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Assessment And Mechanisms Of Autonomic Function In Health And Disease
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Book Synopsis Assessment and Mechanisms of Autonomic Function in Health and Disease by : Peter Ricci Pellegrino
Download or read book Assessment and Mechanisms of Autonomic Function in Health and Disease written by Peter Ricci Pellegrino and published by . This book was released on 2016 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The autonomic nervous system is a master regulator of homeostasis, and the conviction that autonomic outflow is important on a patient-by-patient, minute-to-minute basis in both health and disease is the motivation for this thesis. The dissertation explores three aims that advance our understanding of the autonomic nervous system by elucidating the molecular mechanisms of autonomic regulation, validating widely used techniques for autonomic assessment, and developing and applying a new method to assess sympathetic vascular control. The first aim of the dissertation was to investigate the role of the Rho kinase pathway as a mediator of the autonomic effects of central angiotensin-II. This study was performed in conscious, chronically instrumented rabbits that received intracerebroventricular infusions of angiotensin-II, angiotensin-II with the specific Rho kinase inhibitor Fasudil, Fasudil alone, or a vehicle control over two weeks. Baseline hemodynamics were assessed daily, and cardiac and global vasomotor sympathetic tone was assessed by the hemodynamic response to autonomic blockers. Angiotensin-II raised blood pressure and cardiac and global vasomotor sympathetic outflow in a Rho-kinase dependent manner. In a separate cohort, renal sympathetic nerve activity was directly recorded and sympathetic baroreflex sensitivity was assessed, providing clear evidence that angiotensin-II increases renal sympathetic nerve activity and impairs baroreflex control thereof via a Rho kinase-dependent mechanism. In summary, the pressor, sympatho-excitatory, and baroreflex dysfunction caused by central angiotensin-II depend on Rho kinase activation. The second aim was to investigate the relationship between measures of pulse rate variability obtained by a chronically implanted arterial pressure telemeter with measures of heart rate variability derived by the standard electrocardiogram and the ability of pulse rate variability to reflect the autonomic contributions of heart rate variability. This study was conducted in conscious rabbits chronically instrumented with epicardial leads and arterial pressure telemeters. The autonomic contribution to pulse rate variability was assessed by pharmacological blockade, and the intrinsic variability of pulse rate was assessed by ventricular pacing. This study showed that pulse rate variability is a generally acceptable surrogate for heart rate variability for time- and frequency-domain measures, but the additional contribution of respiration to and the differing nonlinear properties of pulse rate variability should be considered by investigators. The third aim was to critically test the idea that the renal sympathetic nerves do not participate in the physiological control of renal blood flow. This study was conducted in conscious rabbits that underwent unilateral renal denervation and chronic instrumentation with arterial pressure telemeters and bilateral renal blood flow probes. Using time-varying transfer function analysis, this study showed active, rhythmic vasoconstriction of the renal vasculature with baroreflex properties in normally innervated kidneys, consistent with sympathetic vasomotion, which was absent in denervated kidneys. This refutes the long-held idea that sympathetic control of the renal vasculature is not physiological and has important applications to the burgeoning field of therapeutic renal denervation for cardiovascular disease.
Book Synopsis Understanding the Role of the Autonomic Nervous System in Health and Disease by : Vitor Engracia Valenti
Download or read book Understanding the Role of the Autonomic Nervous System in Health and Disease written by Vitor Engracia Valenti and published by Frontiers Media SA. This book was released on 2024-07-03 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The parasympathetic and sympathetic autonomic systems are involved in several body functions. Cardiovascular risk factors can be estimated through autonomic nervous system (ANS) activity. Previous studies have already supported the relevance of improved parasympathetic function to maintain a good health status. Currently, it is well documented that people with high physical activity status present better ANS function, as well as non-smokers subjects. Many factors are related to impaired ANS function, including, sedentary habits, smoking, high fat intake, genetic changes, etc.
