Advances In Structure And Activity Relationship Of Coumarin Derivatives

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Advances in Structure and Activity Relationship of Coumarin Derivatives

Author : Santhosh Penta
Publisher : Academic Press
ISBN 13 : 012803873X
Total Pages : 191 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Advances in Structure and Activity Relationship of Coumarin Derivatives by : Santhosh Penta

Download or read book Advances in Structure and Activity Relationship of Coumarin Derivatives written by Santhosh Penta and published by Academic Press. This book was released on 2015-08-07 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Structure and Activity Relationship of Coumarin Derivatives covers the structural behavior of various coumarin derivatives for various potential pharmaceutical applications. Based on substitution targeted for active sites, the book takes a rational approach for designing new and specific potent drugs, optimizing existing ones, and developing novel reactions. This focused primer describes the chemical structure and activity of coumarin derivatives to explore the effects of different substituents at specific positions, and their properties for effective bioactivity. Accessible and current coverage of coumarin derivatives from structure to potential applications Application of SAR technology to predict bioactivity of the derivatives based on its chemical structure Information for researchers in medicinal chemistry, pharmaceutical sciences, and related fields

Synthetic Utility of Coumarin Derivatives: Recent Advances

Author : Manoj N. Bhoi
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659764486
Total Pages : 76 pages
Book Rating : 4.7/5 (644 download)

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Book Synopsis Synthetic Utility of Coumarin Derivatives: Recent Advances by : Manoj N. Bhoi

Download or read book Synthetic Utility of Coumarin Derivatives: Recent Advances written by Manoj N. Bhoi and published by LAP Lambert Academic Publishing. This book was released on 2015-07-28 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coumarin acts as a versatile framework in organic synthesis and drug development due to exhibit useful and diverse biological activities. We summarizes recent instances of coumarin derivative. As interest in the synthesis of coumarins fused or linked with different heterocycle derivatives has been ahead importance over past eras, reflecting the importance of such compounds in both medical and chemical research. Emphasis is placed on the search for innovative coumarin synthesis techniques and the diverse array of biological activities of coumarins. It is believed that the information compiled in this article will update scientists with recent findings of the synthesis and biological activities of coumarin derivatives and inspire them to use this promising moiety for further backbone derivatization and screening, as several novel compounds with biological and chemical properties are possible. Future goals for this field of research include the discovery, synthesis and development of compounds which display increased potency, as well as fuelling structure activity relationship studies aimed at understanding the modes of action of the most biologically active compounds.

Coumarin and Its Derivatives

Author : Maria João Matos
Publisher : Mdpi AG
ISBN 13 : 9783036527758
Total Pages : 416 pages
Book Rating : 4.5/5 (277 download)

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Book Synopsis Coumarin and Its Derivatives by : Maria João Matos

Download or read book Coumarin and Its Derivatives written by Maria João Matos and published by Mdpi AG. This book was released on 2021-12-29 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers.

Recent Advances in Natural Products Analysis

Author : Seyed Mohammad Nabavi
Publisher : Elsevier
ISBN 13 : 0128164557
Total Pages : 878 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Recent Advances in Natural Products Analysis by : Seyed Mohammad Nabavi

Download or read book Recent Advances in Natural Products Analysis written by Seyed Mohammad Nabavi and published by Elsevier. This book was released on 2020-03-18 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included. Focuses on the latest analytical techniques used for studying phytochemical and other biological compounds Authored and edited by the top worldwide experts in their field Discusses the current and potential applications and predicts future trends of each compound group

Non-Conventional Synthesis

Author : György Keglevich
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110980185
Total Pages : 584 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Non-Conventional Synthesis by : György Keglevich

Download or read book Non-Conventional Synthesis written by György Keglevich and published by Walter de Gruyter GmbH & Co KG. This book was released on 2023-11-06 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-conventional synthetic methods may provide new and green methods for the preparation of bioactive heterocycles. These methods, such as microwave and ultrasound assisted synthesis, biocatalysis, photochemistry and electrosynthesis use less energy and may produce less waste to get the desired products when compared to traditional methods. This book explores the use of these methods when synthesizing various biologically relevant heterocyclic scaffolds. THE SERIES: GREEN BIOACTIVE HETEROCYCLES Heterocycles are a widely utilized group of molecules as they often contain bioactivity that is useful in drug development, agriculture, and other applications. However, their synthesis remains challenging with diffi cult to control functional groups. With a greater focus on sustainable synthesis practices, there is a need to develop greener synthetic methods for the synthesis of structurally diverse bioactive heterocyclic scaffolds. This series aims to do so, by collecting developments into common themes.

