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Author : Michał Mleczko
Publisher :
ISBN 13 : 9783868539172
Total Pages : 187 pages
Book Rating : 4.5/5 (391 download)
Download or read book Acoustic Analysis of Ultrasound Contrast Agents written by Michał Mleczko and published by . This book was released on 2011 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : L. Hoff
Publisher : Springer Science & Business Media
ISBN 13 : 9401706131
Total Pages : 218 pages
Book Rating : 4.4/5 (17 download)
Download or read book Acoustic Characterization of Contrast Agents for Medical Ultrasound Imaging written by L. Hoff and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contrast agents for medical ultrasound imaging is a field of growing interest. A large amount of literature has been published on the medical applications of such contrast agents. However, there is no textbook giving a broad overview of the physics and acoustics of the agents. This monograph aims to fill this gap. The book is written by a physicist, from a physics point of view, and it tries to draw links from the physics and acoustics to the medical imaging methods, but medical applications are mainly included for background information. The book consists of nine chapters. The first three chapters give a broad overview of the acoustic theory for bubble-sound interaction, both linear and nonlinear. Most contrast agents are stabilized in a shell, and this shell can have a strong influence on the interaction between the bubbles and the ultrasound. The effect of the shell is given special attention, as this is not easily found in other bubble literature. The following chapters, 4, 5, 6, and 7, describe experimental and theoretical methods used to characterize the acoustic properties of the agents, and results of studies on some agents. Chapter 8 shows how the theory and the experimental results can be combined and used to model various phenomena by means of computer simulations. The main purpose of the simulations is to get insight into the mechanisms behind the described phenomena, not to get accurate predictions and values. The book is aimed at both newcomers into the field, as well as those who are more experienced but want better insight into the acoustics of the contrast bubbles.
Author : Peter Johan Anton Frinking
Publisher :
ISBN 13 : 9789090132785
Total Pages : 149 pages
Book Rating : 4.1/5 (327 download)
Download or read book Ultrasound Contrast Agents written by Peter Johan Anton Frinking and published by . This book was released on 1999 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gaio Paradossi
Publisher : Springer Science & Business Media
ISBN 13 : 8847014948
Total Pages : 199 pages
Book Rating : 4.8/5 (47 download)
Download or read book Ultrasound contrast agents written by Gaio Paradossi and published by Springer Science & Business Media. This book was released on 2010-07-16 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advancements in nano/micro materials and related characterization approaches allow the design of a new type of ultrasound contrast agents (UCAs) with enhanced multifunctional behaviour. This is chance is also supported by the recent achievements in modelling and signal processing. This book provides the state of art of the research activity of two successful European projects, TAMIRUT and SIGHT, addressing an integrated system, encompassing the contrast agent, the hardware equipment and the processing strategies, as a key tool for a combined diagnostic and therapeutic approaches (theranostics) in medical ultrasound. The work provides a highlight of the state of art in the research of novel ultrasound contrast agents (UCAs). Main progresses on the multifunctional aspects of next-generation UCAs concern targeting and drug release properties, perfusion and biointerface behaviour, ultrasound scattering performance, signal processing, electronic equipment.
Author : Riccardo Lencioni
Publisher : Springer Science & Business Media
ISBN 13 : 8847004764
Total Pages : 252 pages
Book Rating : 4.8/5 (47 download)
Download or read book Enhancing the Role of Ultrasound with Contrast Agents written by Riccardo Lencioni and published by Springer Science & Business Media. This book was released on 2006-08-06 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date overview on the clinical value of contrast agents in ultrasound. The volume moves from a background section on technique and methodology to the main sections on the clinical application of contrast ultrasound in the liver and in vascular diseases. A final section discusses results and prospects of contrast ultrasound modality in the other fields.
