Analysing The Association Of Vitamin D Status On Selected Cardiovascular Risk Markers Using Seasonal And Genetic Variations

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Analysing the Association of Vitamin D Status on Selected Cardiovascular Risk Markers Using Seasonal and Genetic Variations

Author : D. J. Berry
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (829 download)

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Book Synopsis Analysing the Association of Vitamin D Status on Selected Cardiovascular Risk Markers Using Seasonal and Genetic Variations by : D. J. Berry

Download or read book Analysing the Association of Vitamin D Status on Selected Cardiovascular Risk Markers Using Seasonal and Genetic Variations written by D. J. Berry and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D deficiency is common and has been proposed as a risk factor for cardiovascular disease (CVD), but much of this evidence is inconsistent. The aim of the thesis was to explore the associations between vitamin D status (25(OH)D) and selected risk biomarkers of CVD, in participants of the British 1958 birth cohort free from CVD. Different methodologies were used in an attempt to avoid confounded associations. Mediation analysis was used to infer an association between 25(OH)D and biomarkers from seasonal variations. A genome-wide association study (GWAS) was done to find single nucleotide polymorphisms (SNPs) associated with 25(OH)D. SNPs found by the GWAS and SNPs in candidate genes were evaluated as proxy markers for 25(OH)D, and used in Mendelian randomisation (MR) analysis with the biomarkers. Higher 25(OH)D concentrations were associated with lower levels of tissue plasminogen activator (tPA), after adjusting for lifestyle, socio-economic and adiposity covariates. An association between 25(OH)D and tPA was inferred using mediation analysis. In the GWAS, SNPs from genes involved in the synthesis, hydroxylation and transportation of vitamin D were associated with 25(OH)D. SNPs passing evaluation as proxy markers for 25(OH)D were classified as "synthesis" and "metabolism" based on gene function, with the former considered to be a more robust proxy than the latter. Statistical power to detect an association was limited in MR analysis. However, there was some evidence that 25(OH)D had a protective association with tPA, when metabolism SNPs were used as proxy for 25(OH)D in MR analysis. Findings from the different analyses were inconsistent for CRP, D-dimer and fibrinogen. In conclusion, the findings tentatively suggest that vitamin D has a beneficial influence on CVD through the mechanism of fibrinolysis. However, more evidence is required from large MR studies and randomised controlled trials before the role of vitamin D in CVD is conclusively understood.

Vitamin D

Author : Joyanna Gilmour Hansen
Publisher :
ISBN 13 :
Total Pages : 150 pages
Book Rating : 4.:/5 (913 download)

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Book Synopsis Vitamin D by : Joyanna Gilmour Hansen

Download or read book Vitamin D written by Joyanna Gilmour Hansen and published by . This book was released on 2013 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D, a pleiotropic hormone essential for calcium homeostasis, has generated widespread interest due to associations with numerous health outcomes. Cross-sectional studies of vitamin D and lung function reported strong, positive associations, but representative, longitudinal population-based studies are lacking, and biological mechanisms are unclear. Lung function decline is the primary characteristic of chronic obstructive pulmonary disease (COPD), the 3rd leading cause of mortality in the United States; given limited treatments to delay progression, identifying preventative approaches is critical. This work aims to elucidate determinants of vitamin D status, and investigate the role of vitamin D as a determinant of lung function. First, we explored genetic and non-genetic determinants of serum vitamin D [25(OH)D] in African Americans. Approximately 25% of 25(OH)D variability was explained by non-genetic factors, and multivitamin supplement use was the strongest predictor. A single nucleotide polymorphism (SNP) in the vitamin D binding protein modified the effect of multivitamin supplement use on 25(OH)D. About 23% of 25(OH)D variability was estimated to be attributable to genetic variation, with replication in a separate cohort. However, the influence of genetic ancestry made an exact estimate impossible; further exploration of genetic determinants of 25(OH)D in African Americans is needed. Second, potential mechanisms for vitamin D-lung health associations were explored through a cross-sectional study of SNPs in 13 candidate vitamin Dresponsive genes. SNPs in SGPP2, a phosphatase in the sphingosine-1-phosphate signaling pathway, were associated with lung function and COPD risk. Further, we identified an association between SNPs in SGPP2 and lung-tissue specific expression of SGPP2. While specific mechanisms remain to be investigated, SGPP2 is a promising vitamin D-responsive candidate gene. Finally, associations between variants in vitamin D metabolic genes, serum 25(OH)D and lung function were explored in the Framingham Heart Study. SNPs in four vitamin D metabolic genes were associated with rate of change in FEV1, but there was no association between 25(OH)D and rate of change in FEV1 in the Third Generation cohort, a group of largely vitamin D sufficient middleaged adults. Future studies should consider the influence of baseline nutritional status and underlying genetic variation on vitamin D-disease associations.

