Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Bacterial Virulence Factors And Rho Gtpases
Download Bacterial Virulence Factors And Rho Gtpases full books in PDF, epub, and Kindle. Read online Bacterial Virulence Factors And Rho Gtpases ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Bacterial Virulence Factors and Rho GTPases by : Patrice Boquet
Download or read book Bacterial Virulence Factors and Rho GTPases written by Patrice Boquet and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogenic bacteria for human and animals have developed sophisticated weapons, termed virulence factors, to ensure their replication and persistence into their hosts. The authors in this volume show a synthesis on how the various host cellular Rho GTPases activities are manipulated by bacteria to fulfil their virulence.
Book Synopsis Subversion of Rho GTPases by WxxxE Effectors of Attaching and Effacing Pathogens by :
Download or read book Subversion of Rho GTPases by WxxxE Effectors of Attaching and Effacing Pathogens written by and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of Type III Secreted Bacterial Virulence Factors that Interfere with Rho GTPase Signalling by : Stefan Arens
Download or read book Characterization of Type III Secreted Bacterial Virulence Factors that Interfere with Rho GTPase Signalling written by Stefan Arens and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bacterial Exotoxins: How Bacteria Fight the Immune System by : Inka Sastalla
Download or read book Bacterial Exotoxins: How Bacteria Fight the Immune System written by Inka Sastalla and published by Frontiers Media SA. This book was released on 2016-10-07 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial pathogenicity factors are functionally diverse. They may facilitate the adhesion and colonization of bacteria, influence the host immune response, assist spreading of the bacterium by e.g. evading recognition by immune cells, or allow bacteria to dwell within protected niches inside the eukaryotic cell. Exotoxins can be single polypeptides or heteromeric protein complexes that act on different parts of the cells. At the cell surface, they may insert into the membrane to cause damage; bind to receptors to initiate their uptake; or facilitate the interaction with other cell types. For example, bacterial superantigens specifically bind to major histocompatibility complex (MHC) II molecules on the surface of antigen presenting cells and the T cell receptor, while cytolysins cause pore formation. For intracellular activity, exotoxins need to be translocated across the eukaryotic membrane. Gram-negative bacteria can directly inject effector proteins in a receptor-independent manner by use of specialized needle apparatus such as bacterial type II, III, or type IV secretion systems. Other methods of translocation include the phagocytic uptake of bacteria followed by toxin secretion, or receptor-mediated endocytosis which allows the targeting of distinct cell types. Receptor-based uptake is initiated by the binding of heteromeric toxin complexes to the cell surface and completed by the translocation of the effector protein(s) across the endosomal membrane. In the cytosol, toxins interact with specific eukaryotic target proteins to cause post-translational modifications that often result in the manipulation of cellular signalling cascades and inflammatory responses. It has become evident that the actions of some bacterial toxins may exceed their originally assumed cytotoxic function. For example, pore-forming toxins do not only cause cytolysis, but may also induce autophagy, pyroptosis, or activation of the MAPK pathways, resulting in adjustment of the host immune response to infection and modification of inflammatory responses both locally and systemically. Other recently elucidated examples of the immunomodulatory function of cell death-inducing exotoxins include TcdB of Clostridium difficile which activates the inflammasome through modification of cellular Rho GTPases, or the Staphyloccocus d-toxin which activates mast cells. The goal of this research topic was to gather current knowledge on the interaction of bacterial exotoxins and effector proteins with the host immune system. The following 16 research and review articles in this special issue describe mechanisms of immune modification and evasion and provide an overview over the complexity of bacterial toxin interaction with different cells of the immune system.
Book Synopsis Bacterial Virulence Factors and Rho GTPases by : Patrice Boquet
Download or read book Bacterial Virulence Factors and Rho GTPases written by Patrice Boquet and published by Springer. This book was released on 2005-04-01 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogenic bacteria for human and animals have developed sophisticated weapons, termed virulence factors, to ensure their replication and persistence into their hosts. The authors in this volume show a synthesis on how the various host cellular Rho GTPases activities are manipulated by bacteria to fulfil their virulence.
