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Author : Maria Luisa Mangoni
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (14 download)
Download or read book Antimicrobial Peptides from Amphibian Skin and Their Role Innate Immunity written by Maria Luisa Mangoni and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pieter S. Hiemstra
Publisher : Springer Science & Business Media
ISBN 13 : 3034805411
Total Pages : 389 pages
Book Rating : 4.0/5 (348 download)
Download or read book Antimicrobial Peptides and Innate Immunity written by Pieter S. Hiemstra and published by Springer Science & Business Media. This book was released on 2013-02-01 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic. The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair. Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.
Author : K. Ajesh
Publisher : Academic Press
ISBN 13 : 0323903207
Total Pages : 347 pages
Book Rating : 4.3/5 (239 download)
Download or read book Antimicrobial Peptides written by K. Ajesh and published by Academic Press. This book was released on 2022-11-23 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides. Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development. - Emphasizes antimicrobial peptides targeting various human viruses and multidrug resistant bacteria - Written by internationally recognized experts who provide readers with a wide and useful perspective - Provides in-depth resources for undertaking a research work in antimicrobial peptides with the inclusion of chapters on purification techniques and structural details - Addresses the possibility and availability of peptide antibiotics in the global drug market - Serves as a complete resource from the discovery to drug development of peptide antibiotics
Author : Mark W. Robinson
Publisher : Frontiers E-books
ISBN 13 : 2889190773
Total Pages : 63 pages
Book Rating : 4.8/5 (891 download)
Download or read book Antimicrobial Peptides: Utility Players in Innate Immunity written by Mark W. Robinson and published by Frontiers E-books. This book was released on with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial peptides (AMPs) represent an ancient group of molecules with diverse functions in innate immunity. To date, more than 1000 naturally-occurring AMPs have been identified which display considerable diversity in their primary sequences, lengths, structures and biological activities. Despite this variability, AMPs are broadly classified according to homologous secondary structures as cathelicidins (linear a-helical peptides), defensins (ß-strand peptides connected by disulfide bonds) and bactenecins (loop peptides). Most, but not all, AMPs are cationic with amphipathic faces. These biochemical properties bestow many peptides with potent antimicrobial activity by facilitating interactions with negatively charged microbial cell membrane components, thereby increasing membrane permeability and resulting in microbial death. Other indirect effects on microbial physiology have been reported including inhibition of DNA/RNA synthesis, impaired protein synthesis and folding, disruption of cell wall formation and inhibition of microbial cell metabolism. Thus, with the spread of antibiotic-resistant microbial pathogens, AMPs have emerged as exciting candidates for next generation anti-infective therapies. However, recent studies suggest that AMPs have evolved other mechanisms of pathogen clearance. Immunomodulation is a novel approach to antimicrobial therapy that centres on boosting host immunity rather than direct microbial killing. This is also an attractive means to treat sepsis and other immune-mediated diseases. Whilst several cationic peptides are under investigation as antimicrobial agents, a select few show a remarkable ability to protect against lethal endotoxaemia and clinically-relevant bacterial infections including methicillin-resistant Staphylococcus aureus (MRSA). The molecular mechanisms responsible for this protection are only beginning to emerge but include prevention of innate cell activation by targeting key stages of bacterial endotoxin-mediated cell signalling. In this research topic, hosted by Frontiers in Molecular Innate Immunity, we aim to highlight key areas of AMP research including peptide diversity, structure-function relationships, antimicrobial activity and mechanisms of immune-modulation. We also aim to stimulate discussion on the emerging therapeutic potential of AMPs including antifungal, antiviral and anticancer applications.
Author : Jürgen Harder
Publisher : Springer
ISBN 13 : 3319241990
Total Pages : 161 pages
Book Rating : 4.3/5 (192 download)
Download or read book Antimicrobial Peptides written by Jürgen Harder and published by Springer. This book was released on 2015-12-24 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the importance of human antimicrobial peptides (AMP) in keeping the host healthy and preventing infectious diseases. The first chapters deal with several examples of the role of AMP in different epithelial organs (skin and wound healing, eye, lung, genito-urinary tract, gut), which are exposed to different kinds of infectious microorganisms and as a result produce different patterns of AMP. Examples of the dysregulation of AMP expression and function promoting infections are discussed. The capacity of AMP to restrict the availability of essential metals to bacteria as an efficient antibacterial strategy in nutritional immunity is discussed in the next chapter. Our current understanding of how vitamin D, the sunshine vitamin, influences AMP-expression and how this can affect our health is also addressed. Last but not least, the role of AMP in HIV infection and the immunomodulatory properties of AMP highlight the diverse facets of AMP in host immunity. AMP’s specific functions, including in fighting multi-resistant bacteria, suggest that they may offer therapeutic benefits – a question that is discussed in the final chapter.
Author : William E. Duellman
Publisher : JHU Press
ISBN 13 : 9780801847806
Total Pages : 702 pages
Book Rating : 4.8/5 (478 download)
Download or read book Biology of Amphibians written by William E. Duellman and published by JHU Press. This book was released on 1994-02 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now reissued in paperback with an updated preface by the authors, Biology of Amphibians remains the standard work in its field.
Author : David A. Phoenix
Publisher : John Wiley & Sons
ISBN 13 : 9783527332632
Total Pages : 0 pages
Book Rating : 4.3/5 (326 download)
Download or read book Antimicrobial Peptides written by David A. Phoenix and published by John Wiley & Sons. This book was released on 2013-04-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers. The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application. They do this by discussing their design principles, target membranes and structure-activity relationships. The final part of the book describes recent successes in the application of peptides as anticancer agents.
Author : Joan Marsh
Publisher : John Wiley & Sons
ISBN 13 : 0470514663
Total Pages : 292 pages
Book Rating : 4.4/5 (75 download)
Download or read book Antimicrobial Peptides written by Joan Marsh and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the structure and function of important peptides from several different organisms. An exciting development is the use of these peptides or their analogues in the treatment and prevention of infectious diseases. Considers ways in which these peptides may be used to control the insect vectors of key pathogens including the malarial parasite. Discusses the role of antimicrobial peptides in the mammalian immune system and their interaction with other components of that system.
Author : Myung-Dae Seong
Publisher : Nova Science Publishers
ISBN 13 : 9781622578436
Total Pages : 0 pages
Book Rating : 4.5/5 (784 download)
Download or read book Antimicrobial Peptides written by Myung-Dae Seong and published by Nova Science Publishers. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial peptides (AMPs) are small peptides which exhibit broad-spectrum antimicrobial activity and often activity against virus. In addition, AMPs exert several functions including endotoxin neutralization, chemotactic and immunomodulating activities, angiogenesis, and wound repair. In this book, the authors discuss the innate immune system and lipopolysaccharides; the biological role of fish antimicrobial peptides; casein-derived peptides; antimicrobial peptides in intestinal inflammation and infection; insect antimicrobial peptides in immunity and mechanisms of action; potential of AMPs as therapeutic tools against infectious disease; and how LC-MS/MS-based quantitative protein profiling can aid mechanistic studies of antimicrobial peptides.
Author : Katsumi Matsuzaki
Publisher : Springer
ISBN 13 : 9811335885
Total Pages : 304 pages
Book Rating : 4.8/5 (113 download)
Download or read book Antimicrobial Peptides written by Katsumi Matsuzaki and published by Springer. This book was released on 2019-04-12 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.
Author :
Publisher :
ISBN 13 :
Total Pages : 33 pages
Book Rating : 4.:/5 (754 download)
Download or read book The Synergistic Interaction of Rana Muscosa Antimicrobial Peptides and the Bacterially-produced Metabolite 2,4-diacetylphloroglucinol on the Mortality of the Zoospores of a Lethal Amphibian Fungal Pathogen written by and published by . This book was released on 2011 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: The amphibian disease chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), is responsible for the decline or extinction of over 350 species. Amphibians can combat the disease with antimicrobial peptides (AMP) produced through their innate immune system and with the metabolites secreted by beneficial bacteria. Previous research has shown that bacterial species with anti-Bd properties exist within the suite of microbiota living on amphibian skin. The goal of this study was to determine if an interaction on the mortality of Bd zoospores exists between the anti-microbial peptides of the frog species Rana muscosa and 2,4-diacetylphloroglucinol, a metabolite produced by the bacterium Pseudomonas fluorescens. This bacterial species commonly occurs on the skins of R. muscosa. Results indicate that the minimum inhibitory concentration (MIC) of the chemicals when together was far less than the MIC of the chemicals when they were separate. A synergistic relationship was found to exist between these two chemicals, which provided evidence in support of a mutualistic relationship between the frog species and a member of their skin microbiota. In this relationship, the bacterial species gains resources and habitat on the frogs' skins, while the frog species can allocate less energy to the innate immune system and still be protected from a lethal fungus. My results also suggest that a probiotic strategy of adding P. fluorescens to the skins of at-risk frogs will be successful due to the synergistic effects of the bacterial metabolite and the frogs' AMPs.
