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Approximation For Response Adaptive Designs Using Steins Method
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Book Synopsis Handbook of Adaptive Designs in Pharmaceutical and Clinical Development by : Annpey Pong
Download or read book Handbook of Adaptive Designs in Pharmaceutical and Clinical Development written by Annpey Pong and published by CRC Press. This book was released on 2016-04-19 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the US FDA's Critical Path Initiative, innovative adaptive designs are being used more and more in clinical trials due to their flexibility and efficiency, especially during early phase development. Handbook of Adaptive Designs in Pharmaceutical and Clinical Development provides a comprehensive and unified presentation of the princip
Book Synopsis Modern Issues and Methods in Biostatistics by : Mark Chang
Download or read book Modern Issues and Methods in Biostatistics written by Mark Chang and published by Springer Science & Business Media. This book was released on 2011-07-15 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Classic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a confluence of statistics and knowledge of multiple intertwined fields. The application demands, the advancements in computer technology, and the rapid growth of life science data (e.g., genomics data) have promoted the formation of modern biostatistics. There are at least three characteristics of modern biostatistics: (1) in-depth engagement in the application fields that require penetration of knowledge across several fields, (2) high-level complexity of data because they are longitudinal, incomplete, or latent because they are heterogeneous due to a mixture of data or experiment types, because of high-dimensionality, which may make meaningful reduction impossible, or because of extremely small or large size; and (3) dynamics, the speed of development in methodology and analyses, has to match the fast growth of data with a constantly changing face. This book is written for researchers, biostatisticians/statisticians, and scientists who are interested in quantitative analyses. The goal is to introduce modern methods in biostatistics and help researchers and students quickly grasp key concepts and methods. Many methods can solve the same problem and many problems can be solved by the same method, which becomes apparent when those topics are discussed in this single volume.
Book Synopsis Adaptive Systems in Control and Signal Processing 1995 by : Cs. Banyasz
Download or read book Adaptive Systems in Control and Signal Processing 1995 written by Cs. Banyasz and published by Elsevier. This book was released on 2014-05-23 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading academic and industrial researchers working with adaptive systems and signal processing have been given the opportunity to exchange ideas, concepts and solutions at the IFAC Symposia on Adaptive Systems in Control and Signal Processing. This postprint volume contains all those papers which were presented at the 5th IFAC Symposium in Budapest in 1995. The technical program was composed of a number of invited and contributed sessions and a special case study session, providing a good balance between applications and theory oriented papers.
Download or read book Journal of Mechanical Design written by and published by . This book was released on 2006-07 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Adaptive Design Theory and Implementation Using SAS and R by : Mark Chang
Download or read book Adaptive Design Theory and Implementation Using SAS and R written by Mark Chang and published by CRC Press. This book was released on 2014-12-01 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get Up to Speed on Many Types of Adaptive DesignsSince the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the
Book Synopsis Agent-Mediated Electronic Commerce. Designing Trading Strategies and Mechanisms for Electronic Markets by : Esther David
Download or read book Agent-Mediated Electronic Commerce. Designing Trading Strategies and Mechanisms for Electronic Markets written by Esther David and published by Springer. This book was released on 2013-09-16 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains 11 thoroughly refereed and revised papers detailing recent advances in research on designing trading agents and mechanisms for agent-mediated e-commerce. They were originally presented at the Joint Workshop on Trading Agent Design and Analysis (TADA 2012) and Agent-Mediated Electronic Commerce (AMEC 2012) co-located with AAMAS 2012 in Valencia, Spain, in June 2012. The increasing reliance on software agents has created a range of pressing new research challenges, including the design of appropriate agent decision algorithms, approaches for predicting the complex behaviors and interactions of multiple agents, including the computation of equilibria, and the engineering of protocols and mechanisms that ensure electronic markets behave in a stable manner or fulfill other desirable criteria. Drawing upon a diverse range of scientific disciplines, including computer science, economics, artificial intelligence, operations research and game theory, the papers collected in this volume represent a cross-section of recent research and cover topics such as strategies for individual trading agents, the design of markets and interaction protocols between agents, and a variety of applications.
Book Synopsis Scientific and Technical Aerospace Reports by :
Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1995 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lectures on Global Optimization by : Thomas Frederick Coleman
Download or read book Lectures on Global Optimization written by Thomas Frederick Coleman and published by American Mathematical Soc.. This book was released on 2009 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: A large number of mathematical models in many diverse areas of science and engineering have lead to the formulation of optimization problems where the best solution (globally optimal) is needed. This book covers a small subset of important topics in global optimization with emphasis on theoretical developments and scientific applications.
