Alfa Keto Acid Dehydrogenase Complexes X Regulation Of The Activity Of The Pyruvate Dehydrogenase Complex From Beef Kidney Mitochondria By Phosphorylation And Dephosphorylation

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Alpha-Keto Acid Dehydrogenase Complexes

Author : M.S. Patel
Publisher : Birkhäuser
ISBN 13 : 303488981X
Total Pages : 321 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Alpha-Keto Acid Dehydrogenase Complexes by : M.S. Patel

Download or read book Alpha-Keto Acid Dehydrogenase Complexes written by M.S. Patel and published by Birkhäuser. This book was released on 2012-12-06 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Found in all organisms, the alpha-keto acid dehydrogenase complexes have central roles in cellular metabolism and are major sites of regulation. The understanding of the organization, function and regulation of these quintessential multienzyme complexes has been greatly advanced by studies employing molecular biology and biophysical techniques. Although these enzyme systems have some features in common, their diversity in fulfilling unique organism - or tissue - specific roles is truly amazing. These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (inborn errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis). This book brings together wide-ranging recent findings on the structure(function relationships, gene regulation, and genetic defects of the alpha-keto acid dehydrogenase complexes, namely the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the branched-chain alpha-keto acid dehydrogenase complexes. A wide variety of experimental approaches together with new results presented in this book should serve as a resource for beginning to established investigators in the field as well as scientists who are interested in mitochondria, dehydrogenases, kinases, phosphatases, lipoic acid, thiamine pyrophosphate, and enzyme complexes.

Receptor Phosphorylation

Author : Virinder K. Moudgil
Publisher : CRC Press
ISBN 13 : 1351084690
Total Pages : 394 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Receptor Phosphorylation by : Virinder K. Moudgil

Download or read book Receptor Phosphorylation written by Virinder K. Moudgil and published by CRC Press. This book was released on 2018-05-04 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The following chapters comprise invited contributions from eminent scientists who are internationally recognized authorities on the subject. The chapters have been written to provide the reader with adequate background, necessary experimental details, and discussion that is easy to comprehend. The book has been organized into four different sections. The introductory chapter is meant to briefly summarize the contributions of other authors and discuss phosphorylation of receptor systems not covered in the book in detail. The chapters in the second section, on protein kinases and phosphatases, are quite fundamental to the process of phosphorylation and will aid the reader in appreciating the observations and discussions reported in other chapters. The third and fourth sections present discussions on phosphorylation of various receptor systems which are involved in mediating actions of peptide, amine, and steroid hormones. It is hoped that this book will serve as a valuable resource and will be useful to all workers and students in the area of receptor-ligand interactions.

Cerebral Ischemia and Resuscitation

Author : Avital Schurr
Publisher : CRC Press
ISBN 13 : 9780849367151
Total Pages : 456 pages
Book Rating : 4.3/5 (671 download)

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Book Synopsis Cerebral Ischemia and Resuscitation by : Avital Schurr

Download or read book Cerebral Ischemia and Resuscitation written by Avital Schurr and published by CRC Press. This book was released on 1990-09-24 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fascinating monograph is filled with information formerly found only in periodicals and symposia proceedings. Chapters discuss the different models of cerebral ischemia in use today, including their advantages and disadvantages. This one-of-a-kind resource also contains essential chapters on cellular mechanisms of ion and acid-base homeostases, and energy metabolism of the ischemic brain. It reviews the possible role of lipids, free fatty acids, and free radicals. Four chapters are devoted to neurotransmitters and neuroregulators in cerebral ischemia. This extraordinary work also covers aspects of protection against and resuscitation from cerebral ischemia. An extremely informative volume, this book is an absolute must for every student in the field of cerebral ischemia, as well as the clinician or scientist who is already involved with this worldwide problem.

Mitochondrial Function, Part B

Author :
Publisher : Academic Press
ISBN 13 : 008092350X
Total Pages : 578 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Mitochondrial Function, Part B by :

Download or read book Mitochondrial Function, Part B written by and published by Academic Press. This book was released on 2009-05-05 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second of two new volumes covering mitochondria, methods developed to assess the number and function of nuclear-encoded proteins in the mitochondrion are presented. Chapters focus on the regulation of mitochondrial function and mitochondrial diseases, with a section emphasizing the mitochondrial defects associated with type 2 diabetes. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. With more than 450 volumes published, each volume presents material that is relevant in today's labs, truly an essential publication for researchers in all fields of life sciences. - New methods focusing on the examination of normal and abnormal mitochondrial function are presented in an easy-to-follow format by the researchers who developed them - Along with a companion volume covering topics including mitochondrial electron transport chain complexes and reactive oxygen species, provides a comprehensive overview of modern techniques in the study of mitochondrial malfunction - Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods

Dehydrogenases

Author : Rosa Angela Canuto
Publisher : BoD – Books on Demand
ISBN 13 : 9533070196
Total Pages : 372 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Dehydrogenases by : Rosa Angela Canuto

