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Author : Andrew John Skildum
Publisher :
ISBN 13 :
Total Pages : 302 pages
Book Rating : 4.3/5 (129 download)
Download or read book Antiestrogen Resistance and G1 Phase Cdk Regulation in Human Breast Cancer Cells written by Andrew John Skildum and published by . This book was released on 2002 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Manzoor Mir
Publisher : Springer Nature
ISBN 13 : 9811989117
Total Pages : 379 pages
Book Rating : 4.8/5 (119 download)
Download or read book Therapeutic potential of Cell Cycle Kinases in Breast Cancer written by Manzoor Mir and published by Springer Nature. This book was released on 2023-03-03 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)
Download or read book Resistance to Tamoxifen: A Consequence of Altered P27Kipl Regulation During Breast Cancer Progression written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This grant addresses the molecular mechanisms of resistance to the anti-estrogen, Tamoxifen, in breast cancers. Both estrogens and antiestrogens influence the cell cycle during the GI phase. In breast tumors, loss of the cdk inhibitor, p27, is associated with a poor prognosis and with steroid resistance. We postulate that altered p27 degradation in breast cancer may contribute to resistance to antiestrogen therapy. In the last year, we have assayed cell cycle effects of estradiol in the ER+ breast cancer cell line, MCF-7. MCF-7 arrests in G1 upon removal of estradiol or on addition of Tamoxifen. Upon re-addition of estradiol, cells re-enter the cell cycle with onset of S phase by 12 hours and loss of both p21 and p27 proteins. Cyclin D1 associated kinase activity rose transiently in early G1. Activation of cyclin E/cdk2 kinase in mid-late G1 was accompanied by loss of cyclin E-associated p21 and p27. The requirement for p27 in the quiescence induced by estradiol depletion was investigated using antisense p27 oligonucleotides. Introduction of the antisense oligonucleotides into quiescent estradiol depleted MCF-7 cells reduced p27 levels five fold. Despite the continued absence of estradiol, the p27 antisense treated group entered into S phase, with an S phase fraction of 28 % at 34 hours post-transfection, while control cells remained arrested. Thus, the loss of p27 was sufficient to mimic the effect of estradiol on G1-to-S phase progression in MCF-7 cells. These data suggest that loss of p27 is critical for estradiol dependant stimulation of breast cancer proliferation and an increase in p27 is essential for cell cycle arrest following an inhibition of estradiol signaling. Ongoing studies address how these effects are altered in steroid resistant breast cancer.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)
Download or read book Resistance to Tamoxifen: A Consequence of Altered P27Kipl Regulation During Breast Cancer written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: While approximately 70% of breast cancers express the estrogen receptor (ER) at diagnosis, only two thirds of these will respond to antiestrogens such as Tamoxifen (TAM). Unfortunately, ER positive tumors that are initially responsive, invariably acquire resistance to hormonal therapies (reviewed in (1)).: TAM-resistant tumors usually show continued expression of the ER (2, 3). Estradiol regulates cell proliferation and development in the mammary gland. The elucidation of mechanisms whereby estradiol:ER influences cell cycle regulators and how these are blocked by Tamoxifen is highly relevant to the development of new treatments for steroid resistant breast cancer. Both estrogens and antiestrogens influence the cell cycle during the early Ol phase (4). The cell cycle is governed by a family of cyclin dependent kinases (cdks), whose activity is regulated by positive effectors, the cyclins, by phosphorylation and by negative regulators, the cdk inhibitors (reviewed in (5-7)). p27 or kinase inhibitor protein 1 (KIP 1) is strongly expressed in normal mammary epfthelial cells (8). That p27 protein levels are frequently reduced in primary breast cancers and this correlates with poor prognosis, suggests that p27 is an important negative regulator of the normal breast cell cycle (8-10) . The cellular abundance of p27 is importantly regulated by ubiquitin-mediated proteolysis (11). p27 protein decreases when quiescent MCF-7 breast cancer cells are stimulated to reenter the cell cycle with estradiol treatment and p27 increases when antiestrogens induce Gi arrest ((12, 13) and PNAS manuscript appended).
Author : Shyam Narayan Sundar
Publisher :
ISBN 13 :
Total Pages : 438 pages
Book Rating : 4.:/5 (35 download)
Download or read book Phytochemical Regulation of Estrogen Responsiveness and Proliferation of Human Breast Cancer Cells written by Shyam Narayan Sundar and published by . This book was released on 2006 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Carolyn Merrill Cover
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 (34 download)
Download or read book Indole-3-carbinol Regulation of Breast Cancer Cell Growth written by Carolyn Merrill Cover and published by . This book was released on 1998 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stephen Hiscox
Publisher : Springer Science & Business Media
ISBN 13 : 1402085265
Total Pages : 202 pages
Book Rating : 4.4/5 (2 download)
Download or read book Therapeutic Resistance to Anti-hormonal Drugs in Breast Cancer written by Stephen Hiscox and published by Springer Science & Business Media. This book was released on 2009-01-11 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the main causes of failure in the treatment of breast cancer is the intrinsic presence of, or development of, drug resistance by the cancer cells. Recent studies on the mechanisms of cancer drug resistance have yielded important information highlighting both how tumour cells may escape these therapeutic constraints and that drug resistance may further impinge on tumour cell functions that may ultimately promote an adverse cell phenotype. New targets have been identified with potential therapeutic applications in resistant breast cancer leading to the subsequent evaluation of inhibitors of these targets in preclinical studies. Importantly, there is increasing evidence from such studies demonstrating the benefit of novel combination strategies as potential avenues for future drug regimens. Written by experts in the subject area, this book covers the molecular details and functional consequences of endocrine resistance in breast cancer with particular emphasis on the future applications of novel drug combinations that may be utilized to circumvent resistance and improve anti-tumour effects. This book represents a timely publication in the field of breast cancer research, providing current knowledge in the area of drug resistance and will be important reading material for clinicians and researchers alike.
