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Animal Models
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Book Synopsis Animal Models for the Study of Human Disease by : P. Michael Conn
Download or read book Animal Models for the Study of Human Disease written by P. Michael Conn and published by Academic Press. This book was released on 2013-05-29 with total page 1109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. - Organized by disease orientation for ease of searchability - Provides information on locating resources, animal alternatives and animal ethics - Covers a broad range of animal models used in research for human disease
Book Synopsis Improving the Utility and Translation of Animal Models for Nervous System Disorders by : Institute of Medicine
Download or read book Improving the Utility and Translation of Animal Models for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2013-04-25 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.
Book Synopsis Handbook of Animal Models of Infection by : Merle A. Sande
Download or read book Handbook of Animal Models of Infection written by Merle A. Sande and published by Academic Press. This book was released on 1999-05-28 with total page 1169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for in vivo efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections. - Discusses ethical and safety aspects in an introductory background section - Covers principles of animal care and current techniques appropriate for the use of animal models of infection - Details a wide range of animals including rodents, rabbits, cats, and primates - Provides hands-on descriptions of how to set up the model - Discusses the major advantages and limitations of each model - Ensures full coverage of bacterial, fungal, viral, and parasitic infections
Book Synopsis Computational Anatomical Animal Models by : Habib Zaidi
Download or read book Computational Anatomical Animal Models written by Habib Zaidi and published by Iph001. This book was released on 2019-02-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Anatomical Animal Models: Methodological developments and research applications provides a comprehensive review of the history and technologies used for the development of computational small animal models with a focus on their application in preclinical imaging and experimental radiation therapy, as well as non-ionizing and ionizing radiation dosimetry calculations. It also provides an overview of the overall process involved in the design of these models, including the fundamental elements used for the construction of different types of computational models, the identification of original anatomical data, the simulation tools used for solving various computational problems and the applications of computational animal models in preclinical research. Part of IPEM-IOP Series in Physics and Engineering in Medicine and Biology.
Download or read book Animal Models in Eye Research written by and published by Academic Press. This book was released on 2011-04-28 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eye is a complex sensory organ, which enables visual perception of the world. Thus the eye has several tissues that do different tasks. One of the most basic aspects of eye function is the sensitivity of cells to light and its transduction though the optic nerve to the brain. Different organisms use different ways to achieve these tasks. In this sense, eye function becomes a very important evolutionary aspect as well. This book presents the different animal models that are commonly used for eye research and their uniqueness in evaluating different aspects of eye development, evolution, physiology and disease. - Presents information on the major animal models used in eye research including invertebrates and vertebrates - Provides researchers with information needed to choose between model organisms - Includes an introductory chapter on the different types of eyes, stressing possible common molecular machinery
Book Synopsis Animal Models in Psychopharmacology by : Olivier
Download or read book Animal Models in Psychopharmacology written by Olivier and published by Birkhäuser. This book was released on 2013-11-21 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular and Animal Models in Human Genomics Research by :
Download or read book Cellular and Animal Models in Human Genomics Research written by and published by Academic Press. This book was released on 2019-07-30 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. - Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies - Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health - Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms
Book Synopsis Animal Models in Toxicology by : Shayne C. Gad
Download or read book Animal Models in Toxicology written by Shayne C. Gad and published by CRC Press. This book was released on 2006-10-30 with total page 950 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting more than a decade's worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of me
Book Synopsis Animal Models in Cancer Drug Discovery by : Asfar Azmi
Download or read book Animal Models in Cancer Drug Discovery written by Asfar Azmi and published by Academic Press. This book was released on 2019-04-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field.
Book Synopsis Animal Models in Diabetes Research by : Hans-Georg Joost
Download or read book Animal Models in Diabetes Research written by Hans-Georg Joost and published by Humana Press. This book was released on 2012-08-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans. Thus, there is no alternative to appropriate animal models. In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology. The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series of reviews in model strains. The book then continues with vital, established protocols that are employed in the characterization and study of animal models of diabetes. As a volume in the highly successful Methods in Molecular BiologyTM series, this work contains the type of detailed description and key implementation advice necessary to achieve successful results. Authoritative and cutting-edge, Animal Models in Diabetes Research delivers essential content that will be an important resource to advance diabetes research in the years to come.
Book Synopsis Animal Models of Neurological Disorders by : Puneet Kumar Bansal
Download or read book Animal Models of Neurological Disorders written by Puneet Kumar Bansal and published by Springer. This book was released on 2018-01-17 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.
Book Synopsis Model Behavior by : Nicole C. Nelson
Download or read book Model Behavior written by Nicole C. Nelson and published by University of Chicago Press. This book was released on 2018-04-04 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mice are used as model organisms across a wide range of fields in science today—but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior, Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson’s extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much—if not more—about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm.
Book Synopsis Animal Models and Human Reproduction by : Heide Schatten
Download or read book Animal Models and Human Reproduction written by Heide Schatten and published by John Wiley & Sons. This book was released on 2017-03-20 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Animal Models and Human Reproduction presents a comprehensive reference that reflects the latest scientific research being done in human reproductive biology utilizing domestic animal models. Chapters on canine, equine, cow, pig, frog, and mouse models of reproduction reflect frontier research in placental biology, ovarian function and fertility, non-coding RNAs in gametogenesis, oocyte and embryo metabolism, fertilization, cryopreservation, signal transduction pathways, chromatin dynamics, epigenetics, reproductive aging, and inflammation. Chapters on non-human primate models also highlight recent advancements into such issues as human in vitro fertilization (IVF) and assisted reproductive technologies (ART). This book offers animal scientists, reproductive biology scientists, clinicians and practitioners, invaluable insights into a wide range of issues at the forefront of human reproductive health.
Book Synopsis Comparative Physiology, Natural Animal Models And Clinical Medicine: Insights Into Clinical Medicine From Animal Adaptations by : Michael Alan Singer
Download or read book Comparative Physiology, Natural Animal Models And Clinical Medicine: Insights Into Clinical Medicine From Animal Adaptations written by Michael Alan Singer and published by World Scientific. This book was released on 2007-07-27 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we can gain valuable insights into the treatment of various human clinical disorders. Covering a wide range of disorders, this book describes in detail how medical scientists can take advantage of all the “research” that nature has already performed over billions of years in biological problem solving through extensive animal design testing and selection./a
Book Synopsis Animal Models in Orthopaedic Research by : Yuehuei H. An
Download or read book Animal Models in Orthopaedic Research written by Yuehuei H. An and published by CRC Press. This book was released on 2020-04-30 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models in Orthopaedic Research is a reference book of the major animal models used in the study of orthopaedic conditions and in the in vivo study of biomaterials. Use of animal models provides important knowledge about pathological conditions that can eventually lead to the development of more effective clinical treatment of diseases in bot
Book Synopsis International Animal Research Regulations by : National Research Council
Download or read book International Animal Research Regulations written by National Research Council and published by National Academies Press. This book was released on 2012-06-26 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.
Book Synopsis Animal Models in Light of Evolution by : Niall Shanks
Download or read book Animal Models in Light of Evolution written by Niall Shanks and published by Universal-Publishers. This book was released on 2009 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The central concern of this book is with the "prediction problem" in biomedical research. In particular, the authors examine the use of animal models to predict human responses in drug and disease research. The arguments discussed are drawn from both biological and biomedical theory (with numerous examples and case studies drawn from evolutionary biology, complex systems theory, oncology, teratology, and AIDS research), and analyses of empirical evidence (concerning, for example, data on intra- and inter-species differences revealed by recent results from genome analyses of various species, human population studies, and statistical studies of the predictive utility of animal models). This book comes to the unique conclusion that while animals can be successfully used for many endeavors in science such as basic and comparative research, they cannot be used to predict drug and disease response in humans. The arguments presented are rooted in the history, philosophy, and methodology of biomedical research. This book will be of interest to anyone involved, directly or indirectly, in biomedical research (including physicians, veterinarians and scientists), and anyone interested in the history, philosophy and methodology of science. In contrast to books written by and for the animal rights movement and books written by and for the animal-based research industry, this book honestly examines all sides of the scientific arguments for using animals in science and concludes that each group in turn exaggerates the flaws or strengths of using animals. There are areas in science where animals can be viably used but there are also areas where they cannot be so used. REVIEWS See Philosophies, Ethics, and Humanities in Medicine 17 August 2010