Advances in Heterocyclic Chemistry

Author :
Publisher : Academic Press
ISBN 13 : 0128137614
Total Pages : 348 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Advances in Heterocyclic Chemistry by :

Download or read book Advances in Heterocyclic Chemistry written by and published by Academic Press. This book was released on 2018-01-02 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Heterocyclic Chemistry, Volume 124, is the definitive series in the field—one of great importance to organic chemists, polymer chemists, and many biological scientists. Updates in this new volume include sections on the Organometallic Complexes of Azines, The Literature of Heterocyclic Chemistry, Part XV, Heterocycles Incorporating a Pentacoordinated, Hypervalent Phosphorus Atom, and Tautomerism and the Structure of Azoles: NMR Spectroscopy, amongst other related topics. Written by established authorities in the field, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Herbal Biomolecules in Healthcare Applications

Author : Subhash C. Mandal
Publisher : Academic Press
ISBN 13 : 0323900801
Total Pages : 752 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Herbal Biomolecules in Healthcare Applications by : Subhash C. Mandal

Download or read book Herbal Biomolecules in Healthcare Applications written by Subhash C. Mandal and published by Academic Press. This book was released on 2021-10-05 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herbal Biomolecules in Healthcare Applications presents extensive detailed information on all the vital principles, basics and fundamental aspects of multiple herbal biomolecules in the healthcare industry. This book examines important herbal biomolecules including alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, terpenes, fats and waxes, proteins and peptides, and vitamins. These herbal biomacromolecules are responsible for different bioactivities as well as pharmacological potentials. A systematic understanding of the extraction, purification, characterization, applications of these herbal biomolecules and their derivatives in healthcare fields is developed in this comprehensive book. Chapters explore the key topics along with an emphasis on recent research and developments in healthcare fields by leading experts. They include updated literature review of the relevant key topics, good quality illustrations, chemical structures, flow charts, well-organized tables and case studies. Herbal Biomolecules in Healthcare Applications will be useful for researchers working on natural products and biomolecules with bioactivity and nutraceutical properties. Professionals specializing in scientific areas such as biochemistry, pharmacology, analytical chemistry, organic chemistry, clinics, or engineering focused on bioactive natural products will find this book useful. - Provides a study of different type of biomolecules from herbal extracts and their bioactivities as well as their application in the healthcare industry - Contributions by global leaders and experts from academia, industry and regulatory agencies, who have been considered as pioneers in the application of herbal biomolecules in the diverse healthcare fields - Includes updated literature review along with practical examples and research case studies

Recent Trends in Human and Animal Mycology

Author : Karuna Singh
Publisher : Springer Nature
ISBN 13 : 9811394350
Total Pages : 280 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Recent Trends in Human and Animal Mycology by : Karuna Singh

Download or read book Recent Trends in Human and Animal Mycology written by Karuna Singh and published by Springer Nature. This book was released on 2019-11-06 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal pathogens pose an on-going and serious threat for poikilotherms and homeotherms, and can cause a broad spectrum of diseases ranging from innocuous to life-threatening. In addition, long-term exposure to some mycotoxigenic moulds can lead to mycotoxicoses in human and animals. Given the expanding population of immune compromised hosts, the list of fungal opportunists grows longer every year. Moreover, antifungal resistance, drug-related toxicity and our limited arsenal of antifungals have exacerbated the situation. To address these problems, strategies such as the identification of novel targets, use of the structure-activity relationship in rational drug design, development of new formulations, modification of existing antifungals to combat resistance, and bioavailability enhancement are called for. For the reader’s convenience, this book has been divided into three sections. The first six chapters of Section I provide a timely review of mycoses, from endemic to cosmopolitan and from generalized to specific, while both chapters of Section II focus on risks associated with mycotoxins. In closing, the two chapters of Section III describe potential antifungal leads and drug candidates based on phytochemicals and coumarin scaffold.

