An Exploration Of Evidence Synthesis Methods For Adverse Events

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Finding What Works in Health Care

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309164257
Total Pages : 267 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Finding What Works in Health Care by : Institute of Medicine

Download or read book Finding What Works in Health Care written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-20 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.

Evidence Synthesis and Meta-analysis for Drug Safety

Author : Council for International Organizations of Medical Sciences (CIOMS)
Publisher : World Health Organization
ISBN 13 : 9789290360858
Total Pages : 0 pages
Book Rating : 4.3/5 (68 download)

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Book Synopsis Evidence Synthesis and Meta-analysis for Drug Safety by : Council for International Organizations of Medical Sciences (CIOMS)

Download or read book Evidence Synthesis and Meta-analysis for Drug Safety written by Council for International Organizations of Medical Sciences (CIOMS) and published by World Health Organization. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: At any point in the drug development process, systematic reviews and meta-analysis can provide important information to guide the future path of the development program and any actions that might be needed in the post-marketing setting. This report gives the rationale for why and when a meta-analysis should be considered, all in the context of regulatory decision-making, and the tasks, data collection, and analyses that need to be carried out to inform those decisions. There is increasing demand by decision-makers in health care, the bio-pharmaceutical industry, and society at large to have access to the best available evidence on benefits and risks of medicinal products. The best strategy will take an overview of all the evidence and where it is possible and sensible, combine the evidence and summarize the results. For efficacy, the outcomes generally use the same or very similar predefined events for each of the trials to be included. Most regulatory guidance and many Cochrane Collaboration reviews have usually given more attention to assessment of benefits, while issues around combining evidence on harms have not been as well-covered. However, the (inevitably) unplanned nature of the data on safety makes the process more difficult. Combining evidence on adverse events (AEs), where these were not the focus of the original studies, is more challenging than combining evidence on pre-specified benefits. This focus on AEs represents the main contribution of the current CIOMS X report. The goal of the CIOMS X report is to provide principles on appropriate application of meta-analysis in assessing safety of pharmaceutical products to inform regulatory decision-making. This report is about meta-analysis in this narrow area, but the present report should also provide conceptually helpful points to consider for a wider range of applications, such as vaccines, medical devices, veterinary medicines or even products that are combinations of medicinal products and medical devices. Although some of the content of this report describes highly technical statistical concepts and methods (in particular Chapter 4), the ambition of the working group has been to make it comprehensible to non-statisticians for its use in clinical epidemiology and regulatory science. To that end, Chapters 3 and 4, which contain the main technical statistical aspects of the appropriate design, analysis and reporting of a meta-analysis of safety data are followed by Chapter 5 with a thought process for evaluating the findings of a meta-analysis and how to communicate these.

Improving Usability, Safety and Patient Outcomes with Health Information Technology

Author : F. Lau
Publisher : IOS Press
ISBN 13 : 1614999511
Total Pages : 570 pages
Book Rating : 4.6/5 (149 download)

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Book Synopsis Improving Usability, Safety and Patient Outcomes with Health Information Technology by : F. Lau

Download or read book Improving Usability, Safety and Patient Outcomes with Health Information Technology written by F. Lau and published by IOS Press. This book was released on 2019-03-26 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information technology is revolutionizing healthcare, and the uptake of health information technologies is rising, but scientific research and industrial and governmental support will be needed if these technologies are to be implemented effectively to build capacity at regional, national and global levels. This book, "Improving Usability, Safety and Patient Outcomes with Health Information Technology", presents papers from the Information Technology and Communications in Health conference, ITCH 2019, held in Victoria, Canada from 14 to 17 February 2019. The conference takes a multi-perspective view of what is needed to move technology forward to sustained and widespread use by transitioning research findings and approaches into practice. Topics range from improvements in usability and training and the need for new and improved designs for information systems, user interfaces and interoperable solutions, to governmental policy, mandates, initiatives and the need for regulation. The knowledge and insights gained from the ITCH 2019 conference will surely stimulate fruitful discussions and collaboration to bridge research and practice and improve usability, safety and patient outcomes, and the book will be of interest to all those associated with the development, implementation and delivery of health IT solutions.

Cochrane Handbook for Systematic Reviews of Interventions

Author : Julian P. T. Higgins
Publisher : Wiley
ISBN 13 : 9780470699515
Total Pages : 672 pages
Book Rating : 4.6/5 (995 download)

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Book Synopsis Cochrane Handbook for Systematic Reviews of Interventions by : Julian P. T. Higgins

Download or read book Cochrane Handbook for Systematic Reviews of Interventions written by Julian P. T. Higgins and published by Wiley. This book was released on 2008-11-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.

