Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
An Introduction To High Content Screening
Download An Introduction To High Content Screening full books in PDF, epub, and Kindle. Read online An Introduction To High Content Screening ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis An Introduction To High Content Screening by : Steven A. Haney
Download or read book An Introduction To High Content Screening written by Steven A. Haney and published by John Wiley & Sons. This book was released on 2015-01-07 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a collaborative and interdisciplinary author base with experience in the pharmaceutical industry and academia, this book is a practical resource for high content (HC) techniques. • Instructs readers on the fundamentals of high content screening (HCS) techniques • Focuses on practical and widely-used techniques like image processing and multiparametric assays • Breaks down HCS into individual modules for training and connects them at the end • Includes a tutorial chapter that works through sample HCS assays, glossary, and detailed appendices
Book Synopsis High Throughput Screening by : William P. Janzen
Download or read book High Throughput Screening written by William P. Janzen and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wish had been available when they started in HTS, these expert seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge.
Book Synopsis Cell-Based Assays for High-Throughput Screening by : Paul A. Clemons
Download or read book Cell-Based Assays for High-Throughput Screening written by Paul A. Clemons and published by Humana Press. This book was released on 2014-11-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the use of high-throughput screening expands and creates more interest in the academic community, the need for detailed reference materials becomes ever more pressing. Cell-Based Assays for High-Throughput Screening: Methods and Protocols aims to fill an important part of this need by providing an easily accessible reference volume for cell-based phenotypic screening. Leading researchers in the field contribute state-of-the-art methods with actionable protocols covering four major areas of study: model biological systems, screening modalities and assay systems, detection technologies, and approaches to data analysis. Written in the highly successful Methods in Molecular BiologyTM series format, each chapter includes a brief introduction to the subject, lists of necessary materials and reagents, step-by-step laboratory protocols, and a Notes section detailing tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy-to-use, Cell-Based Assays for High-Throughput Screening: Methods and Protocols presents an overview of relevant approaches, enabling the direct application of existing methods to new discoveries while also inspiring researchers to approach their screening projects in a conceptually modular fashion, enhancing the power to discover through new combinations of existing approaches.
Book Synopsis High Content Screening by : D. Lansing Taylor
Download or read book High Content Screening written by D. Lansing Taylor and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has always been some tension between proponents of hypothesis-driven and discovery-driven research in the broad field of life sciences. Academic research has been primarily focused on hypothesis-driven research. However, the success of the human genome project, a discovery-driven research approach, has opened the door to adding other types of discovery-driven research to a continuum of research approaches. In contrast, drug discovery research in the pharmaceutical industry has embraced discovery-driven research for many years. A good example has been the discovery of active compounds from large chemical libraries, through screening campaigns. The success of the human genome project has also demonstrated the need for both academic researchers and industrial researchers to now understand the functions of genes and gene products. The cell is the basic unit of life and it has been at the cellular level where function can be demonstrated most cost-effectively and rapidly. High content screening (HCS) was developed by Cellomics Inc. in the mid-1990s to address the need for a platform that could be used in the discovery-driven research and development required to understand the functions of genes and gene products at the level of the cell.
Book Synopsis Optimal High-Throughput Screening by : Xiaohua Douglas Zhang
Download or read book Optimal High-Throughput Screening written by Xiaohua Douglas Zhang and published by Cambridge University Press. This book was released on 2011-02-21 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.
Book Synopsis High Content Screening by : Steven A. Haney
Download or read book High Content Screening written by Steven A. Haney and published by John Wiley & Sons. This book was released on 2008-01-18 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authoritative reference on High Content Screening (HCS) in biological and pharmaceutical research, this guide covers: the basics of HCS: examples of HCS used in biological applications and early drug discovery, emphasizing oncology and neuroscience; the use of HCS across the drug development pipeline; and data management, data analysis, and systems biology, with guidelines for using large datasets. With an accompanying CD-ROM, this is the premier reference on HCS for researchers, lab managers, and graduate students.
Book Synopsis Content Analysis by : Klaus Krippendorff
Download or read book Content Analysis written by Klaus Krippendorff and published by SAGE. This book was released on 2004 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Content Analysis: An Introduction to Its Methodology is a definitive sourcebook of the history and core principles of content analysis as well as an essential resource for present and future studies. The book introduces readers to ways of analyzing meaningful matter such as texts, images, voices - that is, data whose physical manifestations are secondary to the meanings that a particular population of people brings to them. Organized into three parts, the book examines the conceptual and methodological aspects of content analysis and also traces several paths through content analysis protocols. The author has completely revised and updated the Second Edition, integrating new information on computer-aided text analysis. The book also includes a practical guide that incorporates experiences in teaching and how to advise academic and commercial researchers. In addition, Krippendorff clarifies the epistemology and logic of content analysis as well as the methods for achieving its aims. Intended as a textbook for advanced undergraduate and graduate students across the social sciences, Content Analysis, Second Edition will also be a valuable resource for practitioners in a variety of disciplines.
