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Author : Leon Sokoloff
Publisher :
ISBN 13 :
Total Pages : 39 pages
Book Rating : 4.:/5 (31 download)
Download or read book Animal Models of Rheumatoid Arthritis written by Leon Sokoloff and published by . This book was released on 1984 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert A. Greenwald
Publisher : CRC Press
ISBN 13 : 9780849329883
Total Pages : 266 pages
Book Rating : 4.3/5 (298 download)
Download or read book CRC Handbook of Animal Models for the Rheumatic Diseases written by Robert A. Greenwald and published by CRC Press. This book was released on 1988-09-30 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailed methods of the most widely used and best established animal models and related approaches to the study of rheumatic diseases and their treatment are presented in this major reference book. The detailed description of each model allows the reader to select the model most appropriate for his research and to reproduce the model without resorting to additional references. In addition, other methods for induction of the model, sources for procurement of suitable animals and validation of the model are highlighted. Methods for eliciting non-spontaneous phenomena, follow-up examinations and data collection are also described. Specific techniques such as joint-injection, obtaining synovial tissue, methods of assessment and similar non-specific information are emphasized. This easy-to-read resource text is essential for scientists, graduate students, research assistants, physicians and other invbestigators who use animal models for the study of rheumatic diseases.
Author : María Eugenia Castañeda-Lopez
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)
Download or read book Animal Models of Rheumatoid Arthritis written by María Eugenia Castañeda-Lopez and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmunity is a condition in which the host organizes an immune response against its own antigens. Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology, characterized by the presence of chronic inflammatory infiltrates, the development of destructive arthropathy, bone erosion, and degradation of the articular cartilage and subchondral bone. There is currently no treatment that resolves the disease, only the use of palliatives, and not all patients respond to pharmacologic therapy. According to RA multifactorial origin, several in vivo models have been used to evaluate its pathophysiology as well as to identify the usefulness of biomarkers to predict, to diagnose, or to evaluate the prognosis of the disease. This chapter focuses on the most common in vivo models used for the study of RA, including those related with genetic, immunological, hormonal, and environmental interactions. Similarly, the potential of these models to understand RA pathogenesis and to test preventive and therapeutic strategies of autoimmune disorder is also highlighted. In conclusion, of all the animal models discussed, the CIA model could be considered the most successful by generating arthritis using type II collagen and adjuvants and evaluating therapeutic compounds both intra-articularly and systemically.
Author :
Publisher :
ISBN 13 : 9789186253950
Total Pages : 69 pages
Book Rating : 4.2/5 (539 download)
Download or read book From Disease to Genes in Animal Models of Rheumatoid Arthritis and Multiple Sclerosis written by and published by . This book was released on 2009 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : B. Henderson
Publisher : Academic Press
ISBN 13 : 0080536026
Total Pages : 567 pages
Book Rating : 4.0/5 (85 download)
Download or read book Mechanisms and Models in Rheumatoid Arthritis written by B. Henderson and published by Academic Press. This book was released on 1995-03-16 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid arthritis is a bewilderingly complex disease involving the interactions of many, and varied, cell populations and multiple families of low and high molecular mass mediators. We are only slowly beginning to understand the mechanisms that produce the local and systematic pathology clinically recognized as rheumatoid arthritis. Increasingly, use is being made of experimental models of this disease in an effort to test hypotheses about putative pathological mechanisms and to investigate the effect of novel therapeutic agents. A major section of this book covers these experimental models in great detail from their development through to reviews of the most recent information on each model.Mechanisms and Models in Rheumatoid Arthritis brings together a group of eminent researchers from the fields of clinical rheumatology, pathology, experimental pathology, immunology, connective tissue biochemistry, microbiology, pharmacology and developmental biology to describe the current views of the cellular and humoral mechanisms that drive the pathology of rheumatoid arthritis and experimental models of rheumatoid arthritis. Key Features:* The book is divided into five sections:* The clinical spectrum, aetiopathogenesis, the role of microbial superantigens in pathology and the present and future therapies for rheumatoid arthritis* The pathology of rheumatoid arthritis, the development and role of synovial pannus and the use of immunohistochemistry in defining synovial pathology* Cell populations involved in synovitis with chapters on synovial cells, chondrocytes, bone cells, leukocytes and leukocyte trafficking* Mediators, with coverage of: cytokines and cytokine inhibitors, growth factors, free radicals and inflammatory lipid mediators, neuropeptides and proteases* Current studies on experimental models of rheumatoid arthritis
Author : Yuehuei H. An
Publisher : CRC Press
ISBN 13 : 1482234025
Total Pages : 619 pages
Book Rating : 4.4/5 (822 download)
Download or read book Animal Models in Orthopaedic Research written by Yuehuei H. An and published by CRC Press. This book was released on 2020-04-30 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models in Orthopaedic Research is a reference book of the major animal models used in the study of orthopaedic conditions and in the in vivo study of biomaterials. Use of animal models provides important knowledge about pathological conditions that can eventually lead to the development of more effective clinical treatment of diseases in bot
Author : Luis R. Espinoza
Publisher : Springer Nature
ISBN 13 : 3030233111
Total Pages : 460 pages
Book Rating : 4.0/5 (32 download)
Download or read book Infections and the Rheumatic Diseases written by Luis R. Espinoza and published by Springer Nature. This book was released on 2019-09-26 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and up-to-date review of the basic and clinical aspects of infections and infectious processes that trigger or aggravate a variety of autoimmune and inflammatory musculoskeletal disorders. It delivers a timely update on the interactions between infection and rheumatic diseases in order to provide clinicians with the tools they need for proper diagnosis and treatment. The book is divided into five main sections. The first examines the basic aspects of bacterial infections with a discussion of molecular biology, the microbiome, various types of bacteria that cause infection, and recent advances in biologic therapy. The next section focuses on different forms of viral arthritis including hepatitis arthritis, arthritis associated with alpha viruses, and parvovirus-related arthritis. Subsequent chapters then discuss arthritis caused by mycobacteria, fungi, spirochete, and other miscellaneous arthritides. Following this are various analyzations on reactive arthritis and infection-related rheumatic diseases such as Whipple’s Disease, SAPHO Syndrome, rheumatic fever, and HIV-associated rheumatic manifestations. Finally, the book closes with three chapters on external impacts on infectious diseases such as climate change, vaccinations and systemic lupus erythematosus. Infections and the Rheumatic Diseases is an essential resource for physicians and related professionals, residents, fellows, graduate students, and nurses in rheumatology, clinical immunology, and internal medicine.