Systematic Reviews

Author :
Publisher :
ISBN 13 : 9781900640473
Total Pages : 281 pages
Book Rating : 4.6/5 (44 download)

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Book Synopsis Systematic Reviews by :

Download or read book Systematic Reviews written by and published by . This book was released on 2009 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: For adults. There is a pressing need for methodologically sound RCTs to confirm whether such interventions are helpful and, if so, for whom.

Synthesizing Quantitative Evidence

Author :
Publisher :
ISBN 13 : 9781451163865
Total Pages : 76 pages
Book Rating : 4.1/5 (638 download)

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Book Synopsis Synthesizing Quantitative Evidence by :

Download or read book Synthesizing Quantitative Evidence written by and published by . This book was released on 2011 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The objective of a systematic review is to summarize the evidence on a specific clinical question using a transparent, a-priori protocol driven approach. This book provides an overview of the fundamental knowledge, principals and processes for the synthesis of quantitative data in reviews of the effectiveness of health care interventions. As such, it is designed for new reviewers, for students and as an introductory text for academics looking for a book on the fundamentals rather than advanced statistical processes."--[source inconnue].

Network Meta-analysis

Author : Giuseppe Biondi-Zoccai
Publisher : Nova Science Publishers
ISBN 13 : 9781633210011
Total Pages : 0 pages
Book Rating : 4.2/5 (1 download)

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Book Synopsis Network Meta-analysis by : Giuseppe Biondi-Zoccai

Download or read book Network Meta-analysis written by Giuseppe Biondi-Zoccai and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Network meta-analyses and mixed treatment comparisons represent the uppermost level in the evidence hierarchy for decision making, in medicine as well as in other scholarly fields. This book covers the main topics which should be mastered to critically read and interpret as well as, if deemed worthwhile, perform and report independently a network meta-analysis and mixed treatment comparison. The text includes dozens of tables and illustrations to guide visually the reader in understanding the basics as well as the more refined details of network meta-analyses.

Meta-Ethnography

Author : George W. Noblit
Publisher : SAGE
ISBN 13 : 9780803930230
Total Pages : 112 pages
Book Rating : 4.9/5 (32 download)

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Book Synopsis Meta-Ethnography by : George W. Noblit

Download or read book Meta-Ethnography written by George W. Noblit and published by SAGE. This book was released on 1988-02 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can ethnographic studies be generalized, in contrast to concentrating on the individual case? Noblit and Hare propose a new method for synthesizing from qualitative studies: meta-ethnography. After citing the criteria to be used in comparing qualitative research projects, the authors define the ways these can then be aggregated to create more cogent syntheses of research. Using examples from numerous studies ranging from ethnographic work in educational settings to the Mead-Freeman controversy over Samoan youth, Meta-Ethnography offers useful procedural advice from both comparative and cumulative analyses of qualitative data. This provocative volume will be read with interest by researchers and students in qualitative research methods, ethnography, education, sociology, and anthropology. "After defining metaphor and synthesis, these authors provide a step-by-step program that will allow the researcher to show similarity (reciprocal translation), difference (refutation), or similarity at a higher level (lines or argument synthesis) among sample studies....Contain(s) valuable strategies at a seldom-used level of analysis." --Contemporary Sociology "The authors made an important contribution by reframing how we think of ethnography comparison in a way that is compatible with the new developments in interpretive ethnography. Meta-Ethnography is well worth consulting for the problem definition it offers." --The Journal of Nervous and Mental Disease "This book had to be written and I am pleased it was. Someone needed to break the ice and offer a strategy for summarizing multiple ethnographic studies. Noblit and Hare have done a commendable job of giving the research community one approach for doing so. Further, no one else can now venture into this area of synthesizing qualitative studies without making references to and positioning themselves vis-a-vis this volume." -Educational Studies

Umbrella Reviews

Author : Giuseppe Biondi-Zoccai
Publisher : Springer
ISBN 13 : 3319256556
Total Pages : 390 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Umbrella Reviews by : Giuseppe Biondi-Zoccai

