Autism Spectrum Disorder New Insights Into Molecular Pathophysiology And Therapeutic Development

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Autism Spectrum Disorder: New Insights Into Molecular Pathophysiology and Therapeutic Development

Author : Junyu Xu
Publisher : Frontiers Media SA
ISBN 13 : 2889660303
Total Pages : 236 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Autism Spectrum Disorder: New Insights Into Molecular Pathophysiology and Therapeutic Development by : Junyu Xu

Download or read book Autism Spectrum Disorder: New Insights Into Molecular Pathophysiology and Therapeutic Development written by Junyu Xu and published by Frontiers Media SA. This book was released on 2020-09-18 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Autism: New Insights for the Healthcare Professional: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464901600
Total Pages : 239 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Autism: New Insights for the Healthcare Professional: 2011 Edition by :

Download or read book Autism: New Insights for the Healthcare Professional: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Autism. The editors have built Autism: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Autism in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Autism: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Autism Spectrum Disorders

Author : Andreas M. Grabrucker
Publisher :
ISBN 13 :
Total Pages : 117 pages
Book Rating : 4.:/5 (128 download)

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Book Synopsis Autism Spectrum Disorders by : Andreas M. Grabrucker

Download or read book Autism Spectrum Disorders written by Andreas M. Grabrucker and published by . This book was released on 2021 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorders are developmental disorders. Individuals with autism spectrum disorders develop differently. These differences are usually present in social interaction, communication, and sensory processing, and become visible through a wide variety of behavioral responses that differ from individuals without autism spectrum disorders. Despite significant research efforts, the exact causes of autism spectrum disorders remain poorly understood; however, researchers have gained extensive insights into possible pathomechanisms, even at the molecular level of cells. Many diagnostic criteria have been developed, adapted, and improved. The eight chapters in this book highlight the current state-of-the-art in many areas of autism spectrum disorders. Chapter 1 provides an overview of the epidemiology of autism spectrum disorders and the current knowledge of the underlying pathogenic mechanisms. Chapter 2 summarizes the diagnostic criteria and procedures and highlights present and upcoming therapeutic strategies. Chapter 3 reviews the adverse events and trauma in people with autism spectrum disorders. Chapters 4 and 5 focus on atypical sensory processing, and Chapter 6 discusses the genetic overlap of autism spectrum disorders with other neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD), depression, and schizophrenia. Chapter 7 focuses on the contribution of abnormalities in mitochondria, and chapter 8 discusses gut-brain interactions and a potential role for microbiota in autism spectrum disorders. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.

A Time for Metabolism and Hormones

Author : Paolo Sassone-Corsi
Publisher : Springer
ISBN 13 : 3319270699
Total Pages : 141 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis A Time for Metabolism and Hormones by : Paolo Sassone-Corsi

Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Jasper's Basic Mechanisms of the Epilepsies

Author : Jeffrey Noebels
Publisher : OUP USA
ISBN 13 : 0199746540
Total Pages : 1258 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

New Insights into Neurodevelopmental Biology and Autistic Spectrum Disorders

Author : Hongbao Cao
Publisher : Frontiers Media SA
ISBN 13 : 2832535526
Total Pages : 174 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis New Insights into Neurodevelopmental Biology and Autistic Spectrum Disorders by : Hongbao Cao

Download or read book New Insights into Neurodevelopmental Biology and Autistic Spectrum Disorders written by Hongbao Cao and published by Frontiers Media SA. This book was released on 2023-10-03 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Autism Spectrum Disorders

Author : M. Créteil
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318026026
Total Pages : 178 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Autism Spectrum Disorders by : M. Créteil

Download or read book Autism Spectrum Disorders written by M. Créteil and published by Karger Medical and Scientific Publishers. This book was released on 2015-02-11 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accurate and exhaustive, this book provides a wide overview of the current knowledge on phenotypes, mechanisms and treatment of autism spectrum disorders. It covers topics on diagnostic issues, comorbid conditions and therapeutic strategies along with a detailed discussion on the actual understanding of the pathophysiology of autism disorders. More specifically, this book reviews in detail the current knowledge on the comorbidity between mental and medical disorders, describes abnormal cognitive and social development and gives a thorough overview on genetic as well as brain imaging abnormalities observed in autism spectrum disorders. In addition, the current literature on environmental risk factors which may provide an explanation for the increased prevalence of autism is being described. The last chapter gives an extensive review of early detection and early therapeutic interventions encompassing psycho-social and pharmacological strategies. Each chapter is easy to read and gives the reader access to the most important information on each topic covered. This book provides innovative reading material for medical students, psychologists, researchers and clinicians who need accurate information on the best available diagnostic and therapeutic strategies as well as on up-to-date research data.