Book Synopsis Chemogenomics and Chemical Genetics by : ERIC MARECHAL
Download or read book Chemogenomics and Chemical Genetics written by ERIC MARECHAL and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently introduced in academic laboratories. High-throughput and high-content screening allow the identification of bioactive compounds in collections of molecules (chemical libraries), being effective on biological targets defined at various organisational scales, from proteins to cells to complete organisms. These bioactive molecules can be therapeutic drug candidates, molecules for biotech, diagnostic or agronomic applications, or tools for basic research. Handling a large number of biological (genomic and post-genomic), chemical and experimental information, screening approaches cannot be envisaged without any electronic storage and mathematical treatment of the data. “Chemogenomics and Chemical Genetics” is an introductory manual presenting methods and concepts making up the basis for this recent discipline. This book is dedicated to biologists, chemists and computer scientist beginners. It is organized in brief, illustrated chapters with practical examples. Clear definitions of biological, chemical and IT concepts are given in a glossary section to help readers who are not familiar with one of these disciplines. "Chemogenomics and Chemical Genetics" should therefore be helpful for students (from Bachelor's degree level), technological platform engineers, and researchers in biology, chemistry, bioinformatics, cheminformatics, both in biotech and academic laboratories.
Book Synopsis High-Throughput Screening in Drug Discovery by : Jörg Hüser
Download or read book High-Throughput Screening in Drug Discovery written by Jörg Hüser and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.
Book Synopsis Independent Component Analysis by : James V. Stone
Download or read book Independent Component Analysis written by James V. Stone and published by MIT Press. This book was released on 2004 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fundamental problem in neural network research, as well as in many other disciplines, is finding a suitable representation of multivariate data, i.e. random vectors. For reasons of computational and conceptual simplicity, the representation is often sought as a linear transformation of the original data. In other words, each component of the representation is a linear combination of the original variables. Well-known linear transformation methods include principal component analysis, factor analysis, and projection pursuit. Independent component analysis (ICA) is a recently developed method in which the goal is to find a linear representation of nongaussian data so that the components are statistically independent, or as independent as possible. Such a representation seems to capture the essential structure of the data in many applications, including feature extraction and signal separation.
Book Synopsis Qualitative Content Analysis in Practice by : Margrit Schreier
Download or read book Qualitative Content Analysis in Practice written by Margrit Schreier and published by SAGE. This book was released on 2012-02-21 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Qualitative content analysis is a powerful method for analyzing large amounts of qualitative data collected through interviews or focus groups. It is frequently employed by students, but introductory textbooks on content analysis have largely focused on the quantitative version of the method. In one of the first to focus on qualitative content analysis, Margrit Schreier takes students step-by step through: - creating a coding frame - segmenting the material - trying out the coding frame - evaluating the trial coding - carrying out the main coding - what comes after qualitative content analysis - making use of software when conducting qualitative content analysis. Each part of the process is described in detail and research examples are provided to illustrate each step. Frequently asked questions are answered, the most important points are summarized, and end of chapter questions provide an opportunity to revise these points. After reading the book, students are fully equiped to conduct their own qualitative content analysis. Designed for upper level undergraduate, MA, PhD students and researchers across the social sciences, this is essential reading for all those who want to use qualitative content analysis.
Book Synopsis Methods for Analysis of Golgi Complex Function by :
Download or read book Methods for Analysis of Golgi Complex Function written by and published by Elsevier. This book was released on 2013-11-26 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Cell Biology looks at methods for analyzing of golgi complex function. Chapters cover such topics as in vitro reconstitution systems, fluorescence-based analysis of trafficking in mammalian cells and high content screening. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come. Covers sections on model systems and functional studies, imaging-based approaches and emerging studies Chapters are written by experts in the field Cutting-edge material
Download or read book Assay Development written by Ge Wu and published by John Wiley & Sons. This book was released on 2010-04-26 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential principles and practice of assay development The first comprehensive, integrated treatment of the subject, Assay Development: Fundamentals and Practices covers the essentials and techniques involved in carrying out an assay project in either a biotechnology/drug discovery setting or a platform setting. Rather than attempting comprehensive coverage of all assay development technologies, the book introduces the most widely used assay development technologies and illustrates the art of assay development through a few commonly encountered biological targets in assay development (e.g., proteases, kinases, ion channels, and G protein-coupled receptors). Just enough biological background for these biological targets is provided so that the reader can follow the logics of assay development. Chapters discuss: The basics of assay development, including foundational concepts and applications Commonly used instrumental methods for both biochemical assays and cell-based assays Assay strategies for protein binding and enzymatic activity Cell-based assays High-throughput screening An in-depth study of the now popular Caliper's off-chip kinase assay provides an instructive, real-world example of the assay development process.
