The Search for an AIDS Vaccine

Download The Search for an AIDS Vaccine PDF Online Free

Author :
Publisher : Indiana University Press
ISBN 13 : 9780253112729
Total Pages : 220 pages
Book Rating : 4.1/5 (127 download)

DOWNLOAD NOW!


Book Synopsis The Search for an AIDS Vaccine by : Christine Grady

Download or read book The Search for an AIDS Vaccine written by Christine Grady and published by Indiana University Press. This book was released on 1995-05-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The book is a balanced and comprehensive treatment of an important social issue. It is accessible to the general reader and belongs in public as well as academic libraries." -- Religious Studies Review "Painstaking analysis of the knotty ethical problems involved in human-subjects research, and a well-thought-out proposal for a community approach to conducting field trials for an HIV vaccine.... Highly recommended for medical ethicists and anyone concerned about the AIDS epidemic and how HIV research is conducted."Â -- Kirkus Reviews "... a carefully reasoned account of how research for and trial of a preventive vaccine differ from the methods used to discover a therapy."Â -- Booklist "I highly recommend reading this book which I would attest to be a thrilling, ethically challenging, and informative descent into the allopathic solution." -- Ryan Hosken, Bastyr University Library Newsletter "As the scientific effort to produce an efficacious vaccine continues, [Grady's] work provides an ethical compass that will guide us well, regardless of where phase III HIV vaccine trials ultimately occur." -- Journal of the American Medical Association "Highly recommended... " -- AIDS Book Review Journal "A remarkable treatment of a most difficult and complex subject... Grady's book is of special merit because it is simple, readable, and understandable, while conveying in-depth perceptions that are critical to the reader. A useful and essential reference work for those who would engage in the initiative to bring about a resolution of a mighty human health problem." -- Maurice R. Hilleman, Ph.D., D.Sc., Director, Merck Institute for Therapeutic Research "Dr. Grady's important study captures the complexity of the search for an AIDS vaccine with startling clarity. Her insights into the full range of forces that shape our national response to AIDS vaccine development should read like signposts to vaccinologists, AIDS community activists, and most importantly, the Public Health Service. An impressive contribution." -- Derek Hodel, Gay Men's Health Crisis "This book is recommended to medical ethicists, those involved in non-HIV vaccine trials, and all persons involved in HIV vaccine trials, including investigators, sponsors, study subjects and communities at risk." -- Journal of Health Politics, Policy and Law The creation of a vaccine now seems the best hope for controlling AIDS. Yet developing and testing an HIV vaccine raises a host of difficult ethical issues. These concerns are the focus of this timely and important book. Essential reading for everyone interested in ethics and the conduct of HIV vaccine research.

HIV Vaccines and Cure

Download HIV Vaccines and Cure PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 981130484X
Total Pages : 326 pages
Book Rating : 4.8/5 (113 download)

DOWNLOAD NOW!


Book Synopsis HIV Vaccines and Cure by : Linqi Zhang

Download or read book HIV Vaccines and Cure written by Linqi Zhang and published by Springer. This book was released on 2018-07-20 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.

The Social Impact of AIDS in the United States

Download The Social Impact of AIDS in the United States PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309046289
Total Pages : 337 pages
Book Rating : 4.3/5 (9 download)

DOWNLOAD NOW!


Book Synopsis The Social Impact of AIDS in the United States by : National Research Council

Download or read book The Social Impact of AIDS in the United States written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Europe's "Black Death" contributed to the rise of nation states, mercantile economies, and even the Reformation. Will the AIDS epidemic have similar dramatic effects on the social and political landscape of the twenty-first century? This readable volume looks at the impact of AIDS since its emergence and suggests its effects in the next decade, when a million or more Americans will likely die of the disease. The Social Impact of AIDS in the United States addresses some of the most sensitive and controversial issues in the public debate over AIDS. This landmark book explores how AIDS has affected fundamental policies and practices in our major institutions, examining: How America's major religious organizations have dealt with sometimes conflicting values: the imperative of care for the sick versus traditional views of homosexuality and drug use. Hotly debated public health measures, such as HIV antibody testing and screening, tracing of sexual contacts, and quarantine. The potential risk of HIV infection to and from health care workers. How AIDS activists have brought about major change in the way new drugs are brought to the marketplace. The impact of AIDS on community-based organizations, from volunteers caring for individuals to the highly political ACT-UP organization. Coping with HIV infection in prisons. Two case studies shed light on HIV and the family relationship. One reports on some efforts to gain legal recognition for nonmarital relationships, and the other examines foster care programs for newborns with the HIV virus. A case study of New York City details how selected institutions interact to give what may be a picture of AIDS in the future. This clear and comprehensive presentation will be of interest to anyone concerned about AIDS and its impact on the country: health professionals, sociologists, psychologists, advocates for at-risk populations, and interested individuals.