Autism Spectrum Disorder

Author : Michael Fitzgerald
Publisher : BoD – Books on Demand
ISBN 13 : 9535120379
Total Pages : 380 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Autism Spectrum Disorder by : Michael Fitzgerald

Download or read book Autism Spectrum Disorder written by Michael Fitzgerald and published by BoD – Books on Demand. This book was released on 2015-04-02 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism cross culturally. It also examines the issue of hyperandrogenism and evidence-based treatments of autism. In terms of assessment, it focuses on psychological and biological assessment including neurotransmitters systems, structural and functional brain imaging, coping strategies of parents, examines the intertwining of language impairment, specific language impairment and ASD, as well as implicit and spontaneous Theory of Mind reading in ASD. In terms of aetiology, it focuses on genetic factors, epigenetics, synaptic vesicles, toxicity during neurodevelopment, immune system and sex differences. It also examines the link between social cognitive anatomical and neurophysiologic biomarkers and candidate genes. This book will be relevant to all mental health professionals because autism occurs in all the different areas of psychiatry and professionals who will find it helpful will be psychiatrists, psychologists, social workers, nurses, teachers and all those working with persons with Autism including parents who nowadays are interested in knowing more and more, at a detailed level about their children or adults with autism.

Handbook of Life Course Health Development

Author : Neal Halfon
Publisher : Springer
ISBN 13 : 3319471430
Total Pages : 667 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Handbook of Life Course Health Development by : Neal Halfon

Download or read book Handbook of Life Course Health Development written by Neal Halfon and published by Springer. This book was released on 2017-11-20 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.

Autism and Talent

Author : Francesca Happé
Publisher : OUP Oxford
ISBN 13 : 0199560145
Total Pages : 244 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Autism and Talent by : Francesca Happé

Download or read book Autism and Talent written by Francesca Happé and published by OUP Oxford. This book was released on 2010-03-18 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Originating from a theme issue first published in Philosophical transactions of the Royal Society. B, Biological sciences."

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Handbook of the Behavioral Neurobiology of Serotonin

Author :
Publisher : Academic Press
ISBN 13 : 0444641262
Total Pages : 1044 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Handbook of the Behavioral Neurobiology of Serotonin by :

Download or read book Handbook of the Behavioral Neurobiology of Serotonin written by and published by Academic Press. This book was released on 2020-01-23 with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of the Behavioral Neurobiology of Serotonin, Second Edition, builds on the success of the first edition by continuing to provide a detailed and comprehensive overview of the many facets of behavioral serotonin research. The text expands on the two key topics, behavioral control (sensory processing, ultrasonic vocalization, and melatonin and sleep control) and psychiatric disorders, including its role on psychostimulant abuse and addiction. The new edition includes two new sections on the serotonin systems interactions and the involvement of serotonin in neurological disorders and associated treatment. Serotonin is a major neurotransmitters in the serotonergic system which one of the best studied and understood transmitter systems. Both are critically involved in the organization of all behaviors and in the regulation of emotion and mood. - Features two new sections on serotonin systems interactions and serotonin in neurological disorders - Focuses on ionotropic and metabotropic 5-HT receptor involvement in behavior - Maps receptors and receptor signaling pathways to neurochemical and behavioral outcomes - Covers the interactions between serotonin, melatonin and kynurenine pathways

Neurobiology, Diagnosis and Treatment in Autism

Author : Daria Riva
Publisher : John Libbey Eurotext
ISBN 13 : 2742008365
Total Pages : 242 pages
Book Rating : 4.7/5 (42 download)

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Book Synopsis Neurobiology, Diagnosis and Treatment in Autism by : Daria Riva

