Antiviral Methods And Protocols

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Antiviral Methods and Protocols

Author : Derek Kinchington
Publisher : Springer Science & Business Media
ISBN 13 : 1592592457
Total Pages : 398 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Antiviral Methods and Protocols by : Derek Kinchington

Download or read book Antiviral Methods and Protocols written by Derek Kinchington and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This latest addition to the Methods in Molecular Medicine series, Anti- ral Methods and Protocols, is opportune because there is an increasing int- est in discovering compounds that are effective against both chronic and acute viral infections. A number of the methods described in the volume are unp- lished and their inclusion indicates the speed at which this field is moving. This volume is not a review but each chapter contains methods validated by the experts who have spent time in developing the protocols. The hallmark of this series is the comprehensive way in which the me- ods are described, which includes a list of all the reagents needed for each protocol. Of importance is the section on tips and pitfalls that the authors have discovered while developing their protocols. The manual itself is designed to be used by researchers in universities and industry who are familiar with a range of biological techniques but who want to set up quickly a novel assay system. We encourage a dialog between readers and authors, which may also result in useful collaborations.

Advances in Antiviral Research

Author : Naveen Kumar
Publisher : Springer
ISBN 13 : 9789819991945
Total Pages : 0 pages
Book Rating : 4.9/5 (919 download)

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Book Synopsis Advances in Antiviral Research by : Naveen Kumar

Download or read book Advances in Antiviral Research written by Naveen Kumar and published by Springer. This book was released on 2024-03-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates advancements in the sophisticated tools and techniques for discovering and designing new antiviral drugs, identifying approved drugs against new and emerging viruses through large-scale computational virtual screening or drug repurposing approaches, and their evaluation in various in vitro and in vivo models. The chapters also cover the challenges associated with the emergence of antiviral drug resistance and possible ways to counter them. It discusses bioinformatics tools and software and computational approaches for the discovery of antivirals. The books also outline approaches for designing broad-spectrum antivirals effective against viruses by epigenetic- and epitranscriptomic-targeted reprogramming. Further, it provides vital details on the procedures for drug applications, clinical trials, and their regulations. Finally, the book provides a comprehensive yet representative description of advances in antiviral research protocols and methodologies suitable for antiviral researchers at all career stages, including graduate and postgraduate students and policy-makers.

Viruses as Therapeutics

Author : Alexandra R. Lucas
Publisher :
ISBN 13 : 9781071610145
Total Pages : pages
Book Rating : 4.6/5 (11 download)

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Book Synopsis Viruses as Therapeutics by : Alexandra R. Lucas

Download or read book Viruses as Therapeutics written by Alexandra R. Lucas and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Innate Antiviral Immunity

Author : Karen Mossman
Publisher : Humana
ISBN 13 : 9781493984268
Total Pages : 0 pages
Book Rating : 4.9/5 (842 download)

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Book Synopsis Innate Antiviral Immunity by : Karen Mossman

Download or read book Innate Antiviral Immunity written by Karen Mossman and published by Humana. This book was released on 2018-08-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores methods to study the complex and evolving interplay between a virus and its host that range from model systems to the detection of chemical molecules. The collection starts with the application of humanized mice and zebrafish as model organisms to study virus-host interactions and induction of innate immune responses. Subsequent chapters outline diverse methods to detect small interfering RNAs, microRNAs, and virus-derived dsRNA from a variety of cells, tissues, and organisms, as well as to interrogating the cytosolic RNA and DNA sensing pathways, including using RNA PAMPs as molecular tools, purification of cGAMP from virus particles and infected cells, and mechanisms to visualize the subcellular localization and activation of the adaptor proteins MAVS and STING. Cutting-edge methods, including high-throughput and genome-wide CRISPR/Cas9 screens, chromosome conformation capture, and whole-exome sequencing, are described to identify novel mediators, pathways, and variants underlying host susceptibility. Given the importance of studying these pathways and players under physiologic conditions, methods describing the isolation of primary mouse sensory neurons and group 2 innate lymphoid cells are also provided. Finally, this collection comes full circle back to the whole organism level and concludes with epidemiological methods to investigate virus-host interactions and the induction of innate immunity. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Innate Antiviral Immunity: Methods and Protocols spans a diverse array of approaches to study and elucidate the intricacies of this vital area of study. The chapter 'Morphological Separation of Clustered Nuclei in Histological Images' is published open access under a CC BY 4.0 license at link.springer.com.

