Anti Obesity Drug Discovery And Development

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Anti-obesity Drug Discovery and Development

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1681085585
Total Pages : 245 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Anti-obesity Drug Discovery and Development by : Atta-ur-Rahman

Download or read book Anti-obesity Drug Discovery and Development written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2018-12-14 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. The incidence of obesity among populations in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from activities focused on raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is a book series focused on this very important area of healthcare research. Each volume presents insightful updates on pharmaceutical research and development for clinical researchers and healthcare professionals involved in obesity treatment programs. The fourth volume of this series covers 6 reviews on anti-obesity treatment strategies including updates on obesity and cancer prevention through dietary modulation, the role of anti-obesity medications in polycystic ovary syndrome, potential anti-obesity strategies targeting mitochondria, calcium silicate based formulations for anti-obesity therapy, and the identification of obesity medications from natural products and plants.

Anti-Obesity Drug Discovery and Development

Author : Atta-ur Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1681081873
Total Pages : 245 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Anti-Obesity Drug Discovery and Development by : Atta-ur Rahman

Download or read book Anti-Obesity Drug Discovery and Development written by Atta-ur Rahman and published by Bentham Science Publishers. This book was released on 2017-06-09 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. The third volume of this series is dedicated to anti-obesity treatments including updates on new therapeutics for obesity, Nesfatin-1 and its therapeutic uses, the role of proteomics in pediatric anti-obesity treatment, the role of oxidative stress in childhood obesity and a review of data on gut microbiota as a treatment option for obesity.

Anti-obesity Drug Discovery and Development -

Author : Atta Ur-Rahman
Publisher :
ISBN 13 : 9781681081885
Total Pages : 246 pages
Book Rating : 4.0/5 (818 download)

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Book Synopsis Anti-obesity Drug Discovery and Development - by : Atta Ur-Rahman

Download or read book Anti-obesity Drug Discovery and Development - written by Atta Ur-Rahman and published by . This book was released on 2017-06-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. The third volume of this series is dedicated to anti-obesity treatments including updates on new therapeutics for obesity, Nesfatin-1 and its therapeutic uses, the role of proteomics in pediatric anti-obesity treatment, the role of oxidative stress in childhood obesity and a review of data on gut microbiota as a treatment option for obesity."

Anti-Obesity Drug Discovery and Development -

Author : Kunihiro Suzuki
Publisher :
ISBN 13 : 9781608055845
Total Pages : pages
Book Rating : 4.0/5 (558 download)

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Book Synopsis Anti-Obesity Drug Discovery and Development - by : Kunihiro Suzuki

Download or read book Anti-Obesity Drug Discovery and Development - written by Kunihiro Suzuki and published by . This book was released on 2011-07-07 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and th"

Appetite and Body Weight

Author : Tim Kirkham
Publisher : Elsevier
ISBN 13 : 9780080466460
Total Pages : 384 pages
Book Rating : 4.4/5 (664 download)

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Book Synopsis Appetite and Body Weight by : Tim Kirkham

Download or read book Appetite and Body Weight written by Tim Kirkham and published by Elsevier. This book was released on 2011-04-28 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems. Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication. Provides an integrative view of the many systems involved in appetite how they interact to effect food intake (i.e. the brain, endocrine, gut, liver etc.) Considers psychological aspects such as incentive, preference, liking and palatability, and sets these concepts in their behavioural, pharmacological and neural contexts Examines the development of novel anti-obesity drugs, drawing on experience of pharmacological development work, pre-clinical tests for anti-obesity efficacy, and clinical trials of candidate anti-obesity compounds

Pharmacotherapy of Obesity

Author : John P. H. Wilding
Publisher : Springer Science & Business Media
ISBN 13 : 376437425X
Total Pages : 120 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis Pharmacotherapy of Obesity by : John P. H. Wilding

Download or read book Pharmacotherapy of Obesity written by John P. H. Wilding and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: After three introductory chapters that deal with the general theme of obesity – now regarded as a chronic disease – this volume discusses the drugs sibutramine and orlistat, which are approved for long-term use in the US and in much of the rest of the world. The three final chapters discuss future drug targets, like the central nervous system and gut hormones, and how to influence energy expenditure and substrate utilization.

Anti-Obesity Drug Discovery and Development

Author : Atta-ur- Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1608051633
Total Pages : 293 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Anti-Obesity Drug Discovery and Development by : Atta-ur- Rahman

Download or read book Anti-Obesity Drug Discovery and Development written by Atta-ur- Rahman and published by Bentham Science Publishers. This book was released on 2011-07-07 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and th"

Drug Repurposing

Author : Farid A. Badria
Publisher : BoD – Books on Demand
ISBN 13 : 1839685204
Total Pages : 236 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Drug Repurposing by : Farid A. Badria

Download or read book Drug Repurposing written by Farid A. Badria and published by BoD – Books on Demand. This book was released on 2020-12-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

Peptide Drug Discovery and Development

Author : Miguel Castanho
Publisher : John Wiley & Sons
ISBN 13 : 3527636749
Total Pages : 547 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Peptide Drug Discovery and Development by : Miguel Castanho

Download or read book Peptide Drug Discovery and Development written by Miguel Castanho and published by John Wiley & Sons. This book was released on 2011-10-24 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases

Author : Solomon Habtemariam
Publisher : Academic Press
ISBN 13 : 0081029233
Total Pages : 1180 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases by : Solomon Habtemariam

