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Bacterial Evasion Of The Host Immune System
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Book Synopsis Bacterial Evasion of Host Immune Responses by : Brian Henderson
Download or read book Bacterial Evasion of Host Immune Responses written by Brian Henderson and published by Cambridge University Press. This book was released on 2003-04-28 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Table of contents
Book Synopsis Bacterial Evasion of the Host Immune System by : Pedro Escoll
Download or read book Bacterial Evasion of the Host Immune System written by Pedro Escoll and published by Caister Academic Press Limited. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert international authors critically review the most important current research in bacterial evasion of the host immune response. Topics range from an overview of the seven most important bacterial secretion systems to a thorough review of evsaion by mycobacteria. Essential reading for everyone involved in bacterial pathogenesis research.
Book Synopsis Bacterial Evasion of Host Immune Responses by :
Download or read book Bacterial Evasion of Host Immune Responses written by and published by . This book was released on 2003 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Listeria monocytogenes: Pathogenesis and Host Response by : Howard Goldfine
Download or read book Listeria monocytogenes: Pathogenesis and Host Response written by Howard Goldfine and published by Springer Science & Business Media. This book was released on 2007-06-24 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past twenty years Listeria monocytogenes has emerged as one of the most intensely studied bacterial pathogens. New windows are constantly being opened into the complexity of host cell biology and the interplay of the signals connecting the various cells and organs involved in the host response. This volume includes research from studies at the molecular level on the pathogenesis of Listeria monocytogenes and the response of the host to its infections.
Book Synopsis The Pathogenic Spirochetes: strategies for evasion of host immunity and persistence by : Monica E. Embers
Download or read book The Pathogenic Spirochetes: strategies for evasion of host immunity and persistence written by Monica E. Embers and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the many mechanisms by which the most prevalent Spirochetal pathogens persist in a healthy immune-competent host. Among them are the direct and indirect suppression of host immune signals, phase and antigenic variation, escaping recognition by host complement proteins, and seclusion into immune privileged sites. We also explore antibiotic therapy for control of infection, a baffling topic that lends itself to exalted interpretation.
Download or read book Bacterial Pathogenesis written by and published by Academic Press. This book was released on 1998-07-01 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow Covers safety aspects, detection, identification and speciation Includes techniques for the study of host interactions and reactions in animals and plants Describes biochemical and molecular genetic approaches Essential methods for gene expression and analysis Covers strategies and problems for disease control
Book Synopsis Bacterial Exotoxins: How Bacteria Fight the Immune System by : Inka Sastalla
Download or read book Bacterial Exotoxins: How Bacteria Fight the Immune System written by Inka Sastalla and published by Frontiers Media SA. This book was released on 2016-10-07 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial pathogenicity factors are functionally diverse. They may facilitate the adhesion and colonization of bacteria, influence the host immune response, assist spreading of the bacterium by e.g. evading recognition by immune cells, or allow bacteria to dwell within protected niches inside the eukaryotic cell. Exotoxins can be single polypeptides or heteromeric protein complexes that act on different parts of the cells. At the cell surface, they may insert into the membrane to cause damage; bind to receptors to initiate their uptake; or facilitate the interaction with other cell types. For example, bacterial superantigens specifically bind to major histocompatibility complex (MHC) II molecules on the surface of antigen presenting cells and the T cell receptor, while cytolysins cause pore formation. For intracellular activity, exotoxins need to be translocated across the eukaryotic membrane. Gram-negative bacteria can directly inject effector proteins in a receptor-independent manner by use of specialized needle apparatus such as bacterial type II, III, or type IV secretion systems. Other methods of translocation include the phagocytic uptake of bacteria followed by toxin secretion, or receptor-mediated endocytosis which allows the targeting of distinct cell types. Receptor-based uptake is initiated by the binding of heteromeric toxin complexes to the cell surface and completed by the translocation of the effector protein(s) across the endosomal membrane. In the cytosol, toxins interact with specific eukaryotic target proteins to cause post-translational modifications that often result in the manipulation of cellular signalling cascades and inflammatory responses. It has become evident that the actions of some bacterial toxins may exceed their originally assumed cytotoxic function. For example, pore-forming toxins do not only cause cytolysis, but may also induce autophagy, pyroptosis, or activation of the MAPK pathways, resulting in adjustment of the host immune response to infection and modification of inflammatory responses both locally and systemically. Other recently elucidated examples of the immunomodulatory function of cell death-inducing exotoxins include TcdB of Clostridium difficile which activates the inflammasome through modification of cellular Rho GTPases, or the Staphyloccocus d-toxin which activates mast cells. The goal of this research topic was to gather current knowledge on the interaction of bacterial exotoxins and effector proteins with the host immune system. The following 16 research and review articles in this special issue describe mechanisms of immune modification and evasion and provide an overview over the complexity of bacterial toxin interaction with different cells of the immune system.
