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Author : Elhabib Benlhabib
Publisher :
ISBN 13 :
Total Pages : 618 pages
Book Rating : 4.:/5 (319 download)
Download or read book Alternative Treatment for Alcohol-dependence in Alcohol Preferring (P) Rats written by Elhabib Benlhabib and published by . This book was released on 2003 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : American Psychiatric Association
Publisher : American Psychiatric Pub
ISBN 13 : 0890426821
Total Pages : 226 pages
Book Rating : 4.8/5 (94 download)
Download or read book The American Psychiatric Association Practice Guideline for the Pharmacological Treatment of Patients With Alcohol Use Disorder written by American Psychiatric Association and published by American Psychiatric Pub. This book was released on 2018-01-11 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol use disorder (AUD) is a major public health problem in the United States. The estimated 12-month and lifetime prevalence values for AUD are 13.9% and 29.1%, respectively, with approximately half of individuals with lifetime AUD having a severe disorder. AUD and its sequelae also account for significant excess mortality and cost the United States more than $200 billion annually. Despite its high prevalence and numerous negative consequences, AUD remains undertreated. In fact, fewer than 1 in 10 individuals in the United States with a 12-month diagnosis of AUD receive any treatment. Nevertheless, effective and evidence-based interventions are available, and treatment is associated with reductions in the risk of relapse and AUD-associated mortality. The American Psychiatric Association Practice Guideline for the Pharmacological Treatment of Patients With Alcohol Use Disorder seeks to reduce these substantial psychosocial and public health consequences of AUD for millions of affected individuals. The guideline focuses specifically on evidence-based pharmacological treatments for AUD in outpatient settings and includes additional information on assessment and treatment planning, which are an integral part of using pharmacotherapy to treat AUD. In addition to reviewing the available evidence on the use of AUD pharmacotherapy, the guideline offers clear, concise, and actionable recommendation statements, each of which is given a rating that reflects the level of confidence that potential benefits of an intervention outweigh potential harms. The guideline provides guidance on implementing these recommendations into clinical practice, with the goal of improving quality of care and treatment outcomes of AUD.
Author : Henri Begleiter
Publisher : Oxford University Press, USA
ISBN 13 : 9780195100945
Total Pages : 544 pages
Book Rating : 4.1/5 (9 download)
Download or read book The Pharmacology of Alcohol and Alcohol Dependence written by Henri Begleiter and published by Oxford University Press, USA. This book was released on 1996 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive review of the pharmacological effects of alcohol and the mechanisms underlying the pathogenesis of alcoholism. The book draws on general pharmacology, neuropharmacology, and alcohol studies to explore its theme. The second volume in the ALCOHOL AND ALCOHOLISM series, it focuses on the pharmacologic mechanisms underlying the development of alcoholism. The first section on basic pharmacology is concerned with those aspects that are common to all of alcohol's effects. These include pharmacokinetics, general metabolism, and cross-tolerance. The second section on neuropharmacology describes the effects of alcohol on various brain functions, including circulation and metabolism. The third section provides an in-depth review of the neurobiology of physical dependence, withdrawal, and physiological tolerance. The book as a whole gives a comprehensive and authoritative picture of the complex pharmacologic actions of alcohol, particularly on the nervous system. For clinicians and researchers in the field of alcohol and alcoholism, it will serve as a fundamental reference.
Author : Antonio Noronha
Publisher : Elsevier
ISBN 13 : 0124071554
Total Pages : 573 pages
Book Rating : 4.1/5 (24 download)
Download or read book Neurobiology of Alcohol Dependence written by Antonio Noronha and published by Elsevier. This book was released on 2014-05-02 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available
Author : Jerry J. Buccafusco
Publisher : CRC Press
ISBN 13 : 1420041819
Total Pages : 341 pages
Book Rating : 4.4/5 (2 download)
Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Author : Mathis Heydtmann
Publisher : Frontiers Media SA
ISBN 13 : 2889459675
Total Pages : 130 pages
Book Rating : 4.8/5 (894 download)
Download or read book Baclofen in the Treatment of Alcohol Use Disorder written by Mathis Heydtmann and published by Frontiers Media SA. This book was released on 2019-08-19 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a collection on use of the GABA-B agonist Baclofen in the use of alcohol use disorder. The articles center around efficacy of Baclofen ranging from acute withdrawal to maintenance of abstinence, address the issue of dosing and indications and variation of Baclofen use worldwide.