Author : Dil Afroze
Publisher : BoD – Books on Demand
ISBN 13 : 1789239613
Total Pages : 127 pages
Book Rating : 4.7/5 (892 download)
Download or read book Breast Cancer Biology written by Dil Afroze and published by BoD – Books on Demand. This book was released on 2020-07-08 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive overview of recent developments in the field of breast cancer biology. It is a complete and descriptive reference on motioning pathways and new treatment options for the future transnational scientists and clinicians working on cancer research and treatment. We greatly appreciate the work of all the contributors to this book. They have brought with them tremendous diversity of perspectives and fields, which is truly reflective of the complexity of the topic, and they have come together in this project to serve as the node of multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information to significantly progress knowledge in the field in recent years.
Author : Hanh Hong Garcia
Publisher :
ISBN 13 :
Total Pages : 396 pages
Book Rating : 4.:/5 (34 download)
Download or read book Indole Regulation of Cell Cycle in Human Breast Cancer Cells written by Hanh Hong Garcia and published by . This book was released on 2004 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Marc E. Lippman
Publisher : Springer
ISBN 13 :
Total Pages : 476 pages
Book Rating : 4.3/5 (91 download)
Download or read book Regulatory Mechanisms in Breast Cancer written by Marc E. Lippman and published by Springer. This book was released on 1991-01-31 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.
Author : Malathy Shanmugam
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 (555 download)
Download or read book Regulation of the Protein Kinase C Delta Isoform by Estrogen in the MCF-7 Human Breast Cancer Cell Line and a Role for Protein Kinase C Delta in Growth Regulation written by Malathy Shanmugam and published by . This book was released on 1997 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Previous evidence in our laboratory demonstrated the ability of estrogen to regulate specifically the protein kinase C (PKC) $\delta$ isoform in the rat and rabbit corpus luteum. The purpose of this study was to evaluate estrogen's ability to regulate PKC, specifically the PKC $\delta$ isoform, in the estrogen responsive, MCF-7 human breast cancer cell line. With the increasingly characterized role of PKC $\delta$ in growth regulation, we were interested to also determine the ability of PKC $\delta$ to regulate growth in the MCF-7 cell line. Treatment of MCF-7 cells with 10$\sp{-10}$ through 10$\sp{-8}$ M estrogen for 7 days down-regulated specifically PKC $\delta$ mRNA and protein; expression of other PKC isoforms was unchanged. These concentrations of estrogen were maximally proliferative for the MCF-7 cells and an inverse correlation between PKC $\delta$ expression and proliferation in MCF-7 cells was observed. PKC $\delta$ protein levels were found to be 10 fold higher in MCF-7 compared to the estrogen receptor-negative, MDA-MB 231 cells which grow aggressively in the absence of estrogen. In view of the inverse correlation between PKC $\delta$ expression and proliferation in MCF-7 cells we wished to determine whether activation of PKC $\delta$ could signal growth inhibition. Phorbol ester treatments that lead to G1 growth arrest and induction of the cyclin-dependent kinase inhibitor p21$\rm\sp{Waf1/Cip1}$ in MCF-7 cells promoted activation of PKC $\delta$, as evidenced in immunecomplex phosphorylation assays. To show that phorbol ester stimulated G1 growth arrest could be mediated by the induction of p21$\rm\sp{Waf1/Cip1}$ by activated PKC $\delta,$ we demonstrated that constitutively active PKC $\delta$ in the absence but not in the presence of dominant negative PKC $\delta$ activated the WAF1/CIP1 promoter-luciferase construct in transient transfection assays. Activated PKC $\delta$ can therefore signal the transcriptional induction of p21$\rm\sp{WAF1/CIP1}.$ Our results are consistent with the hypothesis that modulation of PKC $\delta$ expression and activation state provides a pathway for growth regulation in breast cancer cells.