Download or read book Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases written by Solomon Habtemariam and published by Academic Press. This book was released on 2019-06-08 with total page 1180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. The book provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries. Provides background knowledge on type-2 diabetes and its pathophysiology and therapeutic targets down to the molecular level Explores, in detail, the chemistry or secondary metabolites of the indicated foods that potentially modify diabetes and/or associated diseases Examines the pharmacological findings on medicinal foods, including available clinical trials

Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders

Author : Robert A. McArthur
Publisher : Academic Press
ISBN 13 : 0123738601
Total Pages : 427 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders by : Robert A. McArthur

Download or read book Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders written by Robert A. McArthur and published by Academic Press. This book was released on 2008-10-06 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Minimize the number of drug candidates that could later fail in human trials! These three volumes provide a unique examination of how animal models are evolving from "behavioral gut baths" to providing cross-species information relevant to human clinical responses. Each volume provides the views and experiences of leading pre-clinical and clinical investigators who are actively involved in translational research and experimental medicine. Each volume is devoted to specific disorders in three scientific fields: Psychiatric, Neurological, and Reward Deficit. - Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process- Critical evaluation of animal and translational models improving transition from drug discovery and clinical development- Emphasis on what results mean to the overall drug discovery process- Exploration of issues in clinical trial design and conductance in each therapeutic area.

The Future of Drug Discovery

Author : Tamas Bartfai
Publisher : Academic Press
ISBN 13 : 0124095194
Total Pages : 376 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis The Future of Drug Discovery by : Tamas Bartfai

Download or read book The Future of Drug Discovery written by Tamas Bartfai and published by Academic Press. This book was released on 2013-05-18 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Future of Drug Discovery: Who decides which diseases to treat? provides a timely and detailed look at the efforts of the pharmaceutical industry and how they relate, or should relate, to societal needs. The authors posit that as a result of increasing risk aversion and accelerated savings in research and development, the industry is not developing drugs for increasingly prevalent diseases, such as Alzheimer’s disease, untreatable pain, antibiotics and more. This book carefully exposes the gap between the medicines and therapies we need and the current business path. By analyzing the situation and discussing prospects for the next decade, the The Future of Drug Discovery is a timely book for all those who care about the development needs for drugs for disease. Provides an in-depth, broad perspective on the crisis in drug industry Exposes the disconnect between what society needs and what the drug companies are working on Analyses and projects over 10 years into the future Explains what it means for scientists and society Determines what is needed to be done to make sure that the industry responds to society's needs, remains commercially attractive and answers the question as to who decides which diseases to treat

Drug Discovery & Development

Author : Bhushan Patwardhan
Publisher : New India Publishing
ISBN 13 : 9788189422295
Total Pages : 368 pages
Book Rating : 4.4/5 (222 download)

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Book Synopsis Drug Discovery & Development by : Bhushan Patwardhan

Download or read book Drug Discovery & Development written by Bhushan Patwardhan and published by New India Publishing. This book was released on 2007 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery. There are two clear tracks where ethnopharmacology has potential to contribute in future drug research. First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines. In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical. This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research. It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine. One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products. The book also gives Regulators' perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.

New Therapeutic Strategies for Type 2 Diabetes

Author : Robert Mark Jones
Publisher : Royal Society of Chemistry
ISBN 13 : 1849734143
Total Pages : 532 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis New Therapeutic Strategies for Type 2 Diabetes by : Robert Mark Jones

Download or read book New Therapeutic Strategies for Type 2 Diabetes written by Robert Mark Jones and published by Royal Society of Chemistry. This book was released on 2012 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a state-of-the art review of new therapeutic strategies towards treatments for T2D.

Drug Discovery and Development

Author : Ramarao Poduri
Publisher : Springer Nature
ISBN 13 : 9811555346
Total Pages : 522 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Drug Discovery and Development by : Ramarao Poduri

Download or read book Drug Discovery and Development written by Ramarao Poduri and published by Springer Nature. This book was released on 2021-02-15 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Plant Lectins

Author : A. Pusztai
Publisher : Cambridge University Press
ISBN 13 : 0521328241
Total Pages : 276 pages
Book Rating : 4.5/5 (213 download)

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Book Synopsis Plant Lectins by : A. Pusztai

Download or read book Plant Lectins written by A. Pusztai and published by Cambridge University Press. This book was released on 1991 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume surveys the chemistry, biochemistry, biosynthesis, metabolism and pharmacological properties of lectins. Lectins, which are most commonly found in plants, are widespread natural products with striking biological activities. Their specific ability to recognise and bind to simple or complex saccharides facilitates their role as effective information protein molecules. As agents of cell-to-cell recognition, lectins promote symbiosis between plants and specific nitrogen-fixing soil bacteria. As natural defensive molecules, they can protect plants against predators such as bacteria, fungi and insects. As part of our diet, lectins are powerful exogenous growth factors in the small intestine and influence our health, the digestive function and the bacterial ecology of the alimentary tract. Lectins are also important research tools in preparative biochemistry and cell science.

Drug Discovery and Evaluation

Author : Hans G. Vogel
Publisher : Springer Science & Business Media
ISBN 13 : 366203333X
Total Pages : 790 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Drug Discovery and Evaluation by : Hans G. Vogel

Download or read book Drug Discovery and Evaluation written by Hans G. Vogel and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.