Activation Of Toll Like Receptor 3 Translates To Long Term Post Viral Lung Disease

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Activation of Toll-like Receptor 3 Translates to Long-term Post-viral Lung Disease

Author : Xinyu Wang (Immunologist)
Publisher :
ISBN 13 :
Total Pages : 48 pages
Book Rating : 4.:/5 (111 download)

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Book Synopsis Activation of Toll-like Receptor 3 Translates to Long-term Post-viral Lung Disease by : Xinyu Wang (Immunologist)

Download or read book Activation of Toll-like Receptor 3 Translates to Long-term Post-viral Lung Disease written by Xinyu Wang (Immunologist) and published by . This book was released on 2019 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic obstructive lung disease (COPD) causes substantial human and economic costs both in the US and worldwide. To identify the molecular mechanisms to allow for targeted therapies for COPD, we developed a high-fidelity mouse model of chronic lung inflammation using the natural rodent pathogen Sendai virus (SeV). While nucleic acid-sensing pattern recognition receptors are important for innate immune responses to viral pathogens, there have been few studies investigating their role in the context of chronic disease. Here we show that Toll-like receptor 3 (Tlr3) signaling is required for the development of chronic lung disease in a postviral mouse model. Activation of Tlr3 in inflammatory monocyte-derived dendritic cells (moDCs) is necessary for the development of chronic lung disease. moDCs form an immune cell niche that drives epithelial alveolar type II cell (AT2) proliferation and interleukin-33 (Il33) expression. Il33 then leads to activation of downstream effector immune cells that produce a chronic inflammatory disease phenotype.

SARS, MERS and other Viral Lung Infections

Author : David S. Hui
Publisher : European Respiratory Society
ISBN 13 : 1849840709
Total Pages : 148 pages
Book Rating : 4.8/5 (498 download)

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Book Synopsis SARS, MERS and other Viral Lung Infections by : David S. Hui

Download or read book SARS, MERS and other Viral Lung Infections written by David S. Hui and published by European Respiratory Society. This book was released on 2016-06-01 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Persistent Viral Infections

Author : R. Ahmed
Publisher : Wiley-Blackwell
ISBN 13 :
Total Pages : 754 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Persistent Viral Infections by : R. Ahmed

Download or read book Persistent Viral Infections written by R. Ahmed and published by Wiley-Blackwell. This book was released on 1999 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.

The Resolution of Inflammation

Author : Adriano Rossi
Publisher : Springer Science & Business Media
ISBN 13 : 376437506X
Total Pages : 246 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis The Resolution of Inflammation by : Adriano Rossi

Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Antiviral Substances (including Interferon).

Author :
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (2 download)

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Book Synopsis Antiviral Substances (including Interferon). by :

Download or read book Antiviral Substances (including Interferon). written by and published by . This book was released on 1977 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of the SARS-Coronavirus

Author : Sunil K. Lal
Publisher : Springer Science & Business Media
ISBN 13 : 364203683X
Total Pages : 330 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Molecular Biology of the SARS-Coronavirus by : Sunil K. Lal

Download or read book Molecular Biology of the SARS-Coronavirus written by Sunil K. Lal and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species of wild and domestic animals were co-housed, providing the ideal opportunities for inter-species tra- mission of viruses and other microbes. Once such a virus jumped species and attacked humans, the increased human mobility allowed the virus the opportunity for rapid spread. An infected patient from Guangdong who stayed for one day at a hotel in Hong Kong led to the transmission of the disease to 16 other guests who travelled on to seed outbreaks of the disease in Toronto, Singapore, and Vietnam, as well as within Hong Kong itself. The virus exploited the practices used in modern intensive care of patients with severe respiratory disease and the weakness in infection control practices within our health care systems to cause outbreaks within hospitals, further amplifying the spread of the disease. Health-care itself has become a two-edged sword.

Toll-Like Receptors (TLRs) and Innate Immunity

Author : Stefan Bauer
Publisher : Springer Science & Business Media
ISBN 13 : 3540721673
Total Pages : 243 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Toll-Like Receptors (TLRs) and Innate Immunity by : Stefan Bauer

Download or read book Toll-Like Receptors (TLRs) and Innate Immunity written by Stefan Bauer and published by Springer Science & Business Media. This book was released on 2007-12-11 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

Maternal Immunization

Author : Elke Leuridan
Publisher : Academic Press
ISBN 13 : 0128145838
Total Pages : 396 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Maternal Immunization by : Elke Leuridan

Download or read book Maternal Immunization written by Elke Leuridan and published by Academic Press. This book was released on 2019-11-26 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunization during pregnancy with currently recommended vaccines prevents infection in the mother, the unborn fetus, and the young infant, and there is an increasing focus from different stakeholders to use this approach for other infections of importance to protect these vulnerable groups. The aim of this Maternal Immunization book is to provide a contemporary overview of vaccines used in pregnancy (and the lactation period), with emphasis on aspects of importance for the target groups, namely, rationale for the use of vaccines in pregnancy, safety, immunogenicity (immunology), timing to vaccinate, repeat doses, protective effects in the mother, fetus, and infant, and public acceptance and implementation, of existing and of future vaccines. - Provides an overview of a quickly evolving topic. This will benefit the reader who wishes to rapidly become informed and up-to-date with new developments in this field - Suitable to a broad audience: scientific researchers, obstetricians, gynecologists, neonatologists, vaccinators, pediatricians, students, and industry. Maternal vaccination impacts a wide range of specialists - Allows health care professionals/researchers to gain insight into other aspects of vaccination in pregnancy outside of their specialism - Is coauthored by specialists from multiple disciplines, providing a diverse view of the subject, increasing its interest and appeal - Creates awareness of the current developments in this area of medicine and of the potential of maternal vaccination to improve the health of mothers and infants worldwide

