconventional Oxygen-based Electrophiles and Total Synthesis of Tubingensin A by : Amanda Leanne Silberstein
Download or read book Base Metal-catalyzed Cross-couplings of Unconventional Oxygen-based Electrophiles and Total Synthesis of Tubingensin A written by Amanda Leanne Silberstein and published by . This book was released on 2014 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transition metal-catalyzed cross-couplings provide a powerful means to assemble carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds. Although halides are the most commonly employed electrophilic partner, phenolic derivatives offer a valuable alternative because phenols are typically inexpensive and readily available. This dissertation describes the development of cross-coupling reactions involving sulfamates and carbamates. Additionally, the total synthesis of tubingensin A utilizing a carbazolyne intermediate is reported. Chapter one reviews the recent advances in transition metal-catalyzed alkylative cross-coupling reactions. This review considers primary and secondary alkylations, tertiary alkylations, and synthetic applications. Particular emphasis is placed on how modern methods have addressed historical challenges. Chapters two and three describe the development of transition metal-catalyzed cross-coupling reactions to form C-C bonds. A nickel-catalyzed Suzuki-Miyaura cross-coupling of aryl sulfamates and carbamates is reported for the formation of sp2-sp2 C-C bonds. An iron-catalyzed Kumada coupling of aryl sulfamates and carbamates is reported for the formation of sp2-sp3 C-C bonds. Chapters four and five pertain to the formation of C-N bonds. The nickel-catalyzed amination of both aryl sulfamates and aryl carbamates are dicussed. The synthetic utility of these methods is highlighted with the synthesis of linezolid, an antibacterial drug, and with sequential, site-selective carbamate and sulfamate cross-couplings. Chapter six describes the total synthesis of natural product tubingensin A. The synthesis features an aryne cyclization to introduce the key vicinal quaternary centers and proceeds efficiently, in only nine linear steps.
Book Synopsis Metal Catalyzed Cross-Coupling Reactions and More by : Armin de Meijere
Download or read book Metal Catalyzed Cross-Coupling Reactions and More written by Armin de Meijere and published by John Wiley & Sons. This book was released on 2013-12-04 with total page 1640 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three volume book is the follow-up handbook to the bestselling volume "Metal-Catalyzed Cross-Coupling Reactions", the definitive reference in the field. In line with the enormous developments in this area, this is not a new edition, but rather a new book in three volumes with over 50% more content. This new content includes C-H activation, shifting the focus away from typical cross-coupling reactions, while those topics and chapters found in de Meijere/Diederich's book have been updated and expanded. With its highly experienced editor team and the list of authors reading like an international Who's-Who in the field, this work will be of great interest to every synthetic chemist working in academia and industry.
Book Synopsis Metal-catalyzed Cross-coupling Reactions by : François Diederich
Download or read book Metal-catalyzed Cross-coupling Reactions written by François Diederich and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-carbon bond forming reactions are arguably the most important processes in chemistry, as they represent key steps in the building of complex molecules from simple precursors. Among these reactions, metal-catalyzed cross-coupling reactions are extensively employed in a wide range of areas of preparative organic chemistry, ranging from the synthesis of complex natural products, to supramolecular chemistry, and materials science. In this work, a dozen internationally renowned experts and leaders in the field bring the reader up to date by documenting and critically analyzing current developments and uses of metal-catalyzed cross-coupling reactions. A particularly attractive and useful feature, that enhances the practical value of this monograph, is the inclusion of key synthetic protocols, in experimental format, chosen for broad utility and application. This practice-oriented book can offer the practitioner short cuts to ensure they remain up-to-date with the latest developments.
