Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition

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Publisher : McGraw Hill Professional
ISBN 13 : 007160393X
Total Pages : 831 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition by : Leon Shargel

Download or read book Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition written by Leon Shargel and published by McGraw Hill Professional. This book was released on 2012-04-11 with total page 831 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics The field’s leading text for more than three decades Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to: Understand the basic concepts in biopharmaceutics and pharmacokinetics. Use raw data and derive the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination Critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Design and evaluate dosage regimens of drugs, using pharmacokinetic and biopharmaceutic parameters Detect potential clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.

Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition

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Publisher : McGraw Hill Professional
ISBN 13 : 0071375503
Total Pages : 915 pages
Book Rating : 4.0/5 (713 download)

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Book Synopsis Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition by : Leon Shargel

Download or read book Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition written by Leon Shargel and published by McGraw Hill Professional. This book was released on 2004-08-19 with total page 915 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive text on the practical applications of biopharmaceuticals and pharmacokinetics! 4 STAR DOODY'S REVIEW! "The updated edition provides the reader with a solid foundation in the basic principles of pharmacokinetics and biopharmaceutics. Students will be able to apply the information to their clinical practice and researchers will find this to be a valuable reference. This modestly priced book should be the gold standard for student use."--Doody's Review Service The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition

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Publisher : McGraw Hill Professional
ISBN 13 : 0071501878
Total Pages : 914 pages
Book Rating : 4.0/5 (715 download)

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Book Synopsis Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition by : Leon Shargel

Download or read book Applied Biopharmaceutics & Pharmacokinetics, Fifth Edition written by Leon Shargel and published by McGraw Hill Professional. This book was released on 2004-09-09 with total page 914 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive text on the practical applications of biopharmaceuticals and pharmacokinetics! 4 STAR DOODY'S REVIEW! "The updated edition provides the reader with a solid foundation in the basic principles of pharmacokinetics and biopharmaceutics. Students will be able to apply the information to their clinical practice and researchers will find this to be a valuable reference. This modestly priced book should be the gold standard for student use."--Doody's Review Service The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Applied Biopharmaceutics and Pharmacokinetics

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Publisher : McGraw-Hill/Appleton & Lange
ISBN 13 : 9780838502396
Total Pages : 625 pages
Book Rating : 4.5/5 (23 download)

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Book Synopsis Applied Biopharmaceutics and Pharmacokinetics by : Leon Shargel

Download or read book Applied Biopharmaceutics and Pharmacokinetics written by Leon Shargel and published by McGraw-Hill/Appleton & Lange. This book was released on 1993 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Applied Biopharmaceutics & Pharmacokinetics

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Author :
Publisher : McGraw-Hill Medical Publishing
ISBN 13 :
Total Pages : 920 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Applied Biopharmaceutics & Pharmacokinetics by : Leon Shargel

Download or read book Applied Biopharmaceutics & Pharmacokinetics written by Leon Shargel and published by McGraw-Hill Medical Publishing. This book was released on 2005 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Applied Biopharmaceutics and Pharmacokinetics

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (142 download)

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Book Synopsis Applied Biopharmaceutics and Pharmacokinetics by : Leon Shargel

Download or read book Applied Biopharmaceutics and Pharmacokinetics written by Leon Shargel and published by . This book was released on 1978 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Applied Biopharmaceutics & Pharmacokinetics, Seventh Edition

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Author :
Publisher : McGraw Hill Professional
ISBN 13 : 0071829644
Total Pages : 928 pages
Book Rating : 4.0/5 (718 download)

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Book Synopsis Applied Biopharmaceutics & Pharmacokinetics, Seventh Edition by : Leon Shargel

Download or read book Applied Biopharmaceutics & Pharmacokinetics, Seventh Edition written by Leon Shargel and published by McGraw Hill Professional. This book was released on 2015-11-22 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: The landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics—now fully updated. Explains how to detect clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them Helps you critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Chapters have been revised to reflect the latest clinical perspectives on drug performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy The field’s leading text for more than three decades, Applied Biopharmaceutics & Pharmacokinetics gets you up to speed on the basics of the discipline like no other resource. Practical problems and clinical examples with discussions are integrated within each chapter to help you apply principles to patient care and drug consultation situations. In addition, outstanding pedagogy, including chapter objectives, chapter summaries, and FAQs, plus additional application questions, identify and focus on key concepts. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics shows you how to use raw data and formulate the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination. The book also helps you work with pharmacokinetic and biopharmaceutic parameters to design and evaluate dosage regimens of drugs. In the seventh edition of this must-have interactive learning tool, most of the chapters are updated to reflect our current understanding of complex issues associated with safe and efficacious drug therapy.

Basic Pharmacokinetics and Pharmacodynamics

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Publisher : John Wiley & Sons
ISBN 13 : 111819778X
Total Pages : 440 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Basic Pharmacokinetics and Pharmacodynamics by : Sara E. Rosenbaum

Download or read book Basic Pharmacokinetics and Pharmacodynamics written by Sara E. Rosenbaum and published by John Wiley & Sons. This book was released on 2012-09-10 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.

Shargel and Yu's Applied Biopharmaceutics & Pharmacokinetics, 8th Edition

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Publisher : McGraw Hill Professional
ISBN 13 : 1260143007
Total Pages : 1035 pages
Book Rating : 4.2/5 (61 download)

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Book Synopsis Shargel and Yu's Applied Biopharmaceutics & Pharmacokinetics, 8th Edition by : Leon Shargel

Download or read book Shargel and Yu's Applied Biopharmaceutics & Pharmacokinetics, 8th Edition written by Leon Shargel and published by McGraw Hill Professional. This book was released on 2022-01-24 with total page 1035 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authoritative textbook on the principles and practical applications of biopharmaceutics and pharmacokinetics Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics has been the standard textbook in its field for over 40 years. This eighth edition includes recent scientific developments in the field and embodies the collective contribution of experts with deep knowledge and experience in the selected subject areas. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition provides the reader with a fundamental understanding of biopharmaceutics and pharmacokinetics principles that can be applied to patient drug therapy and rational drug product development. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition has been expanded and revised to include advancements in biopharmaceutics and pharmacokinetics. The chapter sequence has been reorganized into four main sections, providing a more logical sequence for students. The textbook starts with fundamental concepts, followed by application of these principles to optimize drug therapy and to the rational development of drug products. Each chapter includes theoretical concepts with practical examples and clinical applications. Frequently asked questions provide a discussion of overall concepts. Features: Expanded and revised chapters to include scientific advances in biopharmaceutics and pharmacokinetics Four main sections providing a natural buildup of knowledge: introduction to biopharmaceutics and pharmacokinetics, fundamentals of biopharmaceutics, pharmacokinetic calculations, clinical pharmacokinetics and pharmacodynamics, and biopharmaceutics and pharmacokinetics in drug product development Additional chapters for this edition include: o Physiological factors related to drug absorption o Approaches to pharmacokinetics and pharmacodynamics calculations o Novel and complex dosage Forms o Clinical Development and Therapeutic Equivalence of Generic Drug and Biosimilar Products o Pharmacokinetics and Pharmacodynamics in Clinical Drug Product Development Additional information on drug therapy, drug product performance, and other related topics Frequently asked questions, practice problems, clinical examples and learning questions

Concepts in Clinical Pharmacokinetics

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Publisher : ASHP
ISBN 13 : 1585283894
Total Pages : 467 pages
Book Rating : 4.5/5 (852 download)

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Book Synopsis Concepts in Clinical Pharmacokinetics by : William Spruill

Download or read book Concepts in Clinical Pharmacokinetics written by William Spruill and published by ASHP. This book was released on 2014-04-11 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpu Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpufConcepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf

Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496385896
Total Pages : 864 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications by : Hartmut Derendorf

Download or read book Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications written by Hartmut Derendorf and published by Lippincott Williams & Wilkins. This book was released on 2019-07-11 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.