Download or read book The Immune Response written by Tak W. Mak and published by Academic Press. This book was released on 2005-11-11 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. Current and thorough 30 chapter reference reviewed by luminaries in the field Unique ‘single voice' ensures consistency of definitions and concepts Comprehensive and elegant illustrations bring key concepts to life Provides historical context to allow fuller understanding of key issues Introductory chapters 1-4 serve as an ‘Immunology Primer' before topics are discussed in more detail
Book Synopsis Bacterial Invasion of Host Cells by : Richard J. Lamont
Download or read book Bacterial Invasion of Host Cells written by Richard J. Lamont and published by Cambridge University Press. This book was released on 2004-03-29 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concerns the intimate association between bacteria and host cells. Many bacterial pathogens are able to invade and survive within cells at mucosal membranes. Remarkably, the bacteria themselves orchestrate this process through the exploitation of host cellular signal transduction pathways. Intracellular invasion can lead to disruption of host tissue integrity and perturbation of the immune system. An understanding of the molecular basis of bacterial invasion and of host cell adaptation to intracellular bacteria will provide fundamental insights into the pathophysiology of bacteria and the cell biology of the host. The book details specific examples of bacteria that are masters of manipulation of eukaryotic cell signaling and relates these events to the broader context of host-pathogen interaction. Written by experts in the field, this book will be of interest to researchers and graduate students in microbiology, immunology, biochemistry, as well as molecular medicine and dentistry.
Book Synopsis Outsmarting the Host: How Bacterial Pathogens Modulate Immune Responses in The Lung by : Gee W. Lau
Download or read book Outsmarting the Host: How Bacterial Pathogens Modulate Immune Responses in The Lung written by Gee W. Lau and published by Frontiers Media SA. This book was released on 2021-03-22 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Leishmaniases as Re-emerging Diseases by : Farhat Afrin
Download or read book Leishmaniases as Re-emerging Diseases written by Farhat Afrin and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leishmania parasites plague the mammalian host causing high morbidity and mortality. The parasites persist in the hostile milieu, crippling its defensive arsenal. In the face of mounting resistance to an antiquated drug arsenal, new approaches are urgently desired to keep the infection at bay. Furthermore, to strengthen the leishmaniasis elimination drive, particular emphasis has to be laid on identification of new targets and vaccination strategies. This book gives a brief glimpse of the epidemiology of leishmaniasis, immune evasion, vaccination, and therapeutic modalities that may work by untangling the immunological cross-wires of pathogenic cross-talk. The Conventional treatment and its drawbacks, the prospects of phytotherapy and nanomedicines, are also discussed. The identification of drug targets with the aim of designing inhibitors is also exemplified.
Book Synopsis Understanding and Exploiting Host-Commensal Interactions to Combat Pathogens by : Sudhanshu Shekhar
Download or read book Understanding and Exploiting Host-Commensal Interactions to Combat Pathogens written by Sudhanshu Shekhar and published by Frontiers Media SA. This book was released on 2020-01-14 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trillions of commensal microbes reside on and inside the human body, including the intestinal and respiratory tracts, which encompass various microbial taxa, such as bacteria, fungi, archea and viruses. The close proximity of microbes with the host provides an opportunity to continually interact with each other. Advances in research approaches, including high-throughput sequencing, have allowed us to study host and commensal microbes at the genetic and functional levels. Recent studies suggest that commensal microbes play a crucial role in the development of the host’s immune system and induce innate and adaptive immune responses against pathogens. It is also becoming apparent that the gut commensals are endowed with a capacity to alter immune responses in organs beyond the intestine, such as the lungs, highlighting the significance of the gut commensals in controlling systemic immunity. On the other hand, the host’s immune system possesses the ability to shape the repertoire of commensal microbes and contribute to the establishment of beneficial relationships with them. A better understanding of host-commensal interactions will be important for designing effective vaccines and therapeutics against pathogens. This Research Topic sheds light on our current understanding of the interplay between the host’s immune system and commensal microbes and how this interplay can be exploited for prophylactic and/or therapeutic strategies against pathogens.
