Antifungal Compounds Discovery

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Antifungal Compounds Discovery

Author : Marina Sokovic
Publisher : Elsevier
ISBN 13 : 0128158255
Total Pages : 298 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Antifungal Compounds Discovery by : Marina Sokovic

Download or read book Antifungal Compounds Discovery written by Marina Sokovic and published by Elsevier. This book was released on 2020-09-18 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compounds Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compounds Discovery is a comprehensive guide helping researchers understand the relationship between specific chemical structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds. Provides an overview of the most specific mycotic infections and fungal species as background for compound development Presents the chemical formulas of all natural and synthetic compounds reviewed Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information

Antifungal Drug Discovery: New Theories and New Therapies

Author : Chaminda Jayampath Seneviratne
Publisher : Frontiers Media SA
ISBN 13 : 2889199509
Total Pages : 138 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Antifungal Drug Discovery: New Theories and New Therapies by : Chaminda Jayampath Seneviratne

Download or read book Antifungal Drug Discovery: New Theories and New Therapies written by Chaminda Jayampath Seneviratne and published by Frontiers Media SA. This book was released on 2016-09-13 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Antifungal Compounds: Discovery, development, and uses

Author : Malcolm R. Siegel
Publisher :
ISBN 13 : 9780824765576
Total Pages : 1274 pages
Book Rating : 4.7/5 (655 download)

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Book Synopsis Antifungal Compounds: Discovery, development, and uses by : Malcolm R. Siegel

Download or read book Antifungal Compounds: Discovery, development, and uses written by Malcolm R. Siegel and published by . This book was released on 1977-01-01 with total page 1274 pages. Available in PDF, EPUB and Kindle. Book excerpt: V. 1- Discovery, developments, and uses; v. 2 - Interactions in biological and ecological systems.

New Approaches for Antifungal Drugs

Author : FERNANDES
Publisher : Springer Science & Business Media
ISBN 13 : 148996729X
Total Pages : 211 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis New Approaches for Antifungal Drugs by : FERNANDES

Download or read book New Approaches for Antifungal Drugs written by FERNANDES and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antifungal Agents

Author : G. K. Dixon
Publisher : Taylor & Francis
ISBN 13 :
Total Pages : 330 pages
Book Rating : 4.:/5 (321 download)

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Book Synopsis Antifungal Agents by : G. K. Dixon

Download or read book Antifungal Agents written by G. K. Dixon and published by Taylor & Francis. This book was released on 1995 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores how new molecular technologies are interfacing with chemistry and biology in the search for new fungicide targets.

Recent Trends in Antifungal Agents and Antifungal Therapy

Author : Amit Basak
Publisher : Springer
ISBN 13 : 8132227824
Total Pages : 254 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Recent Trends in Antifungal Agents and Antifungal Therapy by : Amit Basak

Download or read book Recent Trends in Antifungal Agents and Antifungal Therapy written by Amit Basak and published by Springer. This book was released on 2016-09-21 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal infections have taken a new spectrum due to the increased incidence of multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat fungal infections is also narrow because of lesser probability of discovering drugs that would bypass affecting human cells and target fungal cells producing fewer side effects in patients. An approach has gained prominence in research is to look for bioactive antifungal compounds from natural to synthetic sources. It is necessary to discover new classes of antifungals to control the recent emergence of multi-drug resistant fungal infections. This book proposed a details top to bottom outline of antifungal compounds derived naturally or synthetically. The details of their modifications or synthetic analogues have been described, helpful to understand the structure-activity relationship which leads to new compound development in antifungal chemotherapy. Each chapter begins with a comprehensive, top-bottom in-depth discussion of antifungal agents with updated bibliographic references. This compendium will serve as a companion not only for Scientists, Researchers, and Professors, Medical Practitioners but also a valuable reference text for the university students.

Fungi

Author : Sunil K. Deshmukh
Publisher : CRC Press
ISBN 13 : 1315360004
Total Pages : 553 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Fungi by : Sunil K. Deshmukh

Download or read book Fungi written by Sunil K. Deshmukh and published by CRC Press. This book was released on 2018-12-20 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with the application of fungi and the strategic management of some plant pathogens. It covers fungal bioactive metabolites, with emphasis on those secondary metabolites that are produced by various endophytes, their pharmaceutical and agricultural uses, regulation of the metabolites, mycotoxins, nutritional value of mushrooms, prospecting of thermophilic and wood-rotting fungi, and fungi as myconano factories. Strategies for the management of some plant pathogenic fungi of rice and soybean have also been dealt with. Updated information for all these aspects has been presented and discussed in different chapters.

