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Addition Of An Intrafascicular Electrode At The Site Of Application Of A Multipolar Nerve Cuff Enhances The Opportunity For Selective Fascicular Activation
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Book Synopsis Addition of an Intrafascicular Electrode at the Site of Application of a Multipolar Nerve Cuff Enhances the Opportunity for Selective Fascicular Activation by :
Download or read book Addition of an Intrafascicular Electrode at the Site of Application of a Multipolar Nerve Cuff Enhances the Opportunity for Selective Fascicular Activation written by and published by . This book was released on 2001 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multipolar nerve cuffs are being developed to apply to peripheral trunk nerves in an effort to limit the number of implanted components of an FES system, while at the same time allowing specific fascicles within the cuffed nerve to be independently activated. Because the electrode contact sites of a multipolar circumferential fitted cuff are positioned only at the surface of the cuffed nerve, it is difficult to activate fascicules that are located deep within the nerve. This situation might be improved if one or more additional electrode contacts were provided within the core of the nerve. An obvious choice for such a contact is to use an intrafascicular electrode (IFE) such as those described by Horch and his colleagues. In our present study we inserted a single IFE into a trunk nerve that subserves the forelimb muscles in an adult anaesthetized pig. An 18 pole multichannel nerve cuff was then applied to the nerve at the same site. We stimulated different combinations of the cuff contact sites with and without the IFE while monitoring the evoked EMGs from an array of innervated forearm and shoulder muscles to assess the ability to activate different fascicles independently. The results have shown that the use of the IFE in combination with the normal cuff contacts can afford modest improvements in the degree of selective muscle activation that is possible.
Download or read book NTIS Alert written by and published by . This book was released on 2003 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Intrafascicular Electrodes for the Activation of Peripheral Nerves by : Aritra Kundu
Download or read book Intrafascicular Electrodes for the Activation of Peripheral Nerves written by Aritra Kundu and published by . This book was released on 2013-09 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: The success of a neural electrode is often measured by its performance in the selective stimulation of or recording from individual fascicles within a peripheral nerve without damaging the nerve. Neural prostheses are limited by the availability of peripheral neural electrodes that can be used to record the user's intention or to provide sensory feedback through functional electrical stimulation for an extended duration. Improvement in future neural prostheses may be achieved through the availability of multichannel, bidirectional neural interfaces, such as the transverse intrafascicular multichannel electrode (TIME). The aim of this thesis was to investigate the biofunctionality, biostability, and biosafety of the TIME in an animal model that bears a close neuroanatomical resemblance to the human. To this end, four research questions were formulated: 1) Is the pig model neuro-anatomically suitable for the simulation of the actions and reactions of a neural electrode in a large human-sized peripheral nerve? This question was addressed in study 1 in which a comparative morphology study was performed on the median and ulnar nerves of Danish landrace pigs and Gottingen mini-pigs. Nerve specimens were selected at different levels for analysis. The number of fascicles in each nerve was counted, and the fascicle diameters were measured. 2) How selective is the TIME compared to other intrafascicular electrodes, such as the thin-film longitudinal intrafascicular electrode (tfLIFE)? Study 2 was performed to address this question. A comparative stimulation selectivity study was performed in Danish Landrace pigs with the TIME and tfLIFE. Electrodes were implanted in the median nerve, and sequential electric stimulation was applied to individual contacts. The compound muscle action potentials of seven forelimb muscles were recorded to quantify muscle recruitment. 3) Is the TIME biostable and biofunctional for long-term implantation? This question was addressed in study 3 in which the chronic stimulation selectivity of the TIME was evaluated on Gottingen mini-pigs. 4) Does the TIME fulfil the criteria of biocompatibility and chronic stability? Study 4 was conducted to address this question. Immunohistological analysis was conducted on nerve specimens from chronic experiment pigs that had been implanted with TIMEs in study 3.
Book Synopsis Optimization of High Density Nerve Cuff Stimulation in Upper Extremity Nerves by : Natalie Amber Brill
Download or read book Optimization of High Density Nerve Cuff Stimulation in Upper Extremity Nerves written by Natalie Amber Brill and published by . This book was released on 2015 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall goal of this work is to optimize nerve cuff stimulation for selective activation of upper extremity nerves. The characterization of upper extremity nerve dimensions is important for electrode design development. Quantitative measures such as nerve diameter, number of fascicles, and fascicle diameters were used to guide neural electrode dimensions. The quantitative upper extremity measurements were used as a template to create upper extremity simulation models.We constructed physiologically based Finite Element Method (FEM) models of nerve cuff electrodes at low, moderate, and high contact densities at 16 nerve locations in median, ulnar, and radial nerves. We hypothesize that adding two flanking anodes to an active cathode is sufficient for optimal selectivity of fascicles in upper extremity nerves. We exhaustively tested one and two channel configurations, as well as, all three channel configuration within six contacts. Since the number of permutations of stimulation parameters increases exponentially by adding anodes, a genetic algorithm search routine was employed. Seventy-nine percent of all fascicles were selectively activated with high density electrodes and multiple channel stimulation. Only 2.5% of selective fascicles required more than 2 anodes in the stimulation configuration. The important implication of this work is that optimal system design requires high density nerve cuff electrodes, but no more than four simultaneously active stimulation channels routed through a multiplexor. We tested the capabilities of a high density electrode with multipolar stimulation in non-human primate upper extremity nerves. A high density Composite Flat Interface Nerve Electrode (CFINE) was implanted chronically in a non-human primate on the median, radial, and ulnar nerves. Electromyography (EMG) recordings were used to optimize nerve stimulation parameters to increase selective muscle activation of the hand and arm muscles using high density nerve cuffs with multipolar stimulation. The non-human primate nerves resembled human nerve simulations that had demonstrated limited selectivity improvements with multipolar, high density nerve cuffs. High density nerve cuffs with multipolar stimulation in non-human primates, however, increased the number of permutations of muscle activation sets in the non-human primate animal model when compared to single channel stimulation in low density nerve cuffs.