Download or read book Probability Models written by and published by Elsevier. This book was released on 2024-10-24 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probability Models, Volume 51 in the Handbook of Statistics series, highlights new advances in the field, with this new volume presenting interesting chapters on Stein's methods, Probabilities and thermodynamics third law, Random Matrix Theory, General tools for understanding fluctuations of random variables, An approximation scheme to compute the Fisher-Rao distance between multivariate normal distributions, Probability Models Applied to Reliability and Availability Engineering, Backward stochastic differential equation– Stochastic optimization theory and viscous solution of HJB equation, and much more.Additional chapters cover Probability Models in Machine Learning, The recursive stochastic algorithm, randomized urn models and response-adaptive randomization in clinical trials, Random matrix theory: local laws and applications, KOO methods and their high-dimensional consistencies in some multivariate models, Fourteen Lectures on Inference for Stochastic Processes, and A multivariate cumulative damage model and some applications. - Provides the latest information on probability models - Offers outstanding and original reviews on a range of probability models research topics - Serves as an indispensable reference for researchers and students alike
Book Synopsis Modern Approaches to Clinical Trials Using SAS by : Sandeep Menon
Download or read book Modern Approaches to Clinical Trials Using SAS written by Sandeep Menon and published by SAS Institute. This book was released on 2015-12-09 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get the tools you need to use SAS® in clinical trial design! Unique and multifaceted, Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods, edited by Sandeep M. Menon and Richard C. Zink, thoroughly covers several domains of modern clinical trial design: classical, group sequential, adaptive, and Bayesian methods that are applicable to and widely used in various phases of pharmaceutical development. Written for biostatisticians, pharmacometricians, clinical developers, and statistical programmers involved in the design, analysis, and interpretation of clinical trials, as well as students in graduate and postgraduate programs in statistics or biostatistics, the book touches on a wide variety of topics, including dose-response and dose-escalation designs; sequential methods to stop trials early for overwhelming efficacy, safety, or futility; Bayesian designs that incorporate historical data; adaptive sample size re-estimation; adaptive randomization to allocate subjects to more effective treatments; and population enrichment designs. Methods are illustrated using clinical trials from diverse therapeutic areas, including dermatology, endocrinology, infectious disease, neurology, oncology, and rheumatology. Individual chapters are authored by renowned contributors, experts, and key opinion leaders from the pharmaceutical/medical device industry or academia. Numerous real-world examples and sample SAS code enable users to readily apply novel clinical trial design and analysis methodologies in practice.
Book Synopsis Statistical Thinking in Clinical Trials by : Michael A. Proschan
Download or read book Statistical Thinking in Clinical Trials written by Michael A. Proschan and published by CRC Press. This book was released on 2021-11-24 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Thinking in Clinical Trials combines a relatively small number of key statistical principles and several instructive clinical trials to gently guide the reader through the statistical thinking needed in clinical trials. Randomization is the cornerstone of clinical trials and randomization-based inference is the cornerstone of this book. Read this book to learn the elegance and simplicity of re-randomization tests as the basis for statistical inference (the analyze as you randomize principle) and see how re-randomization tests can save a trial that required an unplanned, mid-course design change. Other principles enable the reader to quickly and confidently check calculations without relying on computer programs. The `EZ’ principle says that a single sample size formula can be applied to a multitude of statistical tests. The `O minus E except after V’ principle provides a simple estimator of the log odds ratio that is ideally suited for stratified analysis with a binary outcome. The same principle can be used to estimate the log hazard ratio and facilitate stratified analysis in a survival setting. Learn these and other simple techniques that will make you an invaluable clinical trial statistician.