Antifungal Drug Discovery: New Theories and New Therapies

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Antifungal Drug Discovery: New Theories and New Therapies by :

Download or read book Antifungal Drug Discovery: New Theories and New Therapies written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Antifungal Therapy

Author : Mahmoud Ghannoum
Publisher : CRC Press
ISBN 13 : 0849387868
Total Pages : 484 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Antifungal Therapy by : Mahmoud Ghannoum

Download or read book Antifungal Therapy written by Mahmoud Ghannoum and published by CRC Press. This book was released on 2016-04-19 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a c

Medicinal Plants

Author : Bassam Hassan
Publisher : BoD – Books on Demand
ISBN 13 : 1789858879
Total Pages : 194 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Medicinal Plants by : Bassam Hassan

Download or read book Medicinal Plants written by Bassam Hassan and published by BoD – Books on Demand. This book was released on 2020-03-25 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is focused on clarifying the anticancer effects (i.e., apoptotic, antiproliferative, antimetastatic, antiangiogenic) and mechanisms of most of the medicinal plants found in the world against solid and/or hematological cancers.

Anti-fungal Drug Discovery

Author : Bradley Mark Tebbets
Publisher :
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.:/5 (822 download)

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Book Synopsis Anti-fungal Drug Discovery by : Bradley Mark Tebbets

Download or read book Anti-fungal Drug Discovery written by Bradley Mark Tebbets and published by . This book was released on 2012 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Combating Fungal Infections

Author : Iqbal Ahmad
Publisher : Springer Science & Business Media
ISBN 13 : 364212173X
Total Pages : 549 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Combating Fungal Infections by : Iqbal Ahmad

Download or read book Combating Fungal Infections written by Iqbal Ahmad and published by Springer Science & Business Media. This book was released on 2010-08-03 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents

Author : Robert A. Fromtling
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents by : Robert A. Fromtling

Download or read book Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents written by Robert A. Fromtling and published by . This book was released on 1987 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Discovery, Identification, and Evaluation of Antifungal Compounds Produced by Pseudomonas Syringae

Author : Kevin N. Sorensen
Publisher :
ISBN 13 :
Total Pages : 238 pages
Book Rating : 4.:/5 (439 download)

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Book Synopsis Discovery, Identification, and Evaluation of Antifungal Compounds Produced by Pseudomonas Syringae by : Kevin N. Sorensen

Download or read book Discovery, Identification, and Evaluation of Antifungal Compounds Produced by Pseudomonas Syringae written by Kevin N. Sorensen and published by . This book was released on 1997 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:

New Approaches for Antifungal Drugs

Author : Prabhavathi B. Fernandes
Publisher : Birkhauser
ISBN 13 : 9783764336028
Total Pages : 201 pages
Book Rating : 4.3/5 (36 download)

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Book Synopsis New Approaches for Antifungal Drugs by : Prabhavathi B. Fernandes

Download or read book New Approaches for Antifungal Drugs written by Prabhavathi B. Fernandes and published by Birkhauser. This book was released on 1992-01-01 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews research on the chemotherapy of fungal diseases, which has progressed at a much slower rate than that against bacterial diseases. Emphasizes the search during the past decade for selective targets of therapeutic agents, selection being the main difficulty because of the eukaryotic nature of fungi. In addition to several novel drugs, considers structures, processes, and proteins as potential targets; and new approaches such as antifungal agents from plants, and genetic methods of drug discovery. Annotation copyrighted by Book News, Inc., Portland, OR

Emerging Targets in Antibacterial and Antifungal Chemotherapy

Author : Joyce Sutcliffe
Publisher : Springer Science & Business Media
ISBN 13 : 1461532744
Total Pages : 619 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Emerging Targets in Antibacterial and Antifungal Chemotherapy by : Joyce Sutcliffe

Download or read book Emerging Targets in Antibacterial and Antifungal Chemotherapy written by Joyce Sutcliffe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Targets in Antibacterial and Antifungal Chemotherapy offers constructive ideas to researchers that could lead to the discovery of entirely new classes of drugs. The authors emphasize new topics rather than review work on known antibacterials and antifungals, and identify new targets--either the rate-limiting component of a biochemical pathway or a component of the pathway that is susceptible to a ``screening'' or ``rational drug design'' approach. Each chapter reviews the biochemical pathway and its place in the cellular scheme in order to place the target in perspective. The authors, a mixture of academic researchers and drug-discovery investigators in pharmaceutical companies, also extend these theoretical concerns into practical applications and suggest useful screening methodologies. The importance of this subject area is demonstrated by the increasing number of papers in the literature that point to potential targets and screening methodologies for new antibacterials. This book also deals with antifungals, investigating the inherent limitations in existing antifungals (many of which are extremely toxic or have only limited efficacy), and pointing to major developments in the discovery of novel antifungals. Emerging Targets in Antibacterial and Antifungal Chemotherapy will be of interest to professional microbiologists, biochemists, and cell biologists in both academic and industrial laboratories.

Plant Bioactives and Drug Discovery

Author : Valdir Cechinel-Filho
Publisher : John Wiley & Sons
ISBN 13 : 1118259920
Total Pages : 600 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Plant Bioactives and Drug Discovery by : Valdir Cechinel-Filho

Download or read book Plant Bioactives and Drug Discovery written by Valdir Cechinel-Filho and published by John Wiley & Sons. This book was released on 2012-04-11 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.