Vitamin-Binding Proteins

Author : Krishnamurti Dakshinamurti
Publisher : CRC Press
ISBN 13 : 1439880166
Total Pages : 303 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Vitamin-Binding Proteins by : Krishnamurti Dakshinamurti

Download or read book Vitamin-Binding Proteins written by Krishnamurti Dakshinamurti and published by CRC Press. This book was released on 2013-07-29 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diverse in chemical nature, water soluble and lipid soluble vitamins are essential micronutrients that react with specific protein entities and are transported to sites for participation in intracellular events, both at the genomic and non-genomic levels. Thus, metabolic pathways and intracellular signaling are influenced by vitamins or their derivatives through vitamin binding to specific proteins. Vitamin-Binding Proteins: Functional Consequences examines the function of various vitamins based on this binding, as well as their role as antioxidants, leading to effects on intracellular mechanisms. This book explores the resulting functional consequences at the level of cells, tissues, and organs as well as the neurological, endocrine, and immune systems. The text addresses the effects that lead to both normal physiological function and pharmacological activity with significant therapeutic potential in a wide spectrum of disease processes. Leading experts discuss various vitamins including the function of retinoids in development, immunity, and obesity; the role of vitamin D in the immune system, infectious processes, and cardiovascular disease; and the effects of vitamins E, C, and K on the vascular system. Chapters cover the therapeutic potential of the vitamin B6 vitamer pyridoxamine and the lipid-soluble B1analogue benfotiamine. They also describe various functions of biotin as well as gene transcriptional regulation through biotin and biotin-binding proteins. The text addresses folate receptor-mediated therapeutics, vitamin B12 derivatives in tumor targeting, and implication of ascorbic acid in different disorders. Expounding newer areas of vitamin function, this book explores the interface of physiological vitamin function and pharmacological vitamin action, offering a broad perspective of possible vitamin binding therapeutics.

Nutrition and HIV

Author : Saurabh Mehta
Publisher : CRC Press
ISBN 13 : 1351058185
Total Pages : 326 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Nutrition and HIV by : Saurabh Mehta

Download or read book Nutrition and HIV written by Saurabh Mehta and published by CRC Press. This book was released on 2018-05-15 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world continues to lose more than a million lives each year to the HIV epidemic, and nearly two million individuals were infected with HIV in 2017 alone. The new Sustainable Development Goals, adopted by countries of the United Nations in September 2015, include a commitment to end the AIDS epidemic by 2030. Considerable emphasis on prevention of new infections and treatment of those living with HIV will be needed to make this goal achievable. With nearly 37 million people now living with HIV, it is a communicable disease that behaves like a noncommunicable disease. Nutritional management is integral to comprehensive HIV care and treatment. Improved nutritional status and weight gain can increase recovery and strength of individuals living with HIV/AIDS, improve dietary diversity and caloric intake, and improve quality of life. This book highlights evidence-based research linking nutrition and HIV and identifies research gaps to inform the development of guidelines and policies for the United Nations’ Sustainable Development Goals. A comprehensive approach that includes nutritional interventions is likely to maximize the benefit of antiretroviral therapy in preventing HIV disease progression and other adverse outcomes in HIV-infected men and women. Modification of nutritional status has been shown to enhance the quality of life of those suffering HIV/AIDS, both physically in terms of improved body mass index and immunological markers, and psychologically, by improving symptoms of depression. While the primary focus for those infected should remain on antiretroviral treatment and increasing its availability and coverage, improvement of nutritional status plays a complementary role in the management of HIV infection.

Vitamin D

Author : Michael F. Holick
Publisher : Springer Science & Business Media
ISBN 13 : 1475728611
Total Pages : 456 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Vitamin D by : Michael F. Holick

Download or read book Vitamin D written by Michael F. Holick and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nutrition and Health series of books has as an overriding mission to provide health professionals with texts that are considered essential because each includes: a synthesis of the state of the science; timely, in-depth reviews by the leading researchers in their respective fields; extensive, up-to-date fully annotated reference lists; a detailed index; relevant tables and figures; identification of paradigm shifts and the consequences; of information between chapters, but targeted, inter-chapter refer virtually no overlap rals, suggestions of areas for future research; and balanced, data-driven answers to patient questions that are based on the totality of evidence rather than the findings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matter as well as in the choice of chapter authors. The international perspective, especially with regard to public health initiatives, is emphasized where appropriate. The editors, whose training is both research and practice oriented, have the opportunity to develop a primary objective for their book, define the scope and focus, and then invite the leading authori ties from around the world to be part of their initiative. The authors are encouraged to provide an overview of the field, discuss their own research, and relate the research de findings to potential human health consequences.

