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Adoptive Cellular Therapies In Immunoregulation And Cancer
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Book Synopsis Adoptive cellular therapies in immunoregulation and cancer by : "Patrick" Peishun Shou
Download or read book Adoptive cellular therapies in immunoregulation and cancer written by "Patrick" Peishun Shou and published by Frontiers Media SA. This book was released on 2023-07-05 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Adoptive Cellular Immunotherapy of Cancer by : H. C. Stevenson
Download or read book Adoptive Cellular Immunotherapy of Cancer written by H. C. Stevenson and published by CRC Press. This book was released on 2021-05-30 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the most complicated and powerful cancer biotherapies developed. It provides an overview of human immune system function and the mechanisms by which adoptive cellular immunotherapies (ACI) harnesses the activity. The volume provides a vision on the developments in ACI.
Book Synopsis Adoptive Cellular Immunotherapy of Cancer by : H. C. Stevenson
Download or read book Adoptive Cellular Immunotherapy of Cancer written by H. C. Stevenson and published by CRC Press. This book was released on 1989-07-17 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the most complicated and powerful cancer biotherapies developed. It provides an overview of human immune system function and the mechanisms by which adoptive cellular immunotherapies (ACI) harnesses the activity. The volume provides a vision on the developments in ACI.
Book Synopsis Developments in T Cell Based Cancer Immunotherapies by : Paolo A. Ascierto
Download or read book Developments in T Cell Based Cancer Immunotherapies written by Paolo A. Ascierto and published by Humana Press. This book was released on 2015-11-26 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.
Book Synopsis Cellular Therapy Of Cancer: Development Of Gene Therapy Based Approaches by : Robert E Hawkins
Download or read book Cellular Therapy Of Cancer: Development Of Gene Therapy Based Approaches written by Robert E Hawkins and published by World Scientific. This book was released on 2014-05-05 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer research has progressed enormously in recent years. This review volume will address recent findings in the area of T-cell therapy for cancer, including use of tumour infiltrating lymphocytes (TILs) as a therapy for melanoma, choice of target antigens, advances in engineered receptors, methods of gene transfer to T cells, review of cell processing methods and clinical trial design. Written by leadings scientists in the field, this up-to-date review on cancer research will be an important reference source to the researchers and healthcare professionals in the field.
Book Synopsis Innate Immune Cell Therapy of Cancer by : Asha B. Pillai
Download or read book Innate Immune Cell Therapy of Cancer written by Asha B. Pillai and published by Frontiers Media SA. This book was released on 2023-09-13 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adoptive cellular immunotherapy of cancer, particularly chimeric antigen receptor-transduced T cell (CAR-T) therapies, have enjoyed an explosion of clinical trials and translational and basic research in the past decade. The concept and design of the CAR, though originally intended to optimize targeting of innate natural killer cells (NK cells) to tumor-specific antigens, was laterally applied in the past decade to conventional autologous and later third-party allogeneic T cells with first-in-kind successes in leukemia immunotherapy in both adults and children. This approach also spawned the development of an entire industry focused on cancer immunotherapy, laying the foundation for the current paradigm shifts away from toxic chemo/radiotherapy to immune targeting. Aside from cytokine-release toxicities, specific obstacles plaguing existing CAR-T cell therapies include suboptimal killing by fatigued or senescent autologous patient-derived T cells derived, acquisition of tumor resistance to T-cell based immune therapies, and graft-versus-host disease (GVHD) associated with allogeneic conventional T cell therapies.