The CAPRISA Clinical Trials: HIV Treatment and Prevention

Download The CAPRISA Clinical Trials: HIV Treatment and Prevention PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 9783319837567
Total Pages : 243 pages
Book Rating : 4.8/5 (375 download)

DOWNLOAD NOW!


Book Synopsis The CAPRISA Clinical Trials: HIV Treatment and Prevention by : Quarraisha Abdool Karim

Download or read book The CAPRISA Clinical Trials: HIV Treatment and Prevention written by Quarraisha Abdool Karim and published by Springer. This book was released on 2018-04-29 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA’s high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics. Comprised of 5 sections, the book details the following: HIV epidemic in South Africa and the establishment of a research centre to undertake clinical, epidemiological and laboratory research on HIV. CAPRISA’s clinical trials on HIV and HSV-2 prevention. These studies investigated the impact of tenofovir gel as topical antiretroviral pre-exposure prophylaxis (PrEP), implementation of topical PrEP through family planning clinics, conditional cash incentives for HIV prevention, HIV vaccines, and passive immunisation with broadly neutralising antibodies. CAPRISA’s research on the treatment of HIV and TB co-infection. A review of the major scientific findings from the CAPRISA studies on acute infection and genital mucosal immunology. Essential support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as establishing effective communication and sustainable structures for community engagement to maintain effective and respectful partnerships with participating communities. The book concludes with a chapter about the challenges facing future HIV prevention and treatment trials. The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials – their creation, conduct and impact.

Small Clinical Trials

Download Small Clinical Trials PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309171148
Total Pages : 221 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Small Clinical Trials by : Institute of Medicine

Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.

Good Participatory Practice

Download Good Participatory Practice PDF Online Free

Author :
Publisher : World Health Organization
ISBN 13 :
Total Pages : 68 pages
Book Rating : 4.3/5 ( download)

DOWNLOAD NOW!


Book Synopsis Good Participatory Practice by :

Download or read book Good Participatory Practice written by and published by World Health Organization. This book was released on 2007 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: These Good Participatory Practice guidelines aim to provide systematic guidance on the roles and responsibilities of entities funding and conducting biomedical HIV prevention trials towards participants and their communities. Such entities include investigators, research staff, pharmaceutical industry sponsors, foundations, government-supported research networks, non-governmental research sponsors, and all others involved in designing, financing, and executing clinical trials research.

Shots in the Dark

Download Shots in the Dark PDF Online Free

Author :
Publisher : W. W. Norton & Company
ISBN 13 : 9780393322255
Total Pages : 468 pages
Book Rating : 4.3/5 (222 download)

DOWNLOAD NOW!


Book Synopsis Shots in the Dark by : Jon Cohen

Download or read book Shots in the Dark written by Jon Cohen and published by W. W. Norton & Company. This book was released on 2001 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1984 it was announced that an AIDS vaccine would be ready for testing in two years. More than 15 years later only one vaccine has made it to a field trial. This text explains the reasons for this slow progress.

Design and Analysis of Vaccine Studies

Download Design and Analysis of Vaccine Studies PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0387686363
Total Pages : 390 pages
Book Rating : 4.3/5 (876 download)

DOWNLOAD NOW!


Book Synopsis Design and Analysis of Vaccine Studies by : M. Elizabeth Halloran

Download or read book Design and Analysis of Vaccine Studies written by M. Elizabeth Halloran and published by Springer Science & Business Media. This book was released on 2009-10-27 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: As well as being a reference for the design, analysis, and interpretation of vaccine studies, the text covers all design and analysis stages, from vaccine development to post-licensure surveillance, presenting likelihood, frequentists, and Bayesian approaches.

Jenner on Trial

Download Jenner on Trial PDF Online Free

Author :
Publisher : Upa
ISBN 13 :
Total Pages : 132 pages
Book Rating : 4.X/5 (4 download)

DOWNLOAD NOW!


Book Synopsis Jenner on Trial by : Thomas A. Kerns

Download or read book Jenner on Trial written by Thomas A. Kerns and published by Upa. This book was released on 1997 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines how an Ethics Review Committee using today's ethical standards as articulated in The Nuremburg Code, and the WHO/CIOMS International Ethical Guidelines for Biomedical Research Involving Human Subjects, might assess the scientific and ethical design of Edward Jenner's first experimental vaccine experiment. It explores the potential risks and benefits to young James, the adequacy of the preliminary evidence that Jenner used to justify performing his experiment, and how he might have complied with requirements for informed consent. In addition to its historical interest for 18th century England and for the origins of today's biomedical research ethics standards, the book is significant as a case study in the ethics of basic vaccine research. It thus raises relevant questions about today's vaccine research, particularly HIV vaccine research.

History of Vaccine Development

Download History of Vaccine Development PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1441913394
Total Pages : 352 pages
Book Rating : 4.4/5 (419 download)

DOWNLOAD NOW!