Author : Wolfgang Sommer
Publisher : Springer Science & Business Media
ISBN 13 : 3642287204
Total Pages : 721 pages
Book Rating : 4.6/5 (422 download)
Download or read book Behavioral Neurobiology of Alcohol Addiction written by Wolfgang Sommer and published by Springer Science & Business Media. This book was released on 2012-07-28 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: The question how alcohol alters mood states and why this may end up becoming an addiction is puzzling alcohol researchers since decades. In this volume, an assembly of highly distinguished experts and leaders in alcohol addiction research provides lucid presentations of the current knowledge and research challenges as well as interesting viewpoints on future research directions aimed to stimulate communication and convergence between clinical and preclinical researchers, and to renew interest in the vibrant field of alcohol addiction research among a wide scientifically minded audience. Five Current Topics are discussed in this volume: Neurobiological mechanisms of alcoholism, Genetics, Clinical phenotypes and their preclinical models, Brain imaging, and Translational approaches for treatment development, both pharmacological and non-pharmacological. These areas have in our opinion brought alcohol research substantially forward and influenced our thinking about how to reach our common paramount goal, namely to offer effective treatment solutions for an extensive group of patients with largely unmet medical needs.
Author :
Publisher : Academic Press
ISBN 13 : 0123983606
Total Pages : 759 pages
Book Rating : 4.1/5 (239 download)
Download or read book Biological Research on Addiction written by and published by Academic Press. This book was released on 2013-05-17 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Research on Addiction examines the neurobiological mechanisms of drug use and drug addiction, describing how the brain responds to addictive substances as well as how it is affected by drugs of abuse. The book's four main sections examine behavioral and molecular biology; neuroscience; genetics; and neuroimaging and neuropharmacology as they relate to the addictive process. This volume is especially effective in presenting current knowledge on the key neurobiological and genetic elements in an individual’s susceptibility to drug dependence, as well as the processes by which some individuals proceed from casual drug use to drug dependence. Biological Research on Addiction is one of three volumes comprising the 2,500-page series, Comprehensive Addictive Behaviors and Disorders. This series provides the most complete collection of current knowledge on addictive behaviors and disorders to date. In short, it is the definitive reference work on addictions. Each article provides glossary, full references, suggested readings, and a list of web resources Edited and authored by the leaders in the field around the globe – the broadest, most expert coverage available Discusses the genetic basis of addiction Covers basic science research from a variety of animal studies
Author : Ronald Kadden
Publisher : DIANE Publishing
ISBN 13 : 0788108999
Total Pages : 118 pages
Book Rating : 4.7/5 (881 download)
Download or read book Cognitive-behavioral Coping Skills Therapy Manual written by Ronald Kadden and published by DIANE Publishing. This book was released on 1995 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study is the first national, multi-site trial of patient-treatment matching. Describes cognitive-behavioral coping skills therapy (CBT), one type of treatment approach. Core Sessions include coping with cravings and urges to drink; problem solving; drink refusal skills, and more. Elective Sessions include starting conversations; introduction to assertiveness; anger management; job-seeking skills, and much more. Bibliography.
Author : Joaquin M. Fuster
Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 364 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Prefrontal Cortex written by Joaquin M. Fuster and published by Lippincott Williams & Wilkins. This book was released on 1997 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.:/5 ( download)
Download or read book The Journal of Alternative and Complementary Medicine written by and published by . This book was released on 2007 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309040388
Total Pages : 640 pages
Book Rating : 4.3/5 (9 download)
Download or read book Broadening the Base of Treatment for Alcohol Problems written by Institute of Medicine and published by National Academies Press. This book was released on 1990-02-01 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this congressionally mandated study, an expert committee of the Institute of Medicine takes a close look at where treatment for people with alcohol problems seems to be headed, and provides its best advice on how to get there. Careful consideration is given to how the creative growth of treatment can best be encouraged while keeping costs within reasonable limits. Particular attention is devoted to the importance of developing therapeutic approaches that are sensitive to the special needs of the many diverse groups represented among those who have developed problems related to their use of "man's oldest friend and oldest enemy." This book is the most comprehensive examination of alcohol treatment to date.