Author : Pankaj Jain
Publisher : ProQuest
ISBN 13 : 9780542817083
Total Pages : pages
Book Rating : 4.8/5 (17 download)
Download or read book Acoustical Investigation of Ultrasound Contrast Agents written by Pankaj Jain and published by ProQuest. This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrasound contrast agents are micron size bubbles used for medical purposes such as diagnostic ultrasound imaging and targeted drug delivery. These bubbles are encapsulated with a shell and have a sparingly soluble gas inside to prevent them from premature dissolution. When these bubbles are excited by the ultrasound they scatter and absorb energy from the sound field, thus leading to the attenuation of the ultrasound signal. In this thesis, we have developed a viscous and a viscoelastic model for the shell. Attenuation measured in vitro is compared with model predictions to obtain the characteristic model parameters (surface tension, shell elasticity, dilatational viscosity) for commercially available contrast agents. The viscous model predicts unusually high values of surface tension which motivated the viscoelastic model. We have also used both models to predict the scattered response of microbubbles. (Abstract shortened by UMI.).
Author : Yanjun Gong
Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (946 download)
Download or read book Acoustic Characterization of Ultrasound Contrast Agents with Lipid-coated Monodisperse Microbubbles written by Yanjun Gong and published by . This book was released on 2013 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Lipid-coated microbubbles, which have been widely used in diagnostic ultrasound as contrast agents, also show promising applications in medical therapy. The knowledge of acoustic behaviors and shell properties with respect to Ultrasound Contrast Agents (UCA) microbubbles can greatly enhance and extend their clinical applications. A polydimethylsiloxane (PDMS-based microfluidic flow-focusing device was fabricated to produce lipid-coated microbubbles with narrow size distribution and controllable mean diameters (3-12um). These monodisperse microbubbles show unique acoustic properties compared with commercial UCA microbubbles with wide size distribution, which makes it possible to investigate the relationship between microbubble size and attenuation coefficient, resonance frequency, or backscattering experimentally. Our studies show that monodisperse microbubbles can be tailored for optimal contrast enhancement in ultrasound imaging. By using an ultrasound spectroscopy method, the frequency-dependent attenuation coefficient for monodisperse microbubbles and polydisperse microbubbles were measured and compared. The results showed that decreasing the width of the microbubble size distribution would lead to a reduction in the bandwidth, and an increase in the magnitude of the attenuation spectrum. The resonance frequency determined by the attenuation coefficient peak was inversely proportional to the mean diameter of the monodisperse microbubble suspension. These conclusions corroborated the theoretical predications. The dependence of resonance frequency on acoustic pressure and lipid composition have also been examined and compared with theoretical calculations. The results demonstrated that the lipid shell of microbubbles behaviors nonlinearly, even at low pressure, which results in a decrease of resonance frequency as incident pressure was increased, approaching the resonance frequency of uncoated bubbles. Moreover, the length of the lipid hydrocarbon chain impacts the dependences of shell stiffness, attenuation coefficient, and resonance frequency on the excitation pressure. The frequency-dependent backscattering coefficients for monodisperse microbubbles have been investigated using a broadband pulses technique over different sizes, concentrations and pressures. The experimental results showed the same size-dependent resonance peaks as attenuation coefficient. It demonstrated that increasing the acoustic pressure caused a frequency shift of resonance peak, but no significant changes on magnitude. A linear dependence on microbubble concentration for backscatter coefficient was confirmed. In addition, the pressure-dependent backscattering coefficients at 2.25 MHz were studied. It is interesting to note that with the increase of incident pressure, the change of backscattering coefficients values, increase or decrease, were strongly dependent on the mean size of microbubbles.