Recent Advances in Natural Products Analysis

Author : Seyed Mohammad Nabavi
Publisher : Elsevier
ISBN 13 : 0128175192
Total Pages : 880 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Recent Advances in Natural Products Analysis by : Seyed Mohammad Nabavi

Download or read book Recent Advances in Natural Products Analysis written by Seyed Mohammad Nabavi and published by Elsevier. This book was released on 2020-03-07 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included. Focuses on the latest analytical techniques used for studying phytochemical and other biological compounds Authored and edited by the top worldwide experts in their field Discusses the current and potential applications and predicts future trends of each compound group

Fluorescence Methods for Investigation of Living Cells and Microorganisms

Author : Natalia Grigoryeva
Publisher : BoD – Books on Demand
ISBN 13 : 1839680393
Total Pages : 464 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Fluorescence Methods for Investigation of Living Cells and Microorganisms by : Natalia Grigoryeva

Download or read book Fluorescence Methods for Investigation of Living Cells and Microorganisms written by Natalia Grigoryeva and published by BoD – Books on Demand. This book was released on 2020-09 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence methods play a leading role in the investigation of biological objects. They are the only non-destructive methods for investigating living cells and microorganisms in vivo. Using intrinsic and artificial fluorescence methods provides deep insight into mechanisms underlying physiological and biochemical processes. This book covers a wide range of modern methods involved in experimental biology. It illustrates the use of fluorescence microscopy and spectroscopy, confocal laser scanning microscopy, flow cytometry, delayed fluorescence, pulse-amplitude-modulation fluorometry, and fluorescent dye staining protocols. This book provides an overview of practical and theoretical aspects of fluorescence methods and their successful application in the investigation of static and dynamic processes in living cells and microorganisms.

Microbial Genomics: Clinical, Pharmaceutical, and Industrial Applications

Author : Huseyin Tombuloglu
Publisher : Elsevier
ISBN 13 : 044318867X
Total Pages : 490 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Microbial Genomics: Clinical, Pharmaceutical, and Industrial Applications by : Huseyin Tombuloglu

Download or read book Microbial Genomics: Clinical, Pharmaceutical, and Industrial Applications written by Huseyin Tombuloglu and published by Elsevier. This book was released on 2024-07-27 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the field of genomics has progressed, our understanding of microbiology has also developed. With the advent of next-generation sequencing methods and advancements in instrumental resolution, complex transcriptome, proteome, and metabolome data could be analyzed, as well as detailed annotation of microbial genomes. Microbial Genomics: Clinical, Pharmaceutical and Industrial Applications focuses on the various applications of microbial genomics in clinical, pharmaceutical and industrial fields. It consists of four parts devoted to bacterial, viral, and fungal genomics, as well as their applications in clinical, pharmaceutical, and industrial fields. Chapters are written by experts in their respective disciplines and are tightly organized with an introduction to detailed descriptions, available software implementation, applications, advanced topics, summaries, analytic questions, exercises, and suggested readings. Throughout this book, the latest genomics and biotechnological developments and discoveries as well as open problems and future challenges on microbial genomics will be highlighted. Readers will be introduced to state-of-the-art developments and trends of microbial genomics, its clinical, pharmaceutical, and industrial applications. The book will be beneficial for researchers who study microbial genomics in universities, post-graduate and graduate programs (biology, biotechnology, medicine, genetics, microbiology, industrial and environmental microbiology, etc.), as well as the pharmaceutical and industrial sector. - Presents the recent genomic developments in the industrial applications of microorganisms - Summarizes recent developments in microbial genomics, emphasizing the role of next-generation sequencing in functional genomics - Focus on how transcriptomics can help better understand host responses to pathogen infection - Describes applications of genomics in clinical microbiology

Medicinal Plant Research in Africa

Author : Victor Kuete
Publisher : Newnes
ISBN 13 : 0124059368
Total Pages : 917 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Medicinal Plant Research in Africa by : Victor Kuete

Download or read book Medicinal Plant Research in Africa written by Victor Kuete and published by Newnes. This book was released on 2013-06-19 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pharmacopoeias of most African countries are available and contain an impressive number of medicinal plants used for various therapeutic purposes. Many African scholars have distinguished themselves in the fields of organic chemistry, pharmacology, and pharmacognosy and other areas related to the study of plant medicinal plants. However, until now, there is no global standard book on the nature and specificity of chemicals isolated in African medicinal plants, as well as a book bringing together and discussing the main bioactive metabolites of these plants. This book explores the essence of natural substances from African medicinal plants and their pharmacological potential. In light of possible academic use, this book also scans the bulk of African medicinal plants extract having promising pharmacological activities. - The book contains data of biologically active plants of Africa, plant occurring compounds and synthesis pathways of secondary metabolites - This book explores the essence of natural substances from African medicinal plants and their pharmacological potential - The authors are world reknowned African Scientists

Alternatives to Antibiotics

Author : Tilak Saha
Publisher : Springer Nature
ISBN 13 : 9811918546
Total Pages : 574 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Alternatives to Antibiotics by : Tilak Saha