Author : Andrea Giuliani
Publisher : Humana
ISBN 13 : 9781493961283
Total Pages : 424 pages
Book Rating : 4.9/5 (612 download)
Download or read book Antimicrobial Peptides written by Andrea Giuliani and published by Humana. This book was released on 2016-08-23 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The action of antimicrobial peptides (AMPs), ranging from direct killing of invading pathogens to immune response modulation and other complex biological responses, has stimulated research and clinical interest for more than two decades, but the area is still burgeoning due to emerging discoveries in the functions, roles, and regulation of AMPs, thus making the study of antimicrobial peptides a multi-disciplinary and rapidly evolving field. In Antimicrobial Peptides: Methods and Protocols, leading investigators present a broad, up-to-date collection of current research and experimental methods for the isolation, characterization, production, and optimization of antimicrobial peptides. Additional chapters detail methodologies in several microscopy techniques, high-throughput screening, QSAR modeling, and computer-aided design used to study these compounds, while key review articles survey potential medical applications of antimicrobial peptides as innovative anti-infective and immunomodulatory agents, as well as emerging discoveries in their function, regulation, and roles in innate immunity. As a volume in the highly successful Methods in Molecular BiologyTM series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and wide-ranging in its applications, Antimicrobial Peptides: Methods and Protocols provides both an authoritative guide for lab work on AMPs or related substances and a useful collection of thought stimuli to inspire further scientific endeavours in a wide array of vital fields.
Author : Michael Zasloff
Publisher : Wiley-Interscience
ISBN 13 : 9780470227237
Total Pages : 300 pages
Book Rating : 4.2/5 (272 download)
Download or read book Antimicrobial Peptides written by Michael Zasloff and published by Wiley-Interscience. This book was released on 2013-03-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a pioneer in the field of antimicrobial peptides, who has been involved in discovery, drug development, and the study of the role played by AMPs in human health and disease, Antimicrobial Peptides is the first comprehensive overview of the field of innate immunity. Exploring this "hard wired" system of host defense that has emerged over the past decade as an important system in health and disease, author Michael Zasloff explains why AMPs are of such interest, what has been accomplished commercially to date, the problems, potential solutions, and what the future holds.
Author : Matthew J. Gray
Publisher : Springer
ISBN 13 : 9783319137568
Total Pages : 246 pages
Book Rating : 4.1/5 (375 download)
Download or read book Ranaviruses written by Matthew J. Gray and published by Springer. This book was released on 2015-05-01 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book on ranaviruses. Ranaviruses are double-stranded DNA viruses that cause hemorrhagic disease in amphibians, reptiles, and fish. They have caused mass die-offs of ectothermic vertebrates in wild and captive populations around the globe. There is evidence that this pathogen is emerging and responsible for population declines in certain locations. Considering that amphibians and freshwater turtles are suitable hosts and the most imperiled vertebrate taxa in the world, ranaviruses can have significant impacts on biodiversity and ecosystem function. Additionally, many fish that are raised in aquaculture facilities and traded internationally are suitable hosts; thus, the potential economic impact of ranaviruses is significant. Ranaviruses also serve as a model for replication and gene function of large double-stranded DNA viruses. There is an urgent need to assemble the contemporary information on ranaviruses and provide guidance on how to assess their threats in populations. Through the Global Ranavirus Consortium, 24 experts from six countries were organize to write this volume, the first book on ranaviruses. The book begins with a discussion on the global extent of ranaviruses, case histories of infection and disease in ectothermic vertebrates, and current phylogeny. Basic principles of ranavirus ecology and evolution are covered next, with a focus on host-pathogen interactions and how the virus emerges in its environment. There are two chapters that will discuss the molecular biology of ranaviruses, host response to infection, and the genes responsible for immune system evasion. One chapter establishes standards for testing for infection and diagnosing ranaviral disease. The book ends by providing guidance on how to design ranavirus surveillance studies and analyze data to determine risk, and discussing the role of the Global Ranavirus Consortium in organizing research and outreach activities.