Author : Chao Sun
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (87 download)
Download or read book Acoustic Characterisation of Ultrasound Contrast Agents at High Frequency written by Chao Sun and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hua Lee
Publisher : Springer Science & Business Media
ISBN 13 : 0306471086
Total Pages : 405 pages
Book Rating : 4.3/5 (64 download)
Download or read book Acoustical Imaging written by Hua Lee and published by Springer Science & Business Media. This book was released on 2006-03-02 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Symposium of Acoustical Imaging has been widely recognized as the premier forum for presentations of advanced research results in both theoretical and experimental development. Held regularly since 1968, the symposium brings together th leading international researchers in the area of acoustical imaging. The 24 meeting is the third time Santa Barbara hosted this international conference and it is the first time the meeting was held on the campus of the University of California, Santa Barbara. As many regular participants noticed over the years, this symposium has grown significantly in size due to the quality of the presentations as well as the organization itself. A few years ago multiple and poster sessions were introduced in order to accommodate this growth. In addition, the length of the presentations was shortened so more papers could be included in the sessions. During recent meetings there were discussions regarding the possibility of returning to the wonderful years when the symposium was organized in one single session with sufficient time to allow for in-depth presentation as well as discussions of each paper. And the size of the meeting was small enough that people were able to engage in serious technical interactions and all attendees would fit into one photograph. In light of the constraints of the limited budget with respect to the escalating costs it was not considered feasible.
Author : Alicia Clark
Publisher :
ISBN 13 :
Total Pages : 115 pages
Book Rating : 4.:/5 (19 download)
Download or read book Manipulating Microbubbles written by Alicia Clark and published by . This book was released on 2018 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrasound contrast agents are micron-sized bubbles that are used for ultrasound imaging enhancement and that can potentially be used for targeted drug delivery applications. One strategy to manipulate them inside the cardiovascular system is to use the Bjerknes force, caused by the phase difference between a transmitted ultrasound pressure wave and the microbubble volume oscillations induced by the pressure wave. Although the mechanism causing this force is well established, the balance between ultrasound-induced forces and hydrodynamic forces is poorly understood when the microbubbles are immersed in physiologically-realistic Reynolds and Womersley number flows. In this thesis, experiments were conducted in a cylindrical tube under steady and pulsatile flows over a range of Reynolds and Womersley numbers relevant to drug delivery in the systemic circulation. Two experimental setups were developed: one in which the microbubbles were imaged using a clinical ultrasound imaging system, and a second in which they were imaged by high-speed video using a long distance microscope. In the ultrasound experimental setup, a commercial L15-7io transducer was used to image microbubbles in quiescent, steady, and pulsatile flows. These experiments were extended in the optical experimental setup to explore higher Reynolds numbers. In the optical experiments, individual microbubble trajectories were captured at high magnification and high temporal resolution to determine the relationship between acoustic and hydrodynamic forces. The relative scaling of these forces was computed for different acoustic pressure amplitudes and pulse repetition frequencies. The Bjerknes force scaled linearly with pulse repetition frequency and quadratically with acoustic amplitude. The displacement of the microbubbles due to the ultrasound decreased with increasing Reynolds number suggesting a threshold for clinical applications due to the residence time of microbubbles in the ultrasound beam.
Author : Nicolaas de Jong
Publisher :
ISBN 13 :
Total Pages : 149 pages
Book Rating : 4.:/5 (554 download)
Download or read book Acoustic Properties of Ultrasound Contrast Agents written by Nicolaas de Jong and published by . This book was released on 1993 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Roman Gr. Maev
Publisher : Springer Science & Business Media
ISBN 13 : 1441986065
Total Pages : 510 pages
Book Rating : 4.4/5 (419 download)
Download or read book Acoustical Imaging written by Roman Gr. Maev and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the Proceedings of the 26th Symposium on Acoustical Imaging held inWindsor, Ontario, Canada during September 9-12, 2001. This traditional scientific event is recognized as a premier forum for the presentation of advanced research results in both theoretical and experimental development. The lAIS was conceived at a 1967Acoustical Holography meeting in the USA. Since then, these traditional symposia provide an opportunity for specialists who are working in this area to make new acquaintances, renew old friendships and present recent results of their research. Our Symposium has grown significantly in size due to a broad interest in various topics and to the quality of the presentations. For the firsttime in 40 years, the IAIS was held in the province of Ontario in Windsor, Canada's Automotive Capital and City of Roses. The 26th IAIS attracted over 100specialists from 13countries representing this interdisciplinary field in physical acoustics, image processing, applied mathematics, solid-state physics, biology and medicine, industrial applications and quality control technologies. The 26th lAIS was organized in the traditional way with only one addition-a Special Session "History of Acoustical Imaging" with the involvement of such well known scientists as Andrew Briggs, Noriyoshi Chubachi, Robert Green Jr., Joie Jones, Kenneth Erikson, and Bernhard Tittmann. Many of these speakers are well known scientists in their fields and we would like to thank them for making this session extremely successful.
