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Adp Ribosylation Of Proteins
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Book Synopsis Poly(ADP-Ribosyl)ation by : Alexander Bürkle
Download or read book Poly(ADP-Ribosyl)ation written by Alexander Bürkle and published by Springer Science & Business Media. This book was released on 2008-01-11 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.
Book Synopsis ADP-Ribosylation of Proteins by : Felix R. Althaus
Download or read book ADP-Ribosylation of Proteins written by Felix R. Althaus and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an update on recent advances in the field of ADP ribosylation reactions. The individual chapters represent the synopses of contributions which were presented at the Seventh International Symposium on ADP-Ribosylation Reactions, held in Vitznau, Switzer land, from September 23 to 27, 1984. This volume covers new devel opments in the field since the last meeting was held on this topic in 1982, in Tokyo. Therefore, the present text is not meant to form a comprehensive account of a specialized research area, but encompasses a collection of state-of-the-art reports from the vast majority of laboratories currently involved in ADP-ribosylation work. For the sake of rapid publication, the editorial policy was to ensure easy accessibility of information contained in individual articles rather than to provide elaborate cross references or reference to work published prior to 1982. However, a detailed subject index will help the reader find complementary information. The enzymes of ADP-ribose metabolism have not yet acquired universally acceptable trivial names and the Enzyme Commission has not yet defmitely decided on formal appellations. Consequently, a variety of names for the nuclear enzyme appear in this book, including nuc1ear(ADP-ribosyl)transferase, poly(ADP-ribose) polymerase, or synthetase or synthase. Hopefully, a common convention will soon be established. The Seventh International Symposium on ADP-Ribosylation Reac tions was only possible because of the generous support which we have been given by our sponsors, listed below.
Book Synopsis ADP-Ribosylation Reactions by : Osamu Hayaishi
Download or read book ADP-Ribosylation Reactions written by Osamu Hayaishi and published by Elsevier. This book was released on 2012-12-02 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: ADP-Ribosylation Reactions: Biology and Medicine deals with the biochemical and physiological aspects of poly(ADP-ribose) and ADP-ribosylation of proteins. Topics covered range from pyridine nucleotide metabolism and ADP-ribosylation to the structure and properties of poly(ADP-ribose), along with acceptor proteins of poly(ADP-ribose). ADP-ribosyl protein linkages and poly(ADP-ribose) synthetase are also discussed. Comprised of 39 chapters, this book begins with a historical background on the discovery of poly(ADP-ribose) and the significance of poly- and mono(ADP-ribosyl)ation reactions in molecular biology. The next section explores the role of ADP-ribosylation in NAD metabolism, paying particular attention to poly(ADP-ribose) synthetase-DNA interaction and the link between chromatin structure and poly(ADP-ribosyl)ation. Subsequent chapters focus on subfractions and subcellular distribution of mono(ADP-ribosyl) proteins in eukaryotic cells; polyadenylylation and ADP-ribosylation of reovirus proteins; poly(ADP-ribose) synthesis in plants; and immunohistochemistry of poly(ADP-ribose). The final chapter analyzes the ADP-ribosylation activity of toxin A and exoenzyme S in Pseudomonas aeruginosa. This monograph is written for students, practitioners, and researchers in fields such as molecular biology, medical chemistry, and biochemistry.
