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Advanced Applications Of High Performance Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
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Book Synopsis Advanced Applications of High Performance Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Juan Wei (Researcher in chemistry)
Download or read book Advanced Applications of High Performance Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Juan Wei (Researcher in chemistry) and published by . This book was released on 2014 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advanced Electronics for Fourier-transform Ion Cyclotron Resonance Mass Spectrometry by : Tzu-Yung Lin
Download or read book Advanced Electronics for Fourier-transform Ion Cyclotron Resonance Mass Spectrometry written by Tzu-Yung Lin and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: With the development of mass spectrometry (MS) instruments starting in the late 19th century, more and more research emphasis has been put on MS related subjects, especially the instrumentation and its applications. Instrumentation research has led modern mass spectrometers into a new era where the MS performance, such as resolving power and mass accuracy, is close to its theoretical limit. Such advanced performance releases more opportunities for scientists to conduct analytical research that could not be performed before. This thesis reviews general MS history and some of the important milestones, followed by introductions to ion cyclotron resonance (ICR) technique and quadrupole operation. Existing electronic designs, such as Fourier-transform ion cyclotron resonance (FT-ICR) preamplifiers (for ion signal detection) and radio-frequency (RF) oscillators (for ion transportation/filtering) are reviewed. Then the potential scope for improvement is discussed. Two new FT-ICR preamplifiers are reported; both preamplifiers operate at room temperature. The first preamplifier uses an operational amplifier (op amp) in a transimpedance configuration. When a 18-k feedback resistor is used, this preamplifier delivers a transimpedance of about 85 dB , and an input current noise spectral density of around 1 pA/ p Hz. The total power consumption of this circuit is around 310 mW when tested on the bench. This preamplifier has a bandwidth of fi3 kHz to 10 MHz, which corresponds to the mass-to-charge ratio, m/z, of approximately 18 to 61k at 12 T for FT-ICR MS. The transimpedance and the bandwidth can be adjusted by replacing passive components such as the feedback resistor and capacitor. The feedback and bandwidth limitation of the circuit is also discussed. When using an 0402 type surface mount resistor, the maximum possible transimpedance, without sacrificing its bandwidth, is approximated to 5.3 M . Under this condition, the preamplifier is estimated to be able to detect ~110 charges. The second preamplifier employs a single-transistor design using a different feedback arrangement, a T-shaped feedback network. Such a feedback system allows ~100-fold less feedback resistance at a given transimpedance, hence preserving bandwidth, which is beneficial to applications demanding high gain. The single-transistor preamplifier yields a low power consumption of ~5.7 mW, and a transimpedance of 80 dB in the frequency range between 1 kHz and 1 MHz (m/z of around 180 to 180k for a 12-T FT-ICR system). In trading noise performance for higher transimpedance, an alternative preamplifier design has also been presented with a transimpedance of 120 dB in the same frequency range. The previously reported room-temperature FT-ICR preamplifier had a voltage gain of about 25, a bandwidth of around 1 MHz when bench tested, and a voltage noise spectral density of ~7.4 nV/ p Hz. The bandwidth performance when connecting this preamplifier to an ICR cell has not been reported. However, from the transimpedance theory, the transimpedance preamplifiers reported in this work will have a bandwidth wider by a factor of the open-loop gain of the amplifier. In a separate development, an oscillator is proposed as a power supply for a quadrupole mass filter in a mass spectrometer system. It targets a stabilized output frequency, and a feedback control for output amplitude stabilization. The newly designed circuit has a very stable output frequency at 1 MHz, with a frequency tolerance of 15 ppm specified by the crystal oscillator datasheet. Within this circuit, an automatic gain control (AGC) unit is built for output amplitude stabilisation. A new transformer design is also proposed. The dimension of the quadrupole being used as a mass filter will be determined in the future. This circuit (in particular the transformer and the quadrupole connection/mounting device) will be finalised after the design of the quadrupole. Finally, this thesis concludes with a discussion between the gain and the noise performance of an FT-ICR preamplifier. A brief analysis about the correlation between the gain, cyclotron frequency, and input capacitance is performed. Future work is also suggested for extending this research.