Book Synopsis Total Synthesis of Tubingensin B and Nickel-Catalyzed Methodologies Involving C-O Or C-N Bond Activation by : Junyong Kim
Download or read book Total Synthesis of Tubingensin B and Nickel-Catalyzed Methodologies Involving C-O Or C-N Bond Activation written by Junyong Kim and published by . This book was released on 2018 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation describes the total synthesis of tubingensin B and the development of two nickel-catalyzed methods. The two methodologies include the amination of aryl electrophiles in the green solvent 2-methyl-THF and the Suzuki-Miyaura coupling of aliphatic amides via the activation of amide C-N bonds. Chapter One highlights indole terpenoid natural products as the inspiration for the development of new synthetic methodologies and innovative strategies. This review showcases recent total syntheses of the natural products, penitrem D, emindole SB, paspaline, dixiamycin B, and tubingensins A and B. Chapter Two pertains to the total synthesis of (-)-tubingensin B. Key steps of the synthesis involves a B-alkyl Suzuki-Miyaura reaction, a carbazolyne cyclization, and a radical cyclization to construct the core architecture of the molecule. Key to the synthesis of tubingensin B was the utilization of a heterocyclic aryne intermediate for the formation of a scaffold bearing vicinal quaternary centers. This synthesis illustrates the capability of aryne methodology in generating stereochemically complex structures. Chapter Three describes the development of a green variant of a nickel-catalyzed amination reaction. As solvents comprise 85% of pharmaceutical waste, the use of a green solvent provides a considerable benefit for the potential application of the methodology to industrial problems. We developed a method employing 2-Me-THF as a green solvent for the amination of aryl chlorides and sulfamates. Chapter Four demonstrates the nickel-catalyzed Suzuki-Miyaura coupling of aliphatic amide derivatives. The methodology can be used to activate typically unreactive amide C-N bonds and, in turn, access an array of heterocyclic ketones.
Book Synopsis Transition Metal Catalyzed Oxidative Cross-Coupling Reactions by : Aiwen Lei
Download or read book Transition Metal Catalyzed Oxidative Cross-Coupling Reactions written by Aiwen Lei and published by Springer. This book was released on 2019-02-04 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive text covering the research and development trends in the booming field of transition metal catalyzed oxidative cross-coupling reactions. Oxidative cross-coupling reaction is a new method to forming chemical bonds besides the traditional cross-coupling reactions. This book provides the answers to how this coupling reaction occurs and what its advantages are. The palladium, copper and iron catalyzed oxidative cross-coupling reactions as the main focuses of interest are described in detail. The oxidative cross-coupling reactions catalyzed by other metals and transition-metal-free oxidative coupling reactions are also introduced.This book provides a useful reference source for researchers and graduates in the field of transition metal catalyzed coupling reactions. It is also valuable to researchers working in pharmaceutical companies, fine organic chemical companies, and etc.
Book Synopsis Nickel-Catalyzed Cross-Coupling Reactions by : Luke Edward Hanna
Download or read book Nickel-Catalyzed Cross-Coupling Reactions written by Luke Edward Hanna and published by . This book was released on 2016 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cross-coupling technology has become an indispensable tool for the rapid and efficient synthesis of complex molecules. Over the past few decades a foundational understanding of organometallic chemistry has been laid using palladium and other precious metals. Recent research on first row base metal catalysts such as nickel, cobalt and iron has uncovered new and complementary modes of reactivity compared to their more well-studied precious metal counterparts. While nickel sits one row above palladium on the periodic table, ongoing research has illustrated that nickel possesses a unique reactivity profile. Thus, while nickel is commonly thought of as a cheaper alternative to palladium, research in the field of nickel catalysis has demonstrated far more potential than this. The unique propensity of nickel to undergo single electron chemistry as well as its ability to break strong carbon oxygen bonds make research into nickel reactivity an immensely beneficial endeavor to the fields of inorganic, organometallic and synthetic organic chemistry.Chapter 1 describes the development of a stereospecific Suzuki coupling of benzylic carbamates and pivalates with aryl- and heteroarylboronic esters. The reaction proceeds with selective inversion or retention at the electrophilic carbon, depending on the identity of the ligand used. Tricyclohexylphosphine ligand provides products with retention of configuration at the electrophilic carbon, while an N-heterocyclic carbene ligand SIMes provides products with inversion.Chapter 2 discusses the development of a regio- and stereoselective nickel-catalyzed hydroarylation of alkynes using propargylic carbamates as directing groups. The reaction proceeds under mild reaction conditions using arylboronic acids in the absence of base. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the method is applied to the synthesis of tamoxifen.Chapter 3 details a nickel-catalyzed cross-electrophile coupling reaction of benzylic esters and aryl halides. Both inter- and intramolecular variants proceed under mild reaction conditions. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the first example of a stereospecific cross-electrophile coupling of a secondary benzylic ester is described.Chapter 4 presents secondary benzylzinc reagents generated from 2-pyridylcarbinols using a nickel catalyst and diethylzinc. Substrates are activated in situ using a chlorophosphate reagent. Quenching the organozinc reagents allows for facile deoxygenation of 2-pyridylcarbinols in a one-pot reaction with straightforward incorporation of a deuterium label from deuteromethanol. An intramolecular conjugate addition of a secondary benzylzinc reagent with an alpha,beta-unsaturated ester is also demonstrated.