Book Synopsis Autonomic Dysfunction in Parkinson's Disease by : Cristian Falup-Pecurariu
Download or read book Autonomic Dysfunction in Parkinson's Disease written by Cristian Falup-Pecurariu and published by Academic Press. This book was released on 2021-09-28 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autonomic dysfunction is one of the most prevalent non-motor symptoms that occurs in Parkinson’s disease. Autonomic Dysfunction in Parkinson's Disease provides up to date information on this important topic, which affects quality of life of these patients. This include a large number of domains: orthostatic hypotension, excessive sweating, dry eyes, constipation, weight loss, increased sensitivity to heat and cold, sexual dysfunction. Provides comprehensive reviews on different topics of autonomic dysfunction in Parkinson’s disease Each chapter covers a specific autonomic symptom: classification, assessment, treatment Presents the newest information on each autonomic symptom in Parkinson’s disease
Book Synopsis Autonomic Neurology by : Eduardo E. Benarroch
Download or read book Autonomic Neurology written by Eduardo E. Benarroch and published by Oxford University Press. This book was released on 2014-04-03 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to present a focused approach to the pathophysiology, diagnosis, and management of the most common autonomic disorders that may present to the clinical neurologist. Autonomic Neurology is divided into 3 sections. The first section includes 5 chapters reviewing the anatomical and biochemical mechanisms of central and peripheral nervous system control of autonomic function, principles of autonomic pharmacology, and a clinical and laboratory approach to the diagnosis of autonomic disorders. The second section focuses on the pathophysiology and management of orthostatic hypotension, postural tachycardia, baroreflex failure; syncope, disorders of sweating, neurogenic bladder and sexual dysfunction, gastrointestinal dysmotility, and autonomic hyperactivity. The final section is devoted to specific autonomic disorders, including central neurodegenerative disorders; common peripheral neuropathies with prominent autonomic failure; painful small fiber neuropathies; autoimmune autonomic ganglionopathies and neuropathies; focal brain disorders; focal spinal cord disorders; and chronic pain disorders with autonomic manifestations. This book is the product of the extensive experience of its contributors in the evaluation and management of the many patients with autonomic symptoms who are referred for neurologic consultation at Mayo Clinic in Rochester, Minnesota. Autonomic Neurology focuses on clinical scenarios and presentation of clinical cases and includes several figures showing the results of normal and abnormal autonomic testing in typical conditions. Its abundance of tables summarizing the differential diagnosis, testing, and management of autonomic disorders also help set this book apart from other books focused on the autonomic nervous system.
Book Synopsis Methods in Social Neuroscience by : Eddie Harmon-Jones
Download or read book Methods in Social Neuroscience written by Eddie Harmon-Jones and published by Guilford Press. This book was released on 2012-05-09 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Straightforward and practical, this is the first book to provide detailed guidance for using neurobiological methods in the study of human social behavior, personality, and affect. Each chapter clearly introduces the method at hand, provides examples of the method's applications, discusses its strengths and limitations, and reviews concrete experimental design considerations. Written by acknowledged experts, chapters cover neuroimaging techniques, genetic measurement, hormonal methods, lesion studies, startle eyeblink responses, facial electromyography, autonomic nervous system responses, and modeling based on neural networks.
Book Synopsis Autonomic Failure by : C. J. Mathias
Download or read book Autonomic Failure written by C. J. Mathias and published by Oxford University Press, USA. This book was released on 1999 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of Autonomic Failure (now available in paperback) covers the many recent advances made in our understanding of the autonomic nervous system. There are 20 new chapters and extensive revisions of all other contributions. Autonomic failure, fourth edition makes diagnosis increasingly precise by fully evaluating the underlying anatomical and functional deficits, thereby allowing more effective treatment. This new edition continues to provide practitioners from a variety of fields, including neurology, cardiology, geriatric medicine, diabetology, and internal medicine, with a rational guide to aid in the recognition and management of autonomic disorders. The book starts with an updated classification of autonomic disorders and a history of the autonomic nervous system. The first two sections of the book deal with the fundamental aspects of autonomic structure, function, and integration. There are new chapters dealing with neurobiology, nerve growth factors, genetic mutations, neural and hormonal control of the cerebral circulation, innervation of the lung, and pathophysiological mechanisms causing nausea and vomiting. Advances in the clinical management of autonomic disorders are critically dependent on the bridge made between the basic and applied sciences.
Book Synopsis The Enteric Nervous System by : John Barton Furness
Download or read book The Enteric Nervous System written by John Barton Furness and published by . This book was released on 1987 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Peripheral Nerve Disorders by : Gérard Said
Download or read book Peripheral Nerve Disorders written by Gérard Said and published by Elsevier. This book was released on 2013-08-17 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities. Covers both hereditary and cryptogenic neurologic disorders Includes advances in the basic science of PNS from molecular genetics, biochemistry, immunology, morphology and physiology Detailed coverage of neuropathy in connective tissue disorders, infectious disorders, metabolic disorders and malignancy
Book Synopsis Female Pelvic Medicine by : Kathleen C. Kobashi
Download or read book Female Pelvic Medicine written by Kathleen C. Kobashi and published by Springer Nature. This book was released on 2021-04-13 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed as a guide for management of advanced clinical scenarios encountered by the contemporary pelvic floor surgeon. It is organized by pelvic floor disorder (PFD) and covers the evaluation and treatment of urinary incontinence, fecal incontinence, and pelvic organ prolapse. Opening chapters in each section cover the fundamentals of proper and comprehensive assessment of patient PFDs, as well as the treatment options that are available for each disorder. The book then focuses on more complex and challenging situations that are becoming more frequently encountered as the number of patients being treated for PFD increases and the length of patient follow-up grows. Each chapter finally includes an expert commentary to address these new scenarios and offers a shifted approach from that required for treatment-naïve patients. Female Pelvic Medicine: Challenging Cases with Expert Commentary teaches the reader how to approach the most difficult of clinical situations in a multidisciplinary fashion.
