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Adhesion Molecules Function And Inhibition
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Book Synopsis Adhesion Molecules: Function and Inhibition by : Klaus Ley
Download or read book Adhesion Molecules: Function and Inhibition written by Klaus Ley and published by Springer Science & Business Media. This book was released on 2007-10-27 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
Book Synopsis Adhesion Molecules by : Victor R. Preedy
Download or read book Adhesion Molecules written by Victor R. Preedy and published by CRC Press. This book was released on 2016-04-19 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the structure and classification of adhesion molecules in relation to signaling pathways and gene expression. It discusses immunohistochemical localization, neutrophil migration, and junctional, functional, and inflammatory adhesion molecules in pathologies such as leukocyte decompression sickness and ischemia reperfusion injury. H
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Adhesion Molecules in Health and Disease by : Paul
Download or read book Adhesion Molecules in Health and Disease written by Paul and published by CRC Press. This book was released on 1997-05-16 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an overview of the structure, transcription regulation and binding characteristics of cellular adhesion molecules and their ligands in the maintenance of function, immunological reactions and inflammatory processes with organ systems. The text examines the role of adhesion molecules in biological processes such as morphogenesis, blood coagulation, tumour metastasis, bone tissue remodelling and transplant rejection.
Book Synopsis Inflammation and the Microcirculation by : D. Neil Granger
Download or read book Inflammation and the Microcirculation written by D. Neil Granger and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Book Synopsis Cell Adhesion Molecules by : Martin E. Hemler
Download or read book Cell Adhesion Molecules written by Martin E. Hemler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems. The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression.
Book Synopsis Cell Adhesion Molecules in Cancer and Inflammation by : Agamemnon A. Epenetos
Download or read book Cell Adhesion Molecules in Cancer and Inflammation written by Agamemnon A. Epenetos and published by CRC Press. This book was released on 1995-06-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Begins a series for clinicians, graduate students, and researchers in academia, regulatory agencies, or industry, offering monographs both on classes of adhesion molecules and on the function of such molecules in particular systems. Here the emphasis is on the clinical evaluation of these molecules, particularly as novel biochemical and genetic markers to define tumor differentiation based on functional and morphological assessment, and also their potential use as targets for biological therapy. Includes ten pages of color plates. Annotation copyright by Book News, Inc., Portland, OR
Book Synopsis Cell Adhesion Molecules and Matrix Proteins by : Shaker A. Mousa
Download or read book Cell Adhesion Molecules and Matrix Proteins written by Shaker A. Mousa and published by . This book was released on 1998 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Adhesive Interaction of Cells by : David Garrod
Download or read book The Adhesive Interaction of Cells written by David Garrod and published by Elsevier. This book was released on 1999-03-31 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of "The Adhesive Interaction of Cells" has been to assemble a series of reviews by leading international experts embracing many of the most important recent developments in this rapidly expanding field. The purpose of all biological research is to understand the form and function of living organisms and, by comprehending the normal, to find explanations and remedies for the abnormal and for disease conditions. The molecules involved in cell adhesion are of fundamental importance to the structure and function of all multicellular organisms. In this book, the contributors focus on the systems of vertebrates, especially mammals, since these are most relevant to human disease. It would have been equally possible to concentrate on developmental processes and adhesion in lower organisms. A major function of adhesion molecules is to bind cells to each other or to the extracellular matrix, but they are much more than "glue". Adhesions in animal tissues must be dynamic-forming, persisting, or declining in regulated fashion- to facilitate the mobility and turnover of tissue cells. Moreover, the majority of adhesion molecules are transmembrane molecules and thus provide links between the cells and their surroundings. This gives rise to another major function of adhesion molecules, the capacity to transduce signals across the hydrophobic barrier imposed by the plasma membrane. Such signal transduction is crucially important to many aspects of cellular function including the regulation of cell motility, gene expression, and differentiation. The work in this book progresses through four sections. Part I discusses the four major families of adhesion molecules themselves, the integrins (Green and Humphries), the cadherins (Stappert and Kemler), the selectins (Tedder et al.) and the immunoglobulin superfamily (Simmons); part 2 considers junctional complexes involved in cell interactions: focal adhesions and adherens junctions (Ben Ze'ev), desmosomes (Garrod et al.), and tight junctions (Citi and Cordenonsi). The signaling role of adhesion molecules is the focus of part 3, through integrins and the extracellular matrix (Edwards and Streuli), through platelet adhesion (Du and Ginsberg), and in the nervous system (Hemperley). In part 4, the aim is to show how adhesive phenomena contribute to important aspects of cell behavior and human health. Leukocyte trafficking (Haskard et al.), cancer metastasis (Marshall and Hart), cell migration (Paleck et al.), and implantation and placentation (Damsky et al.) are the topics considered in depth. The different sections are, of course, not mutually exclusive: it is both undesirable and impossible to separate structure from function when considering cell adhesion. Each chapter has its unique features, but some overlap is both invevitable and valuable since it provides different perspectives on closely related topics. We hope that the whole contributes a valuable and stimulating consideration of this important topic.