Author : Niklas Nordquist
Publisher : Uppsala Universitet
ISBN 13 : 9789155451172
Total Pages : 48 pages
Book Rating : 4.4/5 (511 download)
Download or read book Genetic Studies of Rheumatoid Arthritis Using Animal Models written by Niklas Nordquist and published by Uppsala Universitet. This book was released on 2001 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shuang Liu
Publisher : Humana
ISBN 13 : 9781493993932
Total Pages : 253 pages
Book Rating : 4.9/5 (939 download)
Download or read book Rheumatoid Arthritis written by Shuang Liu and published by Humana. This book was released on 2019-10-07 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a summary of the standard laboratory protocols and methodology commonly used in basic and translational studies in the field of rheumatoid arthritis (RA) treatment. Chapters detail including basic RA models, evaluation of disease activity and immunological status, systemic drug delivery, and new research tools. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Rheumatoid Arthritis: Methods and Protocols aims to be a basic manual for clinical researchers who are just getting started in the field of intervention study.
Author : Bartholomew Ibeh
Publisher : BoD – Books on Demand
ISBN 13 : 1789231647
Total Pages : 410 pages
Book Rating : 4.7/5 (892 download)
Download or read book Experimental Animal Models of Human Diseases written by Bartholomew Ibeh and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.
Author : Alexandra Bäcklund
Publisher :
ISBN 13 : 9789185481187
Total Pages : 62 pages
Book Rating : 4.4/5 (811 download)
Download or read book Tolerance Mechanisms in Collagen-induced Arthritis written by Alexandra Bäcklund and published by . This book was released on 2005 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Signe Humle Jørgensen
Publisher :
ISBN 13 :
Total Pages : 170 pages
Book Rating : 4.:/5 (488 download)
Download or read book Neurogenic Inflammation in Rat Adjuvant Arthritis written by Signe Humle Jørgensen and published by . This book was released on 2000 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hai-Tao Yang
Publisher :
ISBN 13 : 9789155447175
Total Pages : 0 pages
Book Rating : 4.4/5 (471 download)
Download or read book Genetic analysis of autoimmune diseases using animal models : mapping susceptibility genes for multiple sclerosis and rheumatoid arthritis written by Hai-Tao Yang and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kristian B. S. Spreckley
Publisher :
ISBN 13 :
Total Pages : 279 pages
Book Rating : 4.:/5 (643 download)
Download or read book Identification of Rheumatoid Arthritis Susceptibility Genes Mapping to Regions of Linkage Homologous to Those Identified in Animal Models of Inflammatory Arthritis written by Kristian B. S. Spreckley and published by . This book was released on 2007 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Thomas McPherson Brown
Publisher :
ISBN 13 :
Total Pages : 37 pages
Book Rating : 4.:/5 (52 download)
Download or read book Natural Occurrence of Rheumatoid Arthritis in Great Apes - a New Animal Model written by Thomas McPherson Brown and published by . This book was released on 1974 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael J. Parnham
Publisher : Springer Nature
ISBN 13 : 3030108112
Total Pages : 888 pages
Book Rating : 4.0/5 (31 download)
Download or read book Nijkamp and Parnham's Principles of Immunopharmacology written by Michael J. Parnham and published by Springer Nature. This book was released on 2019-12-10 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks. The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests. Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions. The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.
Author : Adewale Adebajo
Publisher : Springer
ISBN 13 : 3319195301
Total Pages : 315 pages
Book Rating : 4.3/5 (191 download)
Download or read book Psoriatic Arthritis and Psoriasis written by Adewale Adebajo and published by Springer. This book was released on 2016-01-11 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Educational advancement in the field of psoriatic arthritis which this book will provide is consistent with GRAPPA’s aims and objectives leading to a productive synergy. GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis), is recognized world wide as the leading international society for the study and promotion of awareness of psoriatic arthritis. GRAPPA is an association of leading rheumatologists, dermatologists, representatives of patient service leagues and other stakeholders focused on psoriasis and PsA.Psoriatic Arthritis (PsA) ranks with rheumatoid arthritis and axial spondyloarthritis as one of the most prevalent inflammatory arthropathies worldwide. There is now a significant global awareness among Rheumatologists, Dermatologists, Internal Medicine Specialists, Gastroenterologists, General Practitioners, Family Practitioners, Physiotherapists, Nurse Specialists, Immunogenetics and many other Health Care Professionals with regards to the importance of psoriatic arthritis.