Applied Biopharmaceutics and Pharmacokinetics

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Publisher :
ISBN 13 : 9780071240055
Total Pages : pages
Book Rating : 4.2/5 (4 download)

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Book Synopsis Applied Biopharmaceutics and Pharmacokinetics by : Shargel

Download or read book Applied Biopharmaceutics and Pharmacokinetics written by Shargel and published by . This book was released on 2003-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizing on the application and understanding of concepts, this book provides basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Basic Pharmacokinetics

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Publisher :
ISBN 13 : 9780857114471
Total Pages : 0 pages
Book Rating : 4.1/5 (144 download)

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Book Synopsis Basic Pharmacokinetics by : Sunil S. Jambhekar

Download or read book Basic Pharmacokinetics written by Sunil S. Jambhekar and published by . This book was released on 2023-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Martin's Physical Pharmacy and Pharmaceutical Sciences

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Publisher :
ISBN 13 : 9780781797665
Total Pages : 659 pages
Book Rating : 4.7/5 (976 download)

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Book Synopsis Martin's Physical Pharmacy and Pharmaceutical Sciences by : Alfred N. Martin

Download or read book Martin's Physical Pharmacy and Pharmaceutical Sciences written by Alfred N. Martin and published by . This book was released on 2011 with total page 659 pages. Available in PDF, EPUB and Kindle. Book excerpt: Martin's Physical Pharmacy and Pharmaceutical Sciences is considered the most comprehensive text available on the application of the physical, chemical and biological principles in the pharmaceutical sciences. It helps students, teachers, researchers, and industrial pharmaceutical scientists use elements of biology, physics, and chemistry in their work and study. Since the first edition was published in 1960, the text has been and continues to be a required text for the core courses of Pharmaceutics, Drug Delivery, and Physical Pharmacy. The Sixth Edition features expanded content on drug delivery, solid oral dosage forms, pharmaceutical polymers and pharmaceutical biotechnology, and updated sections to cover advances in nanotechnology.

Applied Biopharmaceutics & Pharmacokinetics, Eigth Edition

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Publisher : McGraw-Hill Education / Medical
ISBN 13 : 9781260142990
Total Pages : 864 pages
Book Rating : 4.1/5 (429 download)

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Book Synopsis Applied Biopharmaceutics & Pharmacokinetics, Eigth Edition by : Andrew B.C. Yu

Download or read book Applied Biopharmaceutics & Pharmacokinetics, Eigth Edition written by Andrew B.C. Yu and published by McGraw-Hill Education / Medical. This book was released on 2020-12-06 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. This authoritative guide has been updated with important new findings about drug therapy, product performance, and other need-to-know topics Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition delivers the knowledge and skills you need to succeed. The authors provide practical problems with specific examples of clinical solutions to help you apply principles to patient care and drug consultation situations. Each chapter includes objectives, summaries, and FAQs highlighting that help you understand and retain key concepts. You’ll learn how to derive models/parameters to describe drug absorption, distribution, and elimination processes; evaluate biopharmaceutic studies involving drug product equivalency and unequivalency; design and evaluate dosage regimens of drugs; detect and solve clinical pharmacokinetic problems; and much more.

Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1469871947
Total Pages : 810 pages
Book Rating : 4.4/5 (698 download)

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Book Synopsis Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems by : Loyd Allen

Download or read book Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems written by Loyd Allen and published by Lippincott Williams & Wilkins. This book was released on 2014-01-30 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long established as a trusted core text for pharmaceutics courses, this gold standard book is the most comprehensive source on pharmaceutical dosage forms and drug delivery systems available today. Reflecting the CAPE, APhA, and NAPLEX® competencies, Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems covers physical pharmacy, pharmacy practice, pharmaceutics, compounding, and dosage forms, as well as the clinical application of the various dosing forms in patient care. This Tenth Edition has been fully updated to reflect new USP standards and features a dynamic new full color design, new coverage of prescription flavoring, and increased coverage of expiration dates.

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition

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Publisher : CRC Press
ISBN 13 : 9789186274924
Total Pages : 926 pages
Book Rating : 4.2/5 (749 download)

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Book Synopsis Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition by : Johan Gabrielsson

Download or read book Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition written by Johan Gabrielsson and published by CRC Press. This book was released on 2001-11-30 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.