Book Synopsis New Reactivity and Selectivity in Transition Metal-catalyzed C-C and C-N Bond Forming Processes by :
Download or read book New Reactivity and Selectivity in Transition Metal-catalyzed C-C and C-N Bond Forming Processes written by and published by . This book was released on 2015 with total page 881 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part I. Palladium-Catalyzed Carbon-Carbon Bond Forming Cross-Couplings Chapter 1. Ligand-Controlled Palladium-Catalyzed Regiodivergent Suzuki-Miyaura Cross-Coupling of Allylboronates and Aryl Halides An orthogonal set of catalyst systems based on the use of two biarylphosphine ligands has been developed for the Suzuki-Miyaura coupling of 3,3-disubstituted and 3-monosubstituted allylboronates with (hetero)aryl halides. These methods allow for the regiodivergent preparation of either the ct- or the [gamma]-isomeric coupling product with high levels of site selectivity using a common allylboron building block. Preliminary investigations have demonstrated the feasibility of an enantioselective variant for the [gamma]-selective cross-coupling using chiral monodentate biarylphosphine ligands. Chapter 2. Palladium-Catalyzed Completely Linear-Selective Negishi Coupling of 3,3-Disubstituted Organozinc Reagents with Aryl and Vinyl Electrophiles A palladium-catalyzed general and completely linear-selective Negishi coupling of 3,3- disubstituted allyl organozinc reagents with (hetero)aryl and vinyl electrophiles has been developed. This method provided an effective means for accessing highly functionalized aromatic and heteroaromatic compounds bearing prenyl-type side chains. The utility of the current protocol was further illustrated in the concise synthesis of the anti-HIV natural product siamenol. Chapter 3. Palladium-Catalyzed Highly Selective Negishi Cross-Coupling of Secondary Alkylzinc Reagents with Aryl and Heteroaryl Halides The palladium-catalyzed Negishi cross-coupling of secondary alkylzinc reagents and heteroaryl halides with high levels of regioisomeric retention has been described. The development of a series of biarylphosphine ligands has led to the identification of an improved catalyst for the coupling of electron-deficient heterocyclic substrates. Preparation and characterization of oxidative addition complex (L)Pd(Ar)(Br) provided insight into the unique reactivity of palladium catalysts based on CPhos-type biarylphosphine ligands in facilitating challenging reductive elimination processes. Chapter 4. Mechanistic Studies on the Aryl-Trifluoromethyl Reductive Elimination from Pd(II) Complexes Based on Biarylphosphine Ligands A series of monoligated (L)Pd(Ar)(CF3) (L = dialkyl biarylphosphine) have been prepared and studied in an effort to shed light on the mechanism of the aryl-trifluoromethyl reductive elimination from these systems. Combined experimental and computational investigations revealed unique reactivity and binding modes of (L)Pd(Ar)(CF3) complexes derived from BrettPhos-type biarylphosphines. In contrast to a variety of C-C and C-heteroatom bond forming reductive eliminations, kinetic measurements showed this Ar-CF3 reductive elimination is largely insensitive to the electronic nature of the to-be-eliminated aryl substituent. Furthermore, the aryl group serves as the nucleophilic coupling partner in this reductive elimination process. The structure-reactivity relationship of biarylphosphine ligands was also investigated, uncovering distinct roles of the ipso-arene and alkoxy interactions in affecting these reductive elimination reactions. Part II. Copper-Catalyzed Carbon-Carbon and Carbon-Nitrogen Bond Formation via Olefin Functionalization Chapter 5. Copper-Catalyzed ortho C-H Cyanation of Vinylarenes A copper-catalyzed regioselective ortho C-H cyanation of vinylarenes has been developed. This method provides an effective means for the selective functionalization of vinylarene derivatives. A copper-catalyzed cyanative dearomatization mechanism is proposed to account for the regiochemical