Book Synopsis Mass Spectrometry-Based Chemical Proteomics by : W. Andy Tao
Download or read book Mass Spectrometry-Based Chemical Proteomics written by W. Andy Tao and published by John Wiley & Sons. This book was released on 2019-07-10 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: PROVIDES STRATEGIES AND CONCEPTS FOR UNDERSTANDING CHEMICAL PROTEOMICS, AND ANALYZING PROTEIN FUNCTIONS, MODIFICATIONS, AND INTERACTIONS—EMPHASIZING MASS SPECTROMETRY THROUGHOUT Covering mass spectrometry for chemical proteomics, this book helps readers understand analytical strategies behind protein functions, their modifications and interactions, and applications in drug discovery. It provides a basic overview and presents concepts in chemical proteomics through three angles: Strategies, Technical Advances, and Applications. Chapters cover those many technical advances and applications in drug discovery, from target identification to validation and potential treatments. The first section of Mass Spectrometry-Based Chemical Proteomics starts by reviewing basic methods and recent advances in mass spectrometry for proteomics, including shotgun proteomics, quantitative proteomics, and data analyses. The next section covers a variety of techniques and strategies coupling chemical probes to MS-based proteomics to provide functional insights into the proteome. In the last section, it focuses on using chemical strategies to study protein post-translational modifications and high-order structures. Summarizes chemical proteomics, up-to-date concepts, analysis, and target validation Covers fundamentals and strategies, including the profiling of enzyme activities and protein-drug interactions Explains technical advances in the field and describes on shotgun proteomics, quantitative proteomics, and corresponding methods of software and database usage for proteomics Includes a wide variety of applications in drug discovery, from kinase inhibitors and intracellular drug targets to the chemoproteomics analysis of natural products Addresses an important tool in small molecule drug discovery, appealing to both academia and the pharmaceutical industry Mass Spectrometry-Based Chemical Proteomics is an excellent source of information for readers in both academia and industry in a variety of fields, including pharmaceutical sciences, drug discovery, molecular biology, bioinformatics, and analytical sciences.
Book Synopsis ADP-Ribose Transfer Reactions by : Myron K. Jacobson
Download or read book ADP-Ribose Transfer Reactions written by Myron K. Jacobson and published by Springer. This book was released on 2012-01-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current interest in NAD (Nicotinamide adenine dinucleotide) in biological systems focuses on its role in ADP-ribose transfer reactions. These appear to be fundamentally involved in the regulation of many physiological processes. The contributions in this monograph thus represent the range of research in the very active investigation of niacin metabolism. The major topics covered are: ??? - Enzymology of ADP-Ribosylation - ADP-Ribosylation and Chromatin Function - Carcinogenesis and Differentiation - NAD Metabolism and Chemotherapy - ADP-Ribosylation and Signal Transduction - Molecular Genetic Approaches to ADP-Ribosylation
Book Synopsis ADP-ribosylation of Proteins by : Felix R. Althaus
Download or read book ADP-ribosylation of Proteins written by Felix R. Althaus and published by Springer. This book was released on 1987-01-01 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1966, a paper entitled "On the formation of a novel adenylylic compound by enzymatic extracts of liver nuclei" from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a rapidly growing new field of biological research focusing on ADP-ribosylation reactions. The development of this field over the past 2 decades reflects very much a modern trend of biological research. As more detailed knowledge accumulates, enigmatic phenomena turn into concepts which create their own enigmata. This process tends to favor the development of multiple, seemingly disconnected, research lines until simplicity emerges from chaos and unifying concepts substitute for controversy. It appears that the field of ADP-ribosylation reactions has not yet attained this latter stage. For example, with the identification of two different classes of ADP-ribosylation reactions, i.e., mono-ADP-ribosyla tion and poly-ADP-ribosylation reactions, the field split very early into two separate branches of research. With the present volume, we have divided the task of reviewing these two classes of ADP ribosylation accordingly, although their coexistence in eukaryotes may involve a closer functional linkage than hitherto recognized.
Book Synopsis Poly(ADP-ribose) and ADP-ribosylation of Proteins by : H. Hilz
Download or read book Poly(ADP-ribose) and ADP-ribosylation of Proteins written by H. Hilz and published by . This book was released on 1976 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis ADP-ribosylating Toxins and G Proteins by : Joel Moss
Download or read book ADP-ribosylating Toxins and G Proteins written by Joel Moss and published by ASM Press. This book was released on 1990 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Twenty-eight contributions topics and authors spanning the disciplines of microbiology, biochemistry, molecular biology, and medicine present what is known in an area that has important implications for aspects of biomedical research. Investigations of the mechanisms of action of the ADP-ribosylatin
Book Synopsis Handbook of Epigenetics by : Trygve O Tollefsbol
Download or read book Handbook of Epigenetics written by Trygve O Tollefsbol and published by Academic Press. This book was released on 2017-07-10 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials
Book Synopsis ADP-Ribosylation: Metabolic Effects and Regulatory Functions by : Joel Moss
Download or read book ADP-Ribosylation: Metabolic Effects and Regulatory Functions written by Joel Moss and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considering the current interest in cellular regulation and intracellular signalling systems, it is surprising that the contribution of ADP-ribosylation reactions to the modulation of a variety of specific cell processes, in parallel with other post-translational modifications such as phosphorylation, has not been generally recognized. While it is not feasible to cover all aspects of ADP-ribosylation, the thirty-one articles contained in this volume provide a valuable overview of recent progress in the field within the context of cell control mechanisms. For the convenience of the reader, the various topics have been grouped into several sections: (a) poly(ADP-ribosyl)ation; (b) mono-ADP-ribosylation; (c) toxin mono-ADP-ribosylation; (d) inhibitors and activators; (e) protein modification with ADP-ribose and its analogues; and (f) non-modification forms of ADP-ribose. The contents of the individual chapters reflect the ideas of the contributors, many of whom have spent their careers attempting to resolve the biological functions of ADP-ribosylation. We hope that this publication will serve as a useful reference for those investigators that are new to the area as well as those who are actively studying ADP-ribosylation.