Download or read book Neurobiology, Diagnosis and Treatment in Autism written by Daria Riva and published by John Libbey Eurotext. This book was released on 2013-05-01 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is an extremely complex neurodevelopmental disorder that is expressed in a spectrum of phenotypes and is characterised by impaired reciprocal social communication and stereotyped patterns of interests and activities. Its aetiopathogenesis remains poorly understood. This exhaustive synthesis discusses various aspects: A focus on the neurobiology of autism: the candidate genes implicate an involvement of numerous brain regions and a concomitant malfunctioning of neurotransmitter, immunologic, and other mechanisms; The most incisive rehabilitation models in their original formulation and the results achieved with the same or similar protocols in Italian centres (understanding, language therapy, social skill training; The psychopharmacologic options for the condition of autism per se and for its associated, very frequent, comorbidities. It suggests a potential influence on professional practice and enables an up-to-date approach to effective diagnosis and treatment.

Autism: New Insights for the Healthcare Professional: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 146497067X
Total Pages : 218 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Autism: New Insights for the Healthcare Professional: 2012 Edition by :

Download or read book Autism: New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Autism. The editors have built Autism: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Autism in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Autism: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Essential Pathways and Circuits of Autism Pathogenesis

Author : Gül Dölen
Publisher : Frontiers Media SA
ISBN 13 : 2889199053
Total Pages : 183 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Essential Pathways and Circuits of Autism Pathogenesis by : Gül Dölen

Download or read book Essential Pathways and Circuits of Autism Pathogenesis written by Gül Dölen and published by Frontiers Media SA. This book was released on 2016-08-15 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Centers for Disease Control and Prevention estimate that 1 in 68 children in the United states is afflicted with autism spectrum disorders (ASD), yet at this time, there is no cure for the disease. Autism is characterized by delays in the development of many basic skills, most notably the ability to socialize and adapt to novelty. The condition is typically identified in children around 3 years of age, however the high heritability of autism suggests that the disease process begins at conception. The identification of over 500 ASD risk genes, has enabled the molecular genetic dissection of the pathogenesis of the disease in model organisms such as mice. Despite the genetic heterogeneity of ASD etiology, converging evidence suggests that these disparate genetic lesions may result in the disruption of a limited number of key biochemical pathways or circuits. Classification of patients into groups by pathogenic rather than etiological categories, will likely aid future therapeutic development and clinical trials. In this set of papers, we explore the existing evidence supporting this view. Specifically, we focus on biochemical cascades such as mTOR and ERK signaling, the mRNA network bound by FMRP and UBE3A, dorsal and ventral striatal circuits, cerebellar circuits, hypothalamic projections, as well as prefrontal and anterior cingulate cortical circuits. Special attention will be given to studies that demonstrate the necessity and/or sufficiency of genetic disruptions (e.g. by molecular deletion and/or replacement) in these pathways and circuits for producing characteristic behavioral features of autism. Necessarily these papers will be heavily weighted towards basic mechanisms elucidated in animal models, but may also include investigations in patients.

The Neuroscience of Autism Spectrum Disorders

Author : Joseph D. Buxbaum
Publisher : Academic Press
ISBN 13 : 0123919304
Total Pages : 493 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis The Neuroscience of Autism Spectrum Disorders by : Joseph D. Buxbaum

Download or read book The Neuroscience of Autism Spectrum Disorders written by Joseph D. Buxbaum and published by Academic Press. This book was released on 2012-12-31 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. - Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions - Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists - Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Fragile X and Related Autism Spectrum Disorders

Author :
Publisher : Elsevier
ISBN 13 : 0443137307
Total Pages : 230 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Fragile X and Related Autism Spectrum Disorders by :

Download or read book Fragile X and Related Autism Spectrum Disorders written by and published by Elsevier. This book was released on 2023-11-22 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fragile X and Related Autism Spectrum Disorders, Volume 172 in the International Review on Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on The dopamine hypothesis of Autism Spectrum Disorder: a comprehensive analysis of the evidence, A Review of the Use of Psychotropic Medication to Address Challenging Behavior in Neurodevelopmental Disorders, Lipid metabolism alterations in fragile X syndrome and other neurodevelopmental disorders, Genesis, modelling and methodological remedies to autism heterogeneity, Toward an Understanding of the Role of the Exposome on Fragile X Phenotypes, Glial-mediated dysregulation of neurodevelopment in Fragile X Syndrome, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in International Review of Neurobiology series - Updated release includes the latest information on Fragile X and Related Autism Spectrum Disorders