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Antigen And Clone Specific Immunoregulation
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Book Synopsis Antigen and Clone-specific Immunoregulation by : Richard L. Edelson
Download or read book Antigen and Clone-specific Immunoregulation written by Richard L. Edelson and published by . This book was released on 1991 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antigen and Clone-specific Immunoregulation by : Richard L. Edelson
Download or read book Antigen and Clone-specific Immunoregulation written by Richard L. Edelson and published by . This book was released on 1991 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Human T Cell Clones by : Marc Feldmann
Download or read book Human T Cell Clones written by Marc Feldmann and published by Springer Science & Business Media. This book was released on 1985-11-20 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most complex biological systems, such as enzyme pathways, are effec tively controlled near the beginning of the process. There is increasing evidence that the same is true for the immune system, with the initial interactions between antigen, antigen-presenting cells, and T cells hav ing a paramount influence on the ensuing events. Thus, analysis of the early stages of the immune responses has been a preoccupation of many immunologists. This has been considerably aided by the capac ity to expand these early events, and 'immortalize' them as clones of T cells, for detailed analysis. The discovery by Morgan, Ruscetti, and Gallo (Science 193, 1007, 1976) of T-cell growth factor (now termed interleukin-2 or IL-2) has had a major impact in immunology that is far from over. The greater ease of handling murine tissues experimentally, with the availability of more precisely defined reagents such as inbred strains, has meant that, to date, most of the work on long-term T-cell cultures has been per formed in the mouse, as summarized by Fathman and Fitch (eds. , Iso lation, Characterization and Utilization of T Lymphocyte Clones, Aca demic Press, NY, 1982). However, the limitations of working with human tissues are counterbalanced by the great long-term importance of understanding disorders of human immune regulation, especially since it is becoming evident that these are far from rare. Immune deficiencies such as agammaglobulinemia and T-cell deficiencies are not common, but immune hyperresponsiveness occurring in allergy and allergiC diseases (e. g.
Download or read book Immunoregulation written by Nicola Fabris and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunoregulation is one of the areas which has witnessed the most explosive advances of immunology during the past decade. It is in this area that the current view of the immune system has arisen and developed. There is indeed little doubt that immune reactions are primarily determined by messages which are genera ted within the immune system and passed among different types of immunologie cells. This cell communication not only determines the type, intensity and duration of the response after perturbation of the immune system by exogenous antigens, but it is also essential for preventing autoimmune reactions and their clinical conse quences. In order to assure aperfect balance within the enormous com plexity of the immune system, it is not surprising that multiple self-regulatory mechanisms are organized at different levels, such as antibody feedback, idiotypic-anti-idiotypic responses, suppres sor and helper T cells, lymphokine signals and genetic require ments. A nu mb er of observations in recent years have, however, demonstrated that consistent contributions to the immunological homeostasis are given also by signals generated outside of the immune system, namely,in the central and autonomous nervous system as weIl as in the endocrine apparatus. Furthermore, the interactions between the immune system and the other body homestatic mechanisms seem to be bidirectional: if immunological cells may be targets of neuroendocrinological factors, immunological products seem in turn to contribute to the neuro endocrine homeostasis.
Book Synopsis Strategies of Immune Regulation by : Eli Sercarz
Download or read book Strategies of Immune Regulation written by Eli Sercarz and published by Academic Press. This book was released on 2013-10-22 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies of Immune Regulation provides an overview of the state of knowledge on how immune regulation works. Many working scientists have taken the time to set down their views in one of two categories: (a) ""conventional"" short papers with standard documentation, (b) short expressions of opinion, with or without references. It is hoped that this book will act as a jumping-off point for new young workers, entering the field, who will ultimately fashion the next paradigm. The book contains 94 chapters organized into two sections. Section I begins with discussions of the general regulatory features of the immune systems. This is followed by papers on the role of the major histocompatibility complex and regulation involving the antibody molecules. The contributions in Section II cover the organization of Ig genes; antibody diversity and the development of the immune repertoire; MHC restriction; lymphocyte interactions and regulatory targets; role of the Ig receptor in triggering; function of IgD; lymphocyte maturation; idiotype regulation; and control of antiself reactions.
Book Synopsis Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin by : W.Clark Lambert
Download or read book Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin written by W.Clark Lambert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based upon a series of papers originally presented at a NATO Advanced Studies Workshop of the same title held at the study Center HI Cappuccini," a converted monastery in San Miniato, a small village located between Pisa and Florence, Italy, in October 1991. Authors were asked to submit their completed chapters by the following February; these were then scanned onto computer disks, edited and returned to the authors for final revision, and updating, with a final deadline of February 1993. The authors were encouraged to make whatever modifications they wanted, especially regarding updating their chapters, with an eye to making the final product both comprehensive and current. In this we succeeded beyond our expectations, with most chapters extensively altered and many completely re-written and significantly expanded. Thus, although the original meeting was held in 1991, the chapters in this volume may be regarded as current from at least February, 1993, with some of the final updated revisions received as late as July, 1993. This book, as agreed in our original contract, has been delivered to the publisher "camera-ready. " This means that all of the scanning, editing, proofing and typesetting were done here, by the office of the Department of Dermatology at the New Jersey Medical School. We essentially produced the book, which the publisher, for the most part, then photocopied. This has been an enormous burden, borne mainly by my colleague in this division, Robert A.
Book Synopsis Immunology and Evolution of Infectious Disease by : Steven A. Frank
Download or read book Immunology and Evolution of Infectious Disease written by Steven A. Frank and published by Princeton University Press. This book was released on 2002-07-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
Download or read book Kuby Immunology written by Jenni Punt and published by Macmillan Higher Education. This book was released on 2018-10-16 with total page 2997 pages. Available in PDF, EPUB and Kindle. Book excerpt: Janis Kuby’s groundbreaking introduction to immunology was the first textbook for the course actually written to be a textbook. Like no other text, it combined an experimental emphasis with extensive pedagogical features to help students grasp basic concepts. Now in a thoroughly updated new edition, Kuby Immunology remains the only undergraduate introduction to immunology written by teachers of the course. In the Kuby tradition, authors Jenni Punt, Sharon Stranford, Patricia Jones, and Judy Owen present the most current topics in an experimental context, conveying the excitement of scientific discovery, and highlight important advances, but do so with the focus on the big picture of the study of immune response, enhanced by unsurpassed pedagogical support for the first-time learner. Punt, Stranford, Jones, and Owen bring an enormous range of teaching and research experiences to the text, as well as a dedication to continue the experiment-based, pedagogical-driven approach of Janis Kuby. For this edition, they have worked chapter by chapter to streamline the coverage, to address topics that students have the most trouble grasping, and to continually remind students where the topic at hand fits in the study of immunology as a whole.
Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomedical Index to PHS-supported Research by :
Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1991 with total page 1104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Lymphocyte Activation and Immune Regulation III by : Sudhir Gupta
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation III written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in the understanding of the major events that shape the immune recog nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest.
Book Synopsis The Dictionary of Cell & Molecular Biology by : John M. Lackie
Download or read book The Dictionary of Cell & Molecular Biology written by John M. Lackie and published by Academic Press. This book was released on 2007-10-04 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: The over 10,000 entries in this comprehensive Dictionary of Cell and Molecular Biology provide clear and concise definitions for anyone working in life sciences today. It incorporates related terms from neuroscience, genetics, microbiology, immunology, pathology, and physiology. This fourth revised edition reflects the enormous changes brought about by the explosion of new technologies, especially high throughput approaches and functional genomics. As a result, this edition is over 30% larger than the previous edition, with 3400 new entries. As with the prior edition, additions are reflective of online search queries performed by users of the dictionary. The entries in this authoritative work have been widely praised for their clarity, brevity, and accuracy throughout. The Dictionary of Cell and Molecular Biology features numerous tables and other useful features. * Thoroughly revised and expanded by over 30% with 3400 new entries* Expanded coverage of areas greatly impacted by genomics* Includes new terms that relate to the recent elucidation of underlying mechanisms of cell cycle regulation, apoptosis, relationship between mitochondria and disease, metabolic control, and stem cell biology* Consistently provides the most complete short definitions of technical terminology for anyone working in life sciences today* Extensively cross-referenced* Provides multiple definitions, notes on word origins, and other useful features
Book Synopsis Mucosal Immunology by : Jiri Mestecky
Download or read book Mucosal Immunology written by Jiri Mestecky and published by Elsevier. This book was released on 2005-02-02 with total page 1995 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mucosal immunology is so important since most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes. Mucosal Immunology, now in its third edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective and excellent organization. The most comprehensive text on mucosal immunology from internationally recognized experts in the field Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases Contains nine new chapters and an expanded appendix
Book Synopsis Mechanisms of Lymphocyte Activation and Immune Regulation by : Sudhir Gupta
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.
Book Synopsis Paradoxes In Immunology by : Geoffrey W. Hoffman
Download or read book Paradoxes In Immunology written by Geoffrey W. Hoffman and published by CRC Press. This book was released on 2019-08-15 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1986: Paradoxes play a key role in the advancement of science. They are associated with excitement, and with the knowledge that we must be looking at something the wrong way. This book discusses in detail Paradoxes in Immunology.
Book Synopsis Immunoregulatory Role of Thymus by : Marek P. Dabrowski
Download or read book Immunoregulatory Role of Thymus written by Marek P. Dabrowski and published by CRC Press. This book was released on 2019-06-04 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1990. This important new text covers a wide area of thymology in both the theoretical and practical aspects. In view of current information, a crucial role of endocrine thymus is presented in the creation, maintenance, and senescence of neuro-endocrine-immune homeostasis. In particular, mechanisms are described (which are basically responsible for the T cell maturation and selection) for the hierarchic organization of the immune system and its thymic dependent immune competence in terms of tolerance and immunity. A detailed presentation of the structure and biological properties of a number of well-defined thymic hormones is included. Their clinical applications and results obtained in inherited or acquired immunodeficiencies and in neoplasmic diseases are also reviewed on the grounds of numerous representative clinical trials. A perspective and potential scope of immunorestorative therapy and prevention with thymic hormones and other thymomimetic drugs are outlined. Researchers, practitioners, and students will find this book to be a useful and essential source of information.