Antibiotic Pharmacokinetic Pharmacodynamic Considerations In The Critically Ill

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Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill

Author : Andrew A. Udy
Publisher : Springer
ISBN 13 : 9811053367
Total Pages : 275 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill by : Andrew A. Udy

Download or read book Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill written by Andrew A. Udy and published by Springer. This book was released on 2017-09-18 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.

Continuous Renal Replacement Therapy

Author : John A. Kellum
Publisher : Oxford University Press
ISBN 13 : 019022553X
Total Pages : 329 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Continuous Renal Replacement Therapy by : John A. Kellum

Download or read book Continuous Renal Replacement Therapy written by John A. Kellum and published by Oxford University Press. This book was released on 2016 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous Renal Replacement Therapy (CRRT) is the standard of care for management of critically ill patients with acute renal failure. Part of the Pittsburgh Critical Care series, Continuous Renal Replacement Therapy provides concise, evidence-based, bedside guidance about this treatment modality, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice. Organized into sections on theory, practice, special situations, and organizational issues, this volume provides a complete view of CRRT theory and practice. Tables summarize and highlight key points, and key studies and trials are included in each chapter. The second edition has been updated to include a new chapter on the use of biomarkers to aid in patient selection and timing, extensive revisions on terminology and nomenclature to match current standards, and the most up-to-date information on newly developed CRRT machines.

Antibiotic Pharmacodynamics

Author : John C. Rotschafer
Publisher : Humana
ISBN 13 : 9781493933211
Total Pages : 0 pages
Book Rating : 4.9/5 (332 download)

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Book Synopsis Antibiotic Pharmacodynamics by : John C. Rotschafer

Download or read book Antibiotic Pharmacodynamics written by John C. Rotschafer and published by Humana. This book was released on 2016-03-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab. Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.

Drug Delivery Approaches

Author : Bret Berner
Publisher : John Wiley & Sons
ISBN 13 : 1119772737
Total Pages : 466 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Drug Delivery Approaches by : Bret Berner

Download or read book Drug Delivery Approaches written by Bret Berner and published by John Wiley & Sons. This book was released on 2021-08-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.

Trauma Intensive Care

Author : Samuel A. Tisherman
Publisher : Oxford University Press, USA
ISBN 13 : 0199777705
Total Pages : 350 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Trauma Intensive Care by : Samuel A. Tisherman

Download or read book Trauma Intensive Care written by Samuel A. Tisherman and published by Oxford University Press, USA. This book was released on 2013-07-11 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: An ideal resource for intensivists caring for trauma victims in the ICU, Trauma Intensive Care provides point-of-care guidelines for establishing the priorities of care, minimizing complications, and returning patients to the best possible functional outcome.

Practical Implementation of an Antibiotic Stewardship Program

Author : Tamar F. Barlam
Publisher : Cambridge University Press
ISBN 13 : 1107166179
Total Pages : 343 pages
Book Rating : 4.1/5 (71 download)

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Book Synopsis Practical Implementation of an Antibiotic Stewardship Program by : Tamar F. Barlam

Download or read book Practical Implementation of an Antibiotic Stewardship Program written by Tamar F. Barlam and published by Cambridge University Press. This book was released on 2018-04-26 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical reference guide from experts in the field details why and how to establish successful antibiotic stewardship programs.

Infection Control in the Intensive Care Unit

Author : Hendrick K.F. van Saene
Publisher : Springer Science & Business Media
ISBN 13 : 8847016002
Total Pages : 509 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Infection Control in the Intensive Care Unit by : Hendrick K.F. van Saene

Download or read book Infection Control in the Intensive Care Unit written by Hendrick K.F. van Saene and published by Springer Science & Business Media. This book was released on 2011-12-26 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intensive care is a rapidly changing area of medicine, and after four years from the 2nd edition the volume editors and authors have deemed necessary to update it. In the recent years, in fact, five new randomised controlled trials and five new meta-analyses demonstrate that selective decontamination of the digestive tract [SDD] is an antimicrobial prophylaxis to prevent severe infections of not only lower airways but also of blood. Additionally, SDD has been shown to reduce inflammation including multiple organ failure and mortality. An intriguing observation is the evidence that SDD using parenteral and enteral antimicrobials reduces rather than increases antimicrobial resistance. Moreover, a new chapter on microcirculation had been added. The volume will be an invaluable tool for all those requiring in depth knowledge in the ever expanding field of infection control.