Book Synopsis Fundamentals and Applications of Fourier Transform Mass Spectrometry by : Philippe Schmitt-Kopplin
Download or read book Fundamentals and Applications of Fourier Transform Mass Spectrometry written by Philippe Schmitt-Kopplin and published by Elsevier. This book was released on 2019-08-11 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals and Applications of Fourier Transform Mass Spectrometry is the first book to delve into the underlying principles on the topic and their linkage to industrial applications. Drs. Schmitt-Kopplin and Kanawati have brought together a team of leading experts in their respective fields to present this technique from many different perspectives, describing, at length, the pros and cons of FT-ICR and Orbitrap. Numerous examples help researchers decide which instruments to use for their particular scientific problem and which data analysis methods should be applied to get the most out of their data. - Covers FT-ICR-MS and Orbitrap's fundamentals, enhancing researcher knowledge - Includes details on ion sources, data processing, chemical analysis and imaging - Provides examples across the wide spectrum of applications, including omics, environmental, chemical, pharmaceutical and food analysis
Download or read book FT-ICR/MS written by Bruce Asamoto and published by Wiley-VCH. This book was released on 1991 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Asphaltenes, Heavy Oils, and Petroleomics by : Oliver C. Mullins
Download or read book Asphaltenes, Heavy Oils, and Petroleomics written by Oliver C. Mullins and published by Springer Science & Business Media. This book was released on 2007-11-08 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: With substantial contributions from experienced industrial scientists and engineers, this work will have real application towards improving process efficiency and improvement in the trillion-dollar global petroleum industry. It presents an overview of the emerging field of petroleomics, which endeavors to understand the fundamental components of crude oil. Petroleomics promises to revolutionize petroleum science in much the same way that genomics transformed the study of medicine not long ago. Asphaltenes are a particular focus, with many chapters devoted to the analysis of their structure and properties.
Download or read book FT-ICR/MS written by B. Asamoto and published by Wiley. This book was released on 1991-11-11 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: An in-depth look at many of the applications where FT-ICR mass spectrometry is implemented. Contributing authors emphasize ways in which FT-ICR provides superior information to that of other types of mass spectrometers as well as where it may be less informative than other mass spectrometers. With the information provided, analytical chemists will be capable of assessing the usefulness of FT-ICR versus other mass spectrometric methods for their particular needs. Comprehensive chapters cover the history of ICR and other techniques based on the cyclotron principles of mass analysis and offer a descriptive explanation of the theory involved in fourier transform detection and analysis. Chapters also detail features and areas of active research in instrumentation and some specifications on commercial instruments as well as the home-built American Cyanamid instrument. Application chapters cover one technique in detail and illustrate its particular area of analysis.
Book Synopsis High Mass Accuracy Analytical Applications of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Rebecca H. Wills
Download or read book High Mass Accuracy Analytical Applications of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Rebecca H. Wills and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis High Mass Accuracy Analytical Applications of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Rebecca Helen Wills
Download or read book High Mass Accuracy Analytical Applications of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Rebecca Helen Wills and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advanced Methods in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry by : Yulin Qi
Download or read book Advanced Methods in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry written by Yulin Qi and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Novel Computational and Instrumentation Methodologies for Biological Fourier-transform Ion Cyclotron Resonance Mass Spectrometric (FT-ICR MS) Imaging by : Konstantin Aizikov