Book Synopsis Implantable Neural Prostheses 1 by : David Zhou
Download or read book Implantable Neural Prostheses 1 written by David Zhou and published by Springer Science & Business Media. This book was released on 2009-06-10 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant progress has been made in the development of neural prostheses to restore human functions and improve the quality of human life. Biomedical engineers and neuroscientists around the world are working to improve design and performance of existing devices and to develop novel devices for artificial vision, artificial limbs, and brain–machine interfaces. This book, Implantable Neural Prostheses 1: Devices and Applications,ispart one of a two-book series and describes state-of-the-art advances in techniques associated with implantable neural prosthetic devices and their applications. Devices covered include sensory prosthetic devices, such as visual implants, cochlear implants, auditory midbrain implants, and spinal cord stimulators. Motor prosthetic devices, such as deep brain stimulators, Bion microstimu- tors, the brain control and sensing interface, and cardiac electro-stimulation devices are also included. Progress in magnetic stimulation that may offer a non-invasive approach to prosthetic devices is introduced. Regulatory approval of implantable medical devices in the United States and Europe is also discussed.
Book Synopsis Implantable Sensors and Systems by : Guang-Zhong Yang
Download or read book Implantable Sensors and Systems written by Guang-Zhong Yang and published by Springer. This book was released on 2018-03-27 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implantable sensing, whether used for transient or long-term monitoring of in vivo physiological, bio-electrical, bio-chemical and metabolic changes, is a rapidly advancing field of research and development. Underpinned by increasingly small, smart and energy efficient designs, they become an integral part of surgical prostheses or implants for both acute and chronic conditions, supporting optimised, context aware sensing, feedback, or stimulation with due consideration of system level impact. From sensor design, fabrication, on-node processing with application specific integrated circuits, to power optimisation, wireless data paths and security, this book provides a detailed explanation of both the theories and practical considerations of developing novel implantable sensors. Other topics covered by the book include sensor embodiment and flexible electronics, implantable optical sensors and power harvesting. Implantable Sensors and Systems – from Theory to Practice is an important reference for those working in the field of medical devices. The structure of the book is carefully prepared so that it can also be used as an introductory reference for those about to enter into this exciting research and developing field.
Book Synopsis Targeted Muscle Reinnervation by : Todd A. Kuiken
Download or read book Targeted Muscle Reinnervation written by Todd A. Kuiken and published by Taylor & Francis. This book was released on 2013-07-23 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implement TMR with Your Patients and Improve Their Quality of LifeDeveloped by Dr. Todd A. Kuiken and Dr. Gregory A. Dumanian, targeted muscle reinnervation (TMR) is a new approach to accessing motor control signals from peripheral nerves after amputation and providing sensory feedback to prosthesis users. This practical approach has many advantage
Book Synopsis Neural Interface Engineering by : Liang Guo
Download or read book Neural Interface Engineering written by Liang Guo and published by Springer Nature. This book was released on 2020-05-04 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive reference to major neural interfacing technologies used to transmit signals between the physical world and the nervous system for repairing, restoring and even augmenting body functions. The authors discuss the classic approaches for neural interfacing, the major challenges encountered, and recent, emerging techniques to mitigate these challenges for better chronic performances. Readers will benefit from this book’s unprecedented scope and depth of coverage on the technology of neural interfaces, the most critical component in any type of neural prostheses. Provides comprehensive coverage of major neural interfacing technologies; Reviews and discusses both classic and latest, emerging topics; Includes classification of technologies to provide an easy grasp of research and trends in the field.
Download or read book Neural Engineering written by Bin He and published by Springer Science & Business Media. This book was released on 2013-01-09 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Engineering, 2nd Edition, contains reviews and discussions of contemporary and relevant topics by leading investigators in the field. It is intended to serve as a textbook at the graduate and advanced undergraduate level in a bioengineering curriculum. This principles and applications approach to neural engineering is essential reading for all academics, biomedical engineers, neuroscientists, neurophysiologists, and industry professionals wishing to take advantage of the latest and greatest in this emerging field.