Book Synopsis Cellular Therapies in Cancer by : Katy Rezvani
Download or read book Cellular Therapies in Cancer written by Katy Rezvani and published by Frontiers Media SA. This book was released on 2020-01-16 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Adoptive Cell Transfer written by and published by Academic Press. This book was released on 2022-07-05 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adoptive Cell Transfer, Volume 370 in the International Review of Cell and Molecular Biology series highlights advances in the field, with this new volume presenting interesting chapters written by an international board of authors who expound on topics such as the Impact of tumor microenvironment on Adoptive Cell Transfer activity, Dendritic Cell Transfer, CAR-T Cell dysfunction and exhaustion, NK Cell-based cancer immunotherapy, Enabling CAR-T cells for solid tumors: rage against the suppressive tumor microenvironment, Improving Adoptive T-Cell therapy with cytokines administration, and What will (and should) be improved in Immunotherapy with CAR? Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists and drawn from international sources Offers a wide range of perspectives on specific subjects
Book Synopsis Cancer Immunotherapy by : Richard A. Morgan
Download or read book Cancer Immunotherapy written by Richard A. Morgan and published by Elsevier Inc. Chapters. This book was released on 2013-06-04 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adoptive cell therapy for cancer using tumor antigen-reactive cytotoxic lymphocytes or with tumor infiltrating lymphocytes has been shown to be a potent therapy for metastatic cancer. The generation of tumor-reactive T cells is not always possible in all of the patients. To overcome this limitation, investigators can now insert highly avid T-cell receptors (TCR) into T cells that can recognize tumor antigens. Genetic engineering of TCR genes into normal T cells is a powerful new strategy to generate large numbers of defined antigen-specific cells for therapeutic application. This approach has evolved beyond experimental stage into a clinical reality. The feasibility of TCR engineered T cells has been shown to be an effective clinical strategy resulting in the regression of established tumors in recent clinical trials. In this chapter, the progress and prospects of TCR engineered T cells as a therapeutic strategy for treating patients with cancer are discussed.
Book Synopsis Gene Editing of Tumour Infiltrating Lymphocytes for the Generation of Adoptive Cellular Therapeutics Against Cancer by : Mariana Werner Sunderland
Download or read book Gene Editing of Tumour Infiltrating Lymphocytes for the Generation of Adoptive Cellular Therapeutics Against Cancer written by Mariana Werner Sunderland and published by . This book was released on 2019 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer treatments that are based on the reactivation, expansion, or mobilisation of the immune system, such as adoptive cellular therapies and immune-checkpoint blockade, have achieved long-lasting anti-tumour responses in cancer patients. However, there is still a high proportion of patients that do not benefit from these treatments. This highlights the need for more effective therapies. Based on the notion that adoptive cell therapies do work and are likely limited in vivo by the activation of immune modulatory pathways, this project focused on ablating negative regulation and increasing the intra-tumoural effector activity of tumour-reactive T cells. Specifically, my project aimed to genetically modify tumour infiltrating T cells by knocking-out the expression of immune- checkpoints on their surface so as to render them resistant to checkpoint inhibition, thus generating potent and long-lasting anti-tumour immunity. For this purpose, the CRISPR/Cas9 technology was used to genome edit tumour-reactive T cells using primary human tumour-infiltrating lymphocytes (TILs) obtained from melanoma and non-small-cell lung carcinoma (NSCLC) patients. The project initially focused on the generation of PD1-deficient tumour- reactive T cells as a proof of concept, as targeting this pathway with antibodies has shown clear efficacy in the clinic. Following the generation of PD1-deficient gene edited T cells, we developed LAG3-deficient and TIGIT-deficient tumour-reactive T cells, as well as T cells that were deficient for both PD1 and LAG3 expression. In sum, the overall purpose of this project was to utilise cutting edge gene editing tools to engineer tumour-reactive lymphocytes and render them resistant to checkpoint inhibition. The results from this work have established a clinically relevant pipeline for the generation of potent adoptive cell therapy products for the treatment of cancer.
Book Synopsis Novel Immunotherapeutic Approaches to the Treatment of Cancer by : Paul D. Rennert
Download or read book Novel Immunotherapeutic Approaches to the Treatment of Cancer written by Paul D. Rennert and published by Springer. This book was released on 2016-05-30 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.
