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Applications Of The New Methods For The Synthesis Of Beta Hydroxy Alpha Amino Acids
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Book Synopsis Applications of the New Methods for the Synthesis of [beta]-Hydroxy-[alpha]-Amino Acids by : Zoe Michelle Adams
Download or read book Applications of the New Methods for the Synthesis of [beta]-Hydroxy-[alpha]-Amino Acids written by Zoe Michelle Adams and published by . This book was released on 1998 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applications of the New Methods for the Synthesis of Β-Hydroxy-α-Amino Acids by : Zoe Michelle Adams
Download or read book Applications of the New Methods for the Synthesis of Β-Hydroxy-α-Amino Acids written by Zoe Michelle Adams and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applications of New Methods for the Synthesis of Beta-hydroxy-alpha-amino Acids by : Zoe Michelle Adams
Download or read book Applications of New Methods for the Synthesis of Beta-hydroxy-alpha-amino Acids written by Zoe Michelle Adams and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applications of the New Methods for the Synthesis of Β-Hydroxy-α-Amino Acids by : Zoe Michelle Adams
Download or read book Applications of the New Methods for the Synthesis of Β-Hydroxy-α-Amino Acids written by Zoe Michelle Adams and published by . This book was released on 1998 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Methods for the Synthesis of [beta]-hydroxy-[alpha]-amino Acids and Carbacephems by : Catherine M. Gasparski
Download or read book New Methods for the Synthesis of [beta]-hydroxy-[alpha]-amino Acids and Carbacephems written by Catherine M. Gasparski and published by . This book was released on 1991 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Methods of Non-a-Amino Acid Synthesis by : Michael Smith
Download or read book Methods of Non-a-Amino Acid Synthesis written by Michael Smith and published by CRC Press. This book was released on 1995-05-17 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a comprehensive overview of, and the most common and useful methods for, the synthesis of non-alpha-amino acids, particularly amino acids that are key synthetic intermediates or important compounds in their own right. Attention is paid to acyclic amino acids C3-C10 including amino alkanoic carboxylic acids, aminoalkenoic acids and aminoalkynoic acids.
Book Synopsis A General Method for the Synthesis of Alpha-amino -beta-hydroxy Acids by : Edward John Van Loon
Download or read book A General Method for the Synthesis of Alpha-amino -beta-hydroxy Acids written by Edward John Van Loon and published by . This book was released on 1936 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A New Approach to the Synthesis of Beta-hydroxy-alpha-amino Acids by : Nicholas J. Palmer
Download or read book A New Approach to the Synthesis of Beta-hydroxy-alpha-amino Acids written by Nicholas J. Palmer and published by . This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Optically Active Alpha-Amino Acids by : R. M. Williams
Download or read book Synthesis of Optically Active Alpha-Amino Acids written by R. M. Williams and published by Elsevier. This book was released on 2013-10-22 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to review and critically evaluate the best new methods to synthesize alpha-amino acids in optically active form. There is so much new literature on amino acid synthesis that the experimentalist will undoubtedly have difficulty in selecting the most appropriate methodology for constructing the amino acid of immediate interest. This book is a guide for steering the scientist through the maze of existing reports on the subject and contains the most up-to-date critical reviews of methods of asymmetric synthesis of amino acids. In areas that are relatively new conceptually and less studied experimentally, an effort has been made to review the most salient works with an eye towards future development. Over 330 schemes and figures are presented with references for rapid visual retrieval of information. The book will be of great value to academic and industrial organic research chemists, especially those concerned with medicinal and agricultural chemistry, as well as to graduate and post graduate students, biochemists and biologists.
Book Synopsis Asymmetric Synthesis of [beta]-hydroxy-[alpha]-amino Acids and Carbacephems by Enzymatic and Chemical Methods by : Bruce Timothy Lotz
Download or read book Asymmetric Synthesis of [beta]-hydroxy-[alpha]-amino Acids and Carbacephems by Enzymatic and Chemical Methods written by Bruce Timothy Lotz and published by . This book was released on 1991 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enantioselective Synthesis of Beta-Amino Acids by : Eusebio Juaristi
Download or read book Enantioselective Synthesis of Beta-Amino Acids written by Eusebio Juaristi and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Optically Active [alpha]-amino Acids by : Robert Michael Williams
Download or read book Synthesis of Optically Active [alpha]-amino Acids written by Robert Michael Williams and published by Pergamon. This book was released on 1989 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to review and critically evaluate the best new methods to synthesize alpha-amino acids in optically active form. There is so much new literature on amino acid synthesis that the experimentalist will undoubtedly have difficulty in selecting the most appropriate methodology for constructing the amino acid of immediate interest. This book is a guide for steering the scientist through the maze of existing reports on the subject and contains the most up-to-date critical reviews of methods of asymmetric synthesis of amino acids. In areas that are relatively new conceptually and less studied experimentally, an effort has been made to review the most salient works with an eye towards future development. Over 330 schemes and figures are presented with references for rapid visual retrieval of information. The book will be of great value to academic and industrial organic research chemists, especially those concerned with medicinal and agricultural chemistry, as well as to graduate and post graduate students, biochemists and biologists.