Book Synopsis Encyclopedia of Medical Devices and Instrumentation by : John G. Webster
Download or read book Encyclopedia of Medical Devices and Instrumentation written by John G. Webster and published by Wiley-Interscience. This book was released on 1988 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: This objective, referenced collection of over 300 articles will cover every aspect of medical devices and instrumentation in four volumes, totalling about 3,000 pages. The Encyclopedia will define the discipline by bringing together the core of knowledge from all the fields encompassed by the application of engineering, physics, and computers to problems in medicine. Some of the many areas covered will include: anaesthesiology; burns; cardiology; clinical chemistry and engineering; critical care medicine; dermatology; dentistry; endocrinology; genetics; gynecology; microbiology; oncology; pharmacology; psychiatry; radiology; surgery; and urology. Cross-references and index included.
Book Synopsis Wireless Power Transfer and Data Communication for Neural Implants by : Gürkan Yilmaz
Download or read book Wireless Power Transfer and Data Communication for Neural Implants written by Gürkan Yilmaz and published by Springer. This book was released on 2017-01-01 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents new circuits and systems for implantable biomedical applications targeting neural recording. The authors describe a system design adapted to conform to the requirements of an epilepsy monitoring system. Throughout the book, these requirements are reflected in terms of implant size, power consumption, and data rate. In addition to theoretical background which explains the relevant technical challenges, the authors provide practical, step-by-step solutions to these problems. Readers will gain understanding of the numerical values in such a system, enabling projections for feasibility of new projects.
Book Synopsis Neuroprosthetics by : Kenneth W. Horch
Download or read book Neuroprosthetics written by Kenneth W. Horch and published by World Scientific. This book was released on 2004 with total page 1292 pages. Available in PDF, EPUB and Kindle. Book excerpt: A study of neuroprosthetics. It is broadly divided into three sections which address: neuroanatomy and neurophysiology, biomaterials and biocompatibility, stimulation and recording techniques; clinical applications of neuroprosthetics; and future developments.
Book Synopsis Ultra-thin Chip Technology and Applications by : Joachim Burghartz
Download or read book Ultra-thin Chip Technology and Applications written by Joachim Burghartz and published by Springer Science & Business Media. This book was released on 2010-11-18 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultra-thin chips are the "smart skin" of a conventional silicon chip. This book shows how very thin and flexible chips can be fabricated and used in many new applications in microelectronics, Microsystems, biomedical and other fields. It provides a comprehensive reference to the fabrication technology, post processing, characterization and the applications of ultra-thin chips.
Download or read book Biohybrid Systems written by Ranu Jung and published by John Wiley & Sons. This book was released on 2011-11-30 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discipline of neurodesign is a highly interdisciplinary one, while at the same time in the process of maturing towards real-life applications. The breakthrough about to be achieved is to close the loop in communication between neural systems and electronic and mechatronic systems and actually let the nervous system adapt to the feedback from the man-made systems. To master this loop, scientists need a sound understanding of neurology, from the cellular to the systems scale, of man-made systems and how to connect the two. These scientists comprise medical scientists, neurologists and physiologists, engineers, as well as biophysicists. And they need the topics in a coherently written work with chapters building upon another.
Book Synopsis Neural Prostheses by : William F. Agnew
Download or read book Neural Prostheses written by William F. Agnew and published by . This book was released on 1990 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neural Prostheses for Restoration of Sensory and Motor Function by : John K. Chapin
Download or read book Neural Prostheses for Restoration of Sensory and Motor Function written by John K. Chapin and published by CRC Press. This book was released on 2000-09-27 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prospect of interfacing the nervous system with electronic devices to stimulate or record from neural tissue suggests numerous possibilities in the field of neuroprosthetics. While the creation of a "six million dollar man" may still be far into the future, neural prostheses are rapidly becoming viable theories for a broad range of patients wit
Book Synopsis Micro Electro Mechanical Systems by : Qing-An Huang
Download or read book Micro Electro Mechanical Systems written by Qing-An Huang and published by Springer. This book was released on 2018-05-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook volume aims to provide a comprehensive, self-contained, and authoritative reference in MEMS. It covers the theoretical and practical aspects including but not limited to sensors, actuators, RF MEMS, micro fluids and bio MEMS systems. It is particularly recommended to undergraduates, postgraduates, researchers, scientists, and field experts. This comprehensive summary will provide a solid knowledge background and inspire innovations in this highly interdisciplinary field. The handbook series consists of 5 volumes: Micro/nano fabrication technology, MEMS, Nanomaterial, Nanomedicine and Applications of micro-/nanotechnologies in IT. Experienced researchers and experts are invited to contribute in each of these areas.The series is published under Springer Major Reference works, which allows continuous online update and publication. These features allow newcomers and other readers to keep in touch with the most up-to-date information in micro-/nanotechnologies.It presents an overview of the knowledge base, as well as selected topics and provides comprehensive and authoritative information on the field for researchers, engineers, scientists and graduate students who are involved in different aspects of micro-/nanotechnologies.This publication will provide inspiration for innovative research and application ideas for continued growth of the field.