Book Synopsis Posttranslational Modification of Proteins by : Christopher Walsh
Download or read book Posttranslational Modification of Proteins written by Christopher Walsh and published by Roberts and Company Publishers. This book was released on 2006 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the major classes of posttranslational modifications, Posttranslational Modification of Proteins is the first comprehensive treatment of this burgeoning area of proteome diversification.
Book Synopsis Post-translational Modifications of Proteins by : John J. Harding
Download or read book Post-translational Modifications of Proteins written by John J. Harding and published by CRC Press. This book was released on 1991-12-13 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-Translational Modifications of Proteins discusses several important topics of interest to researchers and students in protein chemistry and biochemistry, including the occurrence and function of hydroxylated residues and the three enzymes required for their formation; the damaging effects of reactions between sugars and proteins; ADP-riboosylation of proteins outside the nucleus; and Monod, Wyman, and Changeux's concerted model for allosteric control of enzyme activity exemplified by studies on glycogen phosphorylase. The application of Fast Atom Bombardment Mass Spectometry (FAB-MS) to studies on the structure and biosynthesis of various oligosaccharide moieties in protein is examined, and the understanding of the structural diversity and function of glycoprotein oligosaccharides is discussed in this volume.
Book Synopsis ARF Family GTPases by : Richard A. Kahn
Download or read book ARF Family GTPases written by Richard A. Kahn and published by Springer Science & Business Media. This book was released on 2004-02-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.
Book Synopsis Epigenetic Biomarkers and Diagnostics by : Jose Luis Garcia-Gimenez
Download or read book Epigenetic Biomarkers and Diagnostics written by Jose Luis Garcia-Gimenez and published by Academic Press. This book was released on 2015-12-07 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies
Book Synopsis Poly(ADP-Ribose) Polymerase by : Alexei V. Tulin
Download or read book Poly(ADP-Ribose) Polymerase written by Alexei V. Tulin and published by Springer Nature. This book was released on 2022-12-14 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores poly(ADP-ribose) polymerases (PARPs) in the biology of eukaryotes and their relevance to human health. Beginning with a section on the detection and quantification of poly(ADP-ribose) polymer (pADPr), the book continues by delving into the identification of protein targets, functional analysis, the poly(ADP-ribosyl)ating pathway in chromatin and genes expression, as well as the use of animal models and PARP1 inhibitor design and testing, and more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Poly(ADP-Ribose) Polymerase: Methods and Protocols, Third Edition presents essential new and classical methods for studying the pADPr-pathway.
Book Synopsis Endogenous ADP-Ribosylation by : Friedrich Koch-Nolte
Download or read book Endogenous ADP-Ribosylation written by Friedrich Koch-Nolte and published by Springer. This book was released on 2014-10-24 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections: · Evolution and detection of endogenous ADP-ribosylation · ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs) · ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs) The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.
Book Synopsis ADP-ribosylation in Animal Tissues by : Friedrich Haag
Download or read book ADP-ribosylation in Animal Tissues written by Friedrich Haag and published by Springer Science & Business Media. This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Documents the first conference on the topic, called in response to opportunities opened by the molecular characterization of the first mammalian mono(ADP-ribosyl)transferase enzyme from rabbit skeletal muscles, and the subsequent realization that one had already been to hand in a well-studied surfac