Download or read book Alternatives to Antibiotics written by Tilak Saha and published by Springer Nature. This book was released on 2022-08-08 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses prospective alternative approaches to fight bacterial infections to minimize the indiscriminate use of conventional antibiotics. It offers the current knowledge on research and development of alternative antibacterial agents such as probiotics, nanobiotics etc. while it also discusses newly emerging trends such as phage therapy, antibody therapy etc. The book highlights on the phytochemicals with potent antibacterial activities as alternatives to conventional antibiotics. Chemical modification to develop next generation antibiotics with enhanced efficacy has also been included. Such modifications are reported to overcome the inherent resistance of the parent antibiotics. Phage therapy and targeted antibodies are considered as potential alternative approaches to treat bacterial ailments and represent areas of cutting-edge research and have therefore been discussed with sufficient care. Mainly, the book highlights various approaches other than conventional antibiotics in treating bacterial infections. The scientific advancements in these areas will strengthen the ‘One Health’ approach benefiting human beings, animals and environment as well. This book is a comprehensive resource to cater researchers, biological scientists, herbalists and clinical practitioners with up-to-date information on antibacterials other than antibiotics.

Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment

Author : Kunal Roy
Publisher : Academic Press
ISBN 13 : 0128016337
Total Pages : 494 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment by : Kunal Roy

Download or read book Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment written by Kunal Roy and published by Academic Press. This book was released on 2015-03-03 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment describes the historical evolution of quantitative structure-activity relationship (QSAR) approaches and their fundamental principles. This book includes clear, introductory coverage of the statistical methods applied in QSAR and new QSAR techniques, such as HQSAR and G-QSAR. Containing real-world examples that illustrate important methodologies, this book identifies QSAR as a valuable tool for many different applications, including drug discovery, predictive toxicology and risk assessment. Written in a straightforward and engaging manner, this is the ideal resource for all those looking for general and practical knowledge of QSAR methods. - Includes numerous practical examples related to QSAR methods and applications - Follows the Organization for Economic Co-operation and Development principles for QSAR model development - Discusses related techniques such as structure-based design and the combination of structure- and ligand-based design tools

Phytochemicals in Human Health

Author : Venketeshwer Rao
Publisher : BoD – Books on Demand
ISBN 13 : 178985587X
Total Pages : 300 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Phytochemicals in Human Health by : Venketeshwer Rao

Download or read book Phytochemicals in Human Health written by Venketeshwer Rao and published by BoD – Books on Demand. This book was released on 2020-02-12 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Naturally present bioactive compounds in plants are referred to as "Phytochemicals" and are being studied extensively for their role in human health. Studies have shown that they can have an important role to play in the prevention and management of several human diseases. Recognizing the increasing interest in this area, this book is being published in response to the need for more current information globally about phytochemicals and their role in human health. Chapters of the book are authored by internationally recognized authors who are experts in their respective field of expertise. The chapters represent both original research as well as up-to-date and comprehensive reviews. We are sure that the book will be an important reference source meeting the needs of a wide range of interest groups.

Molecular Interaction Fields

Author : Gabriele Cruciani
Publisher : John Wiley & Sons
ISBN 13 : 3527607137
Total Pages : 328 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Molecular Interaction Fields by : Gabriele Cruciani

Download or read book Molecular Interaction Fields written by Gabriele Cruciani and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique reference source, edited by the world's most respected expert on molecular interaction field software, covers all relevant principles of the GRID force field and its applications in medicinal chemistry. Entire chapters on 3D-QSAR, pharmacophore searches, docking studies, metabolism predictions and protein selectivity studies, among others, offer a concise overview of this emerging field. As an added bonus, this handbook includes a CD-ROM with the latest commercial versions of the GRID program and related software.

Phytochemicals

Author : Venketeshwer Rao
Publisher : BoD – Books on Demand
ISBN 13 : 9535121707
Total Pages : 351 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Phytochemicals by : Venketeshwer Rao

Download or read book Phytochemicals written by Venketeshwer Rao and published by BoD – Books on Demand. This book was released on 2015-09-30 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global dietary recommendations emphasize the consumption of plant-based foods for the prevention and management of chronic diseases. Plants contain many biologically active compounds referred to as phytochemicals or functional ingredients. These compounds play an important role in human health. Prior to establishing the safety and health benefits of these compounds, they must first be isolated, purified, and their physico-chemical properties established. Once identified, their mechanisms of actions are studied. The chapters are arranged in the order from isolation, purification and identification to in vivo and clinical studies, there by covering not only the analytical procedures used but also their nutraceutical and therapeutic properties.