Book Synopsis A new approach to the synthesis of β-hydroxy-α-amino acids by : Nicholas J. Palmer
Download or read book A new approach to the synthesis of β-hydroxy-α-amino acids written by Nicholas J. Palmer and published by . This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chirospecific Synthesis of Beta-hydroxy-alpha-amino Acids by : Renee Caroline Roemmele
Download or read book Chirospecific Synthesis of Beta-hydroxy-alpha-amino Acids written by Renee Caroline Roemmele and published by . This book was released on 1989 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Asymmetric Synthesis and Application of Alpha-Amino Acids by : Vadim A Soloshonok
Download or read book Asymmetric Synthesis and Application of Alpha-Amino Acids written by Vadim A Soloshonok and published by American Chemical Society. This book was released on 2009-07-09 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the most recent and comprehensive collection of reviews on methodological developments in the field of alpha-amino acids.
Book Synopsis New Methods Towards the Synthesis of [beta]-amino Acids by : Barbara Weiner
Download or read book New Methods Towards the Synthesis of [beta]-amino Acids written by Barbara Weiner and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Development of Palladium-, Zinc-, and Magnesium-catalyzed Asymmetric Transformations by : Sushant Malhotra
Download or read book The Development of Palladium-, Zinc-, and Magnesium-catalyzed Asymmetric Transformations written by Sushant Malhotra and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products have laid the foundation for the discovery and development of medicines for centuries. Early Ayurvedic medicine involved the use of cocktails of several naturally occurring molecules for the treatment of common illnesses. Today natural products remain the mainstay of therapeutic intervention in the treatment of several debilitating diseases. Compounds accessed from natural sources have also been the source of inspiration in the discovery of several non-natural pharmaceuticals. The diverse and complex structural features of natural products and their limited availability, however, presents a significant roadblock in accessing these molecules on scales where they can have the greatest impact. Currently, the de novo synthesis of natural products is challenging, expensive, and low yielding. To address this, chemists strive to access structures with the greatest efficiency and practicality. Despite decades of efforts we are still faced with the challenge of synthetic efficiency. Herein, the cytotoxic agent Peloruside A, the antibiotic tobramycin, the multi-drug resistance reversal agent N-acetyl-ardeemin have inspired the discovery and development of methods to streamline the synthesis of these molecules and their analogs. Detailed is an account of the efforts dedicated towards accessing these natural products in high efficiency and in enantiomerically enriched form using novel disconnections which have led to the development of several new methods. Peloruside A has inspired the development of the asymmetric desymmetrization of 2-alkyl-1,3-propanediols. This method was found to be highly general and rapidly afforded several chiral building blocks. One of these is applied towards the synthesis of an important fragment in this natural product. Peloruside A also highlighted the deficiencies in using esters in direct asymmetric aldol reactions. The development of a diazoester aldol using of commercially available ethyl diazoacetate and a range of aldehydes is a viable alternative to the use of chiral pool-based auxiliaries. To minimize the use of protecting groups the use of an alkyne as a masked [Alpha]-hydroxyketone has been explored in the formation of the pyran ring in peloruside A via a 6-endo-dig cyclization. The development of the asymmetric diazoester aldol reaction led to the synthesis of vicinal diols bearing a tertiary alcohol. The oxidation of [Beta]-hydroxy-[Alpha]-diazoesters affords [Beta]-hydroxy-[Alpha]-ketoesters that undergo alkyl transfer with minimal erosion in chirality and in high diastereocontrol with alkyl, allyl, and propargyl nucleophiles. One of the products from this method is present in azithromycin and related natural products. Furthermore, the asymmetric diazoester aldol reaction enables the exploration of a direct stereospecific C--O to C--N exchange reaction unique to diazoesters towards the synthesis of [Beta]-amido-[Alpha]-diazoesters. The products from this reaction can be transformed into [Beta]-amido-[Alpha]-hydroxyesters and undergo a rather unusual 1,3-C--H insertion reaction to afford aminocyclopropanes. The use of nitrogen nucleophiles in Pd-catalyzed asymmetric allylic alkylations enabled the synthesis of two diastereoisomers of 2-deoxystreptamine. This motif is present in all clinically relevant aminoglycoside antibiotics; however, the biological effects of aminoglycosides that are diastereomeric at the 2-deoxystreptamine core are unexplored. A synthetic sequence that furnishes scaffolds that have the potential of being transformed into novel aminoglycosides is presented. This project highlighted the challenge of generating diamines. Recognizing this, a collaboration with the Du Bois group at Stanford University was initiated where the use of a bifunctional nucleophile in sequential palladium- and rhodium-catalyzed processes afforded several nitrogenated architectures that cannot be readily accessed by pre-existing methods and can serve as building blocks in drug discovery. One interesting facet of this work was the use of [Pi]-prenylpalladium species in directing attack of a nitrogen nucleophile at the more substituted carbon of a prenyl electrophile. The reverse prenylated hexahydropyrrolo[2,3-b]indoline substructure is present in several natural products such as N-acetyl-ardeemin. One reason for the challenge associated in employing [Pi]-prenylpalladium complexes to access these natural products lies in the concomitant control of the regio- and enantioselectivity with sterically more demanding carbon based nucleophiles. Although usually Pd-catalyzed allylic alkylations result in attack at the less hindered terminus of a [Pi]-allyl, described are conditions where the regioselectivity can be controlled in accessing either linear or branched prenylated products in high optical purities. In one example the enantio-, regio- and diastereoselective synthesis of vicinal quaternary stereogenic centers has been achieved using palladium catalyzed allylic alkylations.