course of this reaction. This mechanism has been validated through density functional theory calculations. Computational studies revealed that the high level of ortho selectivity in the electrophilic cyanation event originates from a unique six-membered transition state that minimizes unfavorable steric repulsions. Chapter 6. Regio- and Stereospecific 1,3-Allyl Group Transfer Triggered by a Copper-Catalyzed Borylation/ortho-Cyanation Cascade A copper-catalyzed borylation/cyanation/allyl group transfer cascade has been developed. This process features an unconventional copper-catalyzed electrophilic dearomatization followed by the subsequent regio- and stereospecific 1,3-transposition of the allyl fragment enabled by the aromatization-driven Cope rearrangement. This method provides an effective means for the construction of adjacent tertiary and quaternary stereocenters with high levels of stereochemical purity. Chapter 7. Copper-Catalyzed Asymmetric Hydroamination of Unactivated Internal Olefins: an Effective Means to Access Highly Enantioenriched Aliphatic Amines Catalytic assembly of enantiopure aliphatic amines from abundant and readily available precursors has long been recognized as a paramount challenge in synthetic chemistry. We describe a mild and general copper-catalyzed hydroamination that effectively converts unactivated internal olefins-an important yet unexploited class of abundant feedstock chemicals-into highly enantioenriched [alpha]-branched amines (>/= 96% ee) featuring two minimally differentiated aliphatic substituents. This method provides a powerful means to access a broad range of advanced, highly functionalized enantioenriched amines of interest in pharmaceutical research and other areas.
Book Synopsis Nickel-catalyzed Reductive Coupling of Alkyl, Allyl and Vinyl Electrophiles by : Michael R. Prinsell
Download or read book Nickel-catalyzed Reductive Coupling of Alkyl, Allyl and Vinyl Electrophiles written by Michael R. Prinsell and published by . This book was released on 2013 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The nickel-catalyzed reductive coupling of two organic electrophiles to form new carbon-carbon bonds is a fast emerging field of chemistry, with applications to the synthesis of medicinally interesting compounds. This method is an alternative to traditional transition metal-catalyzed cross-coupling reactions of organic electrophiles with organometallic nucleophiles. This thesis details the author's work towards the development of several reactions to reductively couple organic molecules to form Csp3-Csp3 bonds, including alkyl, allyl and vinyl halides. Chapter 1 delves into the background of traditional metal-catalyzed crosscoupling reactions as well as the advantages and challenges associated with using a reductive method to construct C-C bonds. In particular this chapter presents the specific challenges associated with the formation of a carbon-carbon bond between two Csp3 hybridized carbons. Chapter 2 outlines the development of a mild, general dimerization reaction of alkyl halides. This chapter also focuses on the use of sodium iodide to extend the coupling to molecules that are unreactive to the standard reaction conditions. Chapter 3 details work towards the cross-coupling of two alkyl halides. While cross-selectivity remains a challenge, some potential solutions are discussed. Chapter 4 presents the optimization and reaction scope of the coupling of allyl acetates with secondary alkyl halides, as well as progress towards couplings with primary alkyl halides. In addition, the first report of the catalytic coupling of vinyl bromides with allyl acetates is reported. Chapter 5 focuses on work towards the reductive cyclization of alkyl halides and allyl acetates. Initial results show promising diastereomeric ratios. Chapter 6 details work on the dehydrogenative synthesis of bipyridine and terpyridine ligands. These ligands are useful and are used for many reductive coupling reactions in the Weix group"--Pages vi.