Author : Yan Cheng
Publisher : Frontiers Media SA
ISBN 13 : 2832541844
Total Pages : 198 pages
Book Rating : 4.8/5 (325 download)
Download or read book Molecular Mechanisms of Drug Resistance And Strategies of Sensitization in Breast Cancer, 2nd edition written by Yan Cheng and published by Frontiers Media SA. This book was released on 2024-01-11 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic scientific background Breast cancer is one of the most common cancer and the most frequent cause of cancer death among women worldwide. Currently, subtyping breast cancers into hormone receptor (HR) positive, human epidermal growth factor receptor-2 overexpressing (HER2+), and triple negative breast cancer (TNBC) is the basis of diagnosing and treating this disease. The main treatment strategies for breast cancer include surgery, endocrine therapy, molecular targeted therapy, chemotherapy, radiotherapy, immunotherapy and gene therapy. However, resistance of breast cancer cells to chemotherapeutic agents, molecular targeted therapies and immunotherapy may occur either intrinsically or de nova, and is often ultimately responsible for treatment failure. Therefore, drug resistance poses a major challenge to breast cancer treatment. Current developments: Drug resistance in breast cancer is a complex clinical condition originating from a wide range of molecular alterations. The development of endocrine therapy resistance is believed to be associated with many cellular changes, such as ESR1 gene mutations, bypassing estrogen signaling pathway and altered tamoxifen metabolism. Meanwhile, changes in immune response, alternation of drug-binding property and downstream pathways are involved in the mechanisms of drug resistance in HER2+ breast cancer. In addition, resistance to chemotherapeutic agents predominantly arises from increased drug efflux and cross resistance. Current studies suggest that treatment strategies and therapeutics have to be designed specifically to each patient in different clinical situations. The use of modern genomic, proteomic and functional analytical techniques has contributed to identify novel genes and signaling networks involved in breast cancer drug resistance. Moreover, the use of high-throughput techniques in combination with bioinformatics and systems biology approaches has aided the interrogation of clinical samples and allowed the identification of molecular signatures and genotypes that predict responses to certain drugs. Despite much progress has been made in the field of breast cancer drug resistance, such as combination therapy and drug-loaded nanoparticles, the complexity and variability of drug resistance mechanism still inevitably lead to the continuous occurrence of drug resistance. Therefore, with the increasing amounts of anti-breast cancer agents, there are now unprecedented opportunities to understand and overcome drug resistance through further research into mechanisms and corresponding strategies, which will help achieve lasting disease control and bring survival benefits to patients with advanced cancer. Papers of interest: The current Research Topic of Frontiers in Pharmacology focuses on publishing Original Research, Review articles and Case Reports focusing on (a) elucidating mechanisms of drug resistance in breast cancer, target mutations, tumor microenvironment, undiscovered genes and signaling pathways; (b) promising drug delivery systems that can enhance the sensitivity of anti- breast cancer agents to various tumors; (c) strategies that can improve patient care during bio-chemotherapeutic treatments; (d) small molecule compounds that are effective against drug-resistant breast tumors (e) biomarkers of chemotherapy resistance in breast cancer patients and (f) in vitro and in vivo models. Guidelines for article of submission: - Authors must stick to the set guidelines for ethical practices by the Frontiers journals. - The main content of the article must have certain innovation and research significance. - The authors should describe the construction method of drug-resistant cell lines when using them for experiments in the article.
Author : Erin Jean Cram
Publisher :
ISBN 13 :
Total Pages : 390 pages
Book Rating : 4.:/5 (34 download)
Download or read book Regulation of Cell Cycle in Mammalian Tumor Cells written by Erin Jean Cram and published by . This book was released on 2000 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert Brent Dickson
Publisher : Prentice Hall PTR
ISBN 13 :
Total Pages : 474 pages
Book Rating : 4.3/5 (91 download)
Download or read book Drug and Hormonal Resistance in Breast Cancer written by Robert Brent Dickson and published by Prentice Hall PTR. This book was released on 1995 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring contributions from expert authors of international standing, this book explores emerging studies on the success and/or failure of chemotherapy in breast cancer. Covers the clinical resistance of breast cancer to treatment; chemo-hormonal reactions; anti-hormonal resistance; multidrug resistance; and fu/antimetabolites. For cancer and hormonal researchers and development scientists in pharmaceuticals and biomedicine. Previously announced in 7/93 PTR Catalog.
Author : Shunyuan Jiang
Publisher :
ISBN 13 :
Total Pages : 382 pages
Book Rating : 4.:/5 (89 download)
Download or read book Estrogen and Antiestrogen Regulation of Breast Cancer Cell Growth written by Shunyuan Jiang and published by . This book was released on 1991 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stan Lipkowitz
Publisher : IOS Press
ISBN 13 : 9781586033552
Total Pages : 100 pages
Book Rating : 4.0/5 (335 download)
Download or read book Novel Targets in Breast Disease written by Stan Lipkowitz and published by IOS Press. This book was released on 2003 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is devoted to therapies that take advantage of molecular targets relevant to breast cancer - so called novel molecular therapies. It presents a sampling of both old and new molecularly targeted therapies that are being developed.
Author : Shun-Yuan Jiang
Publisher :
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.:/5 (89 download)
Download or read book Estrogen and Antiestrogen Regulation of Breast Cancer Cell Growth written by Shun-Yuan Jiang and published by . This book was released on 1991 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