Author : Katherine L Krynak
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (93 download)
Download or read book Environmental Influences on Amphibian Innate Immune Defense Traits written by Katherine L Krynak and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease-associated mortality is a leading cause of amphibian declines world-wide; therefore, understanding the influence anthropogenic environmental change has on traits which provide disease resistance is important for successful amphibian conservation. Amphibians are protected from pathogens by two skin-associated immune defense traits: the microbial communities which inhabit their skin (microbiome) and the antimicrobial peptides (AMPs) produced by the skin. Utilizing experimental and observational studies, I investigated the relationships between the environment and amphibian skin-associated immune defense traits. I found that small pH shifts (i.e. from ~ 7 to 6) in the larval environment caused changes in Rana catesbeiana larval microbiome structure, an effect which disappeared after metamorphosis. Additionally, I found post-metamorphic AMP production and bioactivity were significantly affected by interactions between population, pH, and the presence or absence of shade in the larval environment. In an observational field survey I found that Acris blanchardi populations across Ohio and Michigan differed in microbiomes and AMP production, but not AMP bioactivity against Bd (Batrachochytrium dendrobatidis). Microbiomes were associated with water conductivity, ratio of natural to managed land, and latitude. Additionally the microbiomes were affected by interactions between frog sex and latitude, between frog sex and water surface area, and between the ratio of natural to managed land and water surface area. AMP production was influenced by the interaction between water surface12area and conductivity. Finally, I examined the influence of a glyphosate-based herbicide on A. blanchardi skin-associated immune defense traits across life stages and at differing, environmentally relevant concentrations. I found a 37% decrease in survival of larvae exposed to 2.5mg/L of active ingredient (glyphosate) compared to control, but no effects on juvenile survival. Larval herbicide concentration did alter the larval microbiome, but did not alter larval duration and did not carryover to alter post-metamorphic traits. Furthermore, herbicide concentration only marginally affected juvenile mass and the juvenile microbiome. I did not find evidence of effects of the host's AMPs affecting the skin microbiome in any of my studies, indicating that the environment external to the amphibian is relatively more influential on the amphibian skin-associated microbiome compared to this physiological trait of the host.
Author : Paresh Chandra Ray
Publisher : Nova Science Publishers
ISBN 13 : 9781685070052
Total Pages : 0 pages
Book Rating : 4.0/5 (7 download)
Download or read book Antimicrobial Peptides written by Paresh Chandra Ray and published by Nova Science Publishers. This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The increasing prevalence of antibiotic-resistant bacteria, known as superbugs, has threatened the field of infectious disease medicine over most of the past century. Antimicrobial peptides, a crucial part of innate immunity that exists in most living organisms, have become a central pillar for the next generation of medical challenges for infectious diseases, cancer, and other health problems. The development of new antimicrobial peptides to tackle ongoing superbug infections, cancer and other diseases is a fast-growing research area for chemistry, medical physics, biological science, food and agricultural science and different disciplines of medicine. This volume discusses the basic science behind potential pharmacological agents, which is necessary to understand how these peptides can be used in our daily lives. The book provides a foundation for a wide variety of antimicrobial peptide-based therapeutic approaches, which is invaluable for established scientists, junior researchers, and students involved in basic science, material science, the medical field and different disciplines of engineering. It contains nine chapters written by world leaders in this area, covering basic science and possible therapeutic applications with immense societal implications. Antimicrobial peptides are an exciting new therapeutic agent with promising applications for a wide variety of illnesses"--
Author : Whitney Marie Holden
Publisher :
ISBN 13 :
Total Pages : 159 pages
Book Rating : 4.:/5 (876 download)
Download or read book The Antifungal Arsenal in Amphibian Skin written by Whitney Marie Holden and published by . This book was released on 2014 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt:
