Assessing Ocular Toxicology in Laboratory Animals

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Publisher : Springer Science & Business Media
ISBN 13 : 1627031642
Total Pages : 327 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis Assessing Ocular Toxicology in Laboratory Animals by : Andrea B Weir

Download or read book Assessing Ocular Toxicology in Laboratory Animals written by Andrea B Weir and published by Springer Science & Business Media. This book was released on 2012-12-04 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.

Standards for Ocular Toxicology and Inflammation

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Author :
Publisher : Springer
ISBN 13 : 3319783645
Total Pages : 212 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Standards for Ocular Toxicology and Inflammation by : Brian C. Gilger

Download or read book Standards for Ocular Toxicology and Inflammation written by Brian C. Gilger and published by Springer. This book was released on 2018-08-31 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an international effort to standardize the language, terms, and methods used in ocular toxicology.With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. it is essential for industry, pharmaceutical companies, and governmental agencies to help improve the drug development process and to reduce and refine the use of animals in research. Standards for Ocular Toxicology and Inflammation is endorsed by the American College of Veterinary Ophthalmologists.

Guide for the Care and Use of Laboratory Animals

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Publisher : National Academies Press
ISBN 13 : 0309154006
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guide for the Care and Use of Laboratory Animals by : National Research Council

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Ocular Toxicology

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Publisher : Springer Science & Business Media
ISBN 13 : 1461518873
Total Pages : 365 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Ocular Toxicology by : Keith Green

Download or read book Ocular Toxicology written by Keith Green and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: On behalf of the editorial board and the organizing committee of the 4th congress of the International Society of Ocular Toxicology (I SOT), held in AnnecyNeyrier du Lac, France, October 9 -13, 1994, we are pleased to present to the ocular toxicology community this indexed volume of our congress proceedings. The 4th congress was designed primarily to facilitate and update the knowledge in ocular electrophysiology and ocular pharmacokinetics, in both the clinical and preclinical aspects. The outcome of this 4th congress, established in this volume, is a useful contribution to the meth odology in both fields and will hopefully assist in the evaluation and interpretation of ocular findings recorded in animal studies on drugs and other chemicals, in order to protect human health. Undoubtedly, work on the mechanisms of ocular toxicology in the process of pharmaceutical development must continue and these proceedings, embodying the presented papers, will add to the data base. The editors, the congress organizing committee and the members of the International Society of Ocular Toxicology thank the speakers who gave their time, knowledge, and expertise to assist us in this project. The following manuscripts contain the main substance of each of the platform presentations and, in some cases, much more. Moreover, our thanks go to all the participants coming from a range of background- regulatory, academic and industrial -for their attention and excellent contributions during the discussion.

The Clinical Chemistry of Laboratory Animals

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Publisher : CRC Press
ISBN 13 : 142009114X
Total Pages : 1162 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis The Clinical Chemistry of Laboratory Animals by : David M. Kurtz

Download or read book The Clinical Chemistry of Laboratory Animals written by David M. Kurtz and published by CRC Press. This book was released on 2017-10-18 with total page 1162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key features: Serves as the detailed, authoritative source of the clinical chemistry of the most commonly used laboratory animals Includes detailed chapters dedicated to descriptions of clinical chemistry-related topics specific to each laboratory species as well as organ/class-specific chapters Presents information regarding evaluation and interpretation of a variety of individual clinical chemistry end points Concludes with detailed chapters dedicated to descriptions of statistical analyses and biomarker development of clinical chemistry-related topics Provides extensive reference lists at the end of each chapter to facilitate further study Extensively updated and expanded since the publication of Walter F. Loeb and Fred W. Quimby’s second edition in 1999, the new The Clinical Chemistry of Laboratory Animals, Third Edition continues as the most comprehensive reference on in vivo animal studies. By organizing the book into species- and organ/class-specific chapters, this book provides information to enable a conceptual understanding of clinical chemistry across laboratory species as well as information on evaluation and interpretation of clinical chemistry data relevant to specific organ systems. Now sponsored by the American College of Laboratory Animal Medicine (ACLAM), this well-respected resource includes chapters on multiple laboratory species and provides pertinent information on their unique physiological characteristics, methods for sample collection, and preanalytical sources of variation for the particular species. Basic methodology for common procedures for each species is also discussed. New Chapters in the Third Edition Include: The Laboratory Zebrafish and Other Fishes Evaluation of Cardiovascular and Pulmonary Function and Injury Evaluation of Skeletal Muscle Function and Injury Evaluation of Bone Function and Injury Vitamins Development of Biomarkers Statistical Methods The Clinical Chemistry of Laboratory Animals, Third Edition is intended as a reference for use by veterinary students, clinical veterinarians, verterinary toxicologists, veterinary clinical pathologists, and laboratory animal veterinarians to aid in study design, collection of samples, and interpretation of clinical chemistry data for laboratory species.