Download or read book Dehydrogenases written by Rosa Angela Canuto and published by BoD – Books on Demand. This book was released on 2012-11-14 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book takes in consideration some dehydrogenases, enzymes with different functions in the cells by using different substrates, such as hydroxysteroid dehydrogenases, aldehyde dehydrogenases, glucose-6-phosphate dehydrogenase, pyruvate dehydrogenase complex, glutamate dehydrogenase, succinate dehydrogenase. They are examined from the following points of view: biochemistry, physiological functions and role in some diseases and in the development of tumours. For these reasons, the book is divided into three sections: 1. Dehydrogenases and cancer 2. Dehydrogenases and some diseases 3. Dehydrogenases and physiological role

Mitochondrial Signaling in Health and Disease

Author : Sten Orrenius
Publisher : CRC Press
ISBN 13 : 1439880026
Total Pages : 530 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Mitochondrial Signaling in Health and Disease by : Sten Orrenius

Download or read book Mitochondrial Signaling in Health and Disease written by Sten Orrenius and published by CRC Press. This book was released on 2012-06-20 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Mitochondrial Oxidative Phosphorylation

Author : Bernhard Kadenbach
Publisher : Springer Science & Business Media
ISBN 13 : 1461435730
Total Pages : 378 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Mitochondrial Oxidative Phosphorylation by : Bernhard Kadenbach

Download or read book Mitochondrial Oxidative Phosphorylation written by Bernhard Kadenbach and published by Springer Science & Business Media. This book was released on 2012-06-23 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.

Further Milestones in Biochemistry

Author : M.G. Ord
Publisher : Elsevier
ISBN 13 : 0080532217
Total Pages : 361 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Further Milestones in Biochemistry by : M.G. Ord

Download or read book Further Milestones in Biochemistry written by M.G. Ord and published by Elsevier. This book was released on 1997-05-16 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contributors to this text, who are all biochemists who worked during the 1950s and 60s, describe what appears to them to be the conceptually significant developments in biochemistry since the mid 1950s and how these were achieved. Their aim is to make their subjects intelligible to other scientists not expert in their field.

Research Awards Index

Author :
Publisher :
ISBN 13 :
Total Pages : 854 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Physiological and Pathological Responses to Hypoxia and High Altitude

Author : Rodrigo Iturriaga
Publisher : Frontiers Media SA
ISBN 13 : 2889638006
Total Pages : 387 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Physiological and Pathological Responses to Hypoxia and High Altitude by : Rodrigo Iturriaga

Download or read book Physiological and Pathological Responses to Hypoxia and High Altitude written by Rodrigo Iturriaga and published by Frontiers Media SA. This book was released on 2020-06-22 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The appearance of photosynthetic organisms about 3 billion years ago increased the partial pressure of oxygen (PO2) in the atmosphere and enabled the evolution of organisms that use glucose and oxygen to produce ATP by oxidative phosphorylation. Hypoxia is commonly defined as the reduced availability of oxygen in the tissues produced by different causes, which include reduction of atmospheric PO2 as in high altitude, and secondary to pathological conditions such as sleep breathing and pulmonary disorders, anemia, and cardiovascular alterations leading to inadequate transport, delivery, and exchange of oxygen between capillaries and cells. Nowadays, it has been shown that hypoxia plays an important role in the genesis of several human pathologies including cardiovascular, renal, myocardial and cerebral diseases in fetal, young and adult life. Several mechanisms have evolved to maintain oxygen homeostasis. Certainly, all cells respond and adapt to hypoxia, but only a few of them can detect hypoxia and initiate a cascade of signals intended to produce a functional systemic response. In mammals, oxygen detection mechanisms have been extensively studied in erythropoietin-producing cells, chromaffin cells, bulbar and cortical neurons, pulmonary neuroepithelial cells, smooth muscle cells of pulmonary arteries, and chemoreceptor cells. While the precise mechanism underpinning oxygen, sensing is not completely known several molecular entities have been proposed as possible oxygen sensors (i.e. Hem proteins, ion channels, NADPH oxidase, mitochondrial cytochrome oxidase). Remarkably, cellular adaptation to hypoxia is mediated by the master oxygen-sensitive transcription factor, hypoxia-inducible factor-1, which can induce up-regulation of different genes to cope the cellular effects related to a decrease in oxygen levels. Short-term responses to hypoxia included mainly chemoreceptor-mediated reflex ventilatory and hemodynamic adaptations to manage the low oxygen concentration while more prolonged exposures to hypoxia can elicit more sustained physiological responses including switch from aerobic to anaerobic metabolism, vascularization, and enhancement of blood O2 carrying capacity. The focus of this research topic is to provide an up-to-date vision on the current knowledge on oxygen sensing mechanism, physiological responses to acute or chronic hypoxia and cellular/tissue/organ adaptations to hypoxic environment.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1264 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1969 with total page 1264 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Kinetic and Regulatory Properties of Alpha-ketoglutarate Dehydrogenase Complex from Cauliflower

