Animal And Translational Models For Cns Drug Discovery 3 Vols Set

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Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders

Author : Robert A. McArthur
Publisher : Academic Press
ISBN 13 : 008092039X
Total Pages : 528 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders by : Robert A. McArthur

Download or read book Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders written by Robert A. McArthur and published by Academic Press. This book was released on 2008-11-17 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the first volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Psychiatric Disorders is available for purchase individually.

Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders

Author : Robert A. McArthur
Publisher : Academic Press
ISBN 13 : 0080920403
Total Pages : 432 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders by : Robert A. McArthur

Download or read book Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders written by Robert A. McArthur and published by Academic Press. This book was released on 2009-02-24 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. Reward Deficit Disorders also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Neurological Disorders is available for purchase individually.

Animal and Translational Models for CNS Drug Discovery: Neurological Disorders

Author : Robert A. McArthur
Publisher : Academic Press
ISBN 13 : 9780080920382
Total Pages : 416 pages
Book Rating : 4.9/5 (23 download)

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Book Synopsis Animal and Translational Models for CNS Drug Discovery: Neurological Disorders by : Robert A. McArthur

Download or read book Animal and Translational Models for CNS Drug Discovery: Neurological Disorders written by Robert A. McArthur and published by Academic Press. This book was released on 2008-11-18 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer’s disease, Parkinson’s disease, Huntington disease, ALS, and the epilepsies. Neurological Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the second volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasis on what results mean to the overall drug discovery process Exploration of issues in clinical trial design and conductance in each therapeutic area

Animal and Translational Models for CNS Drug Discovery

Author : Robert A. McArthur
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (84 download)

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Book Synopsis Animal and Translational Models for CNS Drug Discovery by : Robert A. McArthur

Download or read book Animal and Translational Models for CNS Drug Discovery written by Robert A. McArthur and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Animal and Translational Models for CNS Drug Discovery: Neurological Disorders

Author : Robert A. McArthur
Publisher : Academic Press
ISBN 13 : 9780123738554
Total Pages : 416 pages
Book Rating : 4.7/5 (385 download)

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Book Synopsis Animal and Translational Models for CNS Drug Discovery: Neurological Disorders by : Robert A. McArthur

Download or read book Animal and Translational Models for CNS Drug Discovery: Neurological Disorders written by Robert A. McArthur and published by Academic Press. This book was released on 2008-10-20 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer's disease, Parkinson's disease, Huntington disease, ALS, and the epilepsies. Neurological Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the second volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasis on what results mean to the overall drug discovery process Exploration of issues in clinical trial design and conductance in each therapeutic area

Translational Animal Models in Drug Discovery and Development

Author : Xinkang Wang
Publisher : Bentham Science Publishers
ISBN 13 : 1608054691
Total Pages : 287 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Translational Animal Models in Drug Discovery and Development by : Xinkang Wang

Download or read book Translational Animal Models in Drug Discovery and Development written by Xinkang Wang and published by Bentham Science Publishers. This book was released on 2012-10-03 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but failed in clinical studies. This e-book focuses on animal models of diseases from a translational perspective and highlights the key advantages and limitations of each model described to facilitate drug discovery and development. A unique feature of the volume is that it contains a selection of details disease models in various therapeutic niches with significant unmet medical needs, including inflammation, neurological diseases, cardiovascular and metabolic diseases, and oncology. This e-book is, therefore, of considerable value to researchers and clinicians involved in drug discovery and development as well as pathology.

Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders

Author : Robert A. McArthur
Publisher : Academic Press
ISBN 13 : 9780123738561
Total Pages : 528 pages
Book Rating : 4.7/5 (385 download)

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Book Synopsis Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders by : Robert A. McArthur

Download or read book Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders written by Robert A. McArthur and published by Academic Press. This book was released on 2008-10-20 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the first volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Psychiatric Disorders is available for purchase individually.

Translational Medicine in CNS Drug Development

Author : George G. Nomikos
Publisher : Academic Press
ISBN 13 : 0128031646
Total Pages : 458 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Translational Medicine in CNS Drug Development by : George G. Nomikos

Download or read book Translational Medicine in CNS Drug Development written by George G. Nomikos and published by Academic Press. This book was released on 2019-06-18 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

Food and Addiction

Author : Kelly D. Brownell
Publisher : Oxford University Press
ISBN 13 : 0199313962
Total Pages : 496 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Food and Addiction by : Kelly D. Brownell

Download or read book Food and Addiction written by Kelly D. Brownell and published by Oxford University Press. This book was released on 2012-08-30 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Can certain foods hijack the brain in ways similar to drugs and alcohol, and is this effect sufficiently strong to contribute to major diseases such as obesity, diabetes, and heart disease, and hence constitute a public health menace? Terms like "chocoholic" and "food addict" are part of popular lore, some popular diet books discuss the concept of addiction, and there are food addiction programs with names like Food Addicts in Recovery Anonymous. Clinicians who work with patients often hear the language of addiction when individuals speak of irresistible cravings, withdrawal symptoms when starting a diet, and increasing intake of palatable foods over time. But what does science show, and how strong is the evidence that food and addiction is a real and important phenomenon? Food and Addiction: A Comprehensive Handbook brings scientific order to the issue of food and addiction, spanning multiple disciplines to create the foundation for what is a rapidly advancing field and to highlight needed advances in science and public policy. The book assembles leading scientists and policy makers from fields such as nutrition, addiction, psychology, epidemiology, and public health to explore and analyze the scientific evidence for the addictive properties of food. It provides complete and comprehensive coverage of all subjects pertinent to food and addiction, from basic background information on topics such as food intake, metabolism, and environmental risk factors for obesity, to diagnostic criteria for food addiction, the evolutionary and developmental bases of eating addictions, and behavioral and pharmacologic interventions, to the clinical, public health, and legal and policy implications of recognizing the validity of food addiction. Each chapter reviews the available science and notes needed scientific advances in the field.

Encyclopedia of Psychopharmacology

Author : Ian Stolerman
Publisher : Springer Science & Business Media
ISBN 13 : 3540686983
Total Pages : 1433 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis Encyclopedia of Psychopharmacology by : Ian Stolerman

Download or read book Encyclopedia of Psychopharmacology written by Ian Stolerman and published by Springer Science & Business Media. This book was released on 2010-07-31 with total page 1433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a broad overview of the central topics and issues in psychopharmacology, biological psychiatry and behavioral neurosciences, with information about developments in the field, including novel drugs and technologies. The more than 2000 entries are written by leading experts in pharmacology and psychiatry and comprise in-depth essays, illustrated with full-color figures, and are presented in a lucid style.

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309292492
Total Pages : 107 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 10

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 9815040685
Total Pages : 362 pages
Book Rating : 4.8/5 (15 download)

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Book Synopsis Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 10 by : Atta-ur-Rahman

Download or read book Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 10 written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2022-04-07 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. Volume 10 of the series continues to present novel information about new and interesting approaches to treat common neurological disorders, with a focus on neurodegeneration and pain medicine. The volume presents 7 detailed reviews in total. - Neurodegenerative disease: prevention and treatment through plant extracts therapy - Emerging novel approaches and recent advances in Parkinson’s disease treatment and diagnosis - Neurotrophic factors to combat neurodegeneration - Neural bases of executive function in ADHD children as assessed using FNIRS - Modulation of mesenchymal stem cells, glial cells and the immune system by oligodeoxynucleotides as a novel multi-target therapeutic approach against chronic pain - Chronic pain: focus on anticonvulsants - A review of the impact of testosterone on brain and aging-related decline in brain behavioural function

Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America

Author : Agustín Ibáñez
Publisher : Frontiers Media SA
ISBN 13 : 2889454940
Total Pages : 217 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America by : Agustín Ibáñez

Download or read book Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America written by Agustín Ibáñez and published by Frontiers Media SA. This book was released on 2018-06-21 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Translational Stroke Research

Author : Paul A. Lapchak
Publisher : Springer Science & Business Media
ISBN 13 : 1441995293
Total Pages : 926 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Translational Stroke Research by : Paul A. Lapchak

Download or read book Translational Stroke Research written by Paul A. Lapchak and published by Springer Science & Business Media. This book was released on 2012-03-23 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.

Blood-Brain Barrier in Drug Discovery

Author : Li Di
Publisher : John Wiley & Sons
ISBN 13 : 1118788354
Total Pages : 604 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Blood-Brain Barrier in Drug Discovery by : Li Di

Download or read book Blood-Brain Barrier in Drug Discovery written by Li Di and published by John Wiley & Sons. This book was released on 2015-02-02 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

Animal Experimentation: Working Towards a Paradigm Change

Author : Kathrin Herrmann
Publisher : BRILL
ISBN 13 : 9004391193
Total Pages : 749 pages
Book Rating : 4.0/5 (43 download)

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Book Synopsis Animal Experimentation: Working Towards a Paradigm Change by : Kathrin Herrmann

Download or read book Animal Experimentation: Working Towards a Paradigm Change written by Kathrin Herrmann and published by BRILL. This book was released on 2019-04-30 with total page 749 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Animal Models of Pain

Author : Chao Ma
Publisher : Humana Press
ISBN 13 : 9781607618799
Total Pages : 0 pages
Book Rating : 4.6/5 (187 download)

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Book Synopsis Animal Models of Pain by : Chao Ma

Download or read book Animal Models of Pain written by Chao Ma and published by Humana Press. This book was released on 2010-10-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the loss of work days, the price of health care and payments for compensation, litigation, and malpractice, and the overwhelming cost of human suffering, chronic pain syndromes affect humanity enormously on both an economic and personal level. In Animal Models of Pain, expert investigators in the field provide a consolidated review of the current state of pain research by capturing the diversity of animal models that are used to investigate pain mechanisms, which range from surgical incision to mechanical compression and from spinal cord injury to cutaneous/local inflammation and beyond. As a volume in the respected Neuromethods series, this book delivers its vital content through detailed descriptions of a wide variety of step-by-step laboratory methods. Authoritative and cutting-edge, Animal Models of Pain seeks to lead scientists closer to the ultimate goal of improving the quality of life and relieving the unbearable burden of chronic pain for millions of people throughout the world.