Author : Thomas L. Szabo
Publisher : Academic Press
ISBN 13 : 012396542X
Total Pages : 829 pages
Book Rating : 4.1/5 (239 download)
Download or read book Diagnostic Ultrasound Imaging: Inside Out written by Thomas L. Szabo and published by Academic Press. This book was released on 2013-12-05 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnostic Ultrasound Imaging provides a unified description of the physical principles of ultrasound imaging, signal processing, systems and measurements. This comprehensive reference is a core resource for both graduate students and engineers in medical ultrasound research and design. With continuing rapid technological development of ultrasound in medical diagnosis, it is a critical subject for biomedical engineers, clinical and healthcare engineers and practitioners, medical physicists, and related professionals in the fields of signal and image processing. The book contains 17 new and updated chapters covering the fundamentals and latest advances in the area, and includes four appendices, 450 figures (60 available in color on the companion website), and almost 1,500 references. In addition to the continual influx of readers entering the field of ultrasound worldwide who need the broad grounding in the core technologies of ultrasound, this book provides those already working in these areas with clear and comprehensive expositions of these key new topics as well as introductions to state-of-the-art innovations in this field. - Enables practicing engineers, students and clinical professionals to understand the essential physics and signal processing techniques behind modern imaging systems as well as introducing the latest developments that will shape medical ultrasound in the future - Suitable for both newcomers and experienced readers, the practical, progressively organized applied approach is supported by hands-on MATLAB® code and worked examples that enable readers to understand the principles underlying diagnostic and therapeutic ultrasound - Covers the new important developments in the use of medical ultrasound: elastography and high-intensity therapeutic ultrasound. Many new developments are comprehensively reviewed and explained, including aberration correction, acoustic measurements, acoustic radiation force imaging, alternate imaging architectures, bioeffects: diagnostic to therapeutic, Fourier transform imaging, multimode imaging, plane wave compounding, research platforms, synthetic aperture, vector Doppler, transient shear wave elastography, ultrafast imaging and Doppler, functional ultrasound and viscoelastic models
Author : Jeroen Sijl
Publisher :
ISBN 13 : 9789036529518
Total Pages : 137 pages
Book Rating : 4.5/5 (295 download)
Download or read book Ultrasound Contrast Agents written by Jeroen Sijl and published by . This book was released on 2009 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pádraig Looney
Publisher :
ISBN 13 :
Total Pages : 199 pages
Book Rating : 4.:/5 (827 download)
Download or read book Theoretical Modelling of Ultrasound Contrast Agents written by Pádraig Looney and published by . This book was released on 2011 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis compares theoretical models of ultrasound contrast agents to the acoustic response from single Microbubbles(MBs). The acoustic response was compared using a range of driving parameters. A rigid shelled contrast agent and a lipid shelled contrast agent were used in the comparison. While attempts to model the behaviour of some contrast agents at low mechanical index (MI) have been successful at higher MI the behaviour of MBs is still not well understood. Understanding and predicting the response ofMBs to medical ultrasound can lead to improvements in the clinical use of MBs through improved contrast agent design or improved signal processing. Numerical models were developed to compare to three specific cases; 1) Rigid shelled contrast agents 2) Lipid shelled contrast agents 3) Responses from lipid shelled contrast agents that are hit by subsequent driving pulses. Three models were used to compare to the responses from single rigid shelled contrast agents. Two of these models have been used before and the third was developed based on the optical observations of the responses of these rigid shelled agents at these MI. Two shelled models were