Download or read book Umbrella Reviews written by Giuseppe Biondi-Zoccai and published by Springer. This book was released on 2016-02-03 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an ideal guide to umbrella reviews, overviews of reviews, and meta-epidemiologic studies for evidence synthesis. Research is conducted at different levels: primary research consists of original studies while secondary research comprises qualitative reviews, systematic reviews, and meta-analyses. Recently, a novel further level of research has been introduced, based on the analysis and pooling of reviews and meta-analysis. This book is the first to focus solely on this new type of research design, which permits a comprehensive and powerful synthesis of scientific evidence in medicine as well as in many other fields in order to inform decision-making. All aspects are covered, including review design and registration, the searching, abstracting, appraisal, and synthesis of evidence, the appraisal of moderators and confounders, and state of the art reporting. Case studies in a range of medical specialties are then presented. The hands-on approach of the book, written by a multinational team of experts, will enable the reader to interpret and independently conduct umbrella reviews.

Evidence Synthesis for Decision Making in Healthcare

Author : Nicky J. Welton
Publisher : John Wiley & Sons
ISBN 13 : 111830540X
Total Pages : 296 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Evidence Synthesis for Decision Making in Healthcare by : Nicky J. Welton

Download or read book Evidence Synthesis for Decision Making in Healthcare written by Nicky J. Welton and published by John Wiley & Sons. This book was released on 2012-04-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish interventions that are both effective and cost-effective. Usually a single study will not fully address these issues and it is desirable to synthesize evidence from multiple sources. This book aims to provide a practical guide to evidence synthesis for the purpose of decision making, starting with a simple single parameter model, where all studies estimate the same quantity (pairwise meta-analysis) and progressing to more complex multi-parameter structures (including meta-regression, mixed treatment comparisons, Markov models of disease progression, and epidemiology models). A comprehensive, coherent framework is adopted and estimated using Bayesian methods. Key features: A coherent approach to evidence synthesis from multiple sources. Focus is given to Bayesian methods for evidence synthesis that can be integrated within cost-effectiveness analyses in a probabilistic framework using Markov Chain Monte Carlo simulation. Provides methods to statistically combine evidence from a range of evidence structures. Emphasizes the importance of model critique and checking for evidence consistency. Presents numerous worked examples, exercises and solutions drawn from a variety of medical disciplines throughout the book. WinBUGS code is provided for all examples. Evidence Synthesis for Decision Making in Healthcare is intended for health economists, decision modelers, statisticians and others involved in evidence synthesis, health technology assessment, and economic evaluation of health technologies.

Small Clinical Trials

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309171148
Total Pages : 221 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Small Clinical Trials by : Institute of Medicine

Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.

Patient Safety and Quality

Author : Ronda Hughes
Publisher : Department of Health and Human Services
ISBN 13 :
Total Pages : 592 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Patient Safety and Quality by : Ronda Hughes

Download or read book Patient Safety and Quality written by Ronda Hughes and published by Department of Health and Human Services. This book was released on 2008 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nurses play a vital role in improving the safety and quality of patient car -- not only in the hospital or ambulatory treatment facility, but also of community-based care and the care performed by family members. Nurses need know what proven techniques and interventions they can use to enhance patient outcomes. To address this need, the Agency for Healthcare Research and Quality (AHRQ), with additional funding from the Robert Wood Johnson Foundation, has prepared this comprehensive, 1,400-page, handbook for nurses on patient safety and quality -- Patient Safety and Quality: An Evidence-Based Handbook for Nurses. (AHRQ Publication No. 08-0043)." - online AHRQ blurb, http://www.ahrq.gov/qual/nurseshdbk/

Decision Making in Health and Medicine

Author : M. G. Myriam Hunink
Publisher : Cambridge University Press
ISBN 13 : 1107690471
Total Pages : 447 pages
Book Rating : 4.1/5 (76 download)

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Book Synopsis Decision Making in Health and Medicine by : M. G. Myriam Hunink

Download or read book Decision Making in Health and Medicine written by M. G. Myriam Hunink and published by Cambridge University Press. This book was released on 2014-10-16 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide for everyone involved in medical decision making to plot a clear course through complex and conflicting benefits and risks.

