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Aseptic Loosening Of Orthopedic Implants
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Author :Mehdi Amirhosseini Publisher :Linköping University Electronic Press ISBN 13 :9176852385 Total Pages :41 pages Book Rating :4.1/5 (768 download)
Book Synopsis Aseptic Loosening of Orthopedic Implants by : Mehdi Amirhosseini
Download or read book Aseptic Loosening of Orthopedic Implants written by Mehdi Amirhosseini and published by Linköping University Electronic Press. This book was released on 2019-05-24 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aseptic loosening is the main cause of failure of orthopedic prostheses. With no pharmaceuticals to prevent or mitigate periprosthetic bone degradation, a surgery to replace the loose implant with a new one is the only choice to restore patients’ function. Most studies on mechanisms for aseptic loosening investigate wear debris particle-induced osteolysis. However, pathological loading conditions around unstable implants can also trigger osteoclast differentiation and bone loss. In the first study, global gene expression changes induced by mechanical instability of implants, and by titanium particles were compared in a validated rat model for aseptic loosening. Microarray analysis showed that similar signaling pathways and gene expression patterns are involved in particle- and instability-induced periprosthetic osteolysis with an early onset innate immune response as a hallmark of osteolysis induced by mechanical instability. Further, effects of potential therapeutics on restriction of excessive osteoclast differentiation were evaluated. Wnt signaling pathway is known to regulate bone remodeling. In the second study, effects of inactivation of glycogen synthase kinase 3 beta (GSK-3?), a negative regulator of canonical Wnt signaling, on instability-induced periprosthetic osteolysis were examined using our rat model for aseptic loosening. Inhibition of GSK-3? led to a decrease in osteoclast numbers in the periprosthetic bone tissue exposed to mechanical instability while osteoblast perimeter showed an increase. This was accompanied by higher bone volume fraction (BV/TV) in animals treated with the GSK-3? inhibitor. In the third study, potential beneficial effects of two selective inhibitors of cyclindependent kinase 8/19 (CDK8/19) on bone tissue were evaluated. CDK8/19 is a Mediator complex-associated transcriptional regulator involved in several signaling pathways. CDK8/19 inhibitors, mainly under investigation as treatments for tumors, are reported to enhance osteoblast differentiation and bone formation. We show in this study, for the first time, that inhibition of CDK8/19 led to marked suppression of osteoclast differentiation from bone marrow macrophages in vitro through disruption of the RANK signaling. In mouse primary osteoblasts downregulation of osteopontin mRNA, a negative regulator of mineralization, together with increased alkaline phosphatase activity and calcium deposition indicated that osteoblast mineralization was promoted by CDK8/19 inhibition. Moreover, local administration of a CDK8/19 inhibitor promoted cancellous bone regeneration in a rat model for bone healing. These studies contribute to better understanding of mechanisms behind mechanical instability-induced periprosthetic osteolysis and propose potential therapeutics to restrict bone loss with effects on both osteoclasts and osteoblasts.
Book Synopsis Postgraduate Orthopaedics by : Paul A. Banaszkiewicz
Download or read book Postgraduate Orthopaedics written by Paul A. Banaszkiewicz and published by Cambridge University Press. This book was released on 2012-08-16 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: The must-have book for candidates preparing for the oral component of the FRCS (Tr and Orth).
Book Synopsis The Effect of Particulate Biomaterials and Motion on Aseptic Loosening of Orthopaedic Implants by : Lynne C. Jones
Download or read book The Effect of Particulate Biomaterials and Motion on Aseptic Loosening of Orthopaedic Implants written by Lynne C. Jones and published by . This book was released on 1997 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Theofilos Karachalios Publisher :Springer Science & Business Media ISBN 13 :1447154096 Total Pages :342 pages Book Rating :4.4/5 (471 download)
Book Synopsis Bone-Implant Interface in Orthopedic Surgery by : Theofilos Karachalios
Download or read book Bone-Implant Interface in Orthopedic Surgery written by Theofilos Karachalios and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Total joint arthroplasty is an effective surgical procedure for end-stage osteoarthritis of major joints with satisfactory long term clinical outcome. A large and growing number of arthroplasties are performed annually worldwide and a great number of orthopaedic surgeons are practicing arthroplasty surgery as their main surgical activity. The biological behavior of the bone-implant interface is crucial for the long term survival of the artificial joint. All factors which have a positive or negative effect on the interface are of great interest for those practicing arthroplasty surgery. Basic scientists and the industry are continuously searching for new implant fixation mechanisms and improved materials. There is an accumulation of a great amount of basic science data (both biological, material and mechanical) related to the incorporation or loosening of the bone-implant interface. However, basic science data does not always translate to satisfactory clinical application, and orthopaedic practitioners often wonder which piece of information is clinically useful. A further problem is that basic scientists often speak their own scientific language and may not fully appreciate common clinical practice needs. In this textbook the biological and mechanical mechanisms of implant incorporation and loosening will be presented. All new data concerning materials and methods for incorporation enhancement will be critically analyzed. Data useful for clinical application will be stressed. Orthopaedic Surgeons will find information which will improve their clinical practice and basic scientists will be helped to understand and appreciate clinical needs.