used to compare to the response of single lipid shelled MBs. Using statistical methods the parameters defining the shell properties were found. The parameters that gave best agreement with the lipid shelled data was then used with a model to account for the molecular diffusion of gas from a MB and a new model to account for the optically observed shedding of the shell from a MB to compare to the multiple response from single MBs. While the theoretical prediction of an acoustic response of a suspension of MBs or the radial oscillation of single MBs has been compared before to experimental data, the successful comparison of the acoustic response of single MBs to the theoretical prediction is the first of it's kind known to the author. The new theoretical model of the rigid shelled MB that was developed in this thesis gave better agreement with the experimental data than the other previously used models. The shell parameters of the lipid shelled MB were determined for the lowest driving amplitude and were in agreement with those measured previously from optical observations. Finally, the model for the shedding of the shell was shown to give quantitative agreement with the multiple acoustic responses from single MBs. When shedding of the shell was included the choice of constitutive equation for the shell was shown to strongly affect subsequent responses from the MB.
Author :
Publisher :
ISBN 13 : 9789175019512
Total Pages : 40 pages
Book Rating : 4.0/5 (195 download)
Download or read book Ultrasound Contrast Agents Loaded with Magnetic Nanoparticles written by and published by . This book was released on 2013 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Matthew Allan Masao Nakatsuka
Publisher :
ISBN 13 : 9781303323935
Total Pages : 124 pages
Book Rating : 4.3/5 (239 download)
Download or read book Development of Microbubble Contrast Agents with Biochemical Recognition and Tunable Acoustic Response written by Matthew Allan Masao Nakatsuka and published by . This book was released on 2013 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbubbles, consisting of gas-filled cores encapsulated within phospholipid or polymer shells, are the most widely used ultrasound contrast agents in the world. Because of their acoustic impedance mismatch with surrounding tissues and compressible gaseous interiors, they have high echogenicities that allow for efficient backscatter of ultrasound. They can also generate unique harmonic frequencies when insonated near their resonance frequency, depending on physical microbubble properties such as the stiffness and thickness of the encapsulating shell. Microbubbles are used to detect a number of cardiovascular diseases, but current methodologies lack the ability to detect and distinguish small, rapidly growing abnormalities that do not produce visible blockage or slowing of blood flow. This work describes the development, formulation, and validation of microbubbles with various polymer shell architectures designed to modulate their acoustic ability. We demonstrate that the addition of a thick disulfide crosslinked, poly(acrylic acid) encapsulating shell increases a bubble's resistance to cavitation and changes its resonance frequency. Modification of this shell architecture to use hybridized DNA strands to form crosslinks between the polymer chains allows for tuning of the bubble acoustic response. When the DNA crosslinks are in place, shell stiffness is increased so the bubbles do not oscillate and acoustic signal is muted. Subsequently, when these DNA strands are displaced, partial acoustic activity is restored. By using aptamer sequences with a specific affinity towards the biomolecule thrombin as the DNA crosslinking strand, this acoustic "ON/OFF" behavior can be specifically tailored towards the presence of a specific biomarker, and produces a change in acoustic signal at concentrations of thrombin consistent with acute deep venous thrombosis. Incorporation of the emulsifying agent poly(ethylene glycol) into the encapsulating shell improves microbubble yield and circulation half-life substantially, allowing for the in vivo detection of a blood clot in a rabbit model. The results presented here show a unique marriage of highly specific molecular imaging and sonography that could be tailored towards a wide variety of cardiovascular abnormalities.
