Applying Quantitative Bias Analysis To Epidemiologic Data

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Applying Quantitative Bias Analysis to Epidemiologic Data

Author : Timothy L. Lash
Publisher : Springer Science & Business Media
ISBN 13 : 0387879595
Total Pages : 200 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Applying Quantitative Bias Analysis to Epidemiologic Data by : Timothy L. Lash

Download or read book Applying Quantitative Bias Analysis to Epidemiologic Data written by Timothy L. Lash and published by Springer Science & Business Media. This book was released on 2011-04-14 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bias analysis quantifies the influence of systematic error on an epidemiology study’s estimate of association. The fundamental methods of bias analysis in epi- miology have been well described for decades, yet are seldom applied in published presentations of epidemiologic research. More recent advances in bias analysis, such as probabilistic bias analysis, appear even more rarely. We suspect that there are both supply-side and demand-side explanations for the scarcity of bias analysis. On the demand side, journal reviewers and editors seldom request that authors address systematic error aside from listing them as limitations of their particular study. This listing is often accompanied by explanations for why the limitations should not pose much concern. On the supply side, methods for bias analysis receive little attention in most epidemiology curriculums, are often scattered throughout textbooks or absent from them altogether, and cannot be implemented easily using standard statistical computing software. Our objective in this text is to reduce these supply-side barriers, with the hope that demand for quantitative bias analysis will follow.

Applying Quantitative Bias Analysis to Epidemiologic Data

Author : Matthew P. Fox
Publisher : Springer Nature
ISBN 13 : 3030826732
Total Pages : 475 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Applying Quantitative Bias Analysis to Epidemiologic Data by : Matthew P. Fox

Download or read book Applying Quantitative Bias Analysis to Epidemiologic Data written by Matthew P. Fox and published by Springer Nature. This book was released on 2022-03-24 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook and guide focuses on methodologies for bias analysis in epidemiology and public health, not only providing updates to the first edition but also further developing methods and adding new advanced methods. As computational power available to analysts has improved and epidemiologic problems have become more advanced, missing data, Bayes, and empirical methods have become more commonly used. This new edition features updated examples throughout and adds coverage addressing: Measurement error pertaining to continuous and polytomous variables Methods surrounding person-time (rate) data Bias analysis using missing data, empirical (likelihood), and Bayes methods A unique feature of this revision is its section on best practices for implementing, presenting, and interpreting bias analyses. Pedagogically, the text guides students and professionals through the planning stages of bias analysis, including the design of validation studies and the collection of validity data from other sources. Three chapters present methods for corrections to address selection bias, uncontrolled confounding, and measurement errors, and subsequent sections extend these methods to probabilistic bias analysis, missing data methods, likelihood-based approaches, Bayesian methods, and best practices.

Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide

Author : Agency for Health Care Research and Quality (U.S.)
Publisher : Government Printing Office
ISBN 13 : 1587634236
Total Pages : 236 pages
Book Rating : 4.5/5 (876 download)

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Book Synopsis Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by : Agency for Health Care Research and Quality (U.S.)

Download or read book Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)

Modern Epidemiology

Author : Kenneth J. Rothman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781755641
Total Pages : 776 pages
Book Rating : 4.7/5 (556 download)

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Book Synopsis Modern Epidemiology by : Kenneth J. Rothman

Download or read book Modern Epidemiology written by Kenneth J. Rothman and published by Lippincott Williams & Wilkins. This book was released on 2008 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thoroughly revised and updated Third Edition of the acclaimed Modern Epidemiology reflects both the conceptual development of this evolving science and the increasingly focal role that epidemiology plays in dealing with public health and medical problems. Coauthored by three leading epidemiologists, with sixteen additional contributors, this Third Edition is the most comprehensive and cohesive text on the principles and methods of epidemiologic research. The book covers a broad range of concepts and methods, such as basic measures of disease frequency and associations, study design, field methods, threats to validity, and assessing precision. It also covers advanced topics in data analysis such as Bayesian analysis, bias analysis, and hierarchical regression. Chapters examine specific areas of research such as disease surveillance, ecologic studies, social epidemiology, infectious disease epidemiology, genetic and molecular epidemiology, nutritional epidemiology, environmental epidemiology, reproductive epidemiology, and clinical epidemiology.

Registries for Evaluating Patient Outcomes

Author : Agency for Healthcare Research and Quality/AHRQ
Publisher : Government Printing Office
ISBN 13 : 1587634333
Total Pages : 385 pages
Book Rating : 4.5/5 (876 download)

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Book Synopsis Registries for Evaluating Patient Outcomes by : Agency for Healthcare Research and Quality/AHRQ

Download or read book Registries for Evaluating Patient Outcomes written by Agency for Healthcare Research and Quality/AHRQ and published by Government Printing Office. This book was released on 2014-04-01 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.

Concepts of Epidemiology

Author : Raj S. Bhopal
Publisher : Oxford University Press
ISBN 13 : 0198739680
Total Pages : 481 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Concepts of Epidemiology by : Raj S. Bhopal

Download or read book Concepts of Epidemiology written by Raj S. Bhopal and published by Oxford University Press. This book was released on 2016 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: First edition published in 2002. Second edition published in 2008.

Epidemiology

Author : Mark Woodward
Publisher : CRC Press
ISBN 13 : 1482243202
Total Pages : 844 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Epidemiology by : Mark Woodward

Download or read book Epidemiology written by Mark Woodward and published by CRC Press. This book was released on 2013-12-19 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highly praised for its broad, practical coverage, the second edition of this popular text incorporated the major statistical models and issues relevant to epidemiological studies. Epidemiology: Study Design and Data Analysis, Third Edition continues to focus on the quantitative aspects of epidemiological research. Updated and expanded, this edition shows students how statistical principles and techniques can help solve epidemiological problems. New to the Third Edition New chapter on risk scores and clinical decision rules New chapter on computer-intensive methods, including the bootstrap, permutation tests, and missing value imputation New sections on binomial regression models, competing risk, information criteria, propensity scoring, and splines Many more exercises and examples using both Stata and SAS More than 60 new figures After introducing study design and reviewing all the standard methods, this self-contained book takes students through analytical methods for both general and specific epidemiological study designs, including cohort, case-control, and intervention studies. In addition to classical methods, it now covers modern methods that exploit the enormous power of contemporary computers. The book also addresses the problem of determining the appropriate size for a study, discusses statistical modeling in epidemiology, covers methods for comparing and summarizing the evidence from several studies, and explains how to use statistical models in risk forecasting and assessing new biomarkers. The author illustrates the techniques with numerous real-world examples and interprets results in a practical way. He also includes an extensive list of references for further reading along with exercises to reinforce understanding. Web Resource A wealth of supporting material can be downloaded from the book’s CRC Press web page, including: Real-life data sets used in the text SAS and Stata programs used for examples in the text SAS and Stata programs for special techniques covered Sample size spreadsheet

Analysis of Cancer Risks in Populations Near Nuclear Facilities

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309255716
Total Pages : 424 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Analysis of Cancer Risks in Populations Near Nuclear Facilities by : National Research Council

Download or read book Analysis of Cancer Risks in Populations Near Nuclear Facilities written by National Research Council and published by National Academies Press. This book was released on 2012-06-29 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity. Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.

Oral Epidemiology

Author : Marco A. Peres
Publisher : Springer Nature
ISBN 13 : 303050123X
Total Pages : 534 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Oral Epidemiology by : Marco A. Peres

Download or read book Oral Epidemiology written by Marco A. Peres and published by Springer Nature. This book was released on 2020-10-19 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: This intermediate textbook on oral epidemiology is designed to meet the needs of advanced students in the fields of Dentistry and Oral Health and dentists in the early stages of their career. Readers will find detailed information on the epidemiology of individual diseases and disorders and on hot topics and methods in oral health research. The extensive first part of the book explores the international epidemiological literature regarding a wide range of conditions, from dental caries and periodontal diseases to halitosis and malocclusions. In each case, the prevalence, disease-specific measures, and associated factors are identified. Attention is then focused on cutting-edge research topics in oral epidemiology, such as the intriguing mechanisms linking oral diseases and chronic general diseases, life course epidemiology, and the role of socioeconomic determinants of oral health. The final part of the book is devoted to description of the epidemiological methods and tools applied in the field of oral health. Here, the coverage includes validation of questionnaires, data collection and data analyses, and systematic reviews and meta-analyses.