Author : George F. Koob
Publisher : Academic Press
ISBN 13 : 0123869595
Total Pages : 351 pages
Book Rating : 4.1/5 (238 download)
Download or read book Drugs, Addiction, and the Brain written by George F. Koob and published by Academic Press. This book was released on 2014-07-12 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle Actual data figures from original sources illustrating key concepts and findings Introduction to basic neuropharmacology terms and concepts Introduction to numerous animal models used to study diverse aspects of drug use. Thorough review of extant work on the neurobiology of addiction
Author : Aparajita Dey
Publisher : Springer Science & Business Media
ISBN 13 : 9400758812
Total Pages : 269 pages
Book Rating : 4.4/5 (7 download)
Download or read book Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism written by Aparajita Dey and published by Springer Science & Business Media. This book was released on 2013-02-12 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.
Author : Abdul Maruf Asif Aziz
Publisher : Linköping University Electronic Press
ISBN 13 : 9176854841
Total Pages : 108 pages
Book Rating : 4.1/5 (768 download)
Download or read book Neuropeptide Receptors as Treatment Targets in Alcohol Use Disorders written by Abdul Maruf Asif Aziz and published by Linköping University Electronic Press. This book was released on 2017-08-21 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol use disorder (AUD) is a complex disorder with multiple pathophysiological processes contributing to the initiation, progression and development of the disease state. AUD is a chronic relapsing disease with escalation of alcohol-intake over time in repeated cycles of tolerance, abstinence and relapse and hence, it is very difficult to treat. There are only a few currently available treatments with narrow efficacy and variable patient response. Thus it is important to find new, more effective medications to increase the number of patients who can benefit from pharmacological treatment of AUD. The research presented in this thesis work focuses on the critical involvement of central neuropeptides in alcohol-related behaviors. The overall aim was to evaluate the nociceptin/orphanin FQ (NOP) receptor, the neuropeptide Y (NPY) Y2 receptor and the melanin-concentrating hormone (MCH) receptor 1 as novel and potential pharmacological treatment targets for AUD by testing the NOP receptor agonist SR-8993, the NPY-Y2 receptor antagonist CYM-9840 and the MCH1 receptor antagonist GW803430 in established animal models. In the first study (Paper I), the novel and selective NOP agonist SR-8993 was assessed in rat models of motivation to obtain alcohol and relapse to alcohol seeking behavior using the operant self-administration (SA) paradigm. Firstly, treatment with SR-8993 (1 mg/kg) showed a mildly anxiolytic effect and reversed acute alcohol withdrawal-induced “hangover” anxiety in the elevated plus-maze (EPM). Next, it potently attenuated alcohol SA and motivation to obtain alcohol in the progressive ratio responding (PRR) and reduced both alcohol cue-induced and yohimbine stress-induced reinstatement of alcohol seeking, without affecting the pharmacology and metabolism of alcohol nor other control behaviors. To extend these findings, SR-8993 was evaluated in escalated alcohol-intake in rats. Treatment with SR-8993 significantly suppressed alcohol-intake and preference in rats that were trained to consume high amounts of alcohol in the two-bottle free choice intermittent access (IA) paradigm. SR-8993 also blocked operant SA of alcohol in rats that showed robust escalation in operant alcohol SA following chronic IA exposure to alcohol. In the second study (Paper II), SR-8993 was further evaluated in a model for escalated alcohol-intake induced by long-term IA exposure to alcohol. The effect of previous experience on operant alcohol SA on two-bottle free choice preference drinking was evaluated and sensitivity to treatment with SR-8993 was tested in rats selected for escalated and non-escalated alcohol seeking behavior. We found that rats exposed to the combined SA-IA paradigm showed greater sensitivity to SR-8993 treatment. In addition, acute escalation of alcohol SA after a three-week period of abstinence was completely abolished by pretreatment with SR-8993. In the