Antiviral RNAi

Author : Ronald P. van Rij
Publisher : Humana Press
ISBN 13 : 9781493958252
Total Pages : 425 pages
Book Rating : 4.9/5 (582 download)

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Book Synopsis Antiviral RNAi by : Ronald P. van Rij

Download or read book Antiviral RNAi written by Ronald P. van Rij and published by Humana Press. This book was released on 2016-08-23 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses and RNAi share an intricate relationship at many levels. RNAi is an important antiviral defense mechanism in plants and invertebrates, microRNAs – of viral or cellular origin – affect many aspects of virus biology, and replication of many, if not all, mammalian viruses can be suppressed by RNAi. Antiviral RNAi: Concepts, Methods, and Applications provides a collection of protocols for the analysis of viral small RNAs and natural antiviral RNAi responses as well as for the development and optimization of RNAi-based antiviral drugs. As RNAi is a central regulatory mechanism in the cell, the methods in this volume can also be applied out of the context of a virus infection. Divided into five convenient parts, this detailed volume reviews important basic concepts in the field of antiviral RNAi, provides experimental and bio-informatic tools for the analysis of small silencing RNAs, covers methods to biochemically dissect RNAi-based antiviral defense and viral counter-defense mechanisms, describes methods for the design, expression, and delivery of therapeutic antiviral siRNAs, and finally presents genome-wide RNAi approaches for the identification of factors involved in virus replication. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Antiviral RNAi: Concepts, Methods, and Applications serves as an ideal guide for both novice and experienced researchers alike striving to dissect the role of RNAi in the viral life cycle or to further boost the development of novel therapeutics and experimental tools based on RNAi technology.

Herpes Simplex Virus

Author : Russell J. Diefenbach
Publisher :
ISBN 13 : 9781493998142
Total Pages : 457 pages
Book Rating : 4.9/5 (981 download)

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Book Synopsis Herpes Simplex Virus by : Russell J. Diefenbach

Download or read book Herpes Simplex Virus written by Russell J. Diefenbach and published by . This book was released on 2019 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with a discussion of new and updated methods used to study the Herpes Simplex Virus (HSV), along with a look at the latest developing technologies such as next generation sequencing, CRISPR/Cas9 engineering, and the use of BioID to identify protein-protein interactions. Chapters cover topics such as the biology, life cycle, and current state of antiviral and vaccine development for HSV-1; protocols on growing viruses in cell culture and manipulating viral DNA; design and application of HSV-1 vectors for cancer- and gene-therapy; and structural analyses, microscopy, proteomics, and testing of antivirals. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Herpes Simplex Virus: Methods and Protocols, Second Edition is a valuable resource for immunologists, and molecular and cell biologists. This book will also be useful for researchers who wish to initiate molecular and/or cellular-based approaches to study HSV. .

Antiviral Resistance in Plants

Author : Kappei Kobayashi
Publisher : Humana
ISBN 13 : 9781493996346
Total Pages : 0 pages
Book Rating : 4.9/5 (963 download)

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Book Synopsis Antiviral Resistance in Plants by : Kappei Kobayashi

Download or read book Antiviral Resistance in Plants written by Kappei Kobayashi and published by Humana. This book was released on 2019-06-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book explores strategies that have been developed to combat plant virus infection. Beginning with a section on techniques for identifying and studying the virus resistance gene involved in plant innate immunity, the volume continues by delving into techniques related to novel mechanisms of plant virus resistance, methods for the analysis and practical use of RNA silencing, as well as methods for the development of plant viral vaccines. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antiviral Resistance in Plants: Methods and Protocols serves as an ideal guide for researchers working to combat the serious threats plant virus diseases represent for agricultural production and beyond.