The Childhood Immunization Schedule and Safety

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309267021
Total Pages : 237 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis The Childhood Immunization Schedule and Safety by : Institute of Medicine

Download or read book The Childhood Immunization Schedule and Safety written by Institute of Medicine and published by National Academies Press. This book was released on 2013-04-27 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines are among the most safe and effective public health interventions to prevent serious disease and death. Because of the success of vaccines, most Americans today have no firsthand experience with such devastating illnesses as polio or diphtheria. Health care providers who vaccinate young children follow a schedule prepared by the U.S. Advisory Committee on Immunization Practices. Under the current schedule, children younger than six may receive as many as 24 immunizations by their second birthday. New vaccines undergo rigorous testing prior to receiving FDA approval; however, like all medicines and medical interventions, vaccines carry some risk. Driven largely by concerns about potential side effects, there has been a shift in some parents' attitudes toward the child immunization schedule. The Childhood Immunization Schedule and Safety identifies research approaches, methodologies, and study designs that could address questions about the safety of the current schedule. This report is the most comprehensive examination of the immunization schedule to date. The IOM authoring committee uncovered no evidence of major safety concerns associated with adherence to the childhood immunization schedule. Should signals arise that there may be need for investigation, however, the report offers a framework for conducting safety research using existing or new data collection systems.

Health Risks from Exposure to Low Levels of Ionizing Radiation

Author : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Publisher : National Academies Press
ISBN 13 : 0309133343
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Health Risks from Exposure to Low Levels of Ionizing Radiation by : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation

Download or read book Health Risks from Exposure to Low Levels of Ionizing Radiation written by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and published by National Academies Press. This book was released on 2006-03-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.

Statistical Analysis of Epidemiologic Data

Author : S. Selvin
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 494 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Statistical Analysis of Epidemiologic Data by : S. Selvin

Download or read book Statistical Analysis of Epidemiologic Data written by S. Selvin and published by Oxford University Press, USA. This book was released on 1996 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book combines applied and theoretical approaches to the analysis of epidemiologic issues. It goes beyond elementary material to deal with real problems generated by disease data, and delves into less usual areas such as the analysis of spatial distributions, survival data, proportional hazards regression, and "computer-intensive" approaches to statistical estimation. Each method discussed in the text is illustrated with examples which include complete sets of data. Using actual data demonstrates the strengths and weaknesses of different analytic approaches in describing a disease process. The goal of the book is to allow the reader to develop a clear understanding of analytic approaches to problems in epidemiologic data analysis without relying on sophisticated mathematics and advanced statistical theory. For the Second Edition a new chapter on the analysis of matched data has been added. This covers both discrete and continuous outcomes and explains both the classic analytic approach and the conditional logistic regression model. New sections have also been added on contingency table data, misclassification, and additive models underlying tabular data. In all the chapters there are new applications and other revisions that make this Second Edition a clearer and more helpful exposition of the way statistical tools are used to analyze epidemiologic data.

Multivariate Methods in Epidemiology

Author : Theodore R. Holford
Publisher : Oxford University Press
ISBN 13 : 0199747768
Total Pages : 427 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Multivariate Methods in Epidemiology by : Theodore R. Holford

Download or read book Multivariate Methods in Epidemiology written by Theodore R. Holford and published by Oxford University Press. This book was released on 2002-05-30 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basis for much of medical public health practice comes from epidemiological research. This text describes current statistical tools that are used to analyze the association between possible risk factors and the actual risk of disease. Beginning with a broad conceptual framework on the disease process, it describes commonly used techniques for analyzing proportions and disease rates. These are then extended to model fitting, and the common threads of logic that bind the two analytic strategies together are revealed. Each chapter provides a descriptive rationale for the method, a worked example using data from a published study, and an exercise that allows the reader to practice the technique. Each chapter also includes an appendix that provides further details on the theoretical underpinnings of the method. Among the topics covered are Mantel-Haenszel methods, rates, survival analysis, logistic regression, and generalized linear models. Methods for incorporating aspects of study design, such as matching, into the analysis are discussed, and guidance is given for determining the power or the sample size requirements of a study. This text will give readers a foundation in applied statistics and the concepts of model fitting to develop skills in the analysis of epidemiological data.

Foundations of Epidemiology

Author : Marit L. Bovbjerg
Publisher :
ISBN 13 : 9781955101035
Total Pages : 176 pages
Book Rating : 4.1/5 (1 download)

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Book Synopsis Foundations of Epidemiology by : Marit L. Bovbjerg

Download or read book Foundations of Epidemiology written by Marit L. Bovbjerg and published by . This book was released on 2020-10 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foundations of Epidemiology is an open access, introductory epidemiology text intended for students and practitioners in public or allied health fields. It covers epidemiologic thinking, causality, incidence and prevalence, public health surveillance, epidemiologic study designs and why we care about which one is used, measures of association, random error and bias, confounding and effect modification, and screening. Concepts are illustrated with numerous examples drawn from contemporary and historical public health issues.

Bootstrap Methods and Their Application

Author : A. C. Davison
Publisher : Cambridge University Press
ISBN 13 : 9780521574716
Total Pages : 606 pages
Book Rating : 4.5/5 (747 download)

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Book Synopsis Bootstrap Methods and Their Application by : A. C. Davison

Download or read book Bootstrap Methods and Their Application written by A. C. Davison and published by Cambridge University Press. This book was released on 1997-10-28 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disk contains the library functions and documentation for use with Splus for Windows.

Critical Appraisal of Epidemiological Studies and Clinical Trials

Author : Mark Elwood
Publisher : OUP Oxford
ISBN 13 : 0191004944
Total Pages : 615 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Critical Appraisal of Epidemiological Studies and Clinical Trials by : Mark Elwood

Download or read book Critical Appraisal of Epidemiological Studies and Clinical Trials written by Mark Elwood and published by OUP Oxford. This book was released on 2007-02-22 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a logical system of critical appraisal, to allow readers to evaluate studies and to carry out their own studies more effectively. This system emphasizes the central importance of cause and effect relationships. Its great strength is that it is applicable to a wide range of issues, and both to intervention trials and observational studies. This system unifies the often different approaches used in epidemiology, health services research, clinical trials, and evidence-based medicine, starting from a logical consideration of cause and effect. The author's approach to the issues of study design, selection of subjects, bias, confounding, and the place of statistical methods has been praised for its clarity and interest. Systematic reviews, meta-analysis, and the applications of this logic to evidence-based medicine, knowledge-based health care, and health practice and policy are discussed. Current and often controversial examples are used, including screening for prostate cancer, publication bias in psychiatry, public health issues in developing countries, and conflicts between observational studies and randomized trials. Statistical issues are explained clearly without complex mathematics, and the most useful methods are summarized in the appendix. The final chapters give six applications of the critical appraisal of major studies: randomized trials of medical treatment and prevention, a prospective and a retrospective cohort study, a small matched case-control study, and a large case-control study. In these chapters, sections of the original papers are reproduced and the original studies placed in context by a summary of current developments.

Musculoskeletal Disorders and the Workplace

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309132991
Total Pages : 510 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Musculoskeletal Disorders and the Workplace by : Institute of Medicine

Download or read book Musculoskeletal Disorders and the Workplace written by Institute of Medicine and published by National Academies Press. This book was released on 2001-05-24 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every year workers' low-back, hand, and arm problems lead to time away from jobs and reduce the nation's economic productivity. The connection of these problems to workplace activities-from carrying boxes to lifting patients to pounding computer keyboards-is the subject of major disagreements among workers, employers, advocacy groups, and researchers. Musculoskeletal Disorders and the Workplace examines the scientific basis for connecting musculoskeletal disorders with the workplace, considering people, job tasks, and work environments. A multidisciplinary panel draws conclusions about the likelihood of causal links and the effectiveness of various intervention strategies. The panel also offers recommendations for what actions can be considered on the basis of current information and for closing information gaps. This book presents the latest information on the prevalence, incidence, and costs of musculoskeletal disorders and identifies factors that influence injury reporting. It reviews the broad scope of evidence: epidemiological studies of physical and psychosocial variables, basic biology, biomechanics, and physical and behavioral responses to stress. Given the magnitude of the problem-approximately 1 million people miss some work each year-and the current trends in workplace practices, this volume will be a must for advocates for workplace health, policy makers, employers, employees, medical professionals, engineers, lawyers, and labor officials.