Book Synopsis Immunotherapy and Small Molecule Inhibitors as Combinational Cancer Therapeutics by : Mohd Wajid Ali Khan
Download or read book Immunotherapy and Small Molecule Inhibitors as Combinational Cancer Therapeutics written by Mohd Wajid Ali Khan and published by Frontiers Media SA. This book was released on 2023-09-26 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a multifactorial chronic disease, in which several factors contribute to its pathogenesis and progression. Our immune system is designed to continuously identify and destroy tumor or aberrant cells. However, a compromised immune system has been associated with the development of cancer. In such immune state, cancer cells often develop the ability to hide from the immune surveillance network and adopt intelligent survival tactics which are continuously developing. Therefore, researchers are focusing on boosting anti-tumor immunity by developing novel cancer immunotherapies. Adoptive cell-based cancer therapies are being used, including in vitro expansion and activation of immune effector cells and transfer to the patients. Tumor cells can be eliminated either by directly targeting the tumor cells or by enhancing various functions of the immune system. Other than CD8+ and NK cell-based cytotoxic cancer cell killing, there are antigen-presenting cells (APCs) such as dendritic, macrophages, B cells, and γδ T cells, which aggressively participate in the activation of anti-tumor immune response against many different cancers (myeloma, lymphoma, colorectal, melanoma, breast, colon, prostate, and ovarian cancers).
Book Synopsis Cancer Immunotherapy and Biological Cancer Treatments by : Hilal Arnouk
Download or read book Cancer Immunotherapy and Biological Cancer Treatments written by Hilal Arnouk and published by BoD – Books on Demand. This book was released on 2019-11-13 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, biological cancer therapies, including immunotherapy, have moved from the bench to mainstream medical treatments of several types of cancer. The success of these treatments relies on innovative approaches to specifically interfere with molecular targets that are involved in the growth, progression, and spread of malignant cells, or to bypass the tumor evasion of the immune system utilizing the latest advances in cancer vaccine development, formulation, and delivery. This book presents an up-to-date overview of novel cancer biological and immunotherapeutic approaches, including cancer vaccines, mimetic vaccines, monoclonal antibodies, adoptive T-cell transfer, chimeric antigen receptor T- cells, tumor infiltrating lymphocytes, dendritic cells, natural killer cells, immune checkpoint inhibitors, laser ablation, and immune stimulating interstitial laser thermotherapy.
Book Synopsis Experimental and Applied Immunotherapy by : Jeffrey Medin
Download or read book Experimental and Applied Immunotherapy written by Jeffrey Medin and published by Springer Science & Business Media. This book was released on 2010-12-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapy is now recognized as an essential component of treatment for a wide variety of cancers. It is an interdisciplinary field that is critically dependent upon an improved understanding of a vast network of cross-regulatory cellular populations and a diversity of molecular effectors; it is a leading example of translational medicine with a favorable concept-to-clinical-trial timeframe of just a few years. There are many established immunotherapies already in existence, but there are exciting new cancer immunotherapies just on the horizon, which are likely to be more potent, less toxic and more cost effective than many therapies currently in use. Experimental and Applied Immunotherapy is a state-of-the-art text offering a roadmap leading to the creation of these future cancer-fighting immunotherapies. It includes essays by leading researchers that cover a wide variety of topics including T cell and non-T cell therapy, monoclonal antibody therapy, dendritic cell-based cancer vaccines, mesenchymal stromal cells, negative regulators in cancer immunology and immunotherapy, non-cellular aspects of cancer immunotherapy, the combining of cancer vaccines with conventional therapies, the combining of oncolytic viruses with cancer immunotherapy, transplantation, and more. The field of immunotherapy holds great promise that will soon come to fruition if creative investigators can bridge seemingly disparate disciplines, such as T cell therapy, gene therapy, and transplantation therapy. This text is a vital tool in the building of that bridge.
Book Synopsis Progress in Cancer Immunotherapy by : Shuren Zhang
Download or read book Progress in Cancer Immunotherapy written by Shuren Zhang and published by Springer. This book was released on 2016-05-30 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. Thanks to rapid advances in molecular biology and immunology, it has become increasingly evident that cancer growth is influenced by host immune responses. With the success of a number of clinical trials, immunotherapy has become a promising treatment modality of cancer. This book covers five major topics, including monoclonal antibodies, biological response modifiers, cancer vaccines, adoptive cellular therapy and oncolytic viruses. It also examines the combination of different immune strategies as well as the combination of immunotherapy with other treatments to increase anti-tumor effects. Through the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors.