Book Synopsis History of Vaccine Development by : Stanley A. Plotkin

Download or read book History of Vaccine Development written by Stanley A. Plotkin and published by Springer Science & Business Media. This book was released on 2011-05-11 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccinology, the concept of a science ranging from the study of immunology to the development and distribution of vaccines, was a word invented by Jonas Salk. This book covers the history of the methodological progress in vaccine development and to the social and ethical issues raised by vaccination. Chapters include "Jenner and the Vaccination against Smallpox," "Viral Vaccines," and "Ethical and Social Aspects of vaccines." Contributing authors include pioneers in the field, such as Samuel L. Katz and Hilary Koprowski. This history of vaccines is relatively short and many of its protagonists are still alive. This book was written by some of the chief actors in the drama whose subject matter is the conquest of epidemic disease.

Experimental Animal Models of Human Diseases

Download Experimental Animal Models of Human Diseases PDF Online Free

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1789231647
Total Pages : 410 pages
Book Rating : 4.7/5 (892 download)

DOWNLOAD NOW!


Book Synopsis Experimental Animal Models of Human Diseases by : Bartholomew Ibeh

Download or read book Experimental Animal Models of Human Diseases written by Bartholomew Ibeh and published by BoD – Books on Demand. This book was released on 2018-05-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

Vaccines for the 21st Century

Download Vaccines for the 21st Century PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309174988
Total Pages : 472 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Vaccines for the 21st Century by : Institute of Medicine

Download or read book Vaccines for the 21st Century written by Institute of Medicine and published by National Academies Press. This book was released on 2001-02-21 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.

Malaria Control and Elimination

Download Malaria Control and Elimination PDF Online Free

Author :
Publisher : Methods in Molecular Biology
ISBN 13 : 9781493995523
Total Pages : 341 pages
Book Rating : 4.9/5 (955 download)

DOWNLOAD NOW!


Book Synopsis Malaria Control and Elimination by : Frédéric Ariey

Download or read book Malaria Control and Elimination written by Frédéric Ariey and published by Methods in Molecular Biology. This book was released on 2020-07-17 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Making Markets for Vaccines

Download Making Markets for Vaccines PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 132 pages
Book Rating : 4.:/5 (321 download)

DOWNLOAD NOW!


Book Synopsis Making Markets for Vaccines by : Owen Barder

Download or read book Making Markets for Vaccines written by Owen Barder and published by . This book was released on 2005 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: A legacy of our generation -- Ch. 1. We need to invest more in vaccines -- Ch. 2. Promoting private investment in vaccine development -- Ch. 3. A market not a prize -- Ch. 4. Design choices -- Ch. 5. $3 billion per disease -- Ch. 6. Meeting industry requirements -- Ch. 7. How sponsors can do it.

AIDS Vaccine Research and Clinical Trials

Download AIDS Vaccine Research and Clinical Trials PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 512 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis AIDS Vaccine Research and Clinical Trials by : Scott D. Putney

Download or read book AIDS Vaccine Research and Clinical Trials written by Scott D. Putney and published by . This book was released on 1990 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses are not cells; they are parasites at the genetic level, bringing into the cells a genetic apparatus that is directed to producing more virus. Vaccination is the best hope for control of the HIV virus, the cause of AIDS. These 23 research reports and summaries review progress in understanding the virus and its interactions with host target cells, the identification of target epitopes for humeral and cellular immune responses to the virus, tests that have been conducted on animal models with candidate immunogens, and the initial trials in humans. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com)

Reviewing Clinical Trials

Download Reviewing Clinical Trials PDF Online Free

Author :
Publisher :
ISBN 13 : 9789881904119
Total Pages : 153 pages
Book Rating : 4.9/5 (41 download)

DOWNLOAD NOW!


Book Synopsis Reviewing Clinical Trials by : Chinese University of Hong Kong

Download or read book Reviewing Clinical Trials written by Chinese University of Hong Kong and published by . This book was released on 2010 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The idea for this manual came from Pfizer in the US, which provided the Clinical Trials Centre at The University of Hong Kong, Hong Kong SAR, PR China with a nonbinding grant for its development. The general project layout protocol was accepted by Pfizer in July 2009. Pfizer has not in any way interfered with the project, except for providing nonbinding comments to the final product. The entire text of this manual was written by Johan PE Karlberg. Marjorie A Speers provided considerable and essential comments on the contents and the first and subsequent drafts. A group of international human research protection experts mostly working in non-profit institutions or organisations - see Contributors for details - reviewed and provided important comments on the contents and final draft. It was solely created with the intention to promote human research protection of participants in clinical trials. This manual will be translated into numerous languages and is provided free of charge as an electronic file over the Internet (http://www.ClinicalTrialMagnifier.com) and offered in print for a fee. The objective beyond this project is to establish educational activities, developed around the manual, and jointly organised with leading academic institutions worldwide.

AIDS Bibliography

Download AIDS Bibliography PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.:/5 (327 download)

DOWNLOAD NOW!


Book Synopsis AIDS Bibliography by :

Download or read book AIDS Bibliography written by and published by . This book was released on 1991 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: