Aryl Hydrocarbon Receptor Based Antiestrogenicity Of Diindolylmethane Analogs

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Aryl-Hydrocarbon Receptor Based Antiestrogenicity of Diindolylmethane Analogs

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis Aryl-Hydrocarbon Receptor Based Antiestrogenicity of Diindolylmethane Analogs by :

Download or read book Aryl-Hydrocarbon Receptor Based Antiestrogenicity of Diindolylmethane Analogs written by and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diindolylmethane (DIM) is formed by acid catalyzed dimerization of indole-3-carbinol, and both compounds inhibit formation and/or growth of mammary tumors in rodents. In this study, we have investigated the aryl hydrocarbon receptor (AhR) agonist activity and inhibitory AhR-estrogen receptor crosstalk induced by the following methyl-substituted DIMs: 1,11-dimethyl-; 2,2'- dimethyl-; 5,5' -dimethyl; 6,6' -dimethyl-; and 7,7' -dimethylDIM; and 1,1',2,2' -tetramethylDIM. The six compounds exhibited minimal to non-detectable AhR agonist or antagonist activities associated with CYPlAl induction. In contrast, the methyl-substituted DIMs inhibited estrogen-induced T47D human breast cancer cell growth. The antitumorigenic activity of these compounds was examined in 7,l2-dimethylbenzAanthracene-induced rat mammary tumor model in which the DIM analogs were orally administered (by gavage in corn oil) at a dose of 1 mg/kg/every second day (Xl0) . l, l'-DimethylDIM, 5,5'-dimethylDIM and l, l',2,2'-tetramethylDIM significantly inhibited mammary tumor growth, and this was not accompanied by changes in organ/body weights or histopathology. These studies demonstrate that methyl-substituted DIMs are selective AhR modulators (SAhRMs) with potential for clinical treatment of breast cancer.

Arl-Hydrocarbon Receptor Based Antiestrogenicity of Diindolylmethane Analogs

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Download or read book Arl-Hydrocarbon Receptor Based Antiestrogenicity of Diindolylmethane Analogs written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in our laboratory has been focused on the mechanism of inhibitory aryl hydrocarbon (Ah) receptor-estrogen receptor a (ER alpha) crosstalk in breast cancer cells, and results indicate that Ah receptor agonists inhibit estrogen (E2)-induced gene expression and cell proliferation (1,2). Moreover, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a high affinity ligand for the Ah receptor, inhibits age-dependent and carcinogen-induced mammary tumor formation and growth in female Sprague-Dawley rats, and a recent study reported that women accidentally exposed to TCDD in Seveso, Italy, over 20 years ago exhibit lower incidence rates of breast and endometrial cancer (3). Studies on various structural classes of AhR agonists have identified alternate substituted (1,3,6,8- or 2,4,6,8- ) alkyl polychlorinated dibenzofurans (PCDFs) and substituted diindolylmethanes (DlMs) as selective Ah receptor modulators (SAhRMs) that are relative nontoxic but inhibit mammary tumor growth in rodent models (4). With financial support from this grant, I have been investigating the indirect antiestrogenic activity of substituted DIMs and applications of these compounds for treating mammary cancer (5-7).

Chemical Abstracts

Author :
Publisher :
ISBN 13 :
Total Pages : 2800 pages
Book Rating : 4.3/5 (91 download)

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Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2800 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Coal Tar Creosote

Author : C. Melber
Publisher : WHO
ISBN 13 :
Total Pages : 154 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Coal Tar Creosote by : C. Melber

Download or read book Coal Tar Creosote written by C. Melber and published by WHO. This book was released on 2004 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: On cover: IPCS International Programme on Chemical Safety. Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization and the World Health Organization, and produced within the framework of the Inter-organization Programme for the Sound Management of Chemicals (IOMC)

Trends in Breast Cancer Prevention

Author : Jose Russo
Publisher : Springer
ISBN 13 : 3319271350
Total Pages : 296 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Trends in Breast Cancer Prevention by : Jose Russo

Download or read book Trends in Breast Cancer Prevention written by Jose Russo and published by Springer. This book was released on 2016-07-14 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, with contributions from the most recognized experts in preventive strategies in breast cancer, presents the accepted as well as the novel ideas that have been introduced for the prevention of breast cancer. There is no single preventive agent that can stop the incidence of breast cancer—the malignant disease most frequently diagnosed in women of all races and nationalities. Furthermore, its incidence around the globe is increasing in industrialized countries. The worldwide incidence of breast cancer has increased 30-40% since the 1970s, reaching an excess of 1,390,000 new cases and a mortality of more than 460,000 cases in 2015. Therefore, what is needed is the development of rational strategies for the prevention of this fatal disease.