Book Synopsis The Actin Cytoskeleton and Bacterial Infection by : Hans Georg Mannherz
Download or read book The Actin Cytoskeleton and Bacterial Infection written by Hans Georg Mannherz and published by Springer. This book was released on 2017-02-07 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the mechanisms which bacteria have created to secure their survival, proliferation and dissemination by subverting the actin cytoskeleton of host cells. Bacteria have developed a veritable arsenal of toxins, effector proteins and virulence factors that allow them to modify the properties of the intracellular actin cytoskeleton for their own purposes. Bacterial factors either modify actin directly as the main component of this part of the cytoskeleton or functionally subvert regulatory or signalling proteins terminating at the actin cytoskeleton. In short, this volume provides an overview of the various tricks bacteria have evolved to “act on actin” in order to hijack this essential host cell component for their own needs. As such, it will be of interest to scientists from many fields, as well as clinicians whose work involves infectious diseases.
Book Synopsis Current Topics in Microbiology and Immunology by :
Download or read book Current Topics in Microbiology and Immunology written by and published by . This book was released on 1967 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Comprehensive Sourcebook of Bacterial Protein Toxins by : Joseph E. Alouf
Download or read book The Comprehensive Sourcebook of Bacterial Protein Toxins written by Joseph E. Alouf and published by Academic Press. This book was released on 2015-05-29 with total page 1201 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. - Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them - Focused chapters on toxin applications and common properties or general features of toxins
Book Synopsis Rho Gtpases: Molecular Biology In Health And Disease by : Philippe Fort
Download or read book Rho Gtpases: Molecular Biology In Health And Disease written by Philippe Fort and published by World Scientific. This book was released on 2017-12-12 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology.This book is divided into three parts. Part 1 gives an evolutionary perspective of the Rho family, its atypical members, and an overview of how Rho activity is regulated. Part 2 addresses two important aspects of multicellularity controlled by Rho-dependent pathways, namely, cell-cell interactions and mechanotransduction. It also describes how post-translational modifications control Rho activity and how this is exploited by pathogenic bacteria. Part 3 explores several examples of the variety of pathophysiological processes controlled by Rho signaling, and gives a successful example of translational research, from the inhibition of Rho activation to the development of new molecules against osteoporosis.This updated review on the biology of Rho GTPases is an essential read for molecular and cell biologists. It is also an invaluable guide to post-graduate and medical students who wish to deepen their knowledge in cell biology.
Book Synopsis Bacterial Pathogens and Their Virulence Factors by : Douglas I. Johnson
Download or read book Bacterial Pathogens and Their Virulence Factors written by Douglas I. Johnson and published by Springer. This book was released on 2017-11-23 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial Pathogens and their Virulence Factors contains a detailed description of 32 major bacterial pathogens that affect human health and their associated virulence determinants. Chapter 1 gives an overview of the different types and classes of general virulence factors involved in host cell adherence and invasion, dissemination within the host, host cell damage, and evasion of host defense systems, as well as mechanisms by which these virulence factors are regulated. Chapters 2 through 33 give concise descriptions of the disease states associated with the 32 bacterial genera and their major pathogenic species, along with an in-depth description of the individual virulence factors that have been found to be functionally involved in pathogenicity. A detailed bibliography derived from primary literature and review articles accompanies each of these chapters, allowing the reader to delve more deeply into individual pathogens and their virulence determinants. Chapter 34 discusses the exciting possibilities and initial successes of using detailed information on a pathogen’s virulence toolkit to design new therapeutics aimed at specific virulence traits.