Multiple Sclerosis

Author : Ian S. Zagon
Publisher :
ISBN 13 : 9780994438133
Total Pages : 137 pages
Book Rating : 4.4/5 (381 download)

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Book Synopsis Multiple Sclerosis by : Ian S. Zagon

Download or read book Multiple Sclerosis written by Ian S. Zagon and published by . This book was released on 2017 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Extraskeletal Effects of Vitamin D

Author : Emilia Pauline Liao
Publisher : Humana Press
ISBN 13 : 3319737422
Total Pages : 258 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Extraskeletal Effects of Vitamin D by : Emilia Pauline Liao

Download or read book Extraskeletal Effects of Vitamin D written by Emilia Pauline Liao and published by Humana Press. This book was released on 2018-04-23 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. Vitamin D receptors are located in nearly every tissue of the body, and low levels of vitamin D are associated with a range of various diseases. This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between vitamin D deficiency and various disease states. Beginning with a review of the biochemistry and physiology of vitamin D, subsequent chapters investigate its relationship to autoimmune and infectious diseases, various forms of cancer, endocrine issues such as diabetes, obesity and reproductive function, cardiovascular disease and muscle weakness. Concluding chapters discuss the role of vitamin D in neurological disorders, including Alzheimer's Disease, and cognitive function. Focusing on extraskeletal effects only across a range of conditions, Extraskeletal Effects of Vitamin D will be an important resource for clinical endocrinologists and primary care physicians.

WHO Child Growth Standards

Author : World Health Organization
Publisher : World Health Organization
ISBN 13 : 9241547189
Total Pages : 238 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis WHO Child Growth Standards by : World Health Organization

Download or read book WHO Child Growth Standards written by World Health Organization and published by World Health Organization. This book was released on 2007 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of the uses and interpretation of anthropometric references undertaken by WHO in the early 1990s concluded that new growth curves were needed to replace the existing international reference. To develop new standards, a multi-country study was carried out to collect primary growth data and related information from 8440 healthy breastfed infants and young children from diverse ethnic backgrounds and cultural settings (Brazil, Ghana, India, Norway, Oman, and the USA). The first set of growth standards (length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age) was published in April 2006. This report presents the second set of growth standards (head circumference-for-age, arm circumference-for-age, triceps skinfold-for-age, and subscapular skinfold-for-age). The standards depict normal early childhood growth under optimal environmental conditions and can be used to assess children everywhere, regardless of ethnicity socioeconomic status and type of feeding. This report will be useful to pediatricians and other healthcare providers, nutritionists, policy makers, researchers, national institutes of health, schools of medicine, and professional associations. Companion volume: WHO Child Growth Standards: Length/Height-for-age Weight-for-age Weight-for-length Weight-for-height and Body Mass Index-for age. Methods and Development

Vitamin D and Human Health

Author : Simon Spedding
Publisher : MDPI
ISBN 13 : 3038975869
Total Pages : 307 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis Vitamin D and Human Health by : Simon Spedding

Download or read book Vitamin D and Human Health written by Simon Spedding and published by MDPI. This book was released on 2019-02-21 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Vitamin D and Human Health" that was published in Nutrients

Sunlight, Vitamin D and Skin Cancer

Author : Jörg Reichrath
Publisher : Springer Nature
ISBN 13 : 3030462277
Total Pages : 428 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Sunlight, Vitamin D and Skin Cancer by : Jörg Reichrath

Download or read book Sunlight, Vitamin D and Skin Cancer written by Jörg Reichrath and published by Springer Nature. This book was released on 2020-09-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.

Nordic Nutrition Recommendations 2012

Author : Nordic Council of Ministers
Publisher : Nordic Council of Ministers
ISBN 13 : 9289326719
Total Pages : 544 pages
Book Rating : 4.2/5 (893 download)

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Book Synopsis Nordic Nutrition Recommendations 2012 by : Nordic Council of Ministers

Download or read book Nordic Nutrition Recommendations 2012 written by Nordic Council of Ministers and published by Nordic Council of Ministers. This book was released on 2014-03-06 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nordic countries have collaborated in setting guidelines for dietary composition and recommended intakes of nutrients for several decades through the joint publication of the Nordic Nutrition Recommendations (NNR). This 5th edition, the NNR 2012, gives Dietary Reference Values (DRVs) for nutrients, and compared with earlier editions more emphasis has been put on evaluating the scientific evidence for the role of food and food patterns contributing to the prevention of the major diet-related chronic diseases. Recommendations on physical activity are included and interaction with physical activity has been taken into account for the individual nutrient recommendations wherever appropriate. A chapter on sustainable food consumption has been added. A Nordic perspective has been accounted for in setting the reference values.The NNR 2012 has used an evidence-based and transparent approach in assessing associations between nutrients and foods and certain health outcomes. Systematic reviews form the basis for the recommendations of several nutrients and topics, while a less stringent update has been done for others. The systematic reviews and individual chapters have been peer reviewed and the systematic reviews are published in the Food & Nutrition Research journal. The draft chapters were subject to an open public consultation. Recommendations have been changed only when sufficient scientific evidence has evolved since the 4th edition. The primary aim of the NNR 2012 is to present the scientific background of the recommendations and their application. A secondary aim is for the NNR 2012 to function as a basis for the national recommendations that are adopted by the individual

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1876 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1876 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Comparative Quantification of Health Risks: Sexual and reproductive health

Author : Majid Ezzati
Publisher : World Health Organization
ISBN 13 : 9241580313
Total Pages : 2282 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Comparative Quantification of Health Risks: Sexual and reproductive health by : Majid Ezzati

Download or read book Comparative Quantification of Health Risks: Sexual and reproductive health written by Majid Ezzati and published by World Health Organization. This book was released on 2004 with total page 2282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive assessment of the scientific evidence on prevalence and the resulting health effects of a range of exposures that are know to be hazardous to human health, including childhood and maternal undernutrition, nutritional and physiological risk factors for adult health, addictive substances, sexual and reproductive health risks, and risks in the physical environments of households and communities, as well as among workers. This book is the culmination of over four years of scientific equiry and data collection, know as the comparative risk assessment (CRA) project.

Physical Status

Author :
Publisher :
ISBN 13 : 9789241208543
Total Pages : 452 pages
Book Rating : 4.2/5 (85 download)

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Book Synopsis Physical Status by :

Download or read book Physical Status written by and published by . This book was released on 1995-01-01 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Feldman and Pike's Vitamin D

Author : Martin Hewison
Publisher : Elsevier
ISBN 13 : 0323913903
Total Pages : 1232 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Feldman and Pike's Vitamin D by : Martin Hewison

Download or read book Feldman and Pike's Vitamin D written by Martin Hewison and published by Elsevier. This book was released on 2023-10-28 with total page 1232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike's Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease. Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field. • A comprehensive reference ranging from basic biochemistry, cell biology, and physiology principles to the clinical diagnostic and management implications of vitamin D • Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of vitamin D, as opposed to searching through thousands of journal articles • Chapters written by the most prominent and well-published names in the field

Nutritional Biochemistry of the Vitamins

Author : David A. Bender
Publisher : Cambridge University Press
ISBN 13 : 1139437739
Total Pages : 514 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Nutritional Biochemistry of the Vitamins by : David A. Bender

Download or read book Nutritional Biochemistry of the Vitamins written by David A. Bender and published by Cambridge University Press. This book was released on 2003-09-18 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative and comprehensive review of our current knowledge of the vitamins, their metabolic functions and the scientific basis for setting recommended intakes for the prevention of deficiency and promotion of optimum health. This publication will be a valuable reference for students and specialists alike in the field of nutritional biochemistry.

Vitamin D and the Lung

Author : Augusto A. Litonjua
Publisher : Springer Science & Business Media
ISBN 13 : 1617798886
Total Pages : 333 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis Vitamin D and the Lung by : Augusto A. Litonjua

Download or read book Vitamin D and the Lung written by Augusto A. Litonjua and published by Springer Science & Business Media. This book was released on 2012-05-23 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D deficiency is a worldwide problem and many associations with diseases are being discovered. Recently, there has been an interest in the role that vitamin D plays in the inception and progression of lung disease. Vitamin D and the Lung: Mechanisms and Disease Associations delivers a concise, evidence-based review of the evidence for a role of vitamin D in various lung disorders. Divided into three sections, the first section of the book delivers a review of how vitamin D deficiency emerged in human populations, and gives a perspective on how humans evolved to maximize the efficiency of production of vitamin D. The second section of the book reviews aspects of vitamin D mechanisms on different immune cells, lung tissue, and genetics that have potential impact on lung disease. The third section follows with chapters on associations of vitamin D with the risk for viral infections, asthma and allergies, chronic obstructive pulmonary disease, cystic fibrosis, tuberculosis, and finally, lung cancer with an emphasis on ongoing research and clinical issues and needs for future research in each field. Written by an international group of expert authors, Vitamin D and the Lung: Mechanisms and Disease Associations is an essential text for researchers in the respiratory field and practicing clinicians including internists, pulmonologists, and primary care personnel.