Cell and Molecular Biology of Endometrial Carcinoma

Author : H. Kuramoto
Publisher : Springer Science & Business Media
ISBN 13 : 4431539816
Total Pages : 316 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Cell and Molecular Biology of Endometrial Carcinoma by : H. Kuramoto

Download or read book Cell and Molecular Biology of Endometrial Carcinoma written by H. Kuramoto and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 15th International Symposium of the Japan Human Cell Society on Cell and Molecular Biology of Endometrial Carcinoma brought together leading researchers from Japan and around the world. The papers collected here are the work of twenty-two leaders in their field and are organized in ten major categories. The first section, in vitro experimental systems, takes up the pioneering work by Kuramoto in 1968 and Nishida in 1980 in establishing, respectively, the HEC-1 and hormone-responsive endometrial carcinoma cell lines. Other topics include apoptosis, proliferation, and growth factors; cell cycle regulators; signaling pathways; angiogenesis; carcinogenesis; hormones and hormone receptors; genes and gene expression; endometrial receptivity; and chemo-resistance and -sensitivity. Presenting the latest work in the cell and molecular biology of endometrial carcinoma, this volume is a valuable resource for gynecologists, pathologists, and molecular biologists.

ACS Style Guide

Author : Anne M. Coghill
Publisher : American Chemical Society
ISBN 13 : 9780841239494
Total Pages : 0 pages
Book Rating : 4.2/5 (394 download)

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Book Synopsis ACS Style Guide by : Anne M. Coghill

Download or read book ACS Style Guide written by Anne M. Coghill and published by American Chemical Society. This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the time since the second edition of The ACS Style Guide was published, the rapid growth of electronic communication has dramatically changed the scientific, technical, and medical (STM) publication world. This dynamic mode of dissemination is enabling scientists, engineers, and medicalpractitioners all over the world to obtain and transmit information quickly and easily. An essential constant in this changing environment is the requirement that information remain accurate, clear, unambiguous, and ethically sound.This extensive revision of The ACS Style Guide thoroughly examines electronic tools now available to assist STM writers in preparing manuscripts and communicating with publishers. Valuable updates include discussions of markup languages, citation of electronic sources, online submission ofmanuscripts, and preparation of figures, tables, and structures. In keeping current with the changing environment, this edition also contains references to many resources on the internet.With this wealth of new information, The ACS Style Guide's Third Edition continues its long tradition of providing invaluable insight on ethics in scientific communication, the editorial process, copyright, conventions in chemistry, grammar, punctuation, spelling, and writing style for any STMauthor, reviewer, or editor. The Third Edition is the definitive source for all information needed to write, review, submit, and edit scholarly and scientific manuscripts.

Environment and Breast Cancer

Author : Jose Russo
Publisher : Springer Science & Business Media
ISBN 13 : 1441998969
Total Pages : 247 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Environment and Breast Cancer by : Jose Russo

Download or read book Environment and Breast Cancer written by Jose Russo and published by Springer Science & Business Media. This book was released on 2011-08-10 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is a complex disease caused by multiple environmental and lifestyle factors interacting with genetic susceptibility across the life span. Therefore, environmental factors are of intense interest to both researchers and community members, including women with breast cancer. There is not adequate literature that addresses this issue comprehensively from epidemiological, experimental, and translational research perspective. This book is aiming to fill this gap by gathering chapters from the most recognized experts in the field of breast biology and cancer with special interests in environmental issues.

Diet-Microbe Interactions in the Gut

Author : Kieran Tuohy
Publisher : Academic Press
ISBN 13 : 0124079415
Total Pages : 268 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Diet-Microbe Interactions in the Gut by : Kieran Tuohy

Download or read book Diet-Microbe Interactions in the Gut written by Kieran Tuohy and published by Academic Press. This book was released on 2014-08-04 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on expert opinions from the fields of nutrition, gut microbiology, mammalian physiology, and immunology, Diet-Microbe Interactions for Human Health investigates the evidence for a unified disease mechanism working through the gut and its resident microbiota, and linking many inflammation-related chronic diet associated diseases. State of the art post-genomic studies can highlight the important role played by our resident intestinal microbiota in determining human health and disease. Many chronic human diseases associated with modern lifestyles and diets — including those localized to the intestinal tract like inflammatory bowel disease and celiac disease, and more pervasive systemic conditions such as obesity, diabetes and cardiovascular disease — are characterized by aberrant profiles of gut bacteria or their metabolites. Many of these diseases have an inflammatory basis, often presenting with a chronic low-grade systemic inflammation, hinting at persistent and inappropriate activation of inflammatory pathways. Through the presentation and analysis of recent nutrition studies, this book discusses the possible mechanisms underpinning the disease processes associated with these pathologies, with high fat diets appearing to predispose to disease, and biologically active plant components, mainly fiber and polyphenols, appearing to reduce the risk of chronic disease development. - One comprehensive, translational source for all aspects of nutrition and diet's effect on gastrointestinal health and disease - Experts in nutrition, diet, microbiology and immunology take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approaches - Clear presentations by leading researchers of the cellular mechanisms underlying diet, immune response, and gastrointestinal disease help practicing nutritionists and clinicians (gastroenterologists, endocrinologists) map out new areas for clinical research and structuring clinical recommendations

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1892 pages
Book Rating : 4.:/5 (31 download)

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Download or read book Cumulated Index Medicus written by and published by . This book was released on 1998 with total page 1892 pages. Available in PDF, EPUB and Kindle. Book excerpt:

An Evidence-based Approach to Phytochemicals and Other Dietary Factors

Author : Jane Higdon
Publisher : Thieme
ISBN 13 : 3132579963
Total Pages : 588 pages
Book Rating : 4.1/5 (325 download)

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Book Synopsis An Evidence-based Approach to Phytochemicals and Other Dietary Factors by : Jane Higdon

Download or read book An Evidence-based Approach to Phytochemicals and Other Dietary Factors written by Jane Higdon and published by Thieme. This book was released on 2012-11-07 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in a completely updated second edition, An Evidence-based Approach to Dietary Phytochemicals and Other Dietary Factors is a trusted resource for all health professionals who need to interpret the explosion of information on the role of a plant-based diet in health and disease. It consolidates a wealth of scientifically accurate, peer-reviewed data on plant foods, dietary phytochemicals, and dietary supplements, and includes information on essential intake recommendations, dietary sources, nutrient and drug interactions, phytochemicals in disease prevention, possible adverse effects, and much more. Special features: All chapters revised and updated, with new sections on choline, coenzyme Q10, L-Carnitine, lipoic acid, and other dietary factors Logically structured for quick access to information: begins with the evidence-based benefits of fruits and vegetables, legumes, nuts, whole grains, coffee, and tea; and goes on to the scientific and clinical data on individual dietary phytochemicals and classes of phytochemicals, including carotenoids, flavonoids, fiber, and more Summaries at the end of each chapter for rapid review Peer-reviewed by experts in the field, ensuring that all material is accurate and up-to-date The well-constructed appendix includes not only a quick reference to diseases and foods and where to find them in the book, but also useful tables on phytochemical-drug interactions, phytochemical-nutrient interactions, and phytochemical-rich foods; a summary of the glycemic index of dietary carbohydrates; and a comprehensive glossary of terms

Studies of the Antiangiogenic and Antitumorigenic Effects of 3,3'-Diindolylmethane and Its Molecular Mechanisms

Author : Xiaofei Chang
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (35 download)

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Book Synopsis Studies of the Antiangiogenic and Antitumorigenic Effects of 3,3'-Diindolylmethane and Its Molecular Mechanisms by : Xiaofei Chang

Download or read book Studies of the Antiangiogenic and Antitumorigenic Effects of 3,3'-Diindolylmethane and Its Molecular Mechanisms written by Xiaofei Chang and published by . This book was released on 2005 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hormonally Active Agents in the Environment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309064198
Total Pages : 453 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Hormonally Active Agents in the Environment by : National Research Council

Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Handbook of Nutraceuticals and Functional Foods

Author :
Publisher : CRC Press
ISBN 13 : 1420036696
Total Pages : 552 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Nutraceuticals and Functional Foods by :

Download or read book Handbook of Nutraceuticals and Functional Foods written by and published by CRC Press. This book was released on 2002-01-01 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: For centuries man has speculated about the medicinal properties of certain foods. Scientific investigation has shown us that hundreds of compounds exist in natural foods that have health promoting properties. The Handbook of Nutraceuticals and Functional Foods presents an up-to-date and comprehensive review of this rapidly growing field for nutriti

Anti-inflammatory Nutraceuticals and Chronic Diseases

Author : Subash Chandra Gupta
Publisher : Springer
ISBN 13 : 3319413341
Total Pages : 479 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Anti-inflammatory Nutraceuticals and Chronic Diseases by : Subash Chandra Gupta

Download or read book Anti-inflammatory Nutraceuticals and Chronic Diseases written by Subash Chandra Gupta and published by Springer. This book was released on 2016-09-26 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in various chronic diseases. Food and Drug Administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. This means that there is enormous potential for dietary agents that can modulate inflammatory pathways in humans. Leading experts describe the latest research on the role of anti-inflammatory nutraceuticals in preventing and treating chronic diseases.

Our Stolen Future

Author : Theo Colborn
Publisher :
ISBN 13 : 9780349108780
Total Pages : 306 pages
Book Rating : 4.1/5 (87 download)

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Book Synopsis Our Stolen Future by : Theo Colborn

Download or read book Our Stolen Future written by Theo Colborn and published by . This book was released on 1997 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: For years, scientists have noticed disruptions in animal breeding cycles, accompanied by increases in birth defects, sexual abnormalities and reproductive failure. Humans are not immune either, with sperm counts dropping by as much as 50% in recent decades and with women seeing a rise in hormone-related cancers, endometriosis and other disorders. This book traces the cause of these aberrations and diseases to the pervasive presence in the environment of chemicals that mimic hormones and trick the reproductive system. The conclusions are as obvious as they are inescapable - unless we make vital changes in the way we manufacture and employ the artefacts of our good life , there will be no life at all.

Bioluminescence: Fundamentals and Applications in Biotechnology - Volume 1

Author : Gérald Thouand
Publisher : Springer
ISBN 13 : 3662433850
Total Pages : 204 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Bioluminescence: Fundamentals and Applications in Biotechnology - Volume 1 by : Gérald Thouand

Download or read book Bioluminescence: Fundamentals and Applications in Biotechnology - Volume 1 written by Gérald Thouand and published by Springer. This book was released on 2014-08-01 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.