Animal Models Of Dementia

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Animal Models of Dementia

Author : Peter Paul De Deyn
Publisher : Humana Press
ISBN 13 : 9781607618973
Total Pages : 732 pages
Book Rating : 4.6/5 (189 download)

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Book Synopsis Animal Models of Dementia by : Peter Paul De Deyn

Download or read book Animal Models of Dementia written by Peter Paul De Deyn and published by Humana Press. This book was released on 2010-12-01 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.

Animal Models of Cognitive Impairment

Author : Edward D. Levin
Publisher : CRC Press
ISBN 13 : 1420004336
Total Pages : 395 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Animal Models of Cognitive Impairment by : Edward D. Levin

Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen

Diagnosis and Treatment of Senile Dementia

Author : Manfred Bergener
Publisher : Springer Science & Business Media
ISBN 13 : 3642466583
Total Pages : 434 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Diagnosis and Treatment of Senile Dementia by : Manfred Bergener

Download or read book Diagnosis and Treatment of Senile Dementia written by Manfred Bergener and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Senile dementia is one of the major health problems confronting mankind in this century. To some extent the problem has, of course, always existed. The condition was sufficiently troubling to classical philosophers and jurists to have apparently provoked comments by Solon in approximately 500 B. C. and Plato in the fourth century B. C. (Plutarch 1967 translation; Plato 1921 translation). Medical recognition can be traced at least as far back as the second century A. D. (Adams 1861). However, several factors have converged in this century to extend the absolute dimensions of the problem of senile dementia and to increase societal, medical, and scientific recogni tion of the magnitude of the condition. Perhaps the most important factor relating to the present importance of senile dementia is demographic. Although the human population has been increasing since the mid-eighteenth century, it has only been since the advent of the twentieth century that a decrease in mortality has been noted for those over the age of 45 (McKeown 1976). Consequently, the absolute number of aged persons and the proportion of increasingly aged persons in the populations of the world's industrial nations have been steadily increasing. For example, in the United States, 4% ofthe population was over the age of 65 in 1900. In the 1970 census, this proportion had grown to 10%.

Animal Models of Dementia

Author : Peter Paul De Deyn
Publisher : Humana Press
ISBN 13 : 9781607618997
Total Pages : 732 pages
Book Rating : 4.6/5 (189 download)

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Book Synopsis Animal Models of Dementia by : Peter Paul De Deyn

Download or read book Animal Models of Dementia written by Peter Paul De Deyn and published by Humana Press. This book was released on 2011-04-06 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer’s disease, Parkinson’s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.

Methods of Behavior Analysis in Neuroscience

Author : Jerry J. Buccafusco
Publisher : CRC Press
ISBN 13 : 1420041819
Total Pages : 341 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Methods of Behavior Analysis in Neuroscience by : Jerry J. Buccafusco

Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Animal Experimentation: Working Towards a Paradigm Change

Author : Kathrin Herrmann
Publisher : BRILL
ISBN 13 : 9004391193
Total Pages : 749 pages
Book Rating : 4.0/5 (43 download)

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Book Synopsis Animal Experimentation: Working Towards a Paradigm Change by : Kathrin Herrmann

Download or read book Animal Experimentation: Working Towards a Paradigm Change written by Kathrin Herrmann and published by BRILL. This book was released on 2019-04-30 with total page 749 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Author : Agustín Ibáñez
Publisher : Frontiers Media SA
ISBN 13 : 2889454940
Total Pages : 217 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America by : Agustín Ibáñez

Download or read book Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America written by Agustín Ibáñez and published by Frontiers Media SA. This book was released on 2018-06-21 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Animal Models of Dementia

Author : Joseph T. Coyle
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Animal Models of Dementia by : Joseph T. Coyle

Download or read book Animal Models of Dementia written by Joseph T. Coyle and published by . This book was released on 1987 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Animal Models in Alzheimer’s Disease

Author : G. Casadesus
Publisher : IOS Press
ISBN 13 : 1607507331
Total Pages : 352 pages
Book Rating : 4.6/5 (75 download)

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Book Synopsis Handbook of Animal Models in Alzheimer’s Disease by : G. Casadesus

Download or read book Handbook of Animal Models in Alzheimer’s Disease written by G. Casadesus and published by IOS Press. This book was released on 2011-07-05 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals – including transgenic animals – has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease.

The Behavioral Neurology of Dementia

Author : Bruce L. Miller
Publisher : Cambridge University Press
ISBN 13 : 1107077206
Total Pages : 491 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis The Behavioral Neurology of Dementia by : Bruce L. Miller

Download or read book The Behavioral Neurology of Dementia written by Bruce L. Miller and published by Cambridge University Press. This book was released on 2016-11-17 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Distils the most valuable discoveries in dementia research into clear, insightful chapters written by international experts.

Animal Models of Neurological Disorders

Author : Puneet Kumar Bansal
Publisher : Springer
ISBN 13 : 9811059810
Total Pages : 343 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Animal Models of Neurological Disorders by : Puneet Kumar Bansal

Download or read book Animal Models of Neurological Disorders written by Puneet Kumar Bansal and published by Springer. This book was released on 2018-01-17 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Cell and Animal Models in Aging and Dementia Research

Author : Siegfried Hoyer
Publisher : Springer Science & Business Media
ISBN 13 : 3709193508
Total Pages : 413 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Cell and Animal Models in Aging and Dementia Research by : Siegfried Hoyer

Download or read book Cell and Animal Models in Aging and Dementia Research written by Siegfried Hoyer and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although age has been recognized as a risk factor for late-onset dementia of Alzheimer type, its etiology is unknown as yet. Several age-related metabolic abnormalities may thus become important for the pathogenesis of the late-onset form. Studies at the cellular/molecular level in brain tissue are possible post mortem, but lack information on the beginning of the disorder. In this supplement, different approaches are dealt with how to induce structural and/or metabolic abnormalities in relevant cell cultures, in brain slices and in experimental animals, and how behavioral changes parallel the metabolic variations.

Cerebral Small Vessel Disease

Author : Leonardo Pantoni
Publisher : Cambridge University Press
ISBN 13 : 1107031664
Total Pages : 375 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Cerebral Small Vessel Disease by : Leonardo Pantoni

Download or read book Cerebral Small Vessel Disease written by Leonardo Pantoni and published by Cambridge University Press. This book was released on 2014-05 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.

Handbook of Animal Models in Alzheimer's Disease

Author :
Publisher :
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.:/5 (19 download)

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Book Synopsis Handbook of Animal Models in Alzheimer's Disease by :

Download or read book Handbook of Animal Models in Alzheimer's Disease written by and published by . This book was released on 2011 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Magnesium in the Central Nervous System

Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)

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Book Synopsis Magnesium in the Central Nervous System by : Robert Vink

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

The Fragile Brain

Author : Kathleen Taylor
Publisher : Oxford University Press
ISBN 13 : 0191039039
Total Pages : 320 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis The Fragile Brain by : Kathleen Taylor

Download or read book The Fragile Brain written by Kathleen Taylor and published by Oxford University Press. This book was released on 2016-11-17 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases, such as a stroke, Alzheimer's and dementia, are now tragically commonplace within the western world. Our brains are a strange and complex organ, and there is much to be discovered about what causes them to fail in such devastating ways. In this book Kathleen Taylor presents the ever-developing research into the cause and cure of these life-changing conditions, focusing on insights arising from the relatively new field of neuroimmunology - the increasing recognition of the important role of the immune system in the brain. Interweaving the latest scientific ideas on neurodegenerative diseases with accounts of the devastation which illnesses affecting the brain can cause to sufferers and to anyone who cares about them, The Fragile Brain is not only an important account of current research in this field, but a very personal study. As instances of dementia rise in our ageing populations, many harbour anxieties concerning the future.This book is about knowing the enemy.