Book Synopsis Microbial Pathogenesis: Infection and Immunity by : Uday Kishore
Download or read book Microbial Pathogenesis: Infection and Immunity written by Uday Kishore and published by Springer. This book was released on 2013-12-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book starts with dissecting mechanisms underlying viral immune evasion via exploiting the host complement system by vaccinia virus, and by modulating the type 1 interferon response by RNA viruses. Yet another chapter looks into how viroporins expressed by different families of viruses causing influenza A virus, SARS, hepatitis C and HIV interact with several cellular pathways. Understanding of these mechanisms can aid the development of novel potential anti‐viral targets. The chapter on tuberculosis discusses the emerging importance of the innate immune mechanisms against Mycobacterium tuberculosis infection and latency. This book has a strong focus on fungal pathogenesis and immunity, starting with virulence and host factors that attain great importance in candidiasis and associated escape tricks of seriously opportunistic fungi. Two chapters on Aspergillus fumigatus elaborate on the pathogenic mechanisms: first discussing A. fumigatus‐airway epithelium interaction, followed by fungal and host factors that are paramount in the development of allergic and invasive aspergillosis. In the subsequent chapter, there is a general discussion on the innate and adaptive immune responses against primary and opportunistic fungal pathogens.
Book Synopsis Microbial Subversion of Immunity by : Peter Julius Lachmann
Download or read book Microbial Subversion of Immunity written by Peter Julius Lachmann and published by Caister Academic Press Limited. This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbes have evolved in an impressive and diverse range of strategies to subvert the host immune system. Two major types of strategies exist. The first is the evasion of recognition by the host, for example by using antigenic variation, masking of epitopes, the use of decoys, molecular mimicry, etc. The second is the modulation and/or suppression of the innate (e.g. complement, NK cells) and adaptive (e.g. antibodies) immune responses. A better understanding of the underlying mechanisms involved is critical for the rational design of novel therapeutic agents and vaccines to treat and/or prevent infectious diseases. Another area of active research is the application of microbial immunomodulatory factors in the treatment of human immunological disorders (e.g. inflammatory bowel disease and asthma) and as sources of pharmacologically active agents. In this book, internationally renown scientists critically review the current cutting-edge research in this area. Topics covered include the subversion of complement, NK cell function, mucosal innate immune response, evasion/subversion mechanisms used by bacteria, helminths, viruses, and the measles model system. Containing over 1,700 references, this book is an essential resource book for researchers in the fields of microbiology, immunology, pharmacology, and molecular medicine.
Book Synopsis Modulation of the immune system by bacteria: from evasion to therapy by : Marina De Bernard
Download or read book Modulation of the immune system by bacteria: from evasion to therapy written by Marina De Bernard and published by Frontiers Media SA. This book was released on 2023-04-10 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Infection and Immunity by : D H Davies
Download or read book Infection and Immunity written by D H Davies and published by CRC Press. This book was released on 2002-09-11 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise text explores the interactions between pathogens and the immune system. Taking a disease-based approach, it explains how micro-organisms adapted to growth in human hosts can evade the immune system and cause disease. The opening chapter overviews the innate and adaptive immune responses to microbes. Subsequent chapters are specific to particular pathogens, beginning with their biology and leading on to illustrate mechanisms of adaptation and ensuing consequences. Each of these chapters ends with a summary, review questions and further reading lists. Summaries, review questions and further reading make this book suitable for self-directed study. Infection and Immunity is ideal for any undergraduates taking a course that explores the interaction between pathogens and the human immune system.
Book Synopsis Essentials of Glycobiology by : Ajit Varki
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.