Oncology Critical Care

Author : Jeffrey Hoag
Publisher : BoD – Books on Demand
ISBN 13 : 9535127810
Total Pages : 188 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Oncology Critical Care by : Jeffrey Hoag

Download or read book Oncology Critical Care written by Jeffrey Hoag and published by BoD – Books on Demand. This book was released on 2016-11-30 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the American Cancer Society, more than 1.6 million people will be diagnosed with cancer during this year. Outcomes have steadily risen over the last several decades with the advent of newer therapies. As outcomes have improved, more and more cancer patients are developing critical illness. In the not-too-distant past, patients with active malignancy were thought not appropriate for critical care services as decreased longevity related to the cancer suggested poor prognosis for intensive care utilization. More recently, evidence supports rapid activation of critical care services leading to improved outcomes in cancer patients. Moreover, just as sub-subspecialty critical care experience in trauma and neurosciences has proved beneficial, the emerging field of oncology critical care warrants specific attention.

Antimicrobial Therapy I

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (143 download)

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Book Synopsis Antimicrobial Therapy I by :

Download or read book Antimicrobial Therapy I written by and published by . This book was released on 1995 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition

Author : Johan Gabrielsson
Publisher : CRC Press
ISBN 13 : 9789186274924
Total Pages : 926 pages
Book Rating : 4.2/5 (749 download)

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Book Synopsis Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition by : Johan Gabrielsson

Download or read book Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition written by Johan Gabrielsson and published by CRC Press. This book was released on 2001-11-30 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.

Clinical Use of Anti-infective Agents

Author : Robert W. Finberg
Publisher : Springer Nature
ISBN 13 : 3030674592
Total Pages : 296 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Clinical Use of Anti-infective Agents by : Robert W. Finberg

Download or read book Clinical Use of Anti-infective Agents written by Robert W. Finberg and published by Springer Nature. This book was released on 2021-07-23 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of Clinical Use of Anti-Infective Agents provides a comprehensive overview of current approaches to using drugs to treat infections, including historical perspectives, definitions, and discussion of pharmacokinetics and pharmacodynamics and their uses. It includes a detailed explanation of different classes of drugs, outlining their spectrum, pharmacokinetics, side effects, and dosing in clinical settings. This book has been designed as a reference tool for pharmacists, clinicians, nurse practitioners, and clinical microbiologists, as well as a teaching vehicle for students studying infection and patient treatment. Each section includes references allowing for in-depth study of specific agents, Q&As, and illustrative case studies accompanied by commentary on how to approach patients and organisms, optimal methods of making a diagnosis, and prescribing treatment.

Antimicrobial Pharmacodynamics in Theory and Clinical Practice

Author : Nightingale
Publisher : CRC Press
ISBN 13 : 082474182X
Total Pages : 427 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Antimicrobial Pharmacodynamics in Theory and Clinical Practice by : Nightingale

Download or read book Antimicrobial Pharmacodynamics in Theory and Clinical Practice written by Nightingale and published by CRC Press. This book was released on 2001-09-25 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-the-minute reference explores the pharmacodynamics of antimicrobials as well as the absorption, distribution, metabolism, and elimination of the major classes of antimicrobials-covering new agents such as ketolide antibiotics and highlighting the pharmacodynamic relationship between drug concentration and antimicrobial activity, as well as the relationship of pharmacodynamics to bacterial resistance. Contains specific examples and practical applications for the design of effective dosing regimens! Written by recognized experts in the field, Antimicrobial Pharmacodynamics in Theory and Clinical Practice describes the pharmacodynamic properties of all major classes of antibiotics parameters for microbiological activity of antimicrobial agents such as minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) serum/tissue protein binding and penetration rates differences between in vivo and in vitro postantibiotic effects (PAE) and more! With nearly 1000 references, tables, drawings, and illustrations, Antimicrobial Pharmacodynamics in Theory and Clinical Practice is a state-of-the-art reference for infectious disease specialists, pulmonologists, pharmacists, pharmacologists, microbiologists, biological chemists, epidemiologists, internists, and students in these disciplines.

Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics

Author : Alexander A. Vinks
Publisher : Springer Science & Business Media
ISBN 13 : 0387756132
Total Pages : 467 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics by : Alexander A. Vinks

Download or read book Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics written by Alexander A. Vinks and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.

Severe Community Acquired Pneumonia

Author : Jordi Rello
Publisher : Springer Science & Business Media
ISBN 13 : 9780792373384
Total Pages : 216 pages
Book Rating : 4.3/5 (733 download)

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Book Synopsis Severe Community Acquired Pneumonia by : Jordi Rello

Download or read book Severe Community Acquired Pneumonia written by Jordi Rello and published by Springer Science & Business Media. This book was released on 2001-06-30 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe Community Acquired Pneumonia is a book in which chapters are authored and the same topics discussed by North American and European experts. This approach provides a unique opportunity to view the different perspectives and points of view on this subject. Severe CAP is a common clinical problem encountered in the ICU setting. This book reviews topics concerning the pathogenesis, diagnosis and management of SCAP. The discussions on the role of alcohol in severe CAP and adjunctive therapies are important topics that further our understanding of this severe respiratory infection.

Antimicrobial Therapy in Veterinary Medicine

Author : Steeve Giguère
Publisher : John Wiley & Sons
ISBN 13 : 111867507X
Total Pages : 49 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Antimicrobial Therapy in Veterinary Medicine by : Steeve Giguère

Download or read book Antimicrobial Therapy in Veterinary Medicine written by Steeve Giguère and published by John Wiley & Sons. This book was released on 2013-07-25 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth Edition of Antimicrobial Therapy in Veterinary Medicine, the most comprehensive reference available on veterinary antimicrobial drug use, has been thoroughly revised and updated to reflect the rapid advancements in the field of antimicrobial therapy. Encompassing all aspects of antimicrobial drug use in animals, the book provides detailed coverage of virtually all types of antimicrobials relevant to animal health. Now with a new chapter on antimicrobial therapy in zoo animals, Antimicrobial Therapy in Veterinary Medicine offers a wealth of invaluable information for appropriately prescribing antimicrobial therapies and shaping public policy. Divided into four sections covering general principles of antimicrobial therapy, classes of antimicrobial agents, special considerations, and antimicrobial drug use in multiple animal species, the text is enhanced by tables, diagrams, and photos. Antimicrobial Therapy in Veterinary Medicine is an essential resource for anyone concerned with the appropriate use of antimicrobial drugs, including veterinary practitioners, students, public health veterinarians, and industry and research scientists.

Kucers' The Use of Antibiotics

Author : M. Lindsay Grayson
Publisher : CRC Press
ISBN 13 : 1498747965
Total Pages : 4894 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Kucers' The Use of Antibiotics by : M. Lindsay Grayson

Download or read book Kucers' The Use of Antibiotics written by M. Lindsay Grayson and published by CRC Press. This book was released on 2017-10-02 with total page 4894 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kucers’ The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections - antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs - and is highly structured for ease of reference. Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses - a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.

Annual Update in Intensive Care and Emergency Medicine 2014

Author : Jean-Louis Vincent
Publisher : Springer Science & Business Media
ISBN 13 : 3319037463
Total Pages : 796 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Annual Update in Intensive Care and Emergency Medicine 2014 by : Jean-Louis Vincent

Download or read book Annual Update in Intensive Care and Emergency Medicine 2014 written by Jean-Louis Vincent and published by Springer Science & Business Media. This book was released on 2014-02-06 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Yearbook compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.