Book Synopsis Radiologic Guide to Orthopedic Devices by : Tim B. Hunter
Download or read book Radiologic Guide to Orthopedic Devices written by Tim B. Hunter and published by Cambridge University Press. This book was released on 2017-05-11 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference on radiologic appearance, uses and complications of orthopedic devices, for radiologists, orthopedists, physicians, and students.
Book Synopsis Biocorrosion and Aseptic Loosening of Metal Implants by : Dieter Cadosch
Download or read book Biocorrosion and Aseptic Loosening of Metal Implants written by Dieter Cadosch and published by . This book was released on 2011 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal orthopaedic devices exposed to a physiological environment remain prone to corrosion by several mechanisms, leading to the production of significant amounts of non-biocompatible wear particles and metal ions. Beside the well-known mechanical wear and electrochemical redox reactions, metal implants undergo corrosion through biological activities. The results presented in this thesis suggest that mature osteoclasts are able to enhance corrosion of titanium and stainless steel implants and contribute to the release of relevant amounts of corresponding metal ions into the peri-implant tissues and the systemic blood circulation. In addition to the increased osteolytic activity caused by wear particles, the results detailed in this thesis strongly suggests that released titanium ions in the 4+ oxidation state (Ti(IV)) contribute to the pathophysiological mechanism of aseptic loosening by stimulating both the bone metabolism and immune system through a series of direct and indirect pathways. Aseptic loosening is believed to be caused by an increased osteolytic activity at the bone-implant interface leading to loss of stability and ultimately implant failure. Titanium (IV) ions are able to directly induce the differentiation of osteoclast precursors toward mature and functional osteoclasts in ~20% of individuals. Additionally, Ti(IV) ions stimulate the secretion of pro-inflammatory cytokines that are known to enhance osteoclast recruitment, differentiation, activation and survival. More evidence is linking the immune system to the bone and to its involvement in the pathophysiology of aseptic loosening. Titanium (IV) ions influence phenotype and function of T-lymphocytes, resulting in activation of a CD69+ and CCR4+ Tlymphocyte and secretion of receptor activator of NF-mB ligand (RANK-L). To date, revision surgery remains the only option for the treatment of a failed orthopaedic implant caused by aseptic loosening. These results represent an important step towards a better understanding of the complex pathophysiological mechanism of aseptic loosening in patients with titanium implants, and may open new research perspectives in this field which could offer innovative therapeutic options and reduce the rate of aseptic loosening.
Book Synopsis Personalized Hip and Knee Joint Replacement by : Charles Rivière
Download or read book Personalized Hip and Knee Joint Replacement written by Charles Rivière and published by Springer Nature. This book was released on 2020-06-30 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes and illustrates the surgical techniques, implants, and technologies used for the purpose of personalized implantation of hip and knee components. This new and flourishing treatment philosophy offers important benefits over conventional systematic techniques, including component positioning appropriate to individual anatomy, improved surgical reproducibility and prosthetic performance, and a reduction in complications. The techniques described in the book aim to reproduce patients’ native anatomy and physiological joint laxity, thereby improving the prosthetic hip/knee kinematics and functional outcomes in the quest of the forgotten joint. They include kinematically aligned total knee/total hip arthroplasty, partial knee replacement, and hip resurfacing. The relevance of available and emerging technological tools for these personalized approaches is also explained, with coverage of, for example, robotics, computer-assisted surgery, and augmented reality. Contributions from surgeons who are considered world leaders in diverse fields of this novel surgical philosophy make this open access book will invaluable to a wide readership, from trainees at all levels to consultants practicing lower limb surgery
Book Synopsis Recent Advances in Arthroplasty by : Samo Fokter
Download or read book Recent Advances in Arthroplasty written by Samo Fokter and published by BoD – Books on Demand. This book was released on 2012-01-27 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book was to offer an overview of recent insights into the current state of arthroplasty. The tremendous long term success of Sir Charnley's total hip arthroplasty has encouraged many researchers to treat pain, improve function and create solutions for higher quality of life. Indeed and as described in a special chapter of this book, arthroplasty is an emerging field in the joints of upper extremity and spine. However, there are inborn complications in any foreign design brought to the human body. First, in the chapter on infections we endeavor to provide a comprehensive, up-to-date analysis and description of the management of this difficult problem. Second, the immune system is faced with a strange material coming in huge amounts of micro-particles from the tribology code. Therefore, great attention to the problem of aseptic loosening has been addressed in special chapters on loosening and on materials currently available for arthroplasty.