third study (Paper III), the effects of the novel, small molecule NPY-Y2 antagonist CYM-9840 were tested in operant alcohol SA, PRR which is a model for motivation to work for alcohol and reinstatement of alcohol-seeking behavior. Treatment with CYM-9840 (10 mg/kg) potently attenuated alcohol SA, progressive ratio responding and stress-induced reinstatement using yohimbine as the stressor, while alcohol cue-induced reinstatement was unaffected. Moreover, a range of control behaviors including taste sensitivity, locomotor and pharmacological sensitivity to the sedative effects of alcohol remained unaffected by CYM-9840 pretreatment, indicating that its effects are specific to the rewarding and motivational aspects of alcohol-intake and related behaviors. CYM-9840 also reversed acute alcohol withdrawal-induced “hangover” anxiety measured in the EPM and reduced alcohol-intake in the 4 hour limited access two-bottle free choice preference drinking model. Finally, in the fourth study (Paper IV), the selective MCH1-R antagonist GW803430 was tested in rat models of escalated alcohol-intake. Pretreatment with GW803430 (effective at 10 & 30 mg/kg) dose-dependently reduced alcohol and food-intake in rats that consumed high amounts of alcohol during IA, while it only decreased food-intake in rats that consumed low amounts of alcohol during IA, likely due to a floor effect. Upon protracted abstinence following IA, GW803430 significantly reduced operant alcohol SA and this was associated with adaptations in MCH and MCH1-R gene-expression. In contrast, GW803430 did not affect escalated alcohol SA induced by chronic alcohol vapor exposure and this was accompanied by no change in MCH or MCH1-R gene expression. Overall, these results suggest that the MCH1-R antagonist affects alcohol-intake through regulation of both motivation for caloric-intake and the rewarding properties of alcohol. In conclusion, our results suggest critical roles for these central neuropeptides in the regulation of anxiety and of alcohol reward, making them potential pharmacological targets in the treatment of AUD.
Author : David H. Overstreet
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128064749
Total Pages : 30 pages
Book Rating : 4.1/5 (28 download)
Download or read book Biological Research on Addiction written by David H. Overstreet and published by Elsevier Inc. Chapters. This book was released on 2013-05-17 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : André Luiz Monezi Andrade
Publisher : Springer
ISBN 13 : 3319431722
Total Pages : 242 pages
Book Rating : 4.3/5 (194 download)
Download or read book Innovations in the Treatment of Substance Addiction written by André Luiz Monezi Andrade and published by Springer. This book was released on 2016-10-06 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging approaches to treating addictions and minimizing relapse are spotlighted in this idea-packed volume, as alternatives or adjuncts to standard psychological and pharmacological therapies. Its biopsychosocial perspective delves into the causes and processes of chemical dependence, and the clinical characteristics it shares with other addictions (e.g., food, sex, gambling, online activities), to identify client needs that substance abuse may fulfill. Accordingly, the diverse modalities featured here address substance addiction on multiple levels, offering clients physical or mental stimulation and/or emotional relief as well as affording different degrees of autonomy. Methods can be mixed and matched to reinforce treatment goals, and clinicians can tailor treatment to individual issues and interests to assure clients nuanced and meaningful care. Included in the coverage: · Use of herbal medicine to treat drug addiction. · EMDR therapy and the treatment of substance abuse and addiction. · Evaluating the change processes in drug users’ interventions. · Web-based interventions for substance abuse. · Physical exercise and treatment of addiction. · Mindfulness to reduce the anxiety during the abstinence · Neurofeedback to deal with craving and anxiety symptoms Psychologists, psychiatrists, clinical social workers, and addiction counselors and educators will find Innovations in the Treatment of Substance Addiction a valuable sourcebook for understanding addiction—and intervention—in its wider context.