Author : David Wheeler Craig
Publisher :
ISBN 13 :
Total Pages : 464 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis The Kinetic and Regulatory Properties of Alpha-ketoglutarate Dehydrogenase Complex from Cauliflower by : David Wheeler Craig

Download or read book The Kinetic and Regulatory Properties of Alpha-ketoglutarate Dehydrogenase Complex from Cauliflower written by David Wheeler Craig and published by . This book was released on 1977 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Alpha-Keto Acid Dehydrogenase Complexes

Author : M.S. Patel
Publisher : Nelson Thornes
ISBN 13 : 9783764351816
Total Pages : 338 pages
Book Rating : 4.3/5 (518 download)

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Book Synopsis Alpha-Keto Acid Dehydrogenase Complexes by : M.S. Patel

Download or read book Alpha-Keto Acid Dehydrogenase Complexes written by M.S. Patel and published by Nelson Thornes. This book was released on 1996-02-29 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (inborn errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis).

Signal Transduction: Pathways, Mechanisms and Diseases

Author : Ari Sitaramayya
Publisher : Springer Science & Business Media
ISBN 13 : 3642021123
Total Pages : 429 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Signal Transduction: Pathways, Mechanisms and Diseases by : Ari Sitaramayya

Download or read book Signal Transduction: Pathways, Mechanisms and Diseases written by Ari Sitaramayya and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

Cerebral Ischemia and Dementia

Author : Alexander Hartmann
Publisher : Springer Science & Business Media
ISBN 13 : 3642762085
Total Pages : 460 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Cerebral Ischemia and Dementia by : Alexander Hartmann

Download or read book Cerebral Ischemia and Dementia written by Alexander Hartmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: In contrast to dementia of the Alzheimer type, the subject of dementia subsequent to cerebral ischemia has been discussed rather rarely. Now this book provides a summary of the brain morphology, neurochemistry and clinical aspects of dementia subsequent to cerebral ischemia. The contributions discuss the similarities and differences between the two predominant dementia types. The broad range of aspects cover 1) the morphology and morphobiology of brain tissue during aging and under the two pathological condi- tions, 2) the neuropathochemistry of post mortem brain tissue of patients as well as brain tissue from experimental animals, 3) CSF changes during aging and in dementia states and 4) clinical research, mainly using brain imaging tech- niques to differentiate between dementia types and to find a basis for rational therapeutic approaches.

Protein Phosphatases and Stress Management in Plants

Author : Girdhar K. Pandey
Publisher : Springer Nature
ISBN 13 : 3030487334
Total Pages : 387 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Protein Phosphatases and Stress Management in Plants by : Girdhar K. Pandey

Download or read book Protein Phosphatases and Stress Management in Plants written by Girdhar K. Pandey and published by Springer Nature. This book was released on 2020-09-26 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The regulation of the phosphorylation/dephosphorylation process, resulting in “cellular switches” that monitor normal plant physiology, growth and development, has immense potential in crop systems. With much of the information in the nascent stages, coming largely from Arabidopsis and rice particularly, the use of cell biology, genetic screens, biochemical approaches aided by an omics approach should help unravel the detail functional information available about signaling pathways in plants. The regulation could be exploited to develop crop varieties better equipped to handle changing environments and enhance agricultural productivity. In the post-genomic era, one of the major challenges is investigation and understanding of multiple genes and gene families regulating a particular physiological and developmental aspect of plant life cycle. One of the important physiological processes is regulation of stress response, which leads to adaptation or adjustment in response to adverse stimuli. With the holistic understanding of the signaling pathways involving phosphatases, one gene family or multiple genes or gene families, plant biologist can lay a foundation for designing and generating future crops, which can withstand the higher degree of environmental stresses. Especially abiotic stresses, which are the major cause of crop loss throughout the world without losing crop yield and productivity. This book incorporates the contributions from leading plant biologists in the field of stress-mediated dephosphorylation by phosphatases as an important task to elucidate the aspects of stress signaling by functional genomic approaches.

Cell Signalling

Author : Sajal Ray
Publisher : BoD – Books on Demand
ISBN 13 : 1838800654
Total Pages : 85 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Cell Signalling by : Sajal Ray

Download or read book Cell Signalling written by Sajal Ray and published by BoD – Books on Demand. This book was released on 2019-04-17 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular signal transduction is an important topic of research in cell and molecular biology. It has a wide range of implications in growth, differentiation, development, animal polarity, cellular response monitoring, and many disease processes, including cancer. The functional homeostasis of a cell is assumed to be maintained by an intricate network of signaling that evolved through natural selection. This book includes chapters written in the frontier areas of research on cell signaling. Issues such as information thermodynamics, master regulation of immune tolerance, genetically encoded reporter circuits and their applications, hypoxia, and vitamin K2 mediated signaling processes are addressed and discussed by eminent researchers of the field.