Book Synopsis Adhesion Protein Protocols by : Elisabetta Dejana
Download or read book Adhesion Protein Protocols written by Elisabetta Dejana and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adhesion molecules are of fundamental importance in the regulation of immunity, inflammation, tissue remodeling, and embryonic development. They comprise different families of homologous proteins, such as selectins, integrins, cadherins, and immunoglobins. In addition, beyond these groups, other str- tures with adhesive properties, such as proteoglycans, occludin, and CD44, have been characterized recently. An understanding of the type and characteristics of adhesive molecules expressed by the different cell types and the possibility of manipulating their activity promises considerable clinical potential. Antibodies, small peptidic and nonpeptidic molecules, have recently been used to inhibit thrombosis by blocking platelet aggregation or inflammation through inhibition of leukocyte infiltration and adhesion. Inhibitors of adhesive molecules are used in expe- mental systems for the study of tumor growth and dissemination. Among major goals in the field are the identification of new members of the known adhesive protein families and of independent new adhesive structures. After structural characterization, even more demanding is the study of the biological activity of the new proteins, and the development of simple, rapid tests for the screening of possible inhibitors. In this regard, the production of such reagents as fragments and antibodies would help define the structure–function relati- ship of individual proteins. Data available in the literature show the complexity of the adhesive process and how different molecular epitopes might contribute to the adhesive properties of a single structure. Finally, a new area of investi- tion is the characterization of the intracellular signaling cascade triggered by the engagement of transmembrane adhesive proteins.
Book Synopsis Cellular Adhesion by : Brian W. Metcalf
Download or read book Cellular Adhesion written by Brian W. Metcalf and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The books in this acclaimed series provide integrated, critical surveys of topics of current interest to the pharmaceutical industry. Cellular Adhesion: Molecular Definition to Therapeutic Potential covers the molecular definition of adhesion molecule structure and function, the biological consequences of cellular adhesion, and the therapeutic potential of targeting adhesion molecules.
Book Synopsis Cell Adhesion Molecules by : Vladimir Berezin
Download or read book Cell Adhesion Molecules written by Vladimir Berezin and published by Springer Science & Business Media. This book was released on 2013-11-18 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Adhesion Molecules: Implications in Neurological Diseases contains review articles on recent developments in the field of neural cell adhesion molecules (CAMs). The main focus is on the role of cell adhesion molecules in various neurological and neurodegenerative diseases. This perspective has been essentially overlooked in recently published books on neural CAMs. In addition, the contributors cover many newly identified cell adhesion molecules and some that have not received much attention in recent years. This books fills an important gap in the currently available literature.
Book Synopsis Adhesion Molecules: Function and Inhibition by : Klaus Ley
Download or read book Adhesion Molecules: Function and Inhibition written by Klaus Ley and published by Springer Science & Business Media. This book was released on 2007-08-16 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
Book Synopsis Adhesion Molecules and Cell Signaling by : Wolfgang Siess
Download or read book Adhesion Molecules and Cell Signaling written by Wolfgang Siess and published by Raven Press (ID). This book was released on 1995 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Adhesion written by D.R. Colman and published by Elsevier. This book was released on 1997-02-24 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: One prerequisite for the evolution of multicellular organisms was the invention of mechanisms by which cells could adhere to one another. At some point in our history, dividing cells no longer went their separate protozoic ways in the primordial oceans, but instead found that by maintaining an association, by sticking together but not fusing, numerous evolutionary advantages became possible. The subsequent development of specialized tissues and organs depended on the elaboration of incredibly sophisticated, regulatable cell-to-cell adhesion mechanisms which are known to operate in biological processes as diverse as the growth of the embryo, the immune response, the establishment of connections between nerve cells, and arteriosclerosis, to name just a few. Although we can only guess at the ancestral mechanisms that fostered the first primitive intercellular unions, some one billion years ago, we now recognize contemporary molecular "themes" with presumably ancient origins that mediate cell-cell interactions. The chapters in this book serve as useful, thought-provoking, but not exhaustive, commentaries on contemporary topics within the broad field of cell adhesion. If the reader detects a slight tilt toward those adhesion molecules that function in the nervous system, this is merely a reflection of this editor's interests, biases, and of course, limitations.
Book Synopsis Signaling Through Cell Adhesion Molecules by : Jun-Lin Guan
Download or read book Signaling Through Cell Adhesion Molecules written by Jun-Lin Guan and published by CRC Press. This book was released on 2019-04-30 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of signal transduction research is one of the fastest growing in all of biomedical research in recent years. Signaling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune responses, wound healing , and malignant transformation. However, it is only recently re
Book Synopsis Cell Adhesion and Human Disease by : Joan Marsh
Download or read book Cell Adhesion and Human Disease written by Joan Marsh and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts in their respective fields present papers concerned with the range of human diseases caused by defective or abnormal functioning of cell adhesion molecules. Discusses new therapeutic approaches to these maladies.