Book Synopsis Principles and Practice of Movement Disorders E-Book by : Joseph Jankovic
Download or read book Principles and Practice of Movement Disorders E-Book written by Joseph Jankovic and published by Elsevier Health Sciences. This book was released on 2011-04-01 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Practice of Movement Disorders provides the complete, expert guidance you need to diagnose and manage these challenging conditions. Drs. Stanley Fahn, Joseph Jankovic and Mark Hallett explore all facets of these disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. This edition features many new full-color images, additional coverage of pediatric disorders, updated Parkinson information, and many other valuable updates. An accompanying Expert Consult website makes the content fully searchable and contains several hundred video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses. Get just the information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. Find the answers you need quickly and easily thanks to a reader-friendly full-color format, with plentiful diagrams, photographs, and tables. Apply the latest advances to diagnosis and treatment of pediatric movement disorders, Parkinson disease, and much more. View the characteristic presentation of each disorder with a complete collection of professional-quality, narrated videos online. Better visualize every concept with new full-color illustrations throughout. Search the complete text online, follow links to PubMed abstracts, and download all of the illustrations, at www.expertconsult.com.
Book Synopsis Brain Mapping: The Methods by : Arthur W. Toga
Download or read book Brain Mapping: The Methods written by Arthur W. Toga and published by Academic Press. This book was released on 2002-09-25 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of scientists and laboratories involved with brain mapping is increasing exponentially; and the second edition of this comprehensive reference has also grown much larger than the first (published in 1996), including, for example, five chapters on structural and functional MRI where the fi
Book Synopsis Clinical Neurophysiology by : Jasper R. Daube
Download or read book Clinical Neurophysiology written by Jasper R. Daube and published by Oxford University Press. This book was released on 2009-05-22 with total page 915 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Neurophysiology, Third Edition will continue the tradition of the previous two volumes by providing a didactic, yet accessible, presentation of electrophysiology in three sections that is of use to both the clinician and the researcher. The first section describes the analysis of electrophysiological waveforms. Section two describes the various methods and techniques of electrophysiological testing. The third section, although short in appearance, has recommendations of symptom complexes and disease entities using electroencephalography, evoked potentials, and nerve conduction studies.
Book Synopsis Autonomic Failure by : Roger Bannister
Download or read book Autonomic Failure written by Roger Bannister and published by Oxford University Press, USA. This book was released on 1992 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of this classic text, extensively revised, is now available in paperback, priced so that all interested physicians can have their own copy. The autonomic nervous system regulates, without conscious awareness, the function of the heart and all other bodily organs. Autonomic failure can cause a variety of seemingly strange symptoms, which may present to general physicians or a wide spectrum of specialists. This book shows how these symptoms can be studied scientifically in order to reach a precise diagnosis and instigate rational treatment.
Book Synopsis The Nervous System and the Heart by : Gert J. Ter Horst
Download or read book The Nervous System and the Heart written by Gert J. Ter Horst and published by Springer Science & Business Media. This book was released on 2000 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are physiological bases for associations of the heart with emotions, and with the apparently universal increased mortality in winter. Thirteen contributions integrate expertise in cardiology and neuroscience in overviewing the latest knowledge about head-heart interactions. The first five chapters explain autonomic control of cardiovascular functions, the neural supply of the heart, and neuropathology. Part II examines the effects of stress on the hypothalamo-pituitary-adrenal system and the heart. Part III treats the neurobiology and neuroimaging of cardiac pain. Next, humoral factors in cardiovascular regulation and as mediators of inflammation in coronary artery disease are considered. Finally, the relationship between heart disease and cognitive/neuropsychiatric disorders is discussed. Includes photomicrographs, schematic drawings, and nice large print.
Book Synopsis The Dysautonomia Project by : Msm Kelly Freeman
Download or read book The Dysautonomia Project written by Msm Kelly Freeman and published by Bardolf. This book was released on 2015-10-05 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Dysautonomia Project" is a much needed tool for physicians, patients, or caregivers looking to arm themselves with the power of knowledge. It combines current publications from leaders in the field of autonomic disorders with explanations for doctors and patients about the signs and symptoms, which will aid in reducing the six-year lead time to diagnosis.
Book Synopsis Pituitary Adenylate Cyclase-Activating Polypeptide by : Hubert Vaudry
Download or read book Pituitary Adenylate Cyclase-Activating Polypeptide written by Hubert Vaudry and published by Springer Science & Business Media. This book was released on 2003 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.