Book Synopsis Targeted Cancer Immune Therapy by : Joseph Lustgarten
Download or read book Targeted Cancer Immune Therapy written by Joseph Lustgarten and published by Springer Science & Business Media. This book was released on 2009-10-09 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stimulation of the immune system’s ability to control and destroy tumors cont- ues to be the goal of cancer immune therapy; but the scope has rapidly expanded; approaches are constantly updated; new molecules are continually introduced; and immune mechanisms are becoming better understood. This book has no intention of covering every aspect of immune therapy but rather focuses on the novelty of cancer immune therapy in an attempt to give readers an opportunity to absorb the new aspects of immune therapy from a single source. In this regard, three areas were selected: cytokine immune therapy, cell-based immune therapy, and targeted immune therapy. In each of these three sections, only the novel aspects of immune therapy were described instead of attempting to cover any historical achievement. In the first section, Cytokine Immune Therapy, the IL12 family, IL18, IL21, IL24, IL28, and IL29 were emphasized in regard to the an- tumor function and application in treating tumors. Most of these selected cyt- ines were discovered in last 10 years. In the second section, Cell-based Immune Therapy, the focus was engineering potent immune regulatory or effector cells such as dendritic cells, T cells, and stem cells. Cell engineering design is primarily based on the increased understanding of the interaction of tumor antigen-presenting cells, antigen- specific effector cells, and the tumor microenvironment.
Book Synopsis Immunotherapy Cancer Battle by : Azhar ul Haque Sario
Download or read book Immunotherapy Cancer Battle written by Azhar ul Haque Sario and published by tredition. This book was released on 2024-08-30 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlock the future of cancer treatment with "Immunotherapy Cancer Battle: Innovative Approaches for Success." This comprehensive guide dives deep into the revolutionary world of cancer immunotherapy, exploring the cutting-edge strategies and breakthroughs that are reshaping how we combat this relentless disease. But this book isn't just about the successes—it's also about the ongoing challenges and innovations in the field. You'll explore how scientists and clinicians are continually pushing the boundaries, combining immunotherapies with traditional treatments like chemotherapy and radiation to maximize efficacy. You'll delve into the world of tumor-infiltrating lymphocytes (TILs) and their potential for personalized treatment, as well as the promise of cancer vaccines that could one day prevent or treat cancers with unparalleled precision. Ever wondered how viruses might be used to fight cancer? You'll find out in the chapter on oncolytic virus therapy, where viruses are re-engineered to selectively infect and destroy cancer cells. Plus, you'll read about the exciting developments in adoptive cell transfer (ACT) therapies, including T-cells, natural killer (NK) cells, and cytokine-induced killer (CIK) cells, all working together to diversify and strengthen our immune responses. The book also covers innovative strategies like bispecific antibodies, which simultaneously engage two different targets, and next-generation immune checkpoints that go beyond PD-1 and CTLA-4 to offer new hope for patients. You'll gain insight into the complexities of the tumor microenvironment and how modulating it can enhance the effectiveness of immunotherapies, creating a more hostile environment for cancer to thrive. And that's not all. "Immunotherapy Cancer Battle" takes you through the futuristic applications of nanotechnology and epigenetic modulation in cancer treatment, showcasing how these cutting-edge fields are being harnessed to boost immune responses and deliver therapies more precisely than ever before. You'll discover the potential of precision immunotherapy, which tailors treatments based on individual genetic and molecular profiles, and the role of artificial intelligence in optimizing these personalized strategies. Whether you are a medical professional, researcher, or someone affected by cancer, this book is an invaluable resource that not only informs but inspires. With its comprehensive coverage and forward-looking insights, "Immunotherapy Cancer Battle: Innovative Approaches for Success" is more than just a book—it's a blueprint for the future of cancer treatment. Join us in exploring these pioneering frontiers and envision a world where cancer is no longer a death sentence but a disease we can outsmart, treat, and one day, perhaps, completely eradicate.