Dengue

Author : Radhakrishnan Padmanabhan
Publisher : Humana
ISBN 13 : 9781493943715
Total Pages : 0 pages
Book Rating : 4.9/5 (437 download)

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Book Synopsis Dengue by : Radhakrishnan Padmanabhan

Download or read book Dengue written by Radhakrishnan Padmanabhan and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infection by flaviviruses such as dengue virus serotypes (DENV 1-4), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBE), yellow fever virus (YFV) and West Nile virus (WNV) impact millions of lives and cause tens of thousands of mortalities each year. Dengue is a global public health emergency especially since there is no preventative vaccine or antiviral treatment for dengue disease. Dengue: Methods and Protocols offers the increasing number of dengue researchers a one-stop protocol book with techniques compiled from the leading laboratories working on dengue. Chapters cover topics such as dengue virus isolation from clinical samples, quantification of human antibodies against the virus, assays to quantify the virus particles, the widely used mouse model to study dengue pathogenesis, vaccine and antiviral efficacies. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Dengue: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies on dengue research.

Influenza Virus

Author : Yoshihiro Kawaoka
Publisher : Humana Press
ISBN 13 : 9781617796203
Total Pages : 234 pages
Book Rating : 4.7/5 (962 download)

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Book Synopsis Influenza Virus by : Yoshihiro Kawaoka

Download or read book Influenza Virus written by Yoshihiro Kawaoka and published by Humana Press. This book was released on 2012-04-07 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reports of influenza-like illnesses date back to the Middle Ages, and outbreaks of influenza likely afflicted humans long before that. Over the last half century, influenza virus research has led to the development of two classes of antivirals – ion channel and neuraminidase inhibitors. Recently, a method of the artificial generation of an influenza virus was established. This system has been instrumental in the development of novel influenza vaccines and in the understanding of viral pathogenicity and the functions of viral proteins. Influenza Virus: Methods and Protocols summarizes the current techniques that have made this progress possible, ranging from protocols for virus isolation, growth, and subtyping to procedures for the efficient generation of any influenza virus. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Influenza Virus: Methods and Protocols seeks to serve both professionals and novices with the techniques used in numerous laboratories around the world that are, thus, the building blocks that underpin almost all influenza virus research.

Human Herpesviruses

Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Ebolaviruses

Author : Thomas Hoenen
Publisher :
ISBN 13 : 9781493971169
Total Pages : 397 pages
Book Rating : 4.9/5 (711 download)

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Book Synopsis Ebolaviruses by : Thomas Hoenen

Download or read book Ebolaviruses written by Thomas Hoenen and published by . This book was released on 2017 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This vital book collects key methods that have supported advancements in the field of ebolavirus molecular biology given the pressing need for the advancement of techniques for diagnostics, the development of vaccines and antivirals, and for furthering our understanding of ebolavirus biology. After an introduction, the volume delves into protocols for studying ebolavirus molecular biology under biosafety level 2 conditions, studying infectious ebolaviruses under biosafety level 4 conditions in vitro as well as in vivo, and working with ebolaviruses in the field.

Hepatitis B Virus

Author : Haitao Guo
Publisher : Springer Nature
ISBN 13 : 1071640275
Total Pages : 278 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Hepatitis B Virus by : Haitao Guo

Download or read book Hepatitis B Virus written by Haitao Guo and published by Springer Nature. This book was released on with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Influenza Virus

Author : Yohei Yamauchi
Publisher : Humana
ISBN 13 : 9781493993635
Total Pages : 663 pages
Book Rating : 4.9/5 (936 download)

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Book Synopsis Influenza Virus by : Yohei Yamauchi

Download or read book Influenza Virus written by Yohei Yamauchi and published by Humana. This book was released on 2019-09-11 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides researchers with widely used techniques for the study of virology, focusing on molecular biology and imaging to encourage mechanistic investigation of virus-host interactions. Chapters detail a broad range of methods from diagnosis, virus propagation, proteomics, haploid screening, lentiviral screening, virus entry, single molecule RNA imaging, correlative light and electron microscopy (CLEM), EM, light-sheet microscopy, biochemistry, viral transcription, physiological infection models, animal models, in vivo imaging, antigenic evolution, immunology to mathematical modelling. Reviews cover general influenza, clinical trials, both sides of the gain-of-function debate, and computational modelling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Influenza Virus: Methods and Protocols aims to motivate experienced researchers and newcomers in the field and improve our overall understanding of influenza.