Rhinoviruses

Author : David A. Jans
Publisher : Humana Press
ISBN 13 : 9781493915705
Total Pages : 0 pages
Book Rating : 4.9/5 (157 download)

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Book Synopsis Rhinoviruses by : David A. Jans

Download or read book Rhinoviruses written by David A. Jans and published by Humana Press. This book was released on 2014-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rhinoviruses: Methods and Protocols highlights the numerous molecular, cellular and in vivo tools now available to conduct human rhinovirus (HRV) research in an effort to increase understanding of the clinical disease caused by HRVs as well as the functions of its individual proteins and its replication. Human rhinoviruses are the major cause of common colds as well as being more recently recognized as the major viral cause of asthma and chronic obstructive pulmonary disease (COPD) exacerbations. The huge advancements in technical applications of biophysics and improvements in high-end imaging techniques have also had implications for HRV research among other infectious diseases. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Rhinoviruses: Methods and Protocols seeks to serve both professionals and novices with the latest technical advances in HRV research to ultimately enable the development of therapeutic approaches to combat HRV, and most importantly, its pathogenic effects in asthma exacerbation.

Advances in Immunology

Author : Frederick W. Alt
Publisher : Academic Press
ISBN 13 : 0080951023
Total Pages : 304 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Advances in Immunology by : Frederick W. Alt

Download or read book Advances in Immunology written by Frederick W. Alt and published by Academic Press. This book was released on 2009-05-26 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future. - Contributions from leading authorities and industry experts - Informs and updates on all the latest developments in the field

Handbook of Sepsis

Author : W. Joost Wiersinga
Publisher : Springer
ISBN 13 : 3319735063
Total Pages : 264 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Handbook of Sepsis by : W. Joost Wiersinga

Download or read book Handbook of Sepsis written by W. Joost Wiersinga and published by Springer. This book was released on 2018-04-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.

Advanced Biosensors for Virus Detection

Author : Raju Khan
Publisher : Academic Press
ISBN 13 : 0323859895
Total Pages : 478 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Advanced Biosensors for Virus Detection by : Raju Khan

Download or read book Advanced Biosensors for Virus Detection written by Raju Khan and published by Academic Press. This book was released on 2022-03-04 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Biosensors for Virus Detection: Smart Diagnostics to Combat Against the SARS-CoV2 Pandemic covers the development of biosensor-based approaches for the diagnosis and prognosis of viral infections, specifically coronaviruses. The book discusses wide-ranging topics of available biosensor-based technologies and their application for early viral detection. Sections cover the emergence of SARS-CoV, MERS-CoV and SARS-CoV2, the global health response, the impact on affected populations, state-of-the art biomarkers, and risk factors. Specific focus is given to COVID-19, with coverage of genomic profiling, strain variation and the pathogenesis of SARS-CoV2. In addition, current therapeutics, nano-abled advancements and challenges in the detection of SARS-CoV2 and COVID-19 management are discussed, along with the role of nanomaterials in the development of biosensors and how biosensors can be scaled up for clinical applications and commercialization. - Deals with biosensors-based approaches that could be exploited to design and develop high throughput, rapid and cost-effective diagnostics technologies for the early detection of viral infections - Illustrates the development of multiplexed, miniaturized analytical systems for point-of-care applications - Provides information about fabrication protocols for various biosensor based diagnostic approaches that could be directly implemented to develop a novel biosensor - Includes the past, present and future status of biosensors, along with information about biosensors currently under clinical trials

Evolving Mechanisms of Disease Tolerance

Author : Maziar Divangahi
Publisher : Frontiers Media SA
ISBN 13 : 2889634582
Total Pages : 183 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Evolving Mechanisms of Disease Tolerance by : Maziar Divangahi

Download or read book Evolving Mechanisms of Disease Tolerance written by Maziar Divangahi and published by Frontiers Media SA. This book was released on 2020-02-03 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NLR-protein functions in immunity

Author : Thomas A. Kufer
Publisher : Frontiers Media SA
ISBN 13 : 2889196216
Total Pages : 222 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis NLR-protein functions in immunity by : Thomas A. Kufer

Download or read book NLR-protein functions in immunity written by Thomas A. Kufer and published by Frontiers Media SA. This book was released on 2015-07-08 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nod-like receptor (NLR) family of proteins are evolutionary conserved molecules that in plants and mammals have been implicated in innate immune sensing of microbes and infection-associated physiological changes, contributing to immune protection of the challenged host organism through the instruction of inflammatory responses, antimicrobial defense and adaptive immunity. Recent data however suggests that the biological roles of NLR go beyond the function of classical pattern recognition molecules (PRM) as they have been implicated in essential cellular processes including autophagy, apoptosis, modification of signal transduction and gene transcription as well as reproductive biology. In this research topic, we aim to provide a comprehensive state-of the art overview of the emerging functions of NLR in plant and mammalian immunity, cell biology and reproductive biology. Potential topics may include, but are not limited to the following areas: • Functions of NLRs as PRMs in infection • Cross-talk of NLRs with other PRMs • Signal transduction pathways of NLRs • New functions of NLRs other than pattern recognition • Structural aspects of NLR activation • Mechanisms of NLRs in cell biological processes • Aspects of NLRs in reproductive biology • Functions of NLRs in plant immune responses