Book Synopsis Practical Considerations for Adaptive Trial Design and Implementation by : Weili He
Download or read book Practical Considerations for Adaptive Trial Design and Implementation written by Weili He and published by Springer. This book was released on 2014-10-15 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low. One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, the need for an advanced infrastructure for complex randomization and clinical supply scenarios, change management for process and behavior modifications, extensive resource requirements for the planning and design of adaptive trials and the potential to relegate key decision makings to outside entities. There have been limited publications that address these practical considerations and recommend best practices and solutions. This book fills this publication gap, providing guidance on practical considerations for adaptive trial design and implementation. The book comprises three parts: Part I focuses on practical considerations from a design perspective, whereas Part II delineates practical considerations related to the implementation of adaptive trials. Putting it all together, Part III presents four illustrative case studies ranging from description and discussion of specific adaptive trial design considerations to the logistic and regulatory issues faced in trial implementation. Bringing together the expertise of leading key opinion leaders from pharmaceutical industry, academia, and regulatory agencies, this book provides a balanced and comprehensive coverage of practical considerations for adaptive trial design and implementation.
Book Synopsis Integrated Design by Optimization of Electrical Energy Systems by : Xavier Roboam
Download or read book Integrated Design by Optimization of Electrical Energy Systems written by Xavier Roboam and published by John Wiley & Sons. This book was released on 2012-12-13 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes systemic design methodologies applied to electrical energy systems, in particular integrated optimal design with modeling and optimization methods and tools. It is made up of six chapters dedicated to integrated optimal design. First, the signal processing of mission profiles and system environment variables are discussed. Then, optimization-oriented analytical models, methods and tools (design frameworks) are proposed. A “multi-level optimization” smartly coupling several optimization processes is the subject of one chapter. Finally, a technico-economic optimization especially dedicated to electrical grids completes the book. The aim of this book is to summarize design methodologies based in particular on a systemic viewpoint, by considering the system as a whole. These methods and tools are proposed by the most important French research laboratories, which have many scientific partnerships with other European and international research institutions. Scientists and engineers in the field of electrical engineering, especially teachers/researchers because of the focus on methodological issues, will find this book extremely useful, as will PhD and Masters students in this field.
Book Synopsis Creative Minds, Charmed Lives: Interviews At Institute For Mathematical Sciences, National University Of Singapore by : Yu Kiang Leong
Download or read book Creative Minds, Charmed Lives: Interviews At Institute For Mathematical Sciences, National University Of Singapore written by Yu Kiang Leong and published by World Scientific. This book was released on 2010-06-09 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features interviews of 38 eminent mathematicians and mathematical scientists who were invited to participate in the programs of the Institute for Mathematical Sciences, National University of Singapore. Originally published in its newsletter Imprints from 2003 to 2009, these interviews give a fascinating and insightful glimpse into the passion driving some of the most creative minds in modern research in pure mathematics, applied mathematics, statistics, economics and engineering.The reader is drawn into a panorama of the past and present developments of some of the ideas that have revolutionized modern science and mathematics. This book should be relevant to those who are interested in the history and psychology of ideas. It should provide motivation, inspiration and guidance to students who aspire to do research and to beginning researchers who are looking for career niches.For those who wish to be broadly educated, it is informative without delving into excessive technical details and is, at the same time, thought provoking enough to arouse their curiosity to learn more about the world around them.
Book Synopsis 1990 Lectures In Complex Systems by : Lynn Nadel
Download or read book 1990 Lectures In Complex Systems written by Lynn Nadel and published by CRC Press. This book was released on 2018-10-08 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: An excellent series presenting top lecturers from the best institute for complex systems. Topics covered include: stochastic processes; fluid flow; pattern formation; information-based complexity; motor system problems; and the nature of adaptive change.
Book Synopsis Computational Modelling of Concrete Structures by : Nenad Bicanic
Download or read book Computational Modelling of Concrete Structures written by Nenad Bicanic and published by CRC Press. This book was released on 2014-03-04 with total page 1120 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EURO-C conference series (Split 1984, Zell am See 1990, Innsbruck 1994, Badgastein 1998, St Johann im Pongau 2003, Mayrhofen 2006, Schladming 2010, St Anton am Alberg 2014) brings together researchers and practising engineers concerned with theoretical, algorithmic and validation aspects associated with computational simulations of concrete and
Book Synopsis Automated Design of Analog and High-frequency Circuits by : Bo Liu
Download or read book Automated Design of Analog and High-frequency Circuits written by Bo Liu and published by Springer. This book was released on 2013-08-16 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational intelligence techniques are becoming more and more important for automated problem solving nowadays. Due to the growing complexity of industrial applications and the increasingly tight time-to-market requirements, the time available for thorough problem analysis and development of tailored solution methods is decreasing. There is no doubt that this trend will continue in the foreseeable future. Hence, it is not surprising that robust and general automated problem solving methods with satisfactory performance are needed.