Download or read book Novel Computational and Instrumentation Methodologies for Biological Fourier-transform Ion Cyclotron Resonance Mass Spectrometric (FT-ICR MS) Imaging written by Konstantin Aizikov and published by . This book was released on 2010 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Mass spectrometry imaging (MSI) is an emerging experimental methodology whose primary objective is the investigation of spatial variation of molecular composition within and across selected biological tissues to enable biomarker discovery, molecular diagnosis, and studies of drug metabolism, among other applications. The two major challenges, therefore, are the unambiguous identification and precise localization of biologically relevant compounds. These challenges can be recast as a problem of improving the accuracy and resolution of mass analyzers as well as the accuracy of the sample positioning robotics. The first part of this work reports on the progress and outlines the strategies of application of a recently developed high resolution spectral analysis technique, called the Filter Diagonalization Method (FDM), for the investigation of space-charge related phenomena inside the detection cell of a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FT-ICR MS), understanding of which lies at the heart of the quest for further improvements in mass accuracy and resolution. The FDM spectrographic analysis revealed previously unobserved rapid isotope- beat space-charge induced ICR frequency modulations, shown to reach up to +/- 400 ppm even on high quality spectra. The application of this methodology to the investigation of a frequently observed but previously unexplained phenomenon in FT-ICR MS, the Spontaneous Loss of Coherence Catastrophe, conclusively demonstrated that it is tied directly to the space charge effect and magnetron expansion. The second part of this work reports on the development of the ionization source and vacuum compatible high precision sample positioning robotics for biological MSI applications, purpose built for FT-ICR MS. The complete design and implementation is reported herein, along with the demonstration of its performance and biological application. The XY-positioning stage capable of operating under 10 -8 mbar vacuum with submicron positioning accuracy along the entire ranges of motion of 100x100 mm was designed, built, and installed into the ionization sources of three MALDI FT-ICR MS instruments. Two dimensional chemo-spatial maps of rat brain tissue selections were constructed with 150 micron spatial resolution, identifying multiple ionic species with their distinct and discreet spatial localizations. These demonstrated performance characteristics greatly surpass current state-of-the-art robotics available for MALDI MSI and shift the effort of further improvements in spatial resolution to the ionization methodologies, and other ion source design issues, such as laser optics.
Book Synopsis Ion Cyclotron Resonance Spectrometry II by : H. Hartmann
Download or read book Ion Cyclotron Resonance Spectrometry II written by H. Hartmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applications in High Resolution Mass Spectrometry by : Roberto Romero-González
Download or read book Applications in High Resolution Mass Spectrometry written by Roberto Romero-González and published by Elsevier. This book was released on 2017-03-07 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications of High Resolution Mass Spectrometry: Food Safety and Pesticide Residue Analysis is the first book to offer complete coverage of all aspects of high resolution mass spectrometry (HRMS) used for the analysis of pesticide residue in food. Aimed at researchers and graduate students in food safety, toxicology, and analytical chemistry, the book equips readers with foundational knowledge of HRMS, including established and state-of-the-art principles and analysis strategies. Additionally, it provides a roadmap for implementation, including discussions of the latest instrumentation and software available. Detailed coverage is given to the application of HRMS coupled to ultra high-performance liquid chromatography (UHPLC-HRMS) in the analysis of pesticide residue in fruits and vegetables and food from animal origin. The book also discusses extraction procedures and the challenges of sample preparation, gas chromatography coupled to high resolution mass spectrometry, flow injection-HRMS, ambient ionization, and identification of pesticide transformation products in food. Responding to the fast development and application of these new procedures, this book is an essential resource in the food safety field. - Arms researchers with an in-depth resource devoted to the rapid advances in HRMS tools and strategies for pesticide residue analysis in food - Provides a complete overview of analytical methodologies and applications of HRMS, including UHPLC-HRMS, HRMS coupled with time of flight (TOF) and/or GC-Orbitrap, and flow injection-HRMS - Discusses the current international regulations and legislation related to the use of HRMS in pesticide residue analysis - Features a chapter on the hardware and software available for HRMS implementation - Offers separate chapters on HRMS applied to pesticide residue analysis in fruits and vegetables and in food from animal origin
Book Synopsis Proteomic Profiling and Analytical Chemistry by : Pawel Ciborowski