Book Synopsis The Infected Implant by : Heino Kienapfel
Download or read book The Infected Implant written by Heino Kienapfel and published by Springer Science & Business Media. This book was released on 2009-11-21 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Musculosketal infections are potentially devastating for the patient, his family and the health care services, as they may lead to functional impairment, long lasting disability, or even permanent handicap. This problem may also have socioeconomic implications. Infection commonly results in prolonged use of antibiotics, multiple operations, complications, extended rehabilitation and long lasting followup visits with additional costs for the health care provider. This book covers contributions from international experts who came together in Potsdam, Germany, at the invitation of Professor Heino Kienapfel, MD PhD, of the Department of Special Orthopaedic Surgery and Traumatology of the Centre of Joint Arthroplasty, Auguste Viktoria Clinics Berlin. The focus of this book is the state of the art of: -Antimicrobial Resistances: Facts and Statistics - Arthroplasty Registers in EU: Status and Development - Microbiology in Arthroplasty - Strategies in Antibiotic Treatment - Spacer Management: Clinical Experiences and Requirements - Biofilm Creation: Low Grade Infection - Revision: Cemented vs. Cementless - Revision: One-stage vs. Two-stage treatment
Book Synopsis Particulate Debris from Medical Implants by : Kenneth R. St. John
Download or read book Particulate Debris from Medical Implants written by Kenneth R. St. John and published by ASTM International. This book was released on 1992 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proceedings of an October 1990 symposium in San Antonio held to address the problem of the release of particulate material debris from medical implants because of wear, physical deterioration, or the harsh chemical environment. Examines tissue responses to such debris in order to identify factors that might moderate it, such as implant material or design, or postoperatic drugs. Member price, $53. Annotation copyrighted by Book News, Inc., Portland, OR
Book Synopsis Prosthetic Joint Infections by : Trisha Peel
Download or read book Prosthetic Joint Infections written by Trisha Peel and published by Springer. This book was released on 2017-11-28 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book outlines the most updated clinical guidelines that are vital for the prevention infections and care of patients with joint infections following a replacement surgery, one of the highest volume medical interventions globally. Sections address the diagnosis, management approaches and prevention of prosthetic joint infections. Written by experts in the field, this text provides a brief overview of the literature and current recommendations in each of the specified areas. Given the rapidly evolving state-of-play in this clinical area, this compendium grows increasingly important to clinicians in their management decisions. Prosthetic Joint Infections is a valuable resource for infectious disease specialists, epidemiologists, surgeons, and orthopedic specialists who may work with patients with prosthetic joint infections.
Download or read book Orthopaedic Bone Cements written by S Deb and published by Elsevier. This book was released on 2008-10-16 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone cements are widely used in orthopaedic applications to anchor implants to existing bone, reconstruct bone and deliver bioactive agents to the body. With an increasing number of bone cements available, it is vital that the correct material is selected for specific clinical procedures. Orthopaedic bone cements reviews the most recent research in this field. Part one discusses the current uses of orthopaedic bone cements with chapters on such topics as hip replacements, verteboplasty and wear particles and osteolysis. Part two reviews materials and types of cement such as acrylic, polymethylmethacrylate and calcium phosphate cements. Chapters in Part three address the mechanical properties of bone cements such as fracture toughness and dynamic creep. The final section examines methods to enhance the properties of bone cements with coverage of themes such as antibiotic loaded bone cements and bioactive cements. With its eminent editor and multidisciplinary team of international contributors, Orthopaedic bone cements is an invaluable reference for materials scientists, medical researchers and all those involved in the development of bone cements for orthopaedic applications and joint replacement. Provides a review of recent research focussing on improving the mechanical and biological performance of bone cements Discusses the current applications of bone cements particularly in hip replacement, verteboplasty and wear particles Reviews types of materials and acrylic, polymethlymethacrylate and calcium phosphate as types of cements
Book Synopsis Total Knee Arthroplasty by : James Alan Rand
Download or read book Total Knee Arthroplasty written by James Alan Rand and published by Lippincott Williams & Wilkins. This book was released on 1993 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference on total knee arthroplasty describes all surgical techniques and prosthetic designs for primary and revision arthroplasty, discusses every aspect of patient selection, preoperative planning, and intraoperative and postoperative care.
Book Synopsis Joint Replacement Technology by : Peter A. Revell
Download or read book Joint Replacement Technology written by Peter A. Revell and published by Woodhead Publishing. This book was released on 2021-07-28 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of Joint Replacement Technology provides a thoroughly updated review of recent developments in joint replacement technology. Joint replacement is a standard treatment for joint degradation and has improved the quality of life of millions of patients. Collaboration between clinicians and researchers is critical to its continued success and to meet the rising expectations of patients and surgeons.This edition covers a range of updated and new content, ranging from chapters on materials analysis and selection, to methodologies and techniques used for joint replacement and clinical challenges of replacing specific joints. Key topics include tribological considerations and experiments; challenges in joint bearing surfaces; cementless fixation techniques; healing responses to implants. Clinical challenges and perspectives are covered with the aid of case studies.Thanks to its widespread collaboration and international contributors, Joint Replacement Technology, Third Edition is useful for materials scientists and engineers in both academia and the biomedical industry. Chemists, clinicians, and other researchers in this area will also find this text invaluable. This third edition provides an updated comprehensive review of recent developments in joint replacement technology Reviews a range of specific joints, biological and mechanical issues and fixation techniques Includes revised and new content, such as sections on regulatory affairs, AI techniques and 3D printing
Download or read book Titanium Alloys written by Jan Sieniawski and published by BoD – Books on Demand. This book was released on 2013-05-15 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book contains six chapters and covers topics dealing with biomedical applications of titanium alloys, surface treatment, relationships between microstructure and mechanical and technological properties, and the effect of radiation on the structure of the titanium alloys.
Book Synopsis Multiscale Biomechanics and Tribology of Inorganic and Organic Systems by : Georg-Peter Ostermeyer
Download or read book Multiscale Biomechanics and Tribology of Inorganic and Organic Systems written by Georg-Peter Ostermeyer and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book gathers authoritative contributions concerning multiscale problems in biomechanics, geomechanics, materials science and tribology. It is written in memory of Sergey Grigorievich Psakhie to feature various aspects of his multifaceted research interests, ranging from theoretical physics, computer modeling of materials and material characterization at the atomic scale, to applications in space industry, medicine and geotectonics, and including organizational, psychological and philosophical aspects of scientific research and teaching as well. This book covers new advances relating to orthopedic implants, concerning the physiological, tribological and materials aspects of their behavior; medical and geological applications of permeable fluid-saturated materials; earthquake dynamics together with aspects relating to their managed and gentle release; lubrication, wear and material transfer in natural and artificial joints; material research in manufacturing processes; hard-soft matter interaction, including adhesive and capillary effects; using nanostructures for influencing living cells and for cancer treatment; manufacturing of surfaces with desired properties; self-organization of hierarchical structures during plastic deformation and thermal treatment; mechanics of composites and coatings; and many more. Covering established knowledge as well as new models and methods, this book provides readers with a comprehensive overview of the field, yet also with extensive details on each single topic.
Book Synopsis Clinical Performance of Skeletal Prostheses by : J. Wilson
Download or read book Clinical Performance of Skeletal Prostheses written by J. Wilson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Larry L. Hench June Wilson OBJECTIVE Millions of people presently enjoy an improved quality of life due to prostheses which repair, augment or replace parts of their skeletal system: bones, joints, teeth, etc. However, all replacement parts have a finite probability of survival. The goal of this book is to compare the survivability data for various skeletal prosthesis systems. All data derive from previously published clinical studies. Where possible statistical comparisons are made and the reasons for failure are discussed. THE NEED FOR SKELETAL PROSTHESES We are an aging population with more than 100 million people in the U. S. and Europe over the age of 50 years. An unfortunate consequence of aging is a progressive deterioration of the quality of skeletal tissues. From the age of 30 years there is a decrease in bone mass for both men and women (Fig. 1. 1). However, for women it is much greater and between 40 and 60 years of age the rate of deterioration of long bones and vertebrae of women is especially severe due to hormonal changes. By the age of 70 most women will have lost from 35 to 60% of their bone mass. The loss of volume of cancellous or trabecular bone leads to a large decrease in mechanical compressive strength (Fig. 1. 2). The clinical consequence is an increasing incidence of vertebral collapse. Cortical bone decreases in tensile strength with age (Fig. 1.