Author :Eleftherios Mylonakis Publisher :Springer Science & Business Media ISBN 13 :1441956387 Total Pages :135 pages Book Rating :4.4/5 (419 download)
Book Synopsis Recent Advances on Model Hosts by : Eleftherios Mylonakis
Download or read book Recent Advances on Model Hosts written by Eleftherios Mylonakis and published by Springer Science & Business Media. This book was released on 2011-12-01 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most studies of bacterial or fungal infectious diseases focus separately on the pathogenic microbe, the host response, or the characterization of therapeutic compounds. Compartmentalization of pathogenesis-related research into an analysis of the “pathogen”, the “host,” or the “antimicrobial compound” has largely been dictated by the lack of model systems in which all of these approaches can be used simultaneously, as well as by the traditional view that microbiology, immunology, and chemical biology and pharmacology are separate disciplines. An increasing number of workers from different fields have turned to insects, fish, worms and other model hosts as facile, ethically expedient, relatively simple, and inexpensive hosts to model a variety of human infectious diseases and to study host responses and innate immunity. Because many of these hosts are genetically tractable, they can be used in conjunction with an appropriate pathogen to facilitate the discovery of novel features of the host innate immune response. This book provides a series of reports from the 1st International Conference on Model Hosts. This first of its kind meeting focused on invertebrate, vertebrate and amoeboid systems used for the study of host-pathogen interactions, virulence and immunity, as well as on the relevance of these pathogenesis systems and mammalian models. Importantly, a common, fundamental set of molecular mechanisms is employed by a significant number of microbial pathogens against a widely divergent array of metazoan hosts. Moreover, the evolutionarily conserved immune responses of these model hosts have contributed important insights to our understanding of the innate immune response of mammals. This book provides a series of reports from the 1st International Conference on Model Hosts. This first of its kind meeting focused on invertebrate, vertebrate and amoeboid systems used for the study of host-pathogen interactions, virulence and immunity, as well as on the relevance of these pathogenesis systems and mammalian models. Importantly, a common, fundamental set of molecular mechanisms is employed by a significant number of microbial pathogens against a widely divergent array of metazoan hosts. Moreover, the evolutionarily conserved immune responses of these model hosts have contributed important insights to our understanding of the innate immune response of mammals.
Book Synopsis Bacterial Protein Toxins by : K. Aktories
Download or read book Bacterial Protein Toxins written by K. Aktories and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
Book Synopsis Bacterial-Epithelial Cell Cross-Talk by : Beth A. McCormick
Download or read book Bacterial-Epithelial Cell Cross-Talk written by Beth A. McCormick and published by Cambridge University Press. This book was released on 2006-09-07 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: An emerging theme in molecular and cellular microbiology has been the ability of many pathogens to usurp the host cell and eventually colonize the host. This interaction between bacteria and host is not unidirectional - both pathogens and host cells engage in a signalling cross-talk. Research focused on this cross-talk and discussed in this volume, reveals not only novel aspects of bacterial pathogenesis, but also key information about epithelial biology with broader implications in the prevention and treatment of infectious diseases. Written by leading researchers in this field, this book provides a valuable overview of the host-bacterial interactions that occur at mucosal surfaces including the gastrointestinal, respiratory, and urogenital tracts. It will therefore be a valuable resource for graduate students and researchers working on these systems or in the fields of molecular and cellular microbiology or infectious disease medicine.
Book Synopsis Treatments from Toxins by : Keith Alan Foster
Download or read book Treatments from Toxins written by Keith Alan Foster and published by CRC Press. This book was released on 2006-11-02 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: As little as two decades ago, deliberately injecting botulinum toxin into patients would have seemed foolhardy at best and criminal at worst. The increased clinical use of botulinum toxins has expanded the body of knowledge available on the structure and function of these proteins. This knowledge can be applied to topics as varied as therapies base
Book Synopsis Phagocytosis of Bacteria and Bacterial Pathogenicity by : Joel D. Ernst
Download or read book Phagocytosis of Bacteria and Bacterial Pathogenicity written by Joel D. Ernst and published by Cambridge University Press. This book was released on 2006-09-07 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on the crucial interaction of pathogenic bacteria and professional phagocytes, the host cells whose purpose is to ingest, kill, and digest bacteria in defense against infection. The introductory chapters focus on the receptors used by professional phagocytes to recognize and phagocytose bacteria, and the signal transduction events that are essential for phagocytosis of bacteria. Subsequent chapters discuss specific bacterial pathogens and the strategies they use in confronting professional phagocytes. Examples include Helicobacter pylori, Streptococcus pneumoniae, and Yersinae, each of which uses distinct mechanisms to avoid being phagocytosed and killed. Contrasting examples include Listeria monocytogenes and Mycobacterium tuberculosis, which survive and replicate intracellularly, and actually cooperate with phagocytes to promote their entry into these cells. Together, the contributions in this book provide an outstanding review of current knowledge regarding the mechanisms of phagocytosis and how specific pathogenic bacteria avoid or exploit these mechanisms.
Book Synopsis Special Issue on Emerging Bacterial Toxins by : Klaus Aktories
Download or read book Special Issue on Emerging Bacterial Toxins written by Klaus Aktories and published by Springer Science & Business Media. This book was released on 2007-05-02 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Book Synopsis Inflammation, 4 Volume Set by : Jean-Marc Cavaillon
Download or read book Inflammation, 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.