Book Synopsis Reaction Discovery Using Nickel Catalysis and Total Syntheses of Indolactam Alkaloids by : Noah Frederick Fine Nathel
Download or read book Reaction Discovery Using Nickel Catalysis and Total Syntheses of Indolactam Alkaloids written by Noah Frederick Fine Nathel and published by . This book was released on 2015 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transition metal-catalyzed cross-coupling reactions are useful tools to assemble carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds. Traditionally, electrophilic halides and pseudohalides have been cross-coupled to their nucleophilic counterparts with palladium. Recently, however, the implementation of nickel as a catalyst for cross-coupling reactions has enabled the use of less reactive cross-coupling partners, such as carbamates, sulfamates, and amides. This dissertation describes the development of nickel-catalyzed cros-couplings of untraditional electrophiles to forge carbon-heteroatom (C-X) bonds. Additionally, the total syntheses of four indolactam alkaloids, indolactam V, pendolmycin, lyngbyatoxin A1 and teleocidin A-2, using both a key distortion-controlled indolyne reaction and palladium-catalyzed sp2-sp3 C-C bond construction, are described. Chapters one and two describe the development of nickel-catalyzed amination reactions of aryl electrophiles to form carbon-nitrogen (C-N) bonds. The amination reaction of aryl carbamates to form aryl amines is discussed. Subsequently, the development of green cross-couplings of aryl sulfamates and chlorides to similarly form aryl amines is reported. Chapter three introduces a means to accomplish a controlled cine substitution. This two-step process is comprised of a carbamate-directed ortho-lithiation/functionalization of an arene, followed by a nickel-catalyzed reductive deoxygenation of the directing group. This sequence provides a new strategy for synthesis and complements the more commonly employed ipso substitution in arene functionalization. Chapter four concerns the utility of amides as electrophilic cross-coupling partners. These traditionally unreactive moieties are activated by nickel and coupled to alcohols to form acyl C--O bonds. This study suggests that amides may serve as useful building blocks to construct C-X and C-C bonds. Chapter five describes the total syntheses of ( - )-indolactam V and its C7-substituted natural product derivatives, ( - )-pendolmycin, ( - )-lyngbyatoxin A1 and ( - )-teleocidin A-2. The C4-N linkage is constructed with a distortion-controlled indolyne functionalization. The total synthesis of ( - )-indolactam V provides a platform for the divergent syntheses of the other three natural products via a palladium-catalyzed cross-coupling to functionalize C7 and introduce a quaternary center.
Book Synopsis Advancements in Nickel-catalyzed Cross-electrophile Coupling by : Keywan Alexander Johnson
Download or read book Advancements in Nickel-catalyzed Cross-electrophile Coupling written by Keywan Alexander Johnson and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, the extension of cross-electrophile coupling to engage vinyl halides, organic chlorides, and dihalides for cyclization will be described in detail. Chapter 1 will provide an introduction to cross-electrophile coupling and the current state of the art for these transformations. Chapter 2 describes the development of improved coupling conditions for the nickel-catalyzed cross-electrophile coupling of vinyl halides with alkyl halides. The application of these conditions to aryl-alkyl coupling, substrate scope and limitations, and preliminary mechanistic insights are also discussed. Chapter 3 describes studies performed for the coupling of aryl and alkyl chlorides. The effects of a dual ligand system on reaction selectivity, as well as implications of dimethoxyethane and diglyme nickel precatalysts are also conferred. Chapter 4 provides a survey of macrocyclization methodologies and details the application of cross-electrophile coupling to the synthesis of macrocyclic rings. Efforts towards the total synthesis of (+/- )-Recifeiolide are also discussed.
Book Synopsis Development of Nickel-Catalyzed Cross-Coupling Reactions by : Liana Hie
Download or read book Development of Nickel-Catalyzed Cross-Coupling Reactions written by Liana Hie and published by . This book was released on 2016 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transition metal-catalyzed cross-couplings provide a powerful means to assemble carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds. Although Pd catalysis is most commonly used in these transformations, Ni catalysis offers a valuable alternative due to the low cost and high reactivity of Ni. More importantly, Ni catalysis has proven effective for the activation of traditionally inert carbon-heteroatom bonds and therefore provides exciting opportunities with regard to chemical reactivity and synthetic applications. Chapter one, two, and three describe the development of practical cross-coupling methodologies. Chapter one explains the amination of aryl sulfamates and carbamates that relies on an air-stable Ni(II) precatalyst. Chapter two introduces the development of green cross-couplings of phenolic derivatives and aryl halides to form biaryls. Subsequently, the couplings of heterocycles, which are commonly encountered in natural product synthesis and in the pharmaceutical sector, are described. Chapter three describes the development of green cross-couplings of aryl sulfamates and chlorides to form aryl amines. Chapter four and seven concern the utility of amides as electrophilic cross-coupling partners. These traditionally unreactive moieties are activated by nickel and coupled to alcohols to form acyl C-O bonds. This study suggests that amides may serve as useful building blocks to construct carbon-carbon and carbon-heteroatom bonds. Chapter four describes the development of nickel-catalyzed activation of benzamides and chapter seven introduces the development of nickel-catalyzed activation of aliphatic amide derivatives. Chapter five describes the nickel-catalyzed activation of the acyl carbon-oxygen bonds of methyl esters through an oxidative addition process. The oxidative addition adducts, formed using nickel catalysis, undergo in situ trapping to provide anilide products. DFT calculations are used to support the proposed reaction mechanism, understand why decarbonylation does not occur competitively, and to elucidate the beneficial role of the substrate structure and Al(OtBu)3 additive on the kinetics and thermodynamics of the reaction. Chapter six focus on the nickel-catalyzed Heck cyclization for the construction of quaternary stereocenters. This transformation is demonstrated in the synthesis of 3,3-disubstituted oxindoles, which are prevalent motifs seen in bioactive molecules.
