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Author :
Publisher : Springer
ISBN 13 : 9781617790386
Total Pages : 424 pages
Book Rating : 4.7/5 (93 download)
Download or read book Antiviral Rnai written by and published by Springer. This book was released on 2011-08-14 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ronald P. van Rij
Publisher : Humana Press
ISBN 13 : 9781617790362
Total Pages : 0 pages
Book Rating : 4.7/5 (93 download)
Download or read book Antiviral RNAi written by Ronald P. van Rij and published by Humana Press. This book was released on 2011-03-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses and RNAi share an intricate relationship at many levels. RNAi is an important antiviral defense mechanism in plants and invertebrates, microRNAs – of viral or cellular origin – affect many aspects of virus biology, and replication of many, if not all, mammalian viruses can be suppressed by RNAi. Antiviral RNAi: Concepts, Methods, and Applications provides a collection of protocols for the analysis of viral small RNAs and natural antiviral RNAi responses as well as for the development and optimization of RNAi-based antiviral drugs. As RNAi is a central regulatory mechanism in the cell, the methods in this volume can also be applied out of the context of a virus infection. Divided into five convenient parts, this detailed volume reviews important basic concepts in the field of antiviral RNAi, provides experimental and bio-informatic tools for the analysis of small silencing RNAs, covers methods to biochemically dissect RNAi-based antiviral defense and viral counter-defense mechanisms, describes methods for the design, expression, and delivery of therapeutic antiviral siRNAs, and finally presents genome-wide RNAi approaches for the identification of factors involved in virus replication. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Antiviral RNAi: Concepts, Methods, and Applications serves as an ideal guide for both novice and experienced researchers alike striving to dissect the role of RNAi in the viral life cycle or to further boost the development of novel therapeutics and experimental tools based on RNAi technology.
Author : Miguel Angel Martínez
Publisher :
ISBN 13 : 9781912530878
Total Pages : pages
Book Rating : 4.5/5 (38 download)
Download or read book RNA Interference and Viruses written by Miguel Angel Martínez and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms, other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, while others describe how this technology is being developed as a new therapeutic tool for fighting.
Author : Volker A. Erdmann
Publisher : Springer
ISBN 13 : 9783642066030
Total Pages : 0 pages
Book Rating : 4.0/5 (66 download)
Download or read book RNA Towards Medicine written by Volker A. Erdmann and published by Springer. This book was released on 2010-02-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developments over the past few years have revealed the remarkable versatility of RNA in any compartment of the cell, tasks that had been thought to be exclusively in the realm of proteins and even beyond. The chapters in this book written by leading investigators in the field provide insight into various promising avenues where RNA and nucleic acid derivatives including antisense RNAs, such as siRNA, miRNAs, amplification/selection (SELEX) generated aptamers as well as ribozymes are at the threshold of impacting medicine.
Author : John M. Watson
Publisher : Humana Press
ISBN 13 : 9781617798832
Total Pages : 380 pages
Book Rating : 4.7/5 (988 download)
Download or read book Antiviral Resistance in Plants written by John M. Watson and published by Humana Press. This book was released on 2012-06-12 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies related to pathogen-mediated virus resistance in plants were instrumental in providing some of the historical observations which ultimately led to the vital discovery of double-stranded RNA (dsRNA)-induced gene silencing or RNA interference (RNAi), which has since revolutionized research on plant-virus interactions. In Antiviral Resistance in Plants: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to study the phenomenon of RNA silencing in relation to viral infections of plants. These include methods and techniques for the isolation and quantitative/qualitative analyses of plant small 21-24 nucleotide RNAs such as small interfering RNAs (siRNAs) and microRNAs (miRNAs) as well as the analysis and manipulation of virus-induced gene silencing (VIGS) in both monocotyledonous and dicotyledenous plants and the use of hairpin RNA (hpRNA) transgenes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antiviral Resistance in Plants: Methods and Protocols seeks to aid scientists in the further study of this crucially important botanical trait.
Author : Bryan R. Cullen
Publisher : Springer Science & Business Media
ISBN 13 : 3642377653
Total Pages : 265 pages
Book Rating : 4.6/5 (423 download)
Download or read book Intrinsic Immunity written by Bryan R. Cullen and published by Springer Science & Business Media. This book was released on 2013-05-17 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.
Author : Patrick Arbuthnot
Publisher : Academic Press
ISBN 13 : 0124114520
Total Pages : 392 pages
Book Rating : 4.1/5 (241 download)
Download or read book Gene Therapy for Viral Infections written by Patrick Arbuthnot and published by Academic Press. This book was released on 2015-06-01 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field
Author : Dr. Prakash Sambhara
Publisher : CRC Press
ISBN 13 : 1498713653
Total Pages : 284 pages
Book Rating : 4.4/5 (987 download)
Download or read book Nucleic Acid Sensors and Antiviral Immunity written by Dr. Prakash Sambhara and published by CRC Press. This book was released on 2012-11-26 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of Toll-like receptors (TLRs) in the late 1990s ushered in a new age of discovery for innate immunity. The importance of TLRs for immunology and biomedical research was recognized with the Nobel Prize for Medicine or Physiology in 2011. The prize was shared by three scientists: Ralph Steinman (for the discovery of dendritic cells, whi
Author : Decheng Yang
Publisher : World Scientific
ISBN 13 : 9812833803
Total Pages : 722 pages
Book Rating : 4.8/5 (128 download)
Download or read book RNA Viruses written by Decheng Yang and published by World Scientific. This book was released on 2009 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection.
Author : Gordon Carmichael
Publisher : Springer Science & Business Media
ISBN 13 : 1592599354
Total Pages : 343 pages
Book Rating : 4.5/5 (925 download)
Download or read book RNA Silencing written by Gordon Carmichael and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of readily reproducible methods for the design, preparation, and use of RNAs for silencing gene expression in cells and organisms. The techniques range widely and include methods addressing the biochemical aspects of the silencing machinery, RNA silencing in non-mammalian organisms, and the in vivo delivery of siRNAs and silencing vectors. There are also techniques for designing, preparing, and using RNAs to silence gene expression, for fine-tuning regulation by targeting specific isoforms of a given gene, and for the study and use of microRNAs. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Author : Volker A. Erdmann
Publisher : Springer Science & Business Media
ISBN 13 : 3540272623
Total Pages : 463 pages
Book Rating : 4.5/5 (42 download)
Download or read book RNA Towards Medicine written by Volker A. Erdmann and published by Springer Science & Business Media. This book was released on 2006-02-04 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developments over the past few years have revealed the remarkable versatility of RNA in any compartment of the cell, tasks that had been thought to be exclusively in the realm of proteins and even beyond. The chapters in this book written by leading investigators in the field provide insight into various promising avenues where RNA and nucleic acid derivatives including antisense RNAs, such as siRNA, miRNAs, amplification/selection (SELEX) generated aptamers as well as ribozymes are at the threshold of impacting medicine.
Author : Bin Wang
Publisher : CRC Press
ISBN 13 : 9814411647
Total Pages : 468 pages
Book Rating : 4.8/5 (144 download)
Download or read book RNA Nanotechnology written by Bin Wang and published by CRC Press. This book was released on 2014-04-02 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few decades there has been incredible growth in "bionano"-related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and healthcare applications. RNA Nanotechnology is a comprehensive volume that details both the traditional approaches and the latest developments in the field of RNA-related technology. This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. The book opens with reviews on the basic aspects of RNA biology, computational approaches for predicting RNA structures, and traditional and emerging experimental approaches for probing RNA structures. This section is followed by explorations of the latest research and discoveries in RNA nanotechnology, including the design and construction of RNA-based nanostructures. The final segment of the book includes descriptions and discussions of the potential biological and therapeutic applications of small RNA molecules, such as small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.
Author : Sailen Barik
Publisher : Humana
ISBN 13 : 9781617378195
Total Pages : 0 pages
Book Rating : 4.3/5 (781 download)
Download or read book RNAi written by Sailen Barik and published by Humana. This book was released on 2011-01-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA interference (RNAi) is the most recent discovery to revolutionize the study of biology. In this book, leaders in the field contribute state-of-the-art, easy to follow methods and bench protocols designed for practical, everyday use of RNAi in biological research. Cutting edge and clearly written, this book enables a researcher with standard molecular biological training to perform major RNAi-related experiments and contribute to this revolutionary, growing field.
Author : Hans-Georg Kräusslich
Publisher : Springer Science & Business Media
ISBN 13 : 3540790861
Total Pages : 386 pages
Book Rating : 4.5/5 (47 download)
Download or read book Antiviral Strategies written by Hans-Georg Kräusslich and published by Springer Science & Business Media. This book was released on 2008-12-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.
Author : Erik De Clercq
Publisher : John Wiley & Sons
ISBN 13 : 3527635963
Total Pages : 632 pages
Book Rating : 4.5/5 (276 download)
Download or read book Antiviral Drug Strategies written by Erik De Clercq and published by John Wiley & Sons. This book was released on 2011-04-08 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.
Author : Daniel R. Pérez
Publisher : Springer Nature
ISBN 13 : 1071635336
Total Pages : 274 pages
Book Rating : 4.0/5 (716 download)
Download or read book Reverse Genetics of RNA Viruses written by Daniel R. Pérez and published by Springer Nature. This book was released on 2023-12-08 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with new and updated chapters that highlight the latest methods and approaches for the manipulation of RNA viruses. The chapters in this book explore the fundamental role in studying RNA viruses; identifying markers of host range, disease, and transmission; and aid readers with the further development of in silico computational biology tools and artificial intelligence algorithms that can help predict the emergence of certain pathogens. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Reverse Genetics of RNA Viruses: Methods and Protocols, Second Edition is a valuable resource for researchers who are interested in learning more about this developing field.
Author : Hildegund C.J. Ertl
Publisher : Springer Nature
ISBN 13 : 3030210847
Total Pages : 207 pages
Book Rating : 4.0/5 (32 download)
Download or read book Rabies and Rabies Vaccines written by Hildegund C.J. Ertl and published by Springer Nature. This book was released on 2020-05-04 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the recent advances in rabies research and rabies vaccine development. The reader is introduced to biology and pathology of the virus, causing agents and the history of rabies vaccination. The book presents regional rabies prophylaxis programs and discusses vaccination strategies for wildlife and humans. Further, innate immune response as well as antibody response to rabies are examined. All chapters are written by renowned experts in rabies research, some of them part of the WHO Collaboration Centre for Rabies Surveillance and Research. The book targets researchers and health professionals working in Virology, Veterinary Medicine and Biomedicine.