Book Synopsis Handbook of Harnessing Biomaterials in Nanomedicine by : Dan Peer
Download or read book Handbook of Harnessing Biomaterials in Nanomedicine written by Dan Peer and published by CRC Press. This book was released on 2012-01-12 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concentrates on the use of biomaterials in nanomedicine. The areas of focus include drug delivery by polymers , lipids and carbohydrates for the delivery of small molecules, RNA interference, and proteins; the use of nano-proteins such as antibodies and peptides as targeting agents for therapeutics and diagnosis; The use of nanocarrier-based biomaterials for manipulation of stem cells; different aspects of toxicity of nanocarriers (the immune response, liver toxicity, and many more); and success stories of biomaterials that have reached the clinics. The book comprises theoretical and experimental analysis of various biomaterials that are used in nanomedicine, research methods and preparation techniques, and several promising applications.
Book Synopsis Introduction to Analysis by : Maxwell Rosenlicht
Download or read book Introduction to Analysis written by Maxwell Rosenlicht and published by Courier Corporation. This book was released on 2012-05-04 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for junior and senior undergraduates, this remarkably clear and accessible treatment covers set theory, the real number system, metric spaces, continuous functions, Riemann integration, multiple integrals, and more. 1968 edition.
Book Synopsis Modeling and Data Analysis: An Introduction with Environmental Applications by : John B. Little
Download or read book Modeling and Data Analysis: An Introduction with Environmental Applications written by John B. Little and published by American Mathematical Soc.. This book was released on 2019-03-28 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Can we coexist with the other life forms that have evolved on this planet? Are there realistic alternatives to fossil fuels that would sustainably provide for human society's energy needs and have fewer harmful effects? How do we deal with threats such as emergent diseases? Mathematical models—equations of various sorts capturing relationships between variables involved in a complex situation—are fundamental for understanding the potential consequences of choices we make. Extracting insights from the vast amounts of data we are able to collect requires analysis methods and statistical reasoning. This book on elementary topics in mathematical modeling and data analysis is intended for an undergraduate “liberal arts mathematics”-type course but with a specific focus on environmental applications. It is suitable for introductory courses with no prerequisites beyond high school mathematics. A great variety of exercises extends the discussions of the main text to new situations and/or introduces new real-world examples. Every chapter ends with a section of problems, as well as with an extended chapter project which often involves substantial computing work either in spreadsheet software or in the R statistical package.
Book Synopsis Scanning Electron Microscopy and X-Ray Microanalysis by : Joseph Goldstein
Download or read book Scanning Electron Microscopy and X-Ray Microanalysis written by Joseph Goldstein and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has evolved by processes of selection and expansion from its predecessor, Practical Scanning Electron Microscopy (PSEM), published by Plenum Press in 1975. The interaction of the authors with students at the Short Course on Scanning Electron Microscopy and X-Ray Microanalysis held annually at Lehigh University has helped greatly in developing this textbook. The material has been chosen to provide a student with a general introduction to the techniques of scanning electron microscopy and x-ray microanalysis suitable for application in such fields as biology, geology, solid state physics, and materials science. Following the format of PSEM, this book gives the student a basic knowledge of (1) the user-controlled functions of the electron optics of the scanning electron microscope and electron microprobe, (2) the characteristics of electron-beam-sample inter actions, (3) image formation and interpretation, (4) x-ray spectrometry, and (5) quantitative x-ray microanalysis. Each of these topics has been updated and in most cases expanded over the material presented in PSEM in order to give the reader sufficient coverage to understand these topics and apply the information in the laboratory. Throughout the text, we have attempted to emphasize practical aspects of the techniques, describing those instru ment parameters which the microscopist can and must manipulate to obtain optimum information from the specimen. Certain areas in particular have been expanded in response to their increasing importance in the SEM field. Thus energy-dispersive x-ray spectrometry, which has undergone a tremendous surge in growth, is treated in substantial detail.