Book Synopsis Natural Product Biosynthesis by : Christopher T. Walsh
Download or read book Natural Product Biosynthesis written by Christopher T. Walsh and published by Royal Society of Chemistry. This book was released on 2017-04-28 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
Book Synopsis The Organic Coloring Book by : Neil Garg
Download or read book The Organic Coloring Book written by Neil Garg and published by . This book was released on 2017-04-22 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: This coloring book brings to life the magic and impact of organic chemistry for children and adults alike. With more than 25 pages to color, kids will have fun and even learn some science too! The molecules featured in this book include sucrose, aspirin, caffeine, cellulose, proteins, and many more. This educational coloring book was created by two children, with the help of their father, a UCLA Chemistry Professor. "This coloring book brings the unbridled curiosity of a young mind together with the wonders of our molecular world in ways that will surely inspire discovery, fun, and perhaps a lifelong appreciation of the ubiquity and impact of chemistry" -Professor Paul Wender (Stanford University)
Book Synopsis Flavin-Dependent Enzymes: Mechanisms, Structures and Applications by :
Download or read book Flavin-Dependent Enzymes: Mechanisms, Structures and Applications written by and published by Academic Press. This book was released on 2020-09-21 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Enzymes, Volume 47, highlights new advances in the field, with this new volume presenting interesting chapters on The Multipurpose Family of Oxidases, Vanillyl alcohol oxidase, Choline oxidases, Aryl alcohol oxidase, D- and L-amino acid oxidases, Sugar oxidases, Phenolic Compounds hydroxylases, Baeyer-Villiger Monooxygenases, Flavin-dependent halogenases, Flavin-dependent dehalogenases, Styrene Monooxygenases, Bacterial luciferases, Cellobiose Dehydrogenases, Prenylated flavoenzymes, Ene-reductases, Flavoenzymes in Biocatalysis. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series
Download or read book Biosynthesis written by Finian J. Leeper and published by Springer. This book was released on 2003-07-01 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). The first volume covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.
Book Synopsis Modern Aryne Chemistry by : Akkattu T. Biju
Download or read book Modern Aryne Chemistry written by Akkattu T. Biju and published by John Wiley & Sons. This book was released on 2021-08-23 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: A groundbreaking book to offer a a comprehensive account of important reactions involving arynes Modern Aryne Chemistry is the first book on the market to offer a conceptual framework to the reactions related to arynes. It also provides a systematic introduction to the cycloaddition reactions, insertion reactions and transition-metal-catalyzed transformations of arynes. The author, a noted expert on the topic, highlights a novel strategy for carbon-carbon and carbon-heteroatom bond construction using arynes. The book reveiws the recent use of aryne chemistry for the development of new multicomponent reactions. New advances in this area has shown rapid emergence of a new class of reactions classified under rearrangement reactions. The author also includes information on aryne methods that have been employed for the synthesis of several natural products. The simplicity and sophistication of the synthetic strategy using arynes can serve as a springboard for organic chemists to explore new possibilities and imagine applications of the concept of arynes. This important book: Presents a one-of-kind comprehensive guide to arynes reactions Offers a proven approach to the synthesis of natural product and polymers Reviews the most recent developments in the carbon-carbon and carbon-heteroatom bond-forming reactions involving arynes Written for organic, pharmaceutical, medicinal, natural products, and catalytic Chemists, Modern Aryne Chemistry offers a comprehensive review of the fundamentals of reactions related to arynes and the most recent developments in the field.
Book Synopsis Organic Synthesis by : Douglass F. Taber
Download or read book Organic Synthesis written by Douglass F. Taber and published by Oxford University Press. This book was released on 2017 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of Douglass Taber's columns originally published between 2013 - 2015 at www.organicchemistry.org