Ophthalmic Toxicology

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Publisher : CRC Press
ISBN 13 : 9781439809983
Total Pages : 398 pages
Book Rating : 4.8/5 (99 download)

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Book Synopsis Ophthalmic Toxicology by : G. C. Y. Chiou

Download or read book Ophthalmic Toxicology written by G. C. Y. Chiou and published by CRC Press. This book was released on 1999-07-01 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updates, this new edition of Ophthalmic Toxicology retains its uniqueness in covering all aspects of ophthalmic toxicology. With chapters from leading authorities incorporating the latest developments in the field, including a new chapter on the molecular basis of ophthalmic toxicity, this edition covers such topics as: *t

Dermal and Ocular Toxicology

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Publisher : CRC Press
ISBN 13 : 1000159701
Total Pages : 682 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Dermal and Ocular Toxicology by : David W. Hobson

Download or read book Dermal and Ocular Toxicology written by David W. Hobson and published by CRC Press. This book was released on 2020-11-26 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dermal and Ocular Toxicology: Fundamentals and Methods is a procedurally-oriented volume of detailed methods and practical examples discussing the dermal and ocular aspects of toxicology. The book is divided into a dermal section and an ocular section. Each section begins with a chapter on the anatomy and physiology of each organ system and then progresses to more specialized chapters discussing such topics as the toxicological pathology of each system, state-of-the-art in vitro and in vivo evaluatory procedures, statistical considerations for test design and data interpretation, and the utilization of test findings. Test methods are provided for acute dermal exposure effects, dermal hypersensitivity and photoallergy assessment, dermal and ocular 0.pharmacokinetics, skin flap and skin grafting techniques, and in vitro alternative methods. This book can be used as an instructional text or as a sourcebook for practicing toxicologists, pharmacologists, industrial hygienists, occupational health professionals, and graduate students.

Atlas of Toxicological Pathology

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Publisher : Springer
ISBN 13 : 1627039988
Total Pages : 291 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis Atlas of Toxicological Pathology by : Chirukandath Gopinath

Download or read book Atlas of Toxicological Pathology written by Chirukandath Gopinath and published by Springer. This book was released on 2014-05-13 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas contains more than 700 illustrations that the authors have collected over the years as well as references and information pertaining to recently developed drug classes, including biologics. It is a useful bench reference for practicing pathologists and may also be used as a reference text by other experts from related fields. The atlas is organised into different chapters based on systemic pathology. Each chapter has illustrations with legends, and the atlas includes some rare examples of unique lesions found during toxicity studies over many years.

Principles and Procedures for Evaluating the Toxicity of Household Substances

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Publisher :
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.1/5 (384 download)

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Book Synopsis Principles and Procedures for Evaluating the Toxicity of Household Substances by : National Research Council (U.S.). Committee for the Revision of NAS publication 1138, Principles and Procedures for Evaluating the Toxicity of Household Substances

Download or read book Principles and Procedures for Evaluating the Toxicity of Household Substances written by National Research Council (U.S.). Committee for the Revision of NAS publication 1138, Principles and Procedures for Evaluating the Toxicity of Household Substances and published by . This book was released on 1977 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Human Endpoints for Experimental Animals Used in Safety Evaluation

Download OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Human Endpoints for Experimental Animals Used in Safety Evaluation PDF Online Free

Author :
Publisher : OECD Publishing
ISBN 13 : 9264078371
Total Pages : 39 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Human Endpoints for Experimental Animals Used in Safety Evaluation by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Human Endpoints for Experimental Animals Used in Safety Evaluation written by OECD and published by OECD Publishing. This book was released on 2002-05-10 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this Guidance Document is to apply the principles of the Three Rs to the use of animals in regulatory toxicity tests.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

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Author :
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Atlas of Histology of the Juvenile Rat

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Publisher : Academic Press
ISBN 13 : 0128026960
Total Pages : 464 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Atlas of Histology of the Juvenile Rat by : George A Parker

Download or read book Atlas of Histology of the Juvenile Rat written by George A Parker and published by Academic Press. This book was released on 2016-05-04 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42. Written and edited by highly experienced, board-certified toxicologic pathologists Includes more than 700 high-resolution microscopic images from organs that are typically examined in safety assessment toxicology studies Detailed figure legends and chapter narratives present the salient features of each organ at each time interval Figures are available for further study via Elsevier’s Virtual Microscope, which allows viewing of microscopic images at higher magnification Valuable resource for toxicologic pathologists who are confronted with interpretation of lesions in juvenile rats in situations where age-matched concurrent controls are not available for comparison, e.g., with unscheduled decedents Figures are available for further study on ScienceDirect with Virtual Microscope, which allows viewing of microscopic images at higher magnification

Fundamental Neuropathology for Pathologists and Toxicologists

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Publisher : John Wiley & Sons
ISBN 13 : 0470227338
Total Pages : 661 pages
Book Rating : 4.4/5 (72 download)

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Book Synopsis Fundamental Neuropathology for Pathologists and Toxicologists by : Brad Bolon

Download or read book Fundamental Neuropathology for Pathologists and Toxicologists written by Brad Bolon and published by John Wiley & Sons. This book was released on 2011-10-04 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology – including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).