Download or read book Proteomic Profiling and Analytical Chemistry written by Pawel Ciborowski and published by Elsevier. This book was released on 2016-03-02 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomic Profiling and Analytical Chemistry: The Crossroads, Second Edition helps scientists without a strong background in analytical chemistry to understand principles of the multistep proteomic experiment necessary for its successful completion. It also helps researchers who do have an analytical chemistry background to break into the proteomics field. Highlighting points of junction between proteomics and analytical chemistry, this resource links experimental design with analytical measurements, data analysis, and quality control. This targeted point of view will help both biologists and chemists to better understand all components of a complex proteomic study. The book provides detailed coverage of experimental aspects such as sample preparation, protein extraction and precipitation, gel electrophoresis, microarrays, dynamics of fluorescent dyes, and more. The key feature of this book is a direct link between multistep proteomic strategy and quality control routinely applied in analytical chemistry. This second edition features a new chapter on SWATH-MS, substantial updates to all chapters, including proteomic database search and analytical quantification, expanded discussion of post-hoc statistical tests, and additional content on validation in proteomics. - Covers the analytical consequences of protein and peptide modifications that may have a profound effect on how and what researchers actually measure - Includes practical examples illustrating the importance of problems in quantitation and validation of biomarkers - Helps in designing and executing proteomic experiments with sound analytics
Book Synopsis Techniques for high performance electrospray ionization fourier transform ion cyclotron resonance mass spectrometric of biomolecules by : Victoria Lynn Degler Campbell
Download or read book Techniques for high performance electrospray ionization fourier transform ion cyclotron resonance mass spectrometric of biomolecules written by Victoria Lynn Degler Campbell and published by . This book was released on 1995 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fundamentals of Contemporary Mass Spectrometry by : Chhabil Dass
Download or read book Fundamentals of Contemporary Mass Spectrometry written by Chhabil Dass and published by John Wiley & Sons. This book was released on 2007-05-11 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern mass spectrometry - the instrumentation and applications in diverse fields Mass spectrometry has played a pivotal role in a variety of scientific disciplines. Today it is an integral part of proteomics and drug discovery process. Fundamentals of Contemporary Mass Spectrometry gives readers a concise and authoritative overview of modern mass spectrometry instrumentation, techniques, and applications, including the latest developments. After an introduction to the history of mass spectrometry and the basic underlying concepts, it covers: Instrumentation, including modes of ionization, condensed phase ionization techniques, mass analysis and ion detection, tandem mass spectrometry, and hyphenated separation techniques Organic and inorganic mass spectrometry Biological mass spectrometry, including the analysis of proteins and peptides, oligosaccharides, lipids, oligonucleotides, and other biological materials Applications to quantitative analysis Based on proven teaching principles, each chapter is complete with a concise overview, highlighted key points, practice exercises, and references to additional resources. Hints and solutions to the exercises are provided in an appendix. To facilitate learning and improve problem-solving skills, several worked-out examples are included. This is a great textbook for graduate students in chemistry, and a robust, practical resource for researchers and scientists, professors, laboratory managers, technicians, and others. It gives scientists in diverse disciplines a practical foundation in modern mass spectrometry.
Book Synopsis Quantum Nanosystems by : Mihai V. Putz
Download or read book Quantum Nanosystems written by Mihai V. Putz and published by CRC Press. This book was released on 2014-09-19 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for economically feasible and multifunctional materials becomes more acute as the natural physical and chemical resources reveal either their limits or reveal the difficulties and increasing costs in storage, transport, and conversion. This reference presents the work from contributors from various fields, of various ages and from differen
Book Synopsis Application of IC-MS and IC-ICP-MS in Environmental Research by : Rajmund Michalski
Download or read book Application of IC-MS and IC-ICP-MS in Environmental Research written by Rajmund Michalski and published by John Wiley & Sons. This book was released on 2016-05-20 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces the reader to the field of ion chromatography, species analysis and hyphenated methods IC-MS and IC-ICP-MS including the theory and theirs applications Covers the importance of species analysis and hyphenated methods in ion chromatography Includes practical applications of IC-MS and IC-ICP-MS in environmental analysis Details sample preparation methods for ion chromatography Discusses hyphenated methods IC-MS and IC-ICP-MS used in determining both the total element contents and its elements Details speciation analysis used in studying biochemical cycles of selected chemical compounds; determining toxicity and ecotoxicity of elements; food and pharmaceuticals quality control; and in technological process control and clinical analytics