Examining the Impact of Real-World Evidence on Medical Product Development

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 030948832X
Total Pages : 231 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Examining the Impact of Real-World Evidence on Medical Product Development by : National Academies of Sciences, Engineering, and Medicine

Download or read book Examining the Impact of Real-World Evidence on Medical Product Development written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-04-05 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized controlled trials (RCTs) have traditionally served as the gold standard for generating evidence about medical interventions. However, RCTs have inherent limitations and may not reflect the use of medical products in the real world. Additionally, RCTs are expensive, time consuming, and cannot answer all questions about a product or intervention. Evidence generated from real-world use, such as real-world evidence (RWE) may provide valuable information, alongside RCTs, to inform medical product decision making. To explore the potential for using RWE in medical product decision making, the National Academies of Sciences, Engineering, and Medicine planned a three-part workshop series. The series was designed to examine the current system of evidence generation and its limitations, to identify when and why RWE may be an appropriate type of evidence on which to base decisions, to learn from successful initiatives that have incorporated RWE, and to describe barriers that prevent RWE from being used to its full potential. This publication summarizes the discussions from the entire workshop series.

Evidence-Based Public Health Practice

Author : Arlene Fink
Publisher : SAGE
ISBN 13 : 1412997445
Total Pages : 329 pages
Book Rating : 4.4/5 (129 download)

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Book Synopsis Evidence-Based Public Health Practice by : Arlene Fink

Download or read book Evidence-Based Public Health Practice written by Arlene Fink and published by SAGE. This book was released on 2013 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for students and practitioners, this practical book shows how to do evidence-based research in public health. As a great deal of evidence-based practice occurs online, it focuses on how to find, use, and interpret online sources of public health information. It also includes examples of community-based participatory research and shows how to link data with community preferences and needs.

Essentials of Epidemiology in Public Health

Author : Ann Aschengrau
Publisher : Jones & Bartlett Publishers
ISBN 13 : 1449657354
Total Pages : 547 pages
Book Rating : 4.4/5 (496 download)

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Book Synopsis Essentials of Epidemiology in Public Health by : Ann Aschengrau

Download or read book Essentials of Epidemiology in Public Health written by Ann Aschengrau and published by Jones & Bartlett Publishers. This book was released on 2013-06-03 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Successfully tested in the authors' courses at Boston University and Harvard University, this text combines theory and practice in presenting traditional and new epidemiologic concepts. Broad in scope, the text opens with five chapters covering the basic epidemiologic concepts and data sources. A major emphasis is placed on study design, with separate chapters devoted to each of the three main analytic designs: experimental, cohort, and case-control studies. Full chapters on bias, confounding, and random error, including the role of statistics in epidemiology, ensure that students are well-equipped with the necessary information to interpret the results of epidemiologic studies. An entire chapter is also devoted to the concept of effect measure modification, an often-neglected topic in introductory textbooks. Up-to-date examples from the epidemiologic literature on diseases of public health importance are provided throughout the book. The Third Edition is a thorough update that offers: • New examples, the latest references, and public health statistics. • Nearly 50 new review questions. • Updated discussion of certain epidemiologic methods. • New figures depicting epidemiologic concepts.

Evidence-Based Practice for Public Health Emergency Preparedness and Response

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309670381
Total Pages : 501 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Evidence-Based Practice for Public Health Emergency Preparedness and Response by : National Academies of Sciences, Engineering, and Medicine

Download or read book Evidence-Based Practice for Public Health Emergency Preparedness and Response written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-11-28 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: When communities face complex public health emergencies, state local, tribal, and territorial public health agencies must make difficult decisions regarding how to effectively respond. The public health emergency preparedness and response (PHEPR) system, with its multifaceted mission to prevent, protect against, quickly respond to, and recover from public health emergencies, is inherently complex and encompasses policies, organizations, and programs. Since the events of September 11, 2001, the United States has invested billions of dollars and immeasurable amounts of human capital to develop and enhance public health emergency preparedness and infrastructure to respond to a wide range of public health threats, including infectious diseases, natural disasters, and chemical, biological, radiological, and nuclear events. Despite the investments in research and the growing body of empirical literature on a range of preparedness and response capabilities and functions, there has been no national-level, comprehensive review and grading of evidence for public health emergency preparedness and response practices comparable to those utilized in medicine and other public health fields. Evidence-Based Practice for Public Health Emergency Preparedness and Response reviews the state of the evidence on PHEPR practices and the improvements necessary to move the field forward and to strengthen the PHEPR system. This publication evaluates PHEPR evidence to understand the balance of benefits and harms of PHEPR practices, with a focus on four main areas of PHEPR: engagement with and training of community-based partners to improve the outcomes of at-risk populations after public health emergencies; activation of a public health emergency operations center; communication of public health alerts and guidance to technical audiences during a public health emergency; and implementation of quarantine to reduce the spread of contagious illness.