Reverse Genetics of RNA Viruses

Author : Daniel R. Pérez
Publisher : Springer Nature
ISBN 13 : 1071635336
Total Pages : 274 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Reverse Genetics of RNA Viruses by : Daniel R. Pérez

Download or read book Reverse Genetics of RNA Viruses written by Daniel R. Pérez and published by Springer Nature. This book was released on 2023-12-08 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with new and updated chapters that highlight the latest methods and approaches for the manipulation of RNA viruses. The chapters in this book explore the fundamental role in studying RNA viruses; identifying markers of host range, disease, and transmission; and aid readers with the further development of in silico computational biology tools and artificial intelligence algorithms that can help predict the emergence of certain pathogens. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Reverse Genetics of RNA Viruses: Methods and Protocols, Second Edition is a valuable resource for researchers who are interested in learning more about this developing field.

Viruses as Therapeutics

Author : Alexandra Lucas
Publisher :
ISBN 13 : 9781071610121
Total Pages : pages
Book Rating : 4.6/5 (11 download)

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Book Synopsis Viruses as Therapeutics by : Alexandra Lucas

Download or read book Viruses as Therapeutics written by Alexandra Lucas and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores methods and techniques reflecting how viruses can be a beneficial force for all levels of life as well as the mammalian microbiota. Beginning with methods for the development and study of viruses, the book continues with current techniques and approaches used to develop new treatments from virus-derived vaccines to vectors and proteins, such as a range of models and methods designed to measure therapeutic efficacy of virus-derived biologics and therapeutic proteins. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Viruses as Therapeutics: Methods and Protocols is an ideal guide for researchers working to further understand how viruses can benefit lifeforms and even prevent damage from other viruses.

Coronaviruses

Author : Helena J. Maier
Publisher : Humana
ISBN 13 : 9781071608999
Total Pages : 0 pages
Book Rating : 4.6/5 (89 download)

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Book Synopsis Coronaviruses by : Helena J. Maier

Download or read book Coronaviruses written by Helena J. Maier and published by Humana. This book was released on 2020-08-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed new edition provides a comprehensive collection of protocols applicable to all members of the Coronavirinae sub-family currently and that are also transferrable to other fields of virology. Beginning with a section on detection, discovery, and evolution, the volume continues with coverage of propagation and titration of coronaviruses, genome manipulation, study of virus-host interactions, as well as imaging coronavirus infections. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Coronaviruses: Methods and Protocols, Second Edition serves as a valuable guide to researchers working to identify and control viruses with increased potential to cross the species barrier and to develop the diagnostics, vaccines, and antiviral therapeutics that are required to manage future outbreaks in both humans and animals.

Practical Guidelines in Antiviral Therapy

Author : Charles A. B. Boucher
Publisher : Elsevier Science Limited
ISBN 13 : 9780444508843
Total Pages : 344 pages
Book Rating : 4.5/5 (88 download)

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Book Synopsis Practical Guidelines in Antiviral Therapy by : Charles A. B. Boucher

Download or read book Practical Guidelines in Antiviral Therapy written by Charles A. B. Boucher and published by Elsevier Science Limited. This book was released on 2002-01 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text was developed with the practicing physician in mind, however, it will be of considerable interest to the virologist, pharmacologist, chemist and all scientists interested in antiviral agents. Progress in the field of antiviral development is now moving rapidly and there is hope that one day there will be successful treatment modalities for most viral diseases. This work contains contributions from experts around the world, capturing worldwide practices. An online version providing the current status of antiviral research is planned for the near future.