Fundamentals of Toxicologic Pathology

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Publisher : Academic Press
ISBN 13 : 0128098422
Total Pages : 902 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Fundamentals of Toxicologic Pathology by : Wanda M. Haschek

Download or read book Fundamentals of Toxicologic Pathology written by Wanda M. Haschek and published by Academic Press. This book was released on 2017-10-25 with total page 902 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development. The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others. Presents revised and updated information for each chapter on systems Contains expanded sections on applied toxicologic pathology Includes the essential information necessary to understand toxicologic pathology in an accessible language

Veterinary Ophthalmology

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Publisher : John Wiley & Sons
ISBN 13 : 1119441811
Total Pages : 6078 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Veterinary Ophthalmology by : Kirk N. Gelatt

Download or read book Veterinary Ophthalmology written by Kirk N. Gelatt and published by John Wiley & Sons. This book was released on 2021-01-26 with total page 6078 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diese vollständig aktualisierte und überarbeitete Ausgabe des Standardwerks der veterinärmedizinischen Augenheilkunde präsentiert die neuesten Diagnose- und Therapieverfahren. Das Fachbuch deckt die Grundlagenwissenschaften und klinische Behandlungsmethoden ab, spiegelt den aktuellen Stand der Forschung wider und beschäftigt sich mit der Augenheilkunde sämtlicher Tierarten, darunter Hunde, Katzen, Pferde, Großtiere und Exoten. Augenerkrankungen bei Katzen, Pferden und Vögeln werden noch ausführlicher und anhand von nahezu zweitausend Farbfotos erläutert. Dieses Fachbuch ist ein Muss für Veterinärmediziner in der Behandlung von Augenkrankheiten. - Die 6. Auflage von Veterinary Ophthalmology präsentiert alle Aspekte, die für die Diagnose, Behandlung und das Management von Augenkrankheiten relevant sind. Zu dieser Auflage gehören auch eine begleitende Website mit Videoclips und Abbildungen aus der Printausgabe im PowerPoint-Format, weiterhin das wohl umfassendste Literaturverzeichnis zu dem Fachgebiet. - Neue Auflage des Standardwerks der Augenheilkunde für Veterinärmediziner. - Bietet noch mehr Inhalte zu Augenerkrankungen bei Katzen, Pferden und Vögeln. - Mit mehr als 2000 Farbfotos, die die Inhalte verdeutlichen. - Die Autoren sind international renommierte Experten des Fachgebiets. - Begleitende Website mit Videoclips und Bildermaterial im PowerPoint-Format zum Herunterladen. Die 6. Auflage von Veterinary Ophthalmology darf in der Handbibliothek von Fachtierärzten mit Spezialisierung auf Augenheilkunde und Veterinärmedizinern, die Augenerkrankungen behandeln, nicht fehlen.

Drug-Induced Ocular Side Effects: Clinical Ocular Toxicology E-Book

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323319858
Total Pages : 425 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Drug-Induced Ocular Side Effects: Clinical Ocular Toxicology E-Book by : Frederick T. Fraunfelder

Download or read book Drug-Induced Ocular Side Effects: Clinical Ocular Toxicology E-Book written by Frederick T. Fraunfelder and published by Elsevier Health Sciences. This book was released on 2014-09-19 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ideal for ophthalmologists, optometrists and busy clinicians, Drug-Induced Ocular Side Effects provides the clinically relevant information you need to diagnose and manage chemical and drug-related ocular problems. An easily accessible format, meticulous revisions and comprehensive coverage of all drugs’ generic and trade names, primary uses, ocular and systemic side effects, and clinical significance make this best-selling resource the ideal reference for quick, on-the-spot consultation. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Manage any challenge in ocular toxicology with extensive coverage of principles of therapy; ocular drug delivery; methods to evaluate drug-induced visual side effects; and the role of electrophysiology and psychophysics. Benefit from the masterful guidance and global perspective of world authorities in the field who provide need-to-know information on all aspects of ocular toxicology—all in one concise reference. Confer with the WHO classification system to determine whether a particular side effect is certain, probable, or likely to occur. Zero in on the key information you need to know with highly templated, concise chapters. Apply the latest knowledge and treatments for newly recognized Adverse Drug Reactions (ADR). Identify which ADR’s are clinically relevant and what to do about them. Experience clinical scenarios with vivid clarity through a wealth of new and updated clinical photographs that provide unmatched, visual diagnostic guidance. Recognize and avoid drug-induced ocular side effects with data from the National Registry of Drug Induced Ocular Side-Effects (Casey Eye Institute, Portland, OR) and the World Health Organization (Uppsala, Sweden). Stay up to date and provide state-of-the-art care with the latest information on approved medications. Access the complete contents online at Expert Consult.

OECD Guidelines for Testing of Chemicals

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Author :
Publisher : Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
ISBN 13 : 9789264122215
Total Pages : pages
Book Rating : 4.1/5 (222 download)

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Book Synopsis OECD Guidelines for Testing of Chemicals by : Organisation for Economic Co-operation and Development

Download or read book OECD Guidelines for Testing of Chemicals written by Organisation for Economic Co-operation and Development and published by Organisation for Economic Co-operation and Development